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1. Impfen bei Immundefizienz

Author

Laws, Hans-Jürgen, Baumann, Ulrich, Bogdan, Christian, Burchard, Gerd, Christopeit, Maximilian, Hecht, Jane, Heininger, Ulrich, Hilgendorf, Inken, Kern, Winfried, Kling, Kerstin, Kobbe, Guido, Külper, Wiebe, Lehrnbecher, Thomas, Meisel, Roland, Simon, Arne, Ullmann, Andrew, de Wit, Maike, and Zepp, Fred

Subjects
Bekanntmachungen – Amtliche Mitteilungen
Published
2020

2. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

Author

Cornely, Oliver A, Alastruey-Izquierdo, Ana, Arenz, Dorothee, Chen, Sharon CA, Dannaoui, Eric, Hochhegger, Bruno, Hoenigl, Martin, Jensen, Henrik E, Lagrou, Katrien, Lewis, Russell E, Mellinghoff, Sibylle C, Mer, Mervyn, Pana, Zoi D, Seidel, Danila, Sheppard, Donald C, Wahba, Roger, Akova, Murat, Alanio, Alexandre, Al-Hatmi, Abdullah MS, Arikan-Akdagli, Sevtap, Badali, Hamid, Ben-Ami, Ronen, Bonifaz, Alexandro, Bretagne, Stéphane, Castagnola, Elio, Chayakulkeeree, Methee, Colombo, Arnaldo L, Corzo-León, Dora E, Drgona, Lubos, Groll, Andreas H, Guinea, Jesus, Heussel, Claus-Peter, Ibrahim, Ashraf S, Kanj, Souha S, Klimko, Nikolay, Lackner, Michaela, Lamoth, Frederic, Lanternier, Fanny, Lass-Floerl, Cornelia, Lee, Dong-Gun, Lehrnbecher, Thomas, Lmimouni, Badre E, Mares, Mihai, Maschmeyer, Georg, Meis, Jacques F, Meletiadis, Joseph, Morrissey, C Orla, Nucci, Marcio, Oladele, Rita, Pagano, Livio, Pasqualotto, Alessandro, Patel, Atul, Racil, Zdenek, Richardson, Malcolm, Roilides, Emmanuel, Ruhnke, Markus, Seyedmousavi, Seyedmojtaba, Sidharthan, Neeraj, Singh, Nina, Sinko, János, Skiada, Anna, Slavin, Monica, Soman, Rajeev, Spellberg, Brad, Steinbach, William, Tan, Ban Hock, Ullmann, Andrew J, Vehreschild, Jörg J, Vehreschild, Maria JGT, Walsh, Thomas J, White, P Lewis, Wiederhold, Nathan P, Zaoutis, Theoklis, Chakrabarti, Arunaloke, and Mucormycosis ECMM MSG Global Guideline Writing Group

Subjects
Good Health and Well Being, Clinical Research, Medical Microbiology, Clinical Sciences, Public Health and Health Services, Humans, Mucormycosis, Disease Management, Mucormycosis ECMM MSG Global Guideline Writing Group, Microbiology
Abstract

Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality. Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical intervention is lifesaving. Guidance on the complex multidisciplinary management has potential to improve prognosis, but approaches differ between health-care settings. From January, 2018, authors from 33 countries in all United Nations regions analysed the published evidence on mucormycosis management and provided consensus recommendations addressing differences between the regions of the world as part of the "One World One Guideline" initiative of the European Confederation of Medical Mycology (ECMM). Diagnostic management does not differ greatly between world regions. Upon suspicion of mucormycosis appropriate imaging is strongly recommended to document extent of disease and is followed by strongly recommended surgical intervention. First-line treatment with high-dose liposomal amphotericin B is strongly recommended, while intravenous isavuconazole and intravenous or delayed release tablet posaconazole are recommended with moderate strength. Both triazoles are strongly recommended salvage treatments. Amphotericin B deoxycholate is recommended against, because of substantial toxicity, but may be the only option in resource limited settings. Management of mucormycosis depends on recognising disease patterns and on early diagnosis. Limited availability of contemporary treatments burdens patients in low and middle income settings. Areas of uncertainty were identified and future research directions specified.

Published
2019

3. Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

Author

Schweizerische Gesellschaft Für Hämatologie, Maschmeyer, Georg, Lilienfeld-Toal, Marie Von, Schweizerische Gesellschaft Für Medizinische Onkologie, Silling, Gerda, Sandherr, Michael, Wolf, Hans-Heinrich, Liss, Blasius Janusch, Buchheidt, Dieter, Egerer, Gerlinde, Österreichische Gesellschaft Für Hämatologie & Medizinische Onkologie, Cornely, Oliver Andreas, Rieger, Christina Theresa, Hentrich, Marcus, Vehreschild, Maria J. G. T., Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie, Ullmann, Andrew, Lehners, Nicola, Heinz, Werner, Mayer, Karin Tina, and Mellinghoff, Sibylle Christiane

Subjects
Medizin und Gesundheit
Published
2019
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4. Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

Author

Karthaus, Meinolf, Penack, Olaf, Ritter, Jörg, Kurzai, Oliver, Maschmeyer, Georg, Lilienfeld-Toal, Marie Von, Schweizerische Gesellschaft Für Medizinische Onkologie, Schmidt-Hieber, Martin, Buchheidt, Dieter, Rieger, Christina Theresa, Schwartz, Stefan, Rickerts, Volker, Hamprecht, Axel, Heinz, Werner, Schuelper, Nikolai, Schweizerische Gesellschaft Für Hämatologie, Weber, Thomas, Wolf, Hans-Heinrich, Vehreschild, Jörg Janne, Horger, Marius Stefan, Österreichische Gesellschaft Für Hämatologie & Medizinische Onkologie, Heußel, Claus Peter, Deutsche Gesellschaft Für Hämatologie Und Onkologie. Arbeitsgemeinschaft Infektiologie, Löffler, Jürgen, Christopeit, Maximilian Erich Joachim, Ruhnke, Markus, Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie, Behre, Gerhard, and Ullmann, Andrew

Subjects
Medizin und Gesundheit
Published
2019
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5. Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

Author

Penack, Olaf, Schweizerische Gesellschaft Für Hämatologie, Kalkreuth, Jana, Lilienfeld-Toal, Marie Von, Maschmeyer, Georg, Weber, Thomas, Klein, Michael, Schweizerische Gesellschaft Für Medizinische Onkologie, Silling, Gerda, Kochanek, Matthias, Wolf, Hans-Heinrich, Hauf, Elke, Schalk, Enrico, Österreichische Gesellschaft Für Hämatologie & Medizinische Onkologie, Berger, Annemarie, Heußel, Claus Peter, Rieger, Christina Theresa, Christopeit, Maximilian Erich Joachim, Hentrich, Marcus, Vehreschild, Maria J. G. T., Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie, Lehners, Nicola, Ullmann, Andrew, and Mayer, Karin Tina

Subjects
Medizin und Gesundheit
Published
2018
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6. Additional file 1: of Screening and contact precautions – A survey on infection control measures for multidrug-resistant bacteria in German university hospitals

Author

Biehl, Lena, Bertz, Hartmut, Bogner, Johannes, Ute-Helke Dobermann, Kessel, Johanna, Krämer, Carolin, Lemmen, Sebastian, Lilienfeld-Toal, Marie Von, Peter, Silke, Pletz, Mathias, Rohde, Holger, Schmiedel, Stefan, Schubert, Sören, Ullmann, Andrew, Fätkenheuer, Gerd, and Vehreschild, Maria

Abstract

English language print-version of survey. (PDF 123 kb)

Published
2017
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7. Stellungnahme zur Nutzenbewertung des IQWiG gemäß § 35a SGB V, Vorgangsnummer 2015-11-15-D-192, G-BA Bericht, veröffentlicht am 15. Februar 2016, IQWiG Bericht Nr. 360, veröffentlicht am 2. Februar 2016

Author

Mousset, Sabine, Ostermann, Helmut, Maschmeyer, Georg, Wörmann, Bernhard, Cornely, Oliver Andreas, Deutsche Krebsgesellschaft. Arbeitsgemeinschaft Für Internistische Onkologie, Deutschland. Gemeinsamer Bundesausschuss, Ullmann, Andrew, and Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie. Arbeitsgemeinschaft Für Internistische Onkologie

Subjects
Medizin und Gesundheit
Published
2016
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8. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management

Author

Denning, David W., Cadranel, Jacques, Beigelman-Aubry, Catherine, Ader, Florence, Chakrabarti, Arunaloke, Blot, Stijn, Ullmann, Andrew J., Dimopoulos, George, Lange, Christoph, Microbiology, European Society, Diseases, Infectious, Society, European Respiratory, The National Aspergillosis Centre, Wythenshawe Hospital-University Hospital of South Manchester, Service de Pneumologie - Oncologie Thoracique - Maladies Pulmonaires Rares [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Departement de radiologie médicale [Lausanne], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Pathogenèse des légionelles- Legionella pathogenesis (LegioPath), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Postgraduate Institute of Medical Education and Research, University of Queensland [Brisbane], University Hospital of Würzburg, 'Attikon' University Hospital, German Centre for Infection Research (DZIF), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Hemoptysis, Antifungal Agents, Bronchial Arteries, Aspergillosis, Antifibrinolytic agent, Amphotericin B, Tomography, Lung, Invasive Pulmonary Aspergillosis, Thoracic Surgery, Video-Assisted, Chronic pulmonary aspergillosis, Thoracic Surgery, Disease Management, Embolization, Therapeutic, Antifibrinolytic Agents, 3. Good health, X-Ray Computed, medicine.anatomical_structure, Tranexamic Acid, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Allergic bronchopulmonary aspergillosis, Therapeutic, Bronchial artery, Immunocompetence, Aspergilloma, medicine.drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 030106 microbiology, Video-Assisted, 03 medical and health sciences, Embolization, Immunocompromised Host, medicine.artery, Internal medicine, Bronchoscopy, medicine, Humans, business.industry, Aspergillosis, Allergic Bronchopulmonary, Allergic Bronchopulmonary, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Surgery, Mycetoma, Chronic Disease, Pulmonary Aspergillosis, business, Tomography, X-Ray Computed
Abstract

Chronic pulmonary aspergillosis (CPA) is an uncommon and problematic pulmonary disease, complicating many other respiratory disorders, thought to affect ∼240 000 people in Europe. The most common form of CPA is chronic cavitary pulmonary aspergillosis (CCPA), which untreated may progress to chronic fibrosing pulmonary aspergillosis. Less common manifestations include:Aspergillusnodule and single aspergilloma. All these entities are found in non-immunocompromised patients with prior or current lung disease. Subacute invasive pulmonary aspergillosis (formerly called chronic necrotising pulmonary aspergillosis) is a more rapidly progressive infection (Aspergillusinfection (microscopy or culture from biopsy) or an immunological response toAspergillusspp. and exclusion of alternative diagnoses, all present for at least 3 months.Aspergillusantibody (precipitins) is elevated in over 90% of patients. Surgical excision of simple aspergilloma is recommended, if technically possible, and preferablyviavideo-assisted thoracic surgery technique. Long-term oral antifungal therapy is recommended for CCPA to improve overall health status and respiratory symptoms, arrest haemoptysis and prevent progression. Careful monitoring of azole serum concentrations, drug interactions and possible toxicities is recommended. Haemoptysis may be controlled with tranexamic acid and bronchial artery embolisation, rarely surgical resection, and may be a sign of therapeutic failure and/or antifungal resistance. Patients with singleAspergillusnodules only need antifungal therapy if not fully resected, but if multiple they may benefit from antifungal treatment, and require careful follow-up.

Published
2015

9. [Infectious diseases as a clinical specialty in Germany and Europe]

Author

Kern, Winfried V, Fätkenheuer, Gerd, Tacconelli, Evelina, and Ullmann, Andrew

Subjects
Cross Infection, Infectious Disease Medicine, rationale Antibiotikaverordnung, Drug Resistance, antibiotic stewardship, Drug Resistance, Microbial, Bacterial Infections, Continuing, healthcare quality, Infektiologie, ärztliche Weiterbildung, Education, Anti-Bacterial Agents, Europe, Microbial, Medical, Germany, Behandlungsqualität, Infectious diseases specialty, postgraduate training, Education, Medical, Continuing, Guideline Adherence, Humans, Specialization
Abstract

Clinical infectious diseases have only slowly been established as a medical specialty in Germany. The density of infectious diseases (ID) specialists and the number of ID divisions in general hospitals is still limited when compared with the situation in many other European countries, and there is also a lack of hospital-based medical microbiologists and infection control doctors for many reasons. Often, there is a lack of understanding of the roles and the performance of ID specialists versus microbiologists. Experience in other countries shows that ID specialists are important as clinical experts at the bedside, can help ascertain healthcare quality and patient safety, and are perfectly suited for undertaking strategic tasks in the field of cost-effective antimicrobial therapy algorithms and antibiotic stewardship (ABS) in hospitals. ID specialists are responsible for infection control in several countries, can improve the utility of diagnostic microbiology and are key partners in translational research. We estimate that more than 1,000 additional ID specialists are needed in this country, and believe that specially trained ABS experts can take over parts of their responsibilities and tasks in smaller hospitals. More capacity and flexibility in postgraduate training in infectious diseases, antibiotic stewardship and infection control in Germany will be critical to address the problem of antimicrobial resistance. (As supplied by publisher).

Published
2015

10. The Epidemiology of Invasive Aspergillosis and Resistance Patterns of Aspergillus spp. in Germany - Interim Analysis of a Multicenter Observational Study

Author

Vehreschild, Maria J.G.T., Hamprecht, Axel, Adam, Thomas, Bader, Oliver, Becker, Caroline, Bekerdijan-Ding, Isabelle, Buchheidt, Dieter, Doelken, Gottfried, Elias, Johannes, Haase, Gerhard, Hahn-Ast, Corinna, Karthaus, Meinolf, Kekulé, Alexander, Krause, Stefan, Neumann, Silke, Keller, Peter, Kiehl, Michael, Rohde, Holger, La Rosée, Paul, Ruhnke, Markus, Schalk, Enrico, Schafhausen, Philippe, Schwartz, Stefan, Silling, Gerda, Schulz, Katrin, Staib, Peter, Ullmann, Andrew, Weber, Thomas, and Cornely, Oliver A.

Subjects
ddc: 610, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract

Introduction: Reports on increasing identification of azole-resistant Aspergillus fumigatus in clinical and environmental isolates have raised concerns with respect to the frequency and clinical relevance of resistant Aspergillus spp. in hematological high-risk patient populations. Methods: In an[for full text, please go to the a.m. URL], Frühjahrstagung der Sektion Antimykotische Chemotherapie 2014

Published
2014

11. Treatment of invasive fungal infections in cancer patients : updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Author

Mousset, Sabine, Buchheidt, Dieter, Heinz, Werner, Ruhnke, Markus, Cornely, Oliver Andreas, Egerer, Gerlinde, Krüger, William, Link, Hartmut, Neumann, Silke, Ostermann, Helmut, Panse, Jens, Penack, Olaf, Rieger, Christina, Schmidt-Hieber, Martin, Silling, Gerda, Südhoff, Thomas, Ullmann, Andrew J., Wolf, Hans-Heinrich, Maschmeyer, Georg, and Böhme, Angelika

Subjects
ddc:610
Abstract

The Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) here presents its updated recommendations for the treatment of documented fungal infections. Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. In recent years, new antifungal agents have been licensed, and agents already approved have been studied in new indications. The choice of the most appropriate antifungal treatment depends on the fungal species suspected or identified, the patient’s risk factors (e.g., length and depth of neutropenia), and the expected side effects. This guideline reviews the clinical studies that served as a basis for the following recommendations. All recommendations including the levels of evidence are summarized in tables to give the reader rapid access to the information.

Published
2013

13. Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

Author

Karthaus, Meinolf, Penack, Olaf, Ritter, Jörg, Krüger, William H., Maschmeyer, Georg, Krause, Stefan, Böhme, Angelika, Sandherr, Michael, Wolf, Hans-Heinrich, Vehreschild, Jörg Janne, Buchheidt, Dieter, Sieniawski, Michael, Deutsche Gesellschaft Für Hämatologie Und Onkologie. Arbeitsgemeinschaft Infektiologie, Cornely, Oliver Andreas, Ruhnke, Markus, Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie, Ullmann, Andrew, Heinz, Werner, and Einsele, Hermann

Subjects
Medizin und Gesundheit
Published
2012
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14. Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

Author

Bertz, Hartmut, Waldschmidt, Dirk Thomas, Karthaus, Meinolf, Penack, Olaf, Salwender, Hans, Krüger, William H., Sandherr, Michael, Wolf, Hans-Heinrich, Kiehl, Michael G., Buchheidt, Dieter, Egerer, Gerlinde, Reuter, Stefan, Cornely, Oliver Andreas, Auner, Holger, Ruhnke, Markus, Weißinger, Florian, Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie, Ullmann, Andrew, and Heinz, Werner

Subjects
Medizin und Gesundheit
Published
2012
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