1. [Primary pathological changes in cells infected with tick-borne encephalitis virus]
- Author
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B A, Erman, N Ia, Pashnina, L S, Subbotina, and V V, Tkhorzhevskií
- Subjects
Cell Nucleus ,Cytoplasm ,Swine ,Kidney ,Tritium ,Virus Replication ,Cell Line ,Encephalitis Viruses, Tick-Borne ,Cytopathogenic Effect, Viral ,Protein Biosynthesis ,Animals ,Autoradiography ,RNA ,Uridine ,Cell Nucleolus - Abstract
Synthesis and the content of RNA and protein in cells of the pig embryo kidneys infected with tick--borne encephalitis virus were studied by means of autoradiography and cytophotometry. Acceleration of synthesis and accumulation of RNA (in cellular structures) were estimated as over 125--200% of the initial level followed by a decrease in 12 hr when the virus release from the cells occurred. By the 2nd and 6--8th hr of infection (in the period of synthesis of early and late virus material), two peaks of protein contents over 123--131% were observed. The RNA and protein shifts are well correlated with the virus reproduction stages.
- Published
- 1975