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11 results on '"Vacher, Claire-Marie"'

2. Leptin but not CNTF induces PTP-1B expression : putative explanation of CNTF efficacy in leptin-resistant state

Author

Berthou, Flavien, Benomar, Yacir, Vacher, Claire-Marie, Bailleux, Virginie, Gertler, A., Djiane, Jean, Taouis, Mohammed, Université Paris-Sud - Paris 11 (UP11), Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), The Hebrew University of Jerusalem (HUJ), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], LEPTIN, [SDV]Life Sciences [q-bio], PTP-1B EXPRESSION, CNTF, CITIARY NEUROTROPHIC FACTOR, NEUROPHYSIOLOGIE, [INFO]Computer Science [cs], [INFO] Computer Science [cs], LEPTIN RESISTANT STATE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

3. Subcellular localization of CNTF and its receptors in the rat arcuate nucleus

Author

Couvreur, Odile, Jaillard, Danielle, Aubourg, Alain, Degrouard, Jeril, Vacher, Claire-Marie, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), Centre Commun de Microscopie Electronique, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], RECEPTORS, CILIARY NEUROTROPHIC FACTOR, [SDV]Life Sciences [q-bio], ARCUATE NUCLEUS, CNTF, RAT, SUBCELLULAR LOCALIZATION, [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

4. Impact d'un régime alimentaire hypercalorique sur la régulation centrale du CNTF et de ses récepteurs dans le noyau arqué de rat

Author

Vacher, Claire-Marie, Aubourg, Alain, Crépin, Delphine, Couvreur, Odile, Bailleux, Virginie, Nicolas, Violaine, Ferezou, Jacqueline, Gripois, Daniel, Gertler, A., Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), and The Hebrew University of Jerusalem (HUJ)

Subjects
CILIARY NEUROTROPHIC FACTOR, [SDV]Life Sciences [q-bio], RAT, NEUROPHYSIOLOGIE, [INFO]Computer Science [cs], REGIME ALIMENTAIRE HYPERCALORIQUE, REGULATION CENTRALE CNTF, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

5. Lack of cross-desensitization between leptin and prolactin signaling pathways despite the induction of SOCS-3 and PTP-1B

Author

Roy, Anne-France, Benomar, Yacir, Bailleux, Virginie, Vacher, Claire-Marie, Aubourg, Alain, Gertler, Arieh, Djiane, Jean, Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, [The Hebrew University of Jerusalem], The Hebrew University of Jerusalem (HUJ), ProdInra, Migration, and Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], endocrine system, endocrine system diseases, PTP-1B, [SDV]Life Sciences [q-bio], [SCCO.NEUR]Cognitive science/Neuroscience, digestive, oral, and skin physiology, [INFO]Computer Science [cs], PROLACTIN, SOCS-3, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, hormones, hormone substitutes, and hormone antagonists
Abstract

International audience; Hyperprolactinemia and hyperleptinemia occur during gestation and lactation with marked hyperphagia associated with leptin resistance. Prolactin (PRL) induces the expression of orexigenic neuropeptide Y (NPY) through the activation of JAK-2/STAT-3 signaling pathway in hypothalamic paraventricular nucleus (PVN) leading to hyperphagia. PRL may also act through the inhibition of anorexigenic effect of leptin via induction of suppressor of cytokine signaling 3 (SOCS-3). This paper aimed to co-localize PRL (PRL-R) and leptin (ObRb) receptors in the hypothalamus of female rats and investigate the possible cross-desensitization between PRL-R and ObRb. We showed that: 1) PRL-R and ObRb are expressed in the PVN and co-localized in the same neurons; 2) in lactating females leptin failed to activate JAK-2/STAT-3 signaling pathway; 3) in Chinese Hamster Ovary (CHO) stably co-expressing PRL-R and ObRb, overexposure to PRL did not affect leptin signaling but totally abolished PRL-dependent STAT-5 phosphorylation. The overexposure to leptin produces similar results with strong alteration of leptin-dependent STAT-3 phosphorylation, whereas PRL-dependent STAT-5 was not affected; and 4) CHO-ObRb/PRL-R cells overexposure to leptin or PRL induces the expression of negative regulators SOCS-3 and PTP-1B. Thus, we conclude that these negative regulators affect specifically the inducer signaling pathway; for instance, SOCS-3 induced by PRL will affect PRL-R signaling but not ObRb signaling and vice versa. Finally, the lack of cross-desensitization between PURL-R and ObRb suggests that hyperphagia observed during gestation and lactation may be attributed to a direct effect of PRL on NPYexpression, and is most likely exacerbated by the physiological leptin resistance state.

Published
2007
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6. Effets comparés du CNTF et de la leptine sur l'expression de leurs récepteurs respectifs dans le noyau arqué de souris

Author

Vacher, Claire-Marie, Aubourg, Alain, Crépin, Delphine, Lorsignol, Anne, Pénicaud, Luc, Gertler, A., Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), Neurobiologie, plasticité tissulaire et métabolisme énergétique (NPTME), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), and The Hebrew University of Jerusalem (HUJ)

Subjects
CILIARY NEUROTROPHIC FACTOR, [SDV]Life Sciences [q-bio], CNTF, [INFO]Computer Science [cs], NEUROBIOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

7. Co-localisation des récepteurs leptine et prolactine dans le noyau paraventriculaire : existe-t-il un dialogue entre leurs voies de signalisation ?

Author

Roy, Anne-France, Benomar, Yacir, Bailleux, Virginie, Vacher, Claire-Marie, Aubourg, Alain, Gertler, A., Djiane, Jean, Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), and Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

8. Co-localization of leptin and prolactin receptors in the paraventricular nucleus : evidence for the absence of cross-talk between the two signaling pathways

Author

Roy, Anne-France, Benomar, Yacir, Bailleux, Virginie, Vacher, Claire-Marie, Aubourg, Alain, Gertler, A., Djiane, Jean, Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), The Hebrew University of Jerusalem (HUJ), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], LEPTIN RECEPTOR, PARAVENTRICULAR NUCLEUS, [SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], SIGNALING PATHWAY, [INFO] Computer Science [cs], PROLACTIN RECEPTOR, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

9. Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice

Author

Vacher, Claire-Marie, Gassmann, M., Desrayaud, S., Challet, E., Bradia, A., Hoyer, D., Waldmeier, P., Kaupmann, K., Bettler, B., Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SCCO.NEUR]Cognitive science/Neuroscience, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

10. Le CNTF, un nouveau régulateur central de la prise alimentaire ?

Author

Vacher, Claire-Marie, Aubourg, Alain, Crépin, Delphine, Couvreur, Odile, Nicolas, V., Degrouard, J., Jaillard, D., Taouis, Mohammed, ProdInra, Migration, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), and Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], NEUROBIOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

11. Hyperdopaminergia and altered locomotor activity in GABA-B1-deficient mice

Author

Vacher, Claire-Marie, Gassmann, Martin, Desrayaud, Sandrine, Challet, Etienne, Bradaia, Amyaouch, Hoyer, Daniel, Waldmeier, Peter, Kaupmann, Klemens, Pevet, Paul, Bettler, Bernhard, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université de Bâle, Novartis, Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], DOPAMINE, GABA, GABA-B RECEPTORS, [SDV]Life Sciences [q-bio], HYPERLOCOMOTOR ACTIVITY, TYROSINE HYDROXYLASE, [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

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