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1. Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-D-aspartate receptor antagonists

Author

Gandolfi O., Dall'Olio R., Rimondini R., Bongrani S., Valsecchi B., Gandolfi O., Dall'Olio R., Rimondini R., Bongrani S., and Valsecchi B.

Subjects
Male, Dextroamphetamine, Repeated administration, H]MK801 binding, Cell Membrane, Synaptic Membranes, Brain, NMDA-antagonist, In Vitro Techniques, Hippocampus, Receptors, N-Methyl-D-Aspartate, Rats, Rats, Sprague-Dawley, Passive avoidance conditioning, 2-Amino-5-phosphonovalerate, Pargyline, Selegiline, Avoidance Learning, Rat, Animals, Ketamine, Dizocilpine Maleate, [, (-)-Deprenyl
Abstract

Repeated but not single administrations of the MAO type B inhibitor (-)-deprenyl (1 μmol/kg s.c. for 21 consecutive days) antagonized the impairment of passive avoidance retention induced by the N-methyl-d-aspartate (NMDA) receptor antagonists 2-amino-5-phosphonovalerate (APV), ketamine and dizocilpine (MK801), in rats. In well-washed membranes prepared from the hippocampi of rats repeatedly treated with (-)-deprenyl, the [3H]MK801 specific binding was increased. In contrast, repeated MAO B-selective doses of pargyline or (+)-amphetamine, as well as single injections with (-)-deprenyl failed to change [3H]MK801 binding. It is suggested that the effects of repeated (-)-deprenyl administrations upon NMDA receptors and upon the impairment of acquisition of a passive avoidance task induced by NMDA antagonists could be independent of MAO inhibition. © 1994.

Published
1994

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