Search

Your search keyword '"Wischnewsky M"' showing total 15 results
Start Over Author "Wischnewsky M" Database OpenAIRE
15 results on '"Wischnewsky M"'

1. Comparison of International Breast Cancer Guidelines - Where do the National Guidelines differ in Treatment Recommendations?

Author

Wöckel, A., Wolters, R., Schwentner, L., Wischnewsky, M., and Kreienberg, R.

Subjects
animal structures, ddc: 610, embryonic structures, 610 Medical sciences, Medicine, human activities
Abstract

Introduction: Numerous Clinical practice guidelines (CPGs) for the diagnosis and treatment of breast cancer have been developed by different national health institutions or medical societies. While a comparison of methodological criteria has been undertaken before, it is unknown whether these CPGs[for full text, please go to the a.m. URL], G-I-N Conference 2012

Published
2012
Full Text
View/download PDF

2. Effects of guideline adherent adjuvant treatment in primary breast cancer – A retrospective multi-center-cohort study of 3,976 patients

Author

Schwentner, L, Wolters, R, Wischnewsky, M, Kreienberg, R, and Wöckel, A

Subjects
body regions, ddc: 610, 610 Medical sciences, Medicine, humanities
Abstract

Background: The aim of that study was to analyze the impact of guideline adherent adjuvant treatment in early breast cancer on survival in a non-selected retrospective clinical cohort. Methods: A retrospective multi-center cohort study called BRENDA (‘breast cancer under evidence based guidelines’)[for full text, please go to the a.m. URL], G-I-N Conference 2012

Published
2012
Full Text
View/download PDF

5. ONCO-CONS (ONCO-DOC, ONCO-HELP)

Author

Wischnewsky, M. B.

Subjects
Medizininformatik, Expertensysteme, Onkologie, ddc:80
Abstract

München

Published
1998

10. Coronary computed tomography angiography indicates complexity of percutaneous coronary interventions

Author

Stähli, B. E., Bonassin, F., Goetti, R., Küest, S. M., Frank, M., Altwegg, L. A., Gebhard, C., Levis, A., Wischnewsky, M. B., Lüscher, T. F., Alkadhi, H., Philipp Kaufmann, Maier, W., University of Zurich, and Stähli, B E

Subjects
Male, 10042 Clinic for Diagnostic and Interventional Radiology, Coronary Stenosis, Calcinosis, 610 Medicine & health, Coronary Disease, 10181 Clinic for Nuclear Medicine, Middle Aged, Coronary Angiography, Radiography, Interventional, 2705 Cardiology and Cardiovascular Medicine, Plaque, Atherosclerotic, Radiographic Image Enhancement, ROC Curve, 10209 Clinic for Cardiology, Image Processing, Computer-Assisted, 2741 Radiology, Nuclear Medicine and Imaging, Humans, Female, Angioplasty, Balloon, Coronary, Tomography, X-Ray Computed, Aged, Retrospective Studies
Abstract

Coronary computed tomography angiography (CCTA) provides information regarding lesion morphology and three-dimensional coronary anatomy incremental to coronary angiography. We addressed the question whether preprocedural CCTA bears potential for guiding percutaneous coronary interventions (PCI).Sixty-six coronary lesions attempted with PCI within 6 months of preprocedural CCTA were retrospectively assessed. Lesion parameters from unenhanced computed tomography (CT) for calcium scoring and CCTA were analyzed and compared with PCI complexity. Complex PCI was defined as use of buddy wire, kissing balloon, necessity of high pressure balloons, or rotablator. Complex PCIs were observed in 32 interventions (48%). Median Agatston score and Hounsfield units were higher in lesions with complex as compared to those with non-complex interventions with 130 (interquartile range, 23-276) vs 29 (0-158; P=.01), and 493 (245-631) vs 341 (68-520 Hounsfield Units; P=.04), respectively. Median local plaque volume and plaque mass were higher in complex PCI with 17 (2-39) vs 5 (0-19.5 mm³; P=.007), and 48 (15-99) vs. 16 (1.5-63 mg hydroxyapatite/mm³; P=.03), respectively. Lesions leading to complex PCI were longer [1.8 (1.2-2.8) vs 1.3 (0.8-1.7) cm; P=.03], and had a higher rate of calcified plaques (23% vs 3%; P=.03). There was a significant correlation between CCTA- and angiography-derived local SYNTAX Scores (P.001); the CCTA-derived score seems to be predictive for failed and complex PCI (area under curve = 0.75 ± 0.13 and 0.66 ± 0.08, respectively).Preprocedural lesion assessment by CCTA indicates complexity of PCI. In patients with suspected complex coronary anatomy, prior CCTA adds important information for planning PCI.

11. Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndrome : new insights from the International Takotsubo Registry

Author

Wolfgang Koenig, John D. Horowitz, Hugo A. Katus, Paul Bridgman, Abhiram Prasad, Carlo Di Mario, Alessandro Cuneo, Johann Bauersachs, Jeroen J. Bax, Mathias Wolfrum, Carsten Tschöpe, Masanori Sano, Vanya Petkova, Lucas Jörg, Fausto J. Pinto, Petr Widimský, Masayuki Takahara, Rodolfo Citro, Iwao Ishibashi, Frank Ruschitzka, Thomas Münzel, Carmine Vecchione, Wolfgang Dichtl, Jan Galuszka, Kan Liu, Leonarda Galiuto, Grzegorz Opolski, Jozef Micek, Susanne Heiner, Florim Cuculi, Gerd Hasenfuß, Jerold S. Shinbane, Maike Knorr, Sebastiano Gili, Filippo Crea, Michael Würdinger, Alexandra Shilova, Malcolm Kohler, Lawrence Rajan, Christian F Clarenbach, Rena A. Levinson, Mikhail Gilyarov, Alexander Pott, Roman Pfister, Ekaterina Gilyarova, Claudius Jacobshagen, Adrian P. Banning, Michael Neuhaus, Jennifer Franke, Christian Templin, Christof Burgdorf, Daniel Beug, K.E. Juhani Airaksinen, Victoria L. Cammann, Thanh H Nguyen, Rafael Sumalinog, Monika Budnik, Wolfgang Rottbauer, Yoshio Kobayashi, Petr Tousek, Stephan B. Felix, Marco Roffi, Michael Böhm, Konrad A. Szawan, Toshiharu Himi, Ibrahim Akin, Christina Chan, Thomas F. Lüscher, Rafal Dworakowski, Annahita Sarcon, Ibrahim El-Battrawy, Miłosz Jaguszewski, Alexandru Patrascu, Eduardo Bossone, David E. Winchester, Michel Noutsias, Guido Michels, Gregor Poglajen, Christian Hauck, Fabrizio D'Ascenzo, Burkert Pieske, Christian Ukena, Thomas Fischer, Matteo Bianco, Lars S. Maier, Christoph Kaiser, Philippe Meyer, P. Christian Schulze, Behrouz Kherad, Gonçalo Pestana, Claudio Bilato, Ken Kato, Martin Kozel, Charanjit S. Rihal, Clément Delmas, Stefan Osswald, Olivier Lairez, Jelena R. Ghadri, Martin Borggrefe, Philip MacCarthy, Heribert Schunkert, Manfred Wischnewsky, Sara Dreiding, Hans Rickli, Tuija Vasankari, L. Christian Napp, Holger Thiele, Richard Kobza, Carla Paolini, Benjamin Meder, Mahir Karakas, Pedro Carrilho-Ferreira, Ruediger C. Braun-Dullaeus, Kato, K., Cammann, V. L., Napp, L. C., Szawan, K. A., Micek, J., Dreiding, S., Levinson, R. A., Petkova, V., Wurdinger, M., Patrascu, A., Sumalinog, R., Gili, S., Clarenbach, C. F., Kohler, M., Wischnewsky, M., Citro, R., Vecchione, C., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Kozel, M., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Sano, M., Ishibashi, I., Takahara, M., Himi, T., Kobayashi, Y., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Opolski, G., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, F., Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Templin, C., and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Acute respiratory insufficiency, acute respiratory insufficiency, Shock, Cardiogenic, 030204 cardiovascular system & hematology, Broken heart syndrome, chronic obstructive pulmonary disease, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Original Research Articles, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, takotsubo syndrome, Registries, Original Research Article, 030212 general & internal medicine, Survival analysis, Outcome, Takotsubo syndrome, intertak registry, business.industry, InterTAK Registry, Incidence (epidemiology), Cardiogenic shock, Chronic obstructive pulmonary disease, Hazard ratio, broken heart syndrome, Shock, Cardiogenic, Prognosis, medicine.disease, Survival Analysis, outcome, Confidence interval, 3. Good health, RC666-701, Heart failure, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Cardiology and Cardiovascular Medicine, business
Abstract

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License., Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002). Conclusions: The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome., C. T. has been supported by the H.H. Sheikh Khalifa binHamad Al-Thani Research Programme and the Swiss HeartFoundation. The InterTAK Registry is supported by the BissDavies Charitable Trust. L. S. M. has been supported by EUHORIZON 2020(SILICOFCM ID777204)

Published
2021

12. Intraventricular thrombus formation and embolism in Takotsubo syndrome insights from the international Takotsubo registry

Author

Alexandra Shilova, Davide Di Vece, Johann Bauersachs, Wolfgang Koenig, Michael Neuhaus, Rodolfo Citro, Jose David Arroja, Adrian P. Banning, Jennifer Franke, Charanjit S. Rihal, Abhiram Prasad, Carlo Di Mario, Michael Böhm, Carsten Tschöpe, Burkhardt Seifert, Filippo Crea, Christian Templin, David E. Winchester, Hugo A. Katus, Clément Delmas, Pedro Carrilho-Ferreira, Paul Bridgman, Petr Tousek, Guido Michels, Fausto J. Pinto, Sebastiano Gili, Jelena R. Ghadri, Petr Widimský, Burkert Pieske, Jeroen J. Bax, Christian Ukena, Christoph Kaiser, Wolfgang Dichtl, Christof Burgdorf, Philippe Meyer, Christina Chan, Gerd Hasenfuß, Philip MacCarthy, Mikhail Gilyarov, Leonarda Galiuto, Grzegorz Opolski, Susanne Heiner, Ruediger C. Braun-Dullaeus, Alexander Pott, Annahita Sarcon, Ekaterina Gilyarova, Michel Noutsias, Lawrence Rajan, Claudius Jacobshagen, Roman Pfister, Behrouz Kherad, John D. Horowitz, Martin Borggrefe, Mahir Karakas, Stefan Osswald, Victoria L. Cammann, Katharina J. Ding, Jan Galuszka, Wolfgang Rottbauer, Ibrahim El-Battrawy, Stephan B. Felix, Martin Kozel, Ibrahim Akin, Thomas F. Lüscher, Frank Ruschitzka, Thomas Fischer, Fabrizio D'Ascenzo, Rafal Dworakowski, Olivier Lairez, L. Christian Napp, Holger Thiele, Eduardo Bossone, Thomas Münzel, Claudio Bilato, Maike Knorr, K.E. Juhani Airaksinen, Florim Cuculi, Carla Paolini, Konrad A. Szawan, Richard Kobza, Alessandro Cuneo, Barbara E. Stähli, Heribert Schunkert, Miłosz Jaguszewski, Manfred Wischnewsky, Tuija Vasankari, Ding, Kj, Cammann, Vl, Szawan, Ka, Stähli, Be, Wischnewsky, M, Di Vece, D, Citro, R, Jaguszewski, M, Seifert, B, Sarcon, A, Knorr, M, Heiner, S, Gili, S, D'Ascenzo, F, Neuhaus, M, Napp, Lc, Franke, J, Noutsias, M, Burgdorf, C, Koenig, W, Kherad, B, Rajan L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Pott, A, Meyer, P, Arroja, Jd, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Paolini, C, Bilato, C, Carrilho-Ferreira, P, Opolski, G, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Chan, C, Bridgman, P, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Gilyarova, E, Shilova, A, Gilyarov, M, Kozel, M, Tousek, P, Widimský, P, Winchester, De, Galuszka, J, Ukena, C, Horowitz, Jd, Di Mario, C, Prasad A, Rihal, C, Pinto, Fj, Crea, F, Borggrefe, M, Braun-Dullaeus, Rc, Rottbauer, W, Bauersachs, J, Katus, Ha, Hasenfuß, G, Tschöpe, C, Pieske, Bm, Thiele, H, Schunkert, H, Böhm, M, Felix, Sb, Münzel, T, Bax, Jj, Lüscher, Tf, Ruschitzka, F, Ghadri, Jr, Bossone, E, and Templin, C.

Subjects
Male, Coronary angiography, Time Factors, Radionuclide ventriculography, 030204 cardiovascular system & hematology, Coronary Angiography, Electrocardiography, 0302 clinical medicine, Risk Factors, Registries, 030212 general & internal medicine, Framingham Risk Score, medicine.diagnostic_test, Incidence, Incidence (epidemiology), Magnetic Resonance Imaging, 3. Good health, Europe, Survival Rate, Cine, thrombus, cardiovascular system, Cardiology, outcome, Female, Cardiology and Cardiovascular Medicine, Takotsubo syndrome, medicine.medical_specialty, Heart Diseases, Heart Ventricles, Magnetic Resonance Imaging, Cine, risk score, Risk Assessment, embolism, 03 medical and health sciences, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, cardiovascular diseases, Thrombus, Radionuclide Ventriculography, Aged, business.industry, Australia, Thrombosis, medicine.disease, United States, Embolism, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, business, Follow-Up Studies
Abstract

Objective: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified. Approach and Results: TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0–38 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction ≤30%, previous vascular disease, and a white blood cell count on admission >10×10 3 cells/μL emerged as independent predictors for thrombus formation or embolism. Conclusions: Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01947621.

Published
2020

13. Long-Term Prognosis of Patients With Takotsubo Syndrome

Author

John D. Horowitz, Thomas Münzel, David E. Winchester, Guido Michels, Katharina J. Ding, Wolfgang Koenig, Jeroen J. Bax, Burkert Pieske, Mahir Karakas, Christian Ukena, K.E. Juhani Airaksinen, Christoph Kaiser, Sebastiano Gili, Stephan B. Felix, Rafal Dworakowski, Christian Templin, Claudius Jacobshagen, Abhiram Prasad, Fabrizio D'Ascenzo, Lawrence Rajan, Martin Borggrefe, Rena A. Levinson, Christof Burgdorf, Florim Cuculi, Petr Tousek, Thomas F. Lüscher, Alexandra Shilova, Mikhail Gilyarov, Victoria L. Cammann, Roman Pfister, Frank Ruschitzka, Alessandro Candreva, Filippo Crea, Davide Di Vece, Wolfgang Rottbauer, Ruediger C. Braun-Dullaeus, Heribert Schunkert, Carsten Tschöpe, Stefan Osswald, Rodolfo Citro, Burkhardt Seifert, Annahita Sarcon, Ibrahim Akin, Gerd Hasenfuß, Leonarda Galiuto, L. Christian Napp, Holger Thiele, Ekaterina Gilyarova, Grzegorz Opolski, Susanne Heiner, Michel Noutsias, Johann Bauersachs, Miłosz Jaguszewski, Alessandro Cuneo, Hugo A. Katus, Olivier Lairez, Ibrahim El-Battrawy, Wolfgang Dichtl, Jozef Micek, Philip MacCarthy, Rahel Bianchi, Maike Knorr, Ken Kato, Adrian P. Banning, Jelena-R. Ghadri, Martin Kozel, Michael Böhm, Konrad A. Szawan, Jennifer Franke, Manfred Wischnewsky, Klaus Empen, Tuija Vasankari, Eduardo Bossone, Richard Kobza, Beatrice Bacchi, Susanne A. Schlossbauer, Petr Widimský, Stjepan Jurisic, Samir M. Said, Thomas Fischer, Clément Delmas, Ghadri, Jr, Kato, K, Cammann, Vl, Gili, S, Jurisic, S, Di Vece, D, Candreva, A, Ding, Kj, Micek, J, Szawan, Ka, Bacchi, B, Bianchi, R, Levinson, Ra, Wischnewsky, M, Seifert, B, Schlossbauer, Sa, Citro, R, Bossone, E, Munzel, T, Knorr, M, Heiner, S, D'Ascenzo, F, Franke, J, Sarcon, A, Napp, Lc, Jaguszewski, M, Noutsias, M, Katus, Ha, Burgdorf, C, Schunkert, H, Thiele, H, Bauersachs, J, Tschope, C, Pieske, Bm, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Hasenfuss, G, Karakas, M, Koenig, W, Rottbauer, W, Said, Sm, Braun-Dullaeus, Rc, Banning, A, Cuculi, F, Kobza, R, Fischer, Ta, Vasankari, T, Airaksinen, Kej, Opolski, G, Dworakowski, R, Maccarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Crea, F, Dichtl, W, Empen, K, Felix, Sb, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Borggrefe, M, Horowitz, J, Kozel, M, Tousek, P, Widimsky, P, Gilyarova, E, Shilova, A, Gilyarov, M, Winchester, De, Ukena, C, Bax, Jj, Prasad, A, Bohm, M, Luscher, Tf, Ruschitzka, F, and Templin, C

Subjects
Male, Acute coronary syndrome, medicine.medical_specialty, Time Factors, 030204 cardiovascular system & hematology, tako tsubo syndrome, acute coronary syndrome, broken heart syndrome, classification, outcome, stress factor, Broken heart syndrome, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, Registries, 030212 general & internal medicine, Mortality, Aged, Aged, 80 and over, Takotsubo syndrome, business.industry, Mortality rate, Electroencephalography, Emotional stress, Middle Aged, ta3121, Prognosis, Stress factor, medicine.disease, 3. Good health, Physical stress, Cardiology and Cardiovascular Medicine, Cohort, Female, Nervous System Diseases, business, Stress, Psychological, Follow-Up Studies
Abstract

Background Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive. Objectives This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers. Methods Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions. Results Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients. Conclusions Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (International Takotsubo Registry [InterTAK Registry]; NCT01947621)

Published
2018

14. Coexistence and outcome of coronary artery disease in Takotsubo syndrome

Author

Jelena R. Ghadri, Pedro Carrilho-Ferreira, Wolfgang Koenig, Carla Paolini, Adrian P. Banning, Alessandro Cuneo, Jeroen J. Bax, Petr Widimský, Manfred Wischnewsky, Yoichi Imori, Hugo A. Katus, Paul Bridgman, Martin Borggrefe, Tuija Vasankari, David E. Winchester, Annahita Sarcon, Abhiram Prasad, Alexander Pott, Claudius Jacobshagen, Sebastiano Gili, John D. Horowitz, Heribert Schunkert, Frank Ruschitzka, Stephan B. Felix, Michael Böhm, Guido Michels, Lars S. Maier, Fausto J. Pinto, Carlo Di Mario, Ruediger C. Braun-Dullaeus, Thomas F. Lüscher, Philippe Meyer, Lawrence Rajan, Burkert Pieske, Thomas Münzel, Stefan Osswald, Gerd Hasenfuß, Rodolfo Citro, Olivier Lairez, Mahir Karakas, Florim Cuculi, Christian Ukena, Victoria L. Cammann, Alexandra Shilova, Jose David Arroja, Leonarda Galiuto, Grzegorz Opolski, Christoph Kaiser, Wolfgang Rottbauer, Christian Templin, Carsten Tschöpe, Ibrahim Akin, Ioana Sorici-Barb, Susanne Heiner, Jennifer Franke, Fabrizio D'Ascenzo, Johann Bauersachs, Richard Kobza, Christof Burgdorf, Michael Neuhaus, P. Christian Schulze, Daniel Beug, Petr Tousek, Filippo Crea, Monika Budnik, Miłosz Jaguszewski, Roman Pfister, Konrad A. Szawan, Ekaterina Gilyarova, Philip MacCarthy, Wolfgang Dichtl, Yoshio Kobayashi, Jan Galuszka, Michel Noutsias, Christina Chan, Thomas Fischer, Matteo Bianco, Ibrahim El-Battrawy, L. Christian Napp, Holger Thiele, Karolina Polednikova, Claudio Bilato, Charanjit S. Rihal, Clément Delmas, Rafal Dworakowski, Mikhail Gilyarov, Eduardo Bossone, Gregor Poglajen, Behrouz Kherad, Ken Kato, Christian Hauck, Maike Knorr, Eugene Braunwald, K.E. Juhani Airaksinen, Christian Napp, L., Cammann, V. L., Jaguszewski, M., Szawan, K. A., Wischnewsky, M., Gili, S., Knorr, M., Heiner, S., Citro, R., Bossone, E., D'Ascenzo, F., Neuhaus, M., Franke, J., Sorici-Barb, I., Noutsias, M., Burgdorf, C., Koenig, W., Kherad, B., Sarcon, A., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Pott, A., Meyer, P., Arroja, J. D., Banning, A., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Juhani Airaksinen, K. E., Hauck, C., Paolini, C., Bilato, C., Imori, Y., Kato, K., Kobayashi, Y., Opolski, G., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Dichtl, W., Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., El-Battrawy, I., Akin, I., Gilyarova, E., Shilova, A., Gilyarov, M., Horowitz, J. D., Polednikova, K., Tousek, P., Widimsky, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Mario, C. D., Prasad, A., Rihal, C. S., Christian Schulze, P., Bianco, M., Crea, F., Borggrefe, M., Maier, L. S., Pinto, F. J., Braun-Dullaeus, R. C., Rottbauer, W., Katus, H. A., Hasenfuss, G., Tschope, C., Pieske, B. M., Thiele, H., Schunkert, H., Bohm, M., Felix, S. B., Munzel, T., Bax, J. J., Bauersachs, J., Braunwald, E., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Templin, C., and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Acute coronary syndrome, medicine.medical_treatment, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Takotsubo Cardiomyopathy, Internal medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Acute Coronary Syndrome, 10. No inequality, Cardiac catheterization, Outcome, medicine.diagnostic_test, business.industry, Incidence, Percutaneous coronary intervention, medicine.disease, 3. Good health, Coronary occlusion, Heart failure, Angiography, Cardiology, Cardiology and Cardiovascular Medicine, business, Takotsubo syndrome
Abstract

Copyright © 2020 European Society of Cardiology, Aims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. Methods and results: Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort. Conclusions: Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome.

Published
2019

15. Age -Related Variations in Takotsubo Syndrome

Author

Behrouz Kherad, Roman Pfister, Ken Kato, Stefan Osswald, Thanh H Nguyen, Benjamin Meder, Alessandro Cuneo, Toshiharu Himi, Stephan B. Felix, Marco Roffi, Lawrence Rajan, Thomas F. Lüscher, David E. Winchester, Sebastiano Gili, Gerd Hasenfuß, Guido Michels, Ibrahim El-Battrawy, Petr Widimský, Olivier Lairez, Victoria L. Cammann, Rafal Dworakowski, Eduardo Bossone, Mahir Karakas, Charanjit S. Rihal, Burkert Pieske, Barbara E. Stähli, Gregor Poglajen, Wolfgang Rottbauer, Leonarda Galiuto, Grzegorz Opolski, Christian Ukena, Susanne Heiner, Christoph Kaiser, Christian Hauck, Filippo Crea, Wolfgang Koenig, Ibrahim Akin, Christof Burgdorf, Carsten Tschöpe, Clément Delmas, Yoshio Kobayashi, K.E. Juhani Airaksinen, Florim Cuculi, Mikhail Gilyarov, Pedro Carrilho-Ferreira, Masayuki Takahara, Ali Al-Shammari, Christina Chan, Jerold S. Shinbane, Miłosz Jaguszewski, Hugo A. Katus, Fabrizio D'Ascenzo, Wolfgang Dichtl, Jehangir Din, Paul Bridgman, John D. Horowitz, Toshihiro Shoji, Jan Galuszka, Monika Budnik, Claudio Bilato, Jelena R. Ghadri, Alexander Pott, Christian Templin, Konrad A. Szawan, Claudius Jacobshagen, Ruediger C. Braun-Dullaeus, Gonçalo Pestana, Abhiram Prasad, Carlo Di Mario, Fausto J. Pinto, Maike Knorr, Iwao Ishibashi, Thomas Münzel, Lars S. Maier, Jennifer Franke, Mathias Wolfrum, Adrian P. Banning, Philippe Meyer, Kan Liu, Alexandra Shilova, Davide Di Vece, Daniel Beug, Michael Neuhaus, Martin Borggrefe, Michael Böhm, Annahita Sarcon, Heribert Schunkert, Petr Tousek, Rena A. Levinson, Ekaterina Gilyarova, Frank Ruschitzka, Carla Paolini, Michel Noutsias, Richard Kobza, Thomas Fischer, Matteo Bianco, P. Christian Schulze, Lucas Jörg, Manfred Wischnewsky, Sara Dreiding, Hans Rickli, Tuija Vasankari, Rodolfo Citro, Jeroen J. Bax, Philip MacCarthy, L. Christian Napp, Holger Thiele, Karolina Polednikova, Johann Bauersachs, Repositório da Universidade de Lisboa, Cammann, V. L., Szawan, K. A., Stahli, B. E., Kato, K., Budnik, M., Wischnewsky, M., Dreiding, S., Levinson, R. A., Di Vece, D., Gili, S., Citro, R., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Napp, L. C., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Polednikova, K., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Kobayashi, Y., Shoji, T., Ishibashi, I., Takahara, M., Himi, T., Din, J., Al-Shammari, A., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, F., Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Opolski, G., and Templin, C.

Subjects
Male, Pediatrics, medicine.medical_specialty, Shock, Cardiogenic, Hospital mortality, 030204 cardiovascular system & hematology, age, broken heart syndrome, outcome, takotsubo syndrome, Global Health, Risk Assessment, Broken heart syndrome, 03 medical and health sciences, 0302 clinical medicine, Age, Takotsubo Cardiomyopathy, Intensive care, Age related, Prevalence, Medicine, Humans, 030212 general & internal medicine, Registries, Hospital Mortality, Mortality, Age of Onset, Aged, Outcome, Takotsubo syndrome, business.industry, Mental Disorders, Age Factors, Shock, Middle Aged, medicine.disease, Prognosis, Cardiogenic, 3. Good health, Causality, Baseline characteristics, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Female, Age of onset, Nervous System Diseases, Cardiology and Cardiovascular Medicine, business
Abstract

© 2020 by the American College of Cardiology Foundation., BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. OBJECTIVES: This study aimed to investigate age-related differences in TTS. METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: #50 years, middle-age: 51 to 74 years, elderly: $75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups. RESULTS Of 2,098 TTS patients, 242 (11.5%) patients were #50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were $75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p ¼ 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p ¼ 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p ¼ 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p ¼ 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p ¼ 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p ¼ 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups. CONCLUSIONS: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.

Catalog

Books, media, physical & digital resources
See catalog results