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Biological cells are built up from many different constituents of varying size and stiffness which all contribute to the cell's mechanical properties. Despite this heterogeneity, in the analysis of experimental measurements such as atomic force microscopy or microfluidic characterisation a strongly simplified homogeneous cell is typically assumed and a single elastic modulus is assigned to the entire cell. This ad-hoc simplification has so far mostly been used without proper justification. Here, we use computer simulations to show that indeed a heterogeneous cell can effectively be replaced by a homogeneous equivalent cell with a volume averaged elastic modulus. To study the validity of this approach, we investigate a hyperelastic cell with a heterogeneous interior under compression as well as in shear and channel flow, mimicking atomic force and microfluidic measurements, respectively. We find that the homogeneous equivalent cell reproduces quantitatively the behavior of its inhomogeneous counterpart, and that this equality is largely independent of the stiffness or spatial distribution of the heterogeneity.

Im Rahmen dieser Arbeit wurde die M��glichkeit zur Steigerung der Formaldehydproduktivit��t von VOx/SiO2-Katalysatoren in der Selektivoxidation von Methan durch Syntheseoptimierung, Wasserzudosierung und Modellierung untersucht.