1. Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study: protocol of a pragmatic clinical effectiveness study to improve birth outcomes in Ethiopia
- Author
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Anne CC Lee, Firehiwot Workneh Abate, Luke C Mullany, Estifanos Baye, Yoseph Yemane Berhane, Mulatu Melese Derebe, Michelle Eglovitch, Nebiyou Fasil, Ingrid E Olson, Workagegnehu Tarekegn Kidane, Tigest Shiferaw, Fisseha Shiferie, Fitsum Tsegaye, Sitota Tsegaye, Kalkidan Yibeltal, Grace J Chan, Parul Christian, Sheila Isanaka, Yunhee Kang, Chunling Lu, Mandefro M Mengistie, Rose L. Molina, Michele D Stojanov, Fred Van Dyk, Amare Worku Tadesse, Asresie T Wondale, Blair J Wylie, Alemayehu Worku, and Yemane Berhane
- Subjects
Iron ,growth ,Infant, Newborn ,Parturition ,Infant ,Infant, Low Birth Weight ,Pediatrics ,neonatology ,RJ1-570 ,Folic Acid ,Treatment Outcome ,Pregnancy ,Pragmatic Clinical Trials as Topic ,Pediatrics, Perinatology and Child Health ,Protocol ,Humans ,Premature Birth ,Female ,Ethiopia ,Randomized Controlled Trials as Topic - Abstract
IntroductionThe WHO Nutrition Target aims to reduce the global prevalence of low birth weight by 30% by the year 2025. The Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study will test the impact of packages of pregnancy interventions to enhance maternal nutrition and infection management on birth outcomes in rural Ethiopia.Methods and analysisENAT is a pragmatic, open-label, 2×2 factorial, randomised clinical effectiveness study implemented in 12 rural health centres in Amhara, Ethiopia. Eligible pregnant women presenting at antenatal care (ANC) visits at Ethics and disseminationENAT is approved by the Institutional Review Boards of Addis Continental Institute of Public Health (001-A1-2019) and Mass General Brigham (2018P002479). Results will be disseminated to local and international stakeholders.Registration numberISRCTN15116516.
- Published
- 2022