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Background Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inherent limitations. Firstly, whole-body PET/MR lacks sensitivity and resolution for focused organs. Secondly, broader clinical access of integrated PET/MR has been significantly restricted due to its prohibitively high cost. The MR-compatible PET insert is an independent and removable PET scanner which can be placed within an MRI bore. However, the mobility and configurability of all existing MR-compatible PET insert prototypes remain limited. Methods An MR-compatible portable PET insert prototype, dual-panel portable PET (DP-PET), has been developed for simultaneous PET/MR imaging. Using SiPM, digital readout electronics, novel carbon fiber shielding, phase-change cooling, and MRI compatible battery power, DP-PET was designed to achieve high-sensitivity and high-resolution with compatibility with a clinical 3-T MRI scanner. A GPU-based reconstruction method with resolution modeling (RM) has been developed for the DP-PET reconstruction. We evaluated the system performance on PET resolution, sensitivity, image quality, and the PET/MR interference. Results The initial results reveal that the DP-PET prototype worked as expected in the MRI bore and caused minimal compromise to the MRI image quality. The PET performance was measured to show a spatial resolution ≤ 2.5 mm (parallel to the detector panels), maximum sensitivity = 3.6% at the center of FOV, and energy resolution = 12.43%. MR pulsing introduces less than 2% variation to the PET performance measurement results. Conclusions We developed a MR-compatible PET insert prototype and performed several studies to begin to characterize the performance of the proposed DP-PET. The results showed that the proposed DP-PET performed well in the MRI bore and would cause little influence on the MRI images. The Derenzo phantom test showed that the proposed reconstruction method could obtain high-quality images using DP-PET.

Abdominal MRI is susceptible to respiratory motion artifacts. The existing clinical solution is using breathing belt to track the movement of the abdomen and trigger MRI acquisition during the end-expiration phase. Attaching respiratory belt to patients often slows down clinical workflow and affects patient comfort especially for those with surgical wounds and respiratory disorders. Herein we, for the first, propose a novel MRI compatible frequency modulated continuous wave (FMCW) radar to track respiratory motion within MRI bore in a non-contact fashion. The electromagnetic wave from FMCW radar can penetrate clothing and MRI RF coils to achieve continuous monitoring of patient’s vital signs. The system consists of a front-end FMCW radar sensor and a FPGA based power management/communication board that interface with a clinical MRI scanner. This design fully integrates the FMCW radar signal with MRI control console to enable real time respiratory triggered MRI acquisition. Consistent respiratory waveform was validated by comparing FMCW signal with traditional breathing belt measurement. Superior image quality from clinical MRI pulse sequence was achieved using the developed system in healthy volunteers.

Minimum variance (MV) adaptive beamforming has been applied in medical ultrasound imaging to improve lateral resolution, but standard MV method is quite sensitive to the perturbation of the received signal. Due to the inhomogeneity of human tissues, sound speed varies and there exists a certain amount of time-delay error for each channel which is referred to as phase aberration. A robust minimum variance adaptive beamforming method was proposed in order to avoid significant degradation under more practical circumstances. The sample covariance matrix was reconstructed with a forward-backward method. And the steering vector was estimated via maximizing the output beamformer power, which was turned into a quadratic convex optimization problem with proper constraints. The simulations with Field II showed that the proposed method was robust in the presence of phase aberration and could maintain its performance for improving imaging quality.