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Non-radiative wireless power transfer (WPT) technology has made considerable progress with the application of the parity-time (PT) symmetry concept. In this letter, we extend the standard second-order PT-symmetric Hamiltonian to high-order symmetric tridiagonal pseudo-Hermitian Hamiltonian, relaxing the limitation of multi-source/multi-load system based on non-Hermitian physics. We proposed a three-mode pseudo-Hermitian dual-transmitter-single-receiver circuit and demonstrate that robust efficiency and stable frequency WPT can be achieved even though PT-symmetry is not satisfied as usual. In addition, no active tuning is required when the coupling coefficient between the intermediate transmitter and the receiver is changed. Moreover, the proposed system has an open frequency band gap with an abrupt frequency change at the phase transition point, which is expected to advance wireless sensing technologies.

In this article, we report a vector-network-analyzer-free and real-time LC wireless capacitance readout system based on perturbed nonlinear parity-time (PT) symmetry. The system is composed of two inductively coupled reader-sensor parallel RLC resonators with gain and loss, respectively. By searching for the real mode that requires the minimum saturation gain, the steady-state frequency evolution as a function of the sensor capacitance perturbation is analytically deduced. The proposed system can work in different modes by setting different perturbation points. In particular, at the exceptional point of PT symmetry, the system exhibits high sensitivity. Experimental demonstrations revealed the viability of the proposed readout mechanism by measuring the steady-state frequency of the reader resonator in response to the change of trimmer capacitor on the sensor side. Our findings could impact many emerging applications such as implantable medical device for health monitoring, parameter detection in harsh environment, sealed food packages, etc.

Table S1. Primers used in this study. Table S2. The statistical analysis between SOX30 and desmosomal genes. (DOCX 19 kb)

Moderate invasion of trophoblasts into the endometrium is crucial for successful pregnancy. Benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) is a carcinogenic metabolite of benzo[a]pyrene which causes various diseases. We investigated the effects of BPDE on migration and invasion of trophoblast HTR-8/SVneo cells. Migration and invasion of cells exposed to 0.25-1.0μM BPDE for 24h were significantly inhibited. Moreover, tube formation of human umbilical vein endothelial cell (HUVEC) was also significantly reduced after incubation with HTR-8/SVneo cells treated with 0.5-1.0μM BPDE. The protein and mRNA levels of FAK, SRC, PI3K, p-PI3K, AKT, p-AKT, endothelial nitric oxide synthase (eNOS) and its activity, and matrix metalloproteinase 2 (MMP2) significantly decreased with increasing BPDE concentration. The presence of SC79, activator of AKT, partially attenuates the inhibition effect of BPDE on migration and invasion, confirming the involvement of AKT pathway. Thus, BPDE suppresses migration and invasion of human trophoblast HTR-8/SVneo cells by inhibiting the expression of FAK, SRC and PI3K, consequently down-regulating PI3K/AKT signaling pathway. This study reveals the mechanism of Polycyclic aromatic hydrocarbons-inhibited migration and invasion of trophoblast, and enhanced our experimental understanding of the adverse effects of PAHs on embryo implantation in early pregnancy.

The correlation between ALX4 expression and methylation was analyzed using TCGA data set ( www.cbioportal.com ). A: Cohort1:TCGA, Cell 2015, n = 552;Cohort2. B: TCGA, Provisional 2012, n = 656 Figure S2. Analysis the relationship between ALX4 and Wnt/β-catenin suppression and activation genes in breast cancer using TCGA Database. (A) ALX4 was positively correlated with WIF1 expression (R = 0.503, P = 0.00). (B) ALX4 was negatively correlated with LEF1 expression (R = −0.062, P = 0.03). (C) AXL4 was positively correlated with the expression of the key members of “β-catenin degradation complex” Figure S3. The illustration of full length human β-catenin promoter (−2760 bp to +27 bp) that was cloned into the PGL3-Basic luciferase reporter vector Figure S4. Relationship between ALX4 expression and survival of breast cancer patients retrieved from public datasets( https://genome-cancer.soe.ucsc.edu/proj/site/xena ). (A) Survival analysis using TCGA dataset, the results showed that high expression of ALX4 predicted longer survival time (n = 1080, p = 0.00, 2 group). (B) Survival analysis using TCGA dataset the results showed that high expression of ALX4 predicted longer survival time (n = 1080, p = 0.03, 3 group) Table S1. Primers used in this study. (DOCX 895 kb)