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Purpose The purpose of this paper is to study the multi-objective optimization design method of high-power high-frequency magnetic-resonance air-core transformer (ACT). Design/methodology/approach First, this paper studies the interleaved winding technology, the process of modeling and simulation, the calculation method of high-frequency loss of Litz wire and the design of magnetic shielding in detail. Second, the multi-objective optimization design process of high-frequency magnetic-resonance ACT is established by parametric scanning method and orthogonal experiment method. Findings An ACT model of 2 kV/100 kW/81.34 kHz was designed. The efficiency, weight power density and volume power density are 99.61%, 21.6 kW/kg and 5.1 kW/kg, respectively. Finally, the multi-physical field coupling simulation method is used to calculate the port excitation voltages and currents and temperature field of ACT. The maximum temperature of the ACT is 95.5 °C, which meets the design requirements. Originality/value The above research provides guidance and basis for the optimization design of high-power high-frequency magnetic-resonance ACT.

The optimal strategy for pulmonary atresia with ventricular septal defect (PA/VSD) without major aortopulmonary collateral arteries (MAPCAs) is yet to be defined. It remains unclear how primary complete repair compares with staged repair.We reviewed the records of 107 patients with PA/VSD managed with systemic-to-pulmonary shunts from February 1989 to November 2019. Tables presenting summary statistics of patient and surgical data and Kaplan-Meier curves presenting repair, mortality and reoperation were created. Logistic regression analysis was performed to identify risk factors for repair, morbidity and mortality.Ninety-one (85%) patients achieved complete repair at a median age of 1 year (interquartile range [IQR] 8-20 months). Survival was 97 (90%) patients at 6 months, 91 (85%) at 20 months and 87 (81%) at 10 years. Shunt diameter of 3.5 mm or less (p = 0.006) and shunt after 2009 (p0.001) were associated with earlier progression to complete repair. Shunt diameter of 3.5 mm or less was an independent risk factor for interstage morbidity (hazard ratio 4.5 [IQR 1.1-18.5], p = 0.039), but was not associated with complete repair (p = 0.75) or mortality (p = 0.62). The median follow-up period was 10.5 years (IQR 3.6-18.8 years) from birth.The complete repair and long-term survival rates of staged PA/VSD repair are high. The use of smaller shunts has resulted in earlier complete repair and is associated with increased risk of morbidity but not mortality.

Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized by accumulation of α-synuclein (α-syn). Neuroinflammation driven by microglia is an important pathological manifestation of PD. α-Syn is a crucial marker of PD, and its accumulation leads to microglia M1-like phenotype polarization, activation of NLRP3 inflammasomes, and impaired autophagy and phagocytosis in microglia. Autophagy of microglia is related to degradation of α-syn and NLRP3 inflammasome blockage to relieve neuroinflammation. Microglial autophagy and phagocytosis of released α-syn or fragments from apoptotic neurons maintain homeostasis in the brain. A variety of PD-related genes such as LRRK2, GBA and DJ-1 also contribute to this stability process.Further studies are needed to determine how α-syn works in microglia.A keyword-based search was performed using the PubMed database for published articles.In this review, we discuss the interaction between microglia and α-syn in PD pathogenesis and the possible mechanism of microglial autophagy and phagocytosis in α-syn clearance and inhibition of neuroinflammation. This may provide a novel insight into treatment of PD.

A novel melilite IR-NLO oxychalcogenide, Sr2FeGe2OS6, has been prepared for the first time, which represents the first Fe-based example capable of achieving phase-matching features in the IR-NLO chalcogenide system.

A magnetic GO-based imprinted adsorbent exhibited a high adsorption capacity, good removal rate and good reusability for Ni(ii) adsorption.

A dual-channel superstructured Ni single-atom catalyst with a unique axial oxygen coordination configuration was controllably constructed and affords a preeminent performance for convergent paired electrosynthesis of dimethyl carbonate from CO2.

To investigate the effect of MMCT in the complexes of cyanidometal-bridges, we synthesized and fully characterized a series of N2+ (N = 1, 2, 3, 4, 5), and their one and two-electron oxidized products N3+ and N4+ are Class II mixed-valence compounds.

A self-supporting MOF-based electrode was prepared via a facile semi-sacrificial anodic electrodeposition strategy, which exhibited improved mass/charge transport and active site accessibility, enhancing urea oxidation-coupled water electrolysis.

Text is a new way to guide human image manipulation. Albeit natural and flexible, text usually suffers from inaccuracy in spatial description, ambiguity in the description of appearance, and incompleteness. We in this paper address these issues. To overcome inaccuracy, we use structured information (e.g., poses) to help identify correct location to manipulate, by disentangling the control of appearance and spatial structure. Moreover, we learn the image-text shared space with derived disentanglement to improve accuracy and quality of manipulation, by separating relevant and irrelevant editing directions for the textual instructions in this space. Our model generates a series of manipulation results by moving source images in this space with different degrees of editing strength. Thus, to reduce the ambiguity in text, our model generates sequential output for manual selection. In addition, we propose an efficient pseudo-label loss to enhance editing performance when the text is incomplete. We evaluate our method on various datasets and show its precision and interactiveness to manipulate human images.

To study the consequences of specific genotype profiles of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone choriogonadotropin receptor (LHCGR) on assisted reproductive technology outcomes when preimplantation genetic testing for aneuploidy is used for controlling the embryo ploidy status. The most common reported single-nucleotide polymorphisms in the amino acid position for the FSHR (N680S; N: asparagine, S: serine; [rs6166]) and the LHCGR (N312S variant; N: asparagine, S: serine [rs2293275]) were chosen for this study.Retrospective cohort study.Private Fertility Clinic.All women aged 18-40 years undergoing their first assisted reproductive technology cycle with aneuploidy screening between 2006 and 2017 with body mass index of18 and40 kg/mAll patients received both recombinant follicle-stimulating hormone and human menopausal gonadotropin or low dose human chorionic gonadotropin. Genomic DNA was isolated from patients' blood. Genotyping of the FSHR and LHCGR polymorphisms was performed using TaqMan genotyping assays. Associations between both receptor genotypes and clinical outcomes were assessed using generalized regression and ANOVA.Live birth rate was the primary outcome. Secondary outcomes included oocyte yield, mature oocytes, blastulation rate, usable blastocyst rate, and implantation rate.A total of 1,183 patients met the inclusion criteria and generated reliable genotype results. The overall genotype frequencies in the study population for the FSHR gene were as follows: 21.7% homozygous for S in codon 680, 29.2% homozygous for N680, and 48.1% heterozygous (N680S). As for the LHCGR, 15.6% were homozygous for N312, 38.5% homozygous for S312 and 45.9% heterozygous (N312S). Our study population consisted of 53.8% non-Hispanic white; 6.1% Hispanic white; 4.1% Afro-American; 15.4% Asian; and 20.6% other or unknown. No significant association was found with any of the studied variables (oocyte yield, usable blastocyst rate, implantation rate, live birth) when genotypes were analyzed per receptor or in combination with one another. There was a statistically significant but clinically irrelevant difference in the rate of mature oocytes across different variant combinations.Our findings suggest that the presence of gonadotropin receptor polymorphisms in both FSHR N680S and LHCGR N312S are not associated with assisted reproductive technology outcomes; therefore, these variants should not be considered reproductive predictors.

Amorphous silicon (a-Si), due to its satisfactory theoretical capacity, moderate discharge potential, and abundant reserves, is treated as one of the most prospective materials for the anode of sodium-ion batteries (SIBs). However, the slow Na

Background. Radiotherapy and chemotherapy in patients with lung cancer can lead to a series of problems such as malnutrition and inflammatory reaction. Some studies have shown that ω-3 polyunsaturated fatty acids (PUFAs) could improve malnutrition and regulate inflammatory reaction in these patients, but no relevant meta-analysis exists. Methods. We systematically searched randomized controlled trials of ω-3 PUFAs in the adjuvant treatment of lung cancer in the PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang databases. Relevant outcomes were extracted, and we pooled standardized mean differences (SMDs) using a random or fixed-effects model. The risk of bias was evaluated according to the Cochrane Handbook (version 15.1). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Results. A total of 7 studies were included. The SMDs (95% CI) of body weight change, albumin change, energy intake, and protein intake at the end of intervention were 1.15 (0.50, 1.80), 0.60 (0.11, 1.09), 0.39 (−0.10, 0.89), and 0.27 (−0.04, 0.58), respectively. The SMDs (95% CI) of CRP change and TNF-α change were −3.44 (−6.15, −0.73) and −1.63 (−2.53, −0.73), respectively. Conclusions. ω-3 PUFAs can improve nutritional status and regulate indicators of inflammation in patients with lung cancer undergoing radiotherapy and chemotherapy. This study was registered in the PROSPERO (registration number: CRD42022307699).

The inter-individual variations of gut microbiome contribute to the different responses toward drug therapy among populations, developing a reliable ex vivo culture method for mixed bacteria is the urgent need for predicting personal reaction to drug therapy. Unfortunately, very few attentions have been paid to the bias that could be introduced during the culture process for mixed bacteria. Here we systemically evaluated the factors that may affect the outcomes of cultured bacteria from human feces. We demonstrated that inter-individual difference of host gut microbiome was the main factor affecting the outcomes of cultured bacteria, followed by the culture medium and time point. We further optimized a new medium termed GB based on our established multi-dimensional evaluation method, which could mimic the status of in situ host gut microbiome to the highest extent. Finally, we assessed the inter-individual metabolism by host gut microbiome from 10 donors on three frequently used clinical drugs (aspirin, levodopa and doxifluridine) based on the optimized GB medium. Our results revealed obvious variation in drug metabolism by microbiome from different donors, especially levodopa and doxifluridine. This work suggested the optimized culture medium had the potential for exploring the inter-individual impacts of host gut microbiome on drug metabolism.

Ammonia has the advantages of being easy to liquefy, easy to store, and having a high hydrogen content of 17.3 wt%, which can be produced without COx through an ammonia decomposition using an appropriate catalyst. In this paper, a series of FeCr bimetallic oxide nanocatalysts with a uniform morphology and regulated composition were synthesized by the urea two-step hydrolysis method, which exhibited the high-performance decomposition of ammonia. The effects of different FeCr metal ratios on the catalyst particle size, morphology, and crystal phase were investigated. The Fe0.75Cr0.25 sample exhibited the highest catalytic activity, with an ammonia conversion of nearly 100% at 650 °C. The dual metal catalysts clearly outperformed the single metal samples in terms of their catalytic performance. Besides XRD, XPS, and SEM being used as the means of the conventional characterization, the local structural changes of the FeCr metal oxide catalysts in the catalytic ammonia decomposition were investigated by XAFS. It was determined that the Fe metal and FeNx of the bcc structure were the active species of the ammonia-decomposing catalyst. The addition of Cr successfully prevented the Fe from sintering at high temperatures, which is more favorable for the formation of stable metal nitrides, promoting the continuous decomposition of ammonia and improving the decomposition activity of the ammonia. This work reveals the internal relationship between the phase and structural changes and their catalytic activity, identifies the active catalytic phase, thus guiding the design and synthesis of catalysts for ammonia decomposition, and excavates the application value of transition-metal-based nanocomposites in industrial catalysis.

Purpose: To explore the mechanisms underlying clear-cell renal cell carcinoma (ccRCC) metastasis using transcriptional profiling and bioinformatics analysis of ccRCC samples, and to elucidate the role of FOXO3a in ccRCC metastasis.Experimental Design: Gene expression profiling was performed using four primary metastatic and five primary nonmetastatic ccRCC samples. The mRNA and protein levels of FOXO3a in ccRCC samples were investigated by real-time reverse transcription PCR and immunohistochemistry, respectively. The association between metastasis-free survival of patients with ccRCC and FOXO3a mRNA levels was analyzed. Biologic functions of FOXO3a in renal cancer cell lines were investigated. The influence of FOXO3a on tumor metastasis was also studied in vivo orthotopic xenograft tumor model. Finally, the mechanism by which FOXO3a attenuation could increase invasion and migration of tumor cells was explored.Results: Bioinformatics analysis of the profiling data identified FOXO3a as a key factor in ccRCC metastasis. FOXO3a expression was decreased in primary metastatic ccRCC samples. Patients with low FOXO3a mRNA levels had poor metastasis-free survival (P = 0.003). Knocking down FOXO3a induced tumor cell invasion and migration in the nonmetastatic ccRCC cells. Induced FOXO3a overexpression in SN12-PM6 cells could inhibit tumor metastasis in vivo. Downregulation of FOXO3a increased SNAIL1 expression, thereby activating the epithelial–mesenchymal transition (EMT) of RCC cell lines.Conclusions: The loss of FOXO3a induced EMT of tumor cells by upregulating SNAIL1, which promoted tumor cells metastasis in vitro and in vivo. Thus, FOXO3a could be considered as an independent prognostic factor in ccRCC metastasis and could be a marker of occult metastases. Clin Cancer Res; 20(7); 1779–90. ©2014 AACR.

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PDF file - 143KB, Pathway analysis based on KEGG, Biocarta, and Reatome database.

PDF file - 136KB, Analysis of expression profiling data for filtering central genes.

PDF file - 2206KB, Scratch wound migration assays in the 786-O and SN12-PM6 cells.

Preference and performance trials were conducted to investigate the effects of extruded corn with different degrees of gelatinization on the feed preference, growth performance, nutrient digestibility, and fecal microbiota of weaning piglets. In the preference trial, 144 piglets who were 35 days old were weighed and allotted to six treatments with four replications per treatment. Piglets in each treatment group were allowed to choose two of the following four corn-supplemented diets: conventional corn (NC) or extruded corn with low (LEC; 41.82% gelatinization), medium (MEC; 62.60% gelatinization), or high (HEC; 89.93% gelatinization) degrees of gelatinization for 18 days. The results showed that the piglets preferred diets supplemented with a low degree of gelatinization of extruded corn. In the performance trial, 144 piglets who were 35 days old were weighed and allotted into four treatments with six replications per treatment. Piglets in each treatment were fed one of the four diets for 28 days. The results showed that LEC and MEC decreased the feed:gain ratio at 14–28 days and 0–28 days, respectively, and increased the apparent total tract digestibility (ATTD) of crude protein compared with NC. Meanwhile, LEC increased the total protein and globulin content in the plasma on day 14, and MEC increased the ATTD of ether extract (EE) compared with NC. Extruded corn with low and medium degrees of gelatinization increased the abundance of Bacteroidetes at the phylum level and Lactobacillus, Alloprevotella, Prevotellaceae_UCG-03, and Prevotella_2 at the genus level. The results showed that extruded corn can improve feed preference, increase growth performance and nutrient digestibility, and modify gut microbiota, and the ideal degree of gelatinization is approximately 41.82–62.60%.