1. MAM 2008 Poster Abstracts
- Author
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T YEO, D LAMPAH, R GITAWATI, E TJITRA, E KENANGALEM, Y MCNEIL, C DARCY, D GRANGER, J WEINBERG, and B LOPANSRI
- Subjects
0303 health sciences ,Thioredoxin reductase ,030231 tropical medicine ,Plasmodium falciparum ,Biology ,Selective inhibition ,medicine.disease_cause ,biology.organism_classification ,Molecular biology ,3. Good health ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,medicine ,Parasitology ,Trichomonas vaginalis ,Thioredoxin ,030304 developmental biology - Abstract
Poster presented at MAM 2008, the 3rd Molecular Approaches to Malaria Meeting. The Trichomonas vaginalis TrxR was analysed to assess the efficacy of the organotellurides against a low Mr TrxR, which act by a very different mechanism to that of the high Mr TrxR. The results that will be presented show that: (a) Selectivity of inhibition between hTrxR and PfTrxR is possible (b) Selective inhibition between high Mr and low Mr TrxR can be achieved (c) The generation of inhibitors that specifically affect parasite viability is feasible.
- Published
- 2008
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