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Accurate property determination of the piezoelectric thin film material Al(1−x)Sc(x)N is necessary for designing the next generation of radio frequency resonators in mobile communication, and for testing results of ab initio calculations. Sound velocity and piezoelectric coupling of both longitudinal and shear mode are evaluated from a single dual mode resonator. This assures a compatible set of coefficients. It is observed that AlScN thin films grew differently on small, isolated bottom electrodes. The investigated film starts growing with a slightly tilted, c‐textured microstructure, and switches after 200 nm to a polycrystalline film with irregularly oriented grains having c‐axis tilt angles in the range of 35°-70°, as revealed by transmission electron microscope nanodiffraction mapping. Based on this information, a finite element model (FEM) is constructed that properly reproduces the resonance behavior of the resonator. The relevant elastic and piezoelectric constants are derived by curve fitting and yield somewhat lower stiffness and higher piezoelectric coefficients than ab initio calculations published in the literature. The FEM modeling results show that the upper film part with the abnormally oriented grains is overall piezoelectric, i.e., the misoriented grains maintain the polarity projected onto the growth direction from the starting layer.

We have successfully measured amyloid beta (Aβ) (1-40) protein added in human serum by a NiCr strain gauge cantilever biosensor immobilized with liposomes incorporating cholesterol. Importantly, we investigated the effect of incorporation of cholesterol in the liposome in order to suppress the interaction between the liposome and many different proteins included in human serum. It was revealed that incorporating cholesterol suppresses the interaction between the proteins other than Aβ in human serum and the liposome. Finally, we detected Aβ(1-40) in human serum with typical chronological behaviors due to Aβ aggregation and fibrillization. Furthermore, as a digital low-pass filtering procedure could reduce external noises, the cantilever sensor immobilized with liposome incorporating cholesterol can detect low-concentrated Aβ in human serum.

制度:新 ; 文部省報告番号:甲1021号 ; 学位の種類:博士(理学) ; 授与年月日:1994-03-15 ; 早大学位記番号:新2044 ; 理工学図書館請求番号:1751