251 results on '"Yang Niu"'
Search Results
2. Polysaccharide H-1-2 Ameliorates High Glucose-Induced Podocyte Dysfunction by Suppressing Epithelial-to-Mesenchymal Transition via Restoration of SIRT1 in Vivo and in Vitro
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Minzhou Li, Zhong Wu, Wei Gao, Kaiying Zhao, Xiaobo Yang, Huiyan Zhang, Bin Deng, and Yang Niu
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General Medicine ,General Biochemistry, Genetics and Molecular Biology - Published
- 2023
3. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer
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Yun-Feng Liang, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato, Paolo Bernardini, Xiao-Jun Bi, Ming-Sheng Cai, Elisabetta Casilli, Enrico Catanzani, Jin Chang, Deng-Yi Chen, Jun-Ling Chen, Zhan-Fang Chen, Ming-Yang Cui, Tian-Shu Cui, Yu-Xing Cui, Hao-Ting Dai, Antonio De Benedittis, Ivan De Mitri, Francesco de Palma, Maksym Deliyergiyev, Margherita Di Santo, Qi Ding, Tie-Kuang Dong, Zhen-Xing Dong, Giacinto Donvito, David Droz, Jing-Lai Duan, Kai-Kai Duan, Domenico D’Urso, Rui-Rui Fan, Yi-Zhong Fan, Fang Fang, Kun Fang, Chang-Qing Feng, Lei Feng, Piergiorgio Fusco, Min Gao, Fabio Gargano, Ke Gong, Yi-Zhong Gong, Dong-Ya Guo, Jian-Hua Guo, Shuang-Xue Han, Yi-Ming Hu, Guang-Shun Huang, Xiao-Yuan Huang, Yong-Yi Huang, Maria Ionica, Wei Jiang, Jie Kong, Andrii Kotenko, Dimitrios Kyratzis, Shi-Jun Lei, Shang Li, Wen-Hao Li, Wei-Liang Li, Xiang Li, Xian-Qiang Li, Yao-Ming Liang, Cheng-Ming Liu, Hao Liu, Jie Liu, Shu-Bin Liu, Yang Liu, Francesco Loparco, Chuan-Ning Luo, Miao Ma, Peng-Xiong Ma, Tao Ma, Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta, Dan Mo, Maria Muñoz Salinas, Xiao-Yang Niu, Xu Pan, Andrea Parenti, Wen-Xi Peng, Xiao-Yan Peng, Chiara Perrina, Rui Qiao, Jia-Ning Rao, Arshia Ruina, Zhi Shangguan, Wei-Hua Shen, Zhao-Qiang Shen, Zhong-Tao Shen, Leandro Silveri, Jing-Xing Song, Mikhail Stolpovskiy, Hong Su, Meng Su, Hao-Ran Sun, Zhi-Yu Sun, Antonio Surdo, Xue-Jian Teng, Andrii Tykhonov, Jin-Zhou Wang, Lian-Guo Wang, Shen Wang, Shu-Xin Wang, Xiao-Lian Wang, Ying Wang, Yan-Fang Wang, Yuan-Zhu Wang, Da-Ming Wei, Jia-Ju Wei, Yi-Feng Wei, Di Wu, Jian Wu, Li-Bo Wu, Sha-Sha Wu, Xin Wu, Zi-Qing Xia, En-Heng Xu, Hai-Tao Xu, Zhi-Hui Xu, Zun-Lei Xu, Zi-Zong Xu, Guo-Feng Xue, Hai-Bo Yang, Peng Yang, Ya-Qing Yang, Hui-Jun Yao, Yu-Hong Yu, Guan-Wen Yuan, Qiang Yuan, Chuan Yue, Jing-Jing Zang, Sheng-Xia Zhang, Wen-Zhang Zhang, Yan Zhang, Yi Zhang, Yong-Jie Zhang, Yun-Long Zhang, Ya-Peng Zhang, Yong-Qiang Zhang, Zhe Zhang, Zhi-Yong Zhang, Cong Zhao, Hong-Yun Zhao, Xun-Feng Zhao, Chang-Yi Zhou, Yan Zhu, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato , Paolo Bernardini , Xiao-Jun Bi , Ming-Sheng Cai , Elisabetta Casilli , Enrico Catanzani , Jin Chang , Deng-Yi Chenj , Jun-Ling Chen , Zhan-Fang Chen , Ming-Yang Cui , Tian- Shu Cuin , Yu-Xin Cui , Hao-Ting Dai , Antonio De Benedittis , Ivan De Mitri , Francesco de Palma , Maksym Deliyergiyev Margherita Di Santo , Qi Ding , Tie-Kuan Dong , Zhen-Xing Dong , Giacinto Donvito , David Droz, Jing-Lai Duan , Kai-Kai Duan , Domenico D’Urso , Rui-Rui Fan , Yi-Zhong Fan , Fan Fang , Kun Fang, Chang-Qin Feng , Lei Feng , Piergiorgio Fusco, Min Gao , Fabio Gargano , Ke Gong , Yi-Zhong Gong , Dong- Ya Guo , Jian-Hua Guo , Shuang-Xue Han, Yi-Ming Hu , Guang- Shun Huang , Xiao-Yuan Huang , Yong-Yi Huang , Maria Ionica , Wei Jiang , Jie Kong , Andrii Kotenko , Dimitrios Kyratzis , Shi- Jun Lei, Shang Li , Wen-Hao Li , Wei-Liang Li , Xiang Li , Xian Qiang Li , Yao-Ming Lian , Cheng-Ming Liu , Hao Liu , Jie Liu , Shu-Bin Liu , Yang Liu , Francesco Loparco , Chuan-Ning Luo , Miao Ma , Peng-Xiong Ma , Tao Ma , Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta , Dan Mo , Maria Muñoz Salinas , Xiao-Yang Niu , Xu Pan , Andrea Parenti , Wen-Xi Peng , Xiao- Yan Peng , Chiara Perrina , Rui Qiao , Jia-Ning Rao , Arshia Ruina , Zhi Shangguan , Wei-Hua Shen , Zhao-Qiang Shen , Zhong-Tao Shen , Leandro Silveri, Jing-Xing Song , Mikhail Stolpovskiy Hong Su , Meng Su , Hao-Ra Sun , Zhi-Yu Sun , Antonio Surdo , Xue-Jian Teng , Andrii Tykhonov , Jin-Zhou Wang , Lian-Guo Wang , Shen Wang , Shu-Xin Wang , Xiao-Lian Wang , Ying Wang , Yan-Fang Wang , Yuan-Zhu Wang , Da-Ming Wei , Jia-Ju Wei , Yi-Feng Wei , Di Wu , Jian Wu , Li-Bo Wu , Sha-Sha Wun , Xin Wu , Zi-Qing Xi , En-Heng Xu , Hai-Tao Xu , Zhi-Hui Xu , Zun-Lei Xu , Zi-Zong Xu , Guo-Feng Xuen , Hai-Bo Yang , Peng Yang , Ya-Qing Yang , Hui-Jun Yao , Yu-Hong Yu , Guan-Wen Yuan , Qiang Yuan , Chuan Yue , JingJing Zang Sheng-Xi Zhang , Wen-Zhang Zhang , Yan Zhang, Yi Zhangj, Yong-Jie Zhang , Yun-Long Zhang , Ya-Peng Zhang , Yong-Qiang Zhang , Zhe Zhang , Zhi-Yong Zhang , Cong Zhao , Hong-Yun Zhao , Xun-Feng Zhao , Chang-Yi Zhou , and Yan Zhu, Alemanno, Francesca, An, Qi, Azzarello, Philipp, Carla Tiziana Barbato, Felicia, Bernardini, Paolo, Bi, Xiao-Jun, Cai, Ming-Sheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, Deng-Yi, Chen, Jun-Ling, Chen, Zhan-Fang, Cui, Ming-Yang, Cui, Tian-Shu, Cui, Yu-Xin, Dai, Hao-Ting, De Benedittis, Antonio, De Mitri, Ivan, DE PALMA, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, Tie-Kuang, Dong, Zhen-Xing, Donvito, Giacinto, Droz, David, Duan, Jing-Lai, Duan, Kai-Kai, D’Urso, Domenico, Fan, Rui-Rui, Fan, Yi-Zhong, Fang, Fang, Fang, Kun, Feng, Chang-Qing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, Yi-Zhong, Guo, Dong-Ya, Guo, Jian-Hua, Han, Shuang-Xue, Hu, Yi-Ming, Huang, Guang-Shun, Huang, Xiao-Yuan, Huang, Yong-Yi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrio, Lei, Shi-Jun, Li, Shang, Li, Wen-Hao, Li, Wei-Liang, Li, Xiang, Li, Xian-Qiang, Lian, Yao-Ming, Liu, Cheng-Min, Liu, Hao, Liu, Jie, Liu, Shu-Bin, Liu, Yang, Loparco, Francesco, Luo, Chuan-Ning, Ma, Miao, Ma, Peng-Xiong, Ma, Tao, Ma, Xiao-Yong, Marsella, Giovanni, Nicola Mazziotta, Mario, Mo, Dan, Muñoz Salinas, Maria, Niu, Xiao-Yang, Pan, Xu, Parenti, Andrea, Peng, Wen-Xi, Peng, Xiao-Yan, Perrina, Chiara, Qiao, Rui, Ra, Jia-Ning, Ruina, Arshia, Shangguan, Zhi, Shen, Wei-Hua, Shen, Zhao-Qiang, Shen, Zhong-Tao, Silveri, Leandro, Song, Jing-Xing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, Hao-Ran, Sun, Zhi-Yu, Surdo, Antonio, Teng, Xue-Jian, Tykhonov, Andrii, Wang, Jin-Zhou, Wang, Lian-Guo, Wang, Shen, Wang, Shu-Xin, Wang, Xiao-Lian, Wang, Ying, Wang, Yan-Fang, Wang, Yuan-Zhu, Wei, Da-Ming, Wei, Jia-Ju, Wei, Yi-Feng, Wu, Di, Wu, Jian, Wu, Li-Bo, Wu, Sha-Sha, Wu, Xin, Xia, Zi-Qing, Xu, En-Heng, Xu, Hai-Tao, Xu, Zhi-Hui, Xu, Zun-Lei, Xu, Zi-Zong, Xue, Guo-Feng, Yang, Hai-Bo, Yang, Peng, Yang, Ya-Qing, Yao, Hui-Jun, Yu, Yu-Hong, Yuan, Guan-Wen, Yuan, Qiang, Yue, Chuan, Zann, Jing-Jing, Zhan, Sheng-Xia, Zhan, Wen-Zhang, Zhan, Yan, Zhan, Yi, Zhang, Yong-Jie, Zhang, Yun-Long, Zhang, Ya-Peng, Zhang, Yong-Qiang, Zhang, Zhe, Zhang, Zhi-Yong, Zhao, Cong, Zhao, Hong-Yun, Zhao, Xun-Feng, Zhou, Chang-Yi, and Yan Zhu, And
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Line-like structure ,High Energy Physics - Experiment (hep-ex) ,Multidisciplinary ,Astrophysics::High Energy Astrophysical Phenomena ,DAMPE, Dark matter, Gamma-ray, Line-like structure ,Settore FIS/01 - Fisica Sperimentale ,DAMPE ,Dark matter ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena ,Gamma-ray ,High Energy Physics - Experiment - Abstract
The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints on the velocity-averaged cross section for $\chi\chi \to \gamma\gamma$ and the decay lifetime for $\chi \to \gamma\nu$, both at 95% confidence level, have been calculated and the systematic uncertainties have been taken into account. Comparing to the previous Fermi-LAT results, though DAMPE has an acceptance smaller by a factor of $\sim 10$, similar constraints on the DM parameters are achieved and below 100 GeV the lower limits on the decay lifetime are even stronger by a factor of a few. Our results demonstrate the potential of high-energy-resolution observations on dark matter detection., Comment: 14 pages, 8 figures. Update the content to keep up with the published version
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- 2022
4. Expression of αA-crystallin (CRYAA) in vivo and in vitro models of age-related cataract and the effect of its silencing on HLEB3 cells
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Xiaoling Ma, Yi Nan, Can Huang, Xiangyang Li, Yifan Yang, Wenjie Jiang, Mengyi Ye, Qian Liu, Yang Niu, and Ling Yuan
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Aging ,Cell Biology - Published
- 2023
5. COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity
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Sai-ya Zhu, Wen-qian Zhou, Yang-yang Niu, Chao Zheng, Xi Liu, Ying-ying Zhang, and Chen Yu
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Pharmacology ,Pharmacology (medical) ,General Medicine - Published
- 2023
6. Camouflaged plants are shorter than non-camouflaged plants in the alpine zone
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Tao Huang, Zhe Chen, Bo Xu, Hang Sun, and Yang Niu
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General Agricultural and Biological Sciences ,Agricultural and Biological Sciences (miscellaneous) - Abstract
Camouflage has been reported as a defensive strategy in plants, while our understanding of the evolution of such defensive coloration is still limited. In the present study, we tested the hypothesis that camouflaged plants are shorter than non-camouflaged ones in the same habitat. Based on a species list from the subnival zone from the Hengduan Mountains, SW China and the herbarium collection, we measured the plant heights of 2915 individuals from 621 species (either camouflaged or not), with elevation information as a reference. We show that camouflaged plants were significantly shorter than non-camouflaged ones, though the effects of phylogeny and elevation were considered. Interestingly, a negative correlation between plant height and elevation was found in non-camouflaged plants, but not in camouflaged ones. These results revealed the correlation between defensive coloration and plant height. Camouflage may have evolved from shorter ancestors because they may suffer stronger selection and provide a more efficient defence.
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- 2023
7. Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications
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Yue Hua, Xiao-xue Xu, Sheng Guo, Hong Xie, Hui Yan, Xin-fei Ma, Yang Niu, and Jin-Ao Duan
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General Chemistry ,General Agricultural and Biological Sciences - Published
- 2022
8. Visual function of red staminal filaments in a bee-pollinated plant
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Ya-Li Hu, Zhe Chen, Jian-Jun Zhao, Yang Niu, and Gang Xu
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Ecology ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
9. Intraspecific floral colour variation in three Pedicularis species
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Qiu-Yu Zhang, Zhe Chen, Hang Sun, and Yang Niu
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Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
10. Combination search strategy‐based improved particle swarm optimisation for resource allocation of multiple jammers for jamming netted radar system
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Wei‐qi Zou, Chao‐yang Niu, Wei Liu, Yan‐yun Wang, and Jia‐qi Zhan
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Signal Processing ,Electrical and Electronic Engineering - Published
- 2023
11. Design and Test of Soil–Fertilizer Collision Mixing and Mulching Device for Manure Deep Application Machine
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Yang Niu, Jiyuan Zhang, Jiangtao Qi, Hewei Meng, Huijie Peng, and Jiahao Li
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agricultural machinery ,stable manure ,mixing ,mulching ,discrete element simulation ,Plant Science ,Agronomy and Crop Science ,Food Science - Abstract
Aiming at the problems of low uniformity and utilization rate in the traditional deep application method of orchard manure, a soil–fertilizer collision mixing and mulching device was designed. The ditching mechanism, the structure of the soil divider, and the fertilizer delivery auger were analyzed and designed. Furthermore, with the rotational speed of the cutter and auger and the deflection angle of the soil divider as factors, as well as the uniformity of soil–fertilizer mixing and mulching as evaluation indexes, the discrete element simulation tests were conducted. The simulation results showed that when the turret speed, the stirrer speed and the soil separator deflection angle were 140 r/min, 146 r/min and 22°, the mixing uniformity and mulching uniformity were the highest, which was 88.35% and 96.86%, respectively. Based on the optimal parameters, the field test was conducted, and the soil–fertilizer mixing uniformity was 87.02%, with a relative error of 1.33% compared with the simulation test results. The relative error of 94.37% of mulch uniformity is 2.49%, which indicates that the simulation optimization results are reliable and the mixing performance of the device is good and can meet the requirements of soil–fertilizer mixing operation. The results of this study can provide an important reference for the design of the soil and fertilizer mixing machine.
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- 2023
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12. Kengiochloa, a new bamboo genus to accommodate the morphologically unique species, Pseudosasa pubiflora (Poaceae)
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Yi-Hua Tong, Zheng-Yang Niu, Zhuo-Yu Cai, Jing-Bo Ni, and Nian-He Xia
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Poales ,Liliopsida ,Plant Science ,Poaceae ,phylogeny ,plastome ,Biota ,synonyms ,Tracheophyta ,taxonomy ,morphology ,Colpodium ,Plantae ,Ecology, Evolution, Behavior and Systematics - Abstract
Pseudosasa was confirmed as polyphyletic by recent phylogenetic analyses, with Chinese species of Pseudosasa distantly related to those from Japan. Among the Chinese species of Pseudosasa, Pseudosasa pubiflora is a morphologically unique as well as taxonomically problematic species endemic to South China, of which the generic designation is still uncertain. Molecular analyses based on both plastid and nuclear genomic data demonstrated that this species is closest to the recently published genus Sinosasa. Morphologically, the two are somewhat similar to each other in flowering branches developing at the nodes of every order of branches, raceme-like units of inflorescence with 3–5 short spikelets, each spikelet with few florets including a rudimentary one at the apex, and each floret with 3 stamens and 2 stigmas. However, P. pubiflora is very different from Sinosasa species in many reproductive and vegetative characters, such as the morphology of paracladia (lateral spikelet “pedicels”), the absence or existence of pulvinus at the base of paracladia, the relative length of the upper glume and the lowest lemma, the shape of lodicules and primary culm buds, the branch complement, the morphology of nodes, culm leaves and dried foliage leaf blades, and the number of foliage leaves per ultimate branchlet. The morphological and molecular evidence warrants recognition of a new genus to accommodate this unique species, which is here named Kengiochloa. After consulting related literature and examination of herbarium specimens or specimen photos, a taxonomic revision of K. pubiflora and its synonyms was made, and it was confirmed that four names, viz. P. gracilis, Yushania lanshanensis, Arundinaria tenuivagina and P. parilis, should be merged with K. pubiflora, while Indocalamus pallidiflorus and Acidosasa paucifolia are distinct species.
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- 2023
13. Mediating role of depressive symptoms on the relationship between sleep duration and cognitive function
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Liqun Wang, Shulan He, Ning Yan, Ruiping Pan, Yang Niu, and Jiangping Li
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Multidisciplinary - Abstract
Although some studies have shown the association between sleep duration and cognitive impairment is positive, the mechanism explaining how sleep duration is linked to cognition remains poor understood. The current study aims to explore it among Chinese population. A cross-sectional study of 12,589 participants aged 45 or over was conducted, cognition was assessed by three measures to capture mental intactness, episodic memory, and visuospatial abilities. The Center for Epidemiologic Studies Depression Scale 10 (CES-D10) was administered during the face-to-face survey to assess depressive status. Sleep duration was reported by the participants themselves. Partial correlation and linear regression were used to explore the association between sleep duration, cognition, and depression. The Bootstrap methods PROCESS program was used to detect the mediation effect of depression. Sleep duration was positively correlated with cognition and negatively with depression (p 10 score (r = − 0.13, p p = 0.001). When depressive symptoms were considered, the association between sleep duration and cognition lost significance (p = 0.468). Depressive symptoms have mediated the relationship between sleep duration and cognitive function. The findings revealed that the relationship between sleep duration and cognition is mainly explained by depressive symptoms and may provide new ideas for interventions for cognitive dysfunction.
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- 2023
14. Historical development of karst evergreen broadleaved forests in East Asia has shaped the evolution of a hemiparasitic genus Brandisia (Orobanchaceae)
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Zhe Chen, Zhuo Zhou, Ze-Min Guo, Truong Van Do, Hang Sun, and Yang Niu
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Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
15. Mediating Role of Depressive Symptoms on the Association Between Neighborhood Social Cohesion and Quality of Life in Individuals with Type 2 Diabetes Mellitus
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Liqun, Wang, Ning, Yan, Rongrong, Guo, Lining, Pu, Yuqi, Dang, Ruiping, Pan, and Yang, Niu
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Patient Preference and Adherence ,Health Policy ,Medicine (miscellaneous) ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Social Sciences (miscellaneous) - Abstract
Liqun Wang,1 Ning Yan,2 Rongrong Guo,3 Lining Pu,1 Yuqi Dang,4 Ruiping Pan,5 Yang Niu3,6 1Department of Epidemiology and Statistics, School of Public Health and Management at Ningxia Medical University, Yinchuan, 750004, Peopleâs Republic of China; 2Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, Peopleâs Republic of China; 3School of traditional Chinese Medicine, Ningxia Medical University, Yinchuan, 750004, Peopleâs Republic of China; 4Department of Endocrinology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, 750001, Peopleâs Republic of China; 5Department of Chinese Medicine, The Second Peopleâs Hospital of Shizuishan, Shizuishan, 753000, Peopleâs Republic of China; 6Key Laboratory of the Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, 750004, Peopleâs Republic of ChinaCorrespondence: Yang Niu, Key Laboratory of the Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, 750004, Peopleâs Republic of China, Tel +8613909574577, Email niuyang0227@163.comPurpose: Few studies have explored the association between neighborhood social cohesion (NSC), a type of social capital, and the quality of life of patients with type 2 diabetes mellitus (T2DM). In addition, the potential mechanism for this association remains unclear. The current study examined the mediation effect of depressive symptoms on the relationship between NSC and quality of life among diabetes patients in China.Patients and Methods: A cross-sectional study of 1747 T2DM patients was conducted. The specific quality of life (DSQL), Center for Epidemiological Survey Depression (CES-D), and social capital scales were administered using a face-to-face survey. Partial correlation analysis and a linear regression model were employed to explore the relationship between NSC, depressive symptoms, and quality of life. Bootstrap analysis using PROCESS was used to test the mediation model.Results: After controlling for covariates, NSC was negatively correlated with depressive symptoms (r=â 0.24, P< 0.01) and DSQL score (r=â 0.20, P< 0.01) while depressive symptoms were positively correlated with DSQL score (r=0.46, P< 0.01). Linear regression analysis also found that NSC was negatively associated with the DSQL score, while depressive symptoms were positively associated with the DSQL score. Depressive symptoms mediated the relationship between NSC and quality of life in T2DM patients (explaining 50.7% of the total variance).Conclusion: NSC was positively associated with improved quality of life among Chinese T2DM patients in this study, and depressive symptoms were likely to partially explain this relationship. These findings may be used to help maintain a good quality of life among at-risk individuals. Additional prospective studies are needed to confirm these findings.Keywords: neighborhood social cohesion, depressive symptoms, quality of life, mediating effect, T2DM patients
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- 2022
16. Papilio butterfly vs. hawkmoth pollination explains floral syndrome dichotomy in a clade of Lilium
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Chang-Qiu Liu, Yang Niu, Qing-Biao Lu, Zhe Chen, Bo Cai, Ye Fang, and Yun-Dong Gao
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Plant Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Pollination niche shifts can drive remarkable floral divergence between closely related plant species. The Leucolirion clade of Lilium contains species with either tepal-recurved or trumpet-shaped flowers. The tepal-recurved flowers are bright orange and might be pollinated by butterflies and/or birds. The trumpet-shaped flowers are mostly pale and strongly fragrant and might permit visitation by a variety of hawkmoths. Lilium leucanthum has trumpet-shaped flowers, and some populations of this species show dark coloration on the floral outer surface, suggesting pollination by mammals. We identified pollinators and examined the dependence of reproduction on pollinators by floral visitor observations, pollen load analysis and pollination experiments. We also analysed floral traits to contrast the two floral syndromes involving different lepidopteran groups. The tepal-recurved lilies are specialized on a group of Papilio butterflies for pollination with pollen predominantly attached to the hindwings. The trumpet-shaped flowers are almost exclusively pollinated by hawkmoths, including diverse species with proboscises of different lengths. No mammal visitation was found to the populations of L. leucanthum with dark outer surfaces of flowers. Self-incompatibility prevails throughout the clade, including the populations in which pollinators were scarce. The butterfly- and hawkmoth-pollinated species display contrasting floral syndromes. Our findings confirmed that the dichotomy in floral syndrome in the Leucolirion clade is associated with Papilio butterfly vs. hawkmoth pollination, whereas intraspecific variation in colour of the floral outer surface of L. leucanthum many need a non-pollinator explanation.
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- 2022
17. Notch signaling, hypoxia, and cancer
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Mingzhou Guo, Yang Niu, Min Xie, Xiansheng Liu, and Xiaochen Li
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Cancer Research ,Oncology - Abstract
Notch signaling is involved in cell fate determination and deregulated in human solid tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia-induced factors (HIFs) and their downstream targets to promote tumorigenesis and cancer development. Recently, HIFs have been shown to trigger the Notch signaling pathway in a variety of organisms and tissues. In this review, we focus on the pro- and anti-tumorigenic functions of Notch signaling and discuss the crosstalk between Notch signaling and cellular hypoxic response in cancer pathogenesis, including epithelia-mesenchymal transition, angiogenesis, and the maintenance of cancer stem cells. The pharmacological strategies targeting Notch signaling and hypoxia in cancer are also discussed in this review.
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- 2023
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18. Roles of Phosphatidylinositol 4-Phosphorylation in Non-vesicular Cholesterol Trafficking
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Tamas Balla, Gergo Gulyas, Amrita Mandal, Alejandro Alvarez-Prats, Yang Niu, Yeun Ju Kim, and Joshua Pemberton
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- 2023
19. Probing temperature effects on lattice distortion and oxidation resistance of high-entropy alloys by in situ SR-XRD and XANES
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Zhongjun Chen, Yu Gong, Ming-Yao Su, Zhoucan Xie, Haiying Wang, Jin-Xi Chen, Yuan-Yuan Tan, Peter K. Liaw, Lanhong Dai, Yang-Yang Niu, and Zhonghua Wu
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Diffraction ,Materials science ,Mechanical Engineering ,High entropy alloys ,Alloy ,Analytical chemistry ,engineering.material ,Condensed Matter Physics ,Microstructure ,XANES ,Grain growth ,Mechanics of Materials ,engineering ,General Materials Science ,Spectroscopy ,Absorption (electromagnetic radiation) - Abstract
To investigate lattice distortion evolutions of CrCoNi medium-entropy alloy (MEA), CrFeCoNi, and CrMnFeCoNi high-entropy alloys (HEAs) with temperature increasing from 300 to 1323 K, we conduct in situ synchrotron-radiation-based X-ray diffraction experiments. Electron backscattering diffraction, energy-dispersive X-ray spectroscopy and X-ray absorption near edge fine structure spectra (XANES) are further carried out to uncover variations of microstructure, morphology and oxidation resistance. Generally, the lattice will expand continuously with temperature increasing, however, the expansion rate is affected by grain growth and oxidation. The oxidation resistance of CrCoNi MEA is slightly higher than CrFeCoNi HEA, and much higher than CrMnFeCoNi HEA. The XANES spectra demonstrate higher oxidation resistance of Ni, Co, and Fe than Cr and Mn. Formation of local short-range order structures around Ni and Co is observed, but no such features are observed around Fe and Mn. The present findings are significant on deepening the understandings of correlations between atomic structure and mechanical properties in advanced HEAs.
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- 2021
20. Improved transdermal permeability of tanshinone IIA from cataplasms by loading onto nanocrystals and porous silica
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Jing Chen, Yang Niu, Xiangshuai Gu, Jueshuo Guo, Qipeng Zhao, Jianhong Yang, and Yaping Mai
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Chemistry ,Pharmaceutical Science ,General Medicine ,Adhesion ,Permeation ,Administration, Cutaneous ,Silicon Dioxide ,Permeability ,Bioavailability ,Mice ,Chemical engineering ,In vivo ,Permeability (electromagnetism) ,Abietanes ,Drug delivery ,Animals ,Nanoparticles ,Porosity ,Dissolution ,Skin ,Transdermal - Abstract
Novel transdermal cataplasms have been designed to improve permeability of poorly soluble drugs by different pretreatments. Nanocrystal and porous silica solid dispersions were loaded with Tanshinone IIA and incorporated into a cross-linked hydrogel matrix of cataplasm. It was shown that the small particle size and improved dissolution would increase dermal bioavailability. The adhesion, rheological properties, drug release, skin permeation, skin deposition and in vivo skin absorption of the different formulations were investigated. In an in vitro experiment using mouse skin, cumulative amount of drug permeated within 24 h was 7.32 ± 0.98 μg/cm2 from conventional cataplasm, 13.14 ± 0.70 μg/cm2 from nanocrystal-loaded cataplasm and 11.40 ± 0.13 μg/cm2 from porous silica solid dispersion-loaded cataplasm. In vitro dissolution profiles showed that drug release was 76.5% and 74.9% from two optimized cataplasms within 24 h, while conventional cataplasm was 55.0%. The cross-linking characteristics of the cataplasms were preserved after incorporation of different drug forms, while the elastic and viscous behaviors of the hydrogel layers increased. In vivo evaluation by CLSM showed the more favorable skin permeation for two optimized cataplasms. These findings suggest that applications of nanocrystal and porous silica systems on cataplasms enable effective transdermal delivery of poorly soluble drugs. The resulting drug delivery and rheological properties are desirable for transdermal application.AbbreviationAll the abbreviations that appear in this article are shown in Table 1.
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- 2021
21. MSC secreted extracellular vesicles carrying TGF-beta upregulate Smad 6 expression and promote the regrowth of neurons in spinal cord injured rats
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Xia Xiang, Zuomeng Wu, Tianyu Han, Ying Wang, Cai-Liang Shen, Yang Niu, Yunlei Liu, Peiwen Song, and Huang Fang
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Neurons ,Gene knockdown ,Smad6 Protein ,Chemistry ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,General Medicine ,SMAD ,Bone morphogenetic protein ,Neural stem cell ,Rats ,Cell biology ,Extracellular Vesicles ,medicine.anatomical_structure ,Transforming Growth Factor beta ,TGF beta signaling pathway ,medicine ,Animals ,Neuron ,Stem cell ,Spinal Cord Injuries - Abstract
Mesenchymal stem cells (MSCs) constitute a promising therapy for spinal cord injury (SCI) because they can provide a favorable environment for the regrowth of neurons by inhibiting receptor-regulated Smads (R-Smads) expression in endogenous neural stem cells (NSCs). However, their mechanism of action and effect on the expression of inhibitory Smads (I-Smads) remain unclear. Herein, we demonstrated that extracellular vesicles (EVs) from MSCs were able to upregulate the Smad 6 expression by carrying TGF-β, and the Smad 6 knockdown in NSCs partially weakened the bone marrow MSC (BMSC)-EV-induced effect on neural differentiation. We found that the expression of Smad 6 did not reduced owing to the TGF-β type I receptor kinase inhibitor, SB 431,542, treatment in the acute phase of injury in rats with SCI, thereby indicating that the Smad 6 expression was not only mediated by TGF-β, but also by the inflammatory factors and bone morphogenetic proteins (BMPs) as well. However, in the later phase of SCI, the Smad 6 expression decreased by the addition of SB 431,542, suggesting that TGF-β plays a key role in the mediation of Smad 6 expression in this phase. In addition, immunohistochemistry staining; hematoxylin–eosin staining; and the Basso, Beattie, and Bresnahan (BBB) scores revealed that the early inhibition of TGF-β did not increase neuron regrowth. However, this inhibition increased the cavity and the caspase-3 expression at 24 h post-injury, leading to a worse functional outcome. Conversely, the later treatment with the TGF-β inhibitor promoted the regrowth of neurons around the cavity, resulting in a better neurological outcome. Together, these results indicate that Smad 6 acts as a feedback regulator to prevent the over-differentiation of NSCs to astrocytes and that BMSC-EVs can upregulate Smad 6 expression by carrying TGF-β. Graphical abstract
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- 2021
22. Species diversity of Ganoderma (Ganodermataceae, Polyporales) with three new species and a key to Ganoderma in Yunnan Province, China
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Jun He, Xiao Han, Zong-Long Luo, E-Xian Li, Song-Ming Tang, Hong-Mei Luo, Kai-Yang Niu, Xi-jun Su, and Shu-Hong Li
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Microbiology (medical) ,Microbiology - Abstract
Ganoderma is a globally distributed genus that encompasses species with forestry ecological, medicinal, economic, and cultural importance. Despite the importance of this fungus, the studies on the species diversity of Ganoderma in Yunnan Province, China (YPC) have poorly been carried out. During this study, opportunistic sampling was used to collect 21 specimens of Ganoderma from YPC. Morphology and multigene phylogeny of the internal transcribed spacer (ITS) regions, the large subunit of nuclear ribosomal RNA gene (nrLSU), the translation elongation factor 1-α gene (TEF1-α), and the second largest subunit of RNA polymerase II (RPB2) were used to identify them. Morphological and molecular characterization of the 21 specimens showed that they belong to 18 species of Ganoderma, of which three are novel viz. G. artocarpicola, G. obscuratum and G. yunnanense. Ganoderma artocarpicola is characterized by the sessile and concrescent basidiomata, reddish brown to yellowish brown pileus surface, heterogeneous context, wavy margin, and ovoid basidiospores. Ganoderma obscuratum is distinguished by small pores (6–9 per mm), dorsolaterally sub-stipitate basidiomata which become greyish-brown when dry, and narrow ellipsoid basidiospores. Ganoderma yunnanense is characterized by cream color pore surface and context, centrally to laterally stipitate basidiomata with reddish-brown to violet-brown strongly laccate pileus surface, and broadly ellipsoid basidiospores. With the help of an extensive literature survey and the results of this study, a checklist of 32 Ganoderma species from YPC was established, which accounts for 71.11% of the known species in China. In addition, a key to the Ganoderma in YPC is also provided.
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- 2022
23. The association between blood glucose levels and lipids or lipid ratios in type 2 diabetes patients: A cross-sectional study
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Liqun, Wang, Ning, Yan, Min, Zhang, Ruiping, Pan, Yuqi, Dang, and Yang, Niu
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Blood Glucose ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Endocrinology, Diabetes and Metabolism ,Cholesterol, HDL ,Humans ,Cholesterol, LDL ,Triglycerides - Abstract
BackgroundLipids and lipid ratios are associated with complications of diabetes mellitus type 2 (T2DM), such as cardiovascular disease, but the relationship between blood glucose levels and lipid or lipid ratios is not fully understood in T2DM patients. This study assesses the association between blood glucose levels and lipid or lipid ratios in a cohort of T2DM patients.MethodsA total of 1,747 Chinese T2DM patients from the Ningxia province of China were included in this cross-sectional study. Lipid parameters, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and fasting blood glucose levels were measured quantitatively using standard methods. Fasting blood glucose was divided into three groups. A multiple mixed-effect linear regression model was conducted to identify a potential association between blood glucose and lipid parameters.ResultsThere was a positive association between blood glucose and TG levels (β=0.34, 95% CI: (0.20, 0.48), p<0.01); every 1 mmol/L increase in blood glucose levels resulted in a 0.34 mmol/L increase in TG. Blood glucose levels were also associated with high LDL (β=0.08, 95% CI: (0.02, 0.14), p<0.01), TG/HDL-C (β=0.31, 95% CI: (0.13, 0.49), p<0.01), and LDL-C/HDL-C (β=0.13, 95% CI: (0.06, 0.20), pCI: (0.17, 0.45), p<0.01) and LDL-C (β=0.08, 95% CI: (0.02, 0.13), p<0.01) levels and an in increase in TG/HDL-C (β=0.28, 95% CI: (0.09, 0.46), p<0.01) and LDL-C/HDL-C (β=0.11, 95% CI: (0.04, 0.18), p<0.01) ratios was found.ConclusionA correlation between blood glucose levels and serum lipids or lipid ratios has been established in this study. Blood glucose levels were positively associated with TG and LDL-C levels and elevated TG/HDL-C and LDL-C/HDL-C ratios.
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- 2022
24. Species diversity of
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Jun, He, Xiao, Han, Zong-Long, Luo, E-Xian, Li, Song-Ming, Tang, Hong-Mei, Luo, Kai-Yang, Niu, Xi-Jun, Su, and Shu-Hong, Li
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- 2022
25. Genome-Wide Analysis and Expression Profiling of the Phenylalanine Ammonia-Lyase Gene Family in Solanum tuberosum
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Fangyu Mo, Long Li, Chao Zhang, Chenghui Yang, Gong Chen, Yang Niu, Jiaxin Si, Tong Liu, Xinxin Sun, Shenglan Wang, Dongdong Wang, Qin Chen, and Yue Chen
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Inorganic Chemistry ,Organic Chemistry ,fungi ,food and beverages ,General Medicine ,Physical and Theoretical Chemistry ,Molecular Biology ,potato ,phenylalanine ammonia-lyase (PAL) ,evolution ,expression ,gene family ,Spectroscopy ,Catalysis ,Computer Science Applications - Abstract
Phenylalanine ammonia-lyase is one of the most widely studied enzymes in the plant kingdom. It is a crucial pathway from primary metabolism to significant secondary phenylpropanoid metabolism in plants, and plays an essential role in plant growth, development, and stress defense. Although PAL has been studied in many actual plants, only one report has been reported on potato, one of the five primary staple foods in the world. In this study, 14 StPAL genes were identified in potato for the first time using a genome-wide bioinformatics analysis, and the expression patterns of these genes were further investigated using qRT-PCR. The results showed that the expressions of StPAL1, StPAL6, StPAL8, StPAL12, and StPAL13 were significantly up-regulated under drought and high temperature stress, indicating that they may be involved in the stress defense of potato against high temperature and drought. The expressions of StPAL1, StPAL2, and StPAL6 were significantly up-regulated after MeJa hormone treatment, indicating that these genes are involved in potato chemical defense mechanisms. These three stresses significantly inhibited the expression of StPAL7, StPAL10, and StPAL11, again proving that PAL is a multifunctional gene family, which may give plants resistance to multiple and different stresses. In the future, people may improve critical agronomic traits of crops by introducing other PAL genes. This study aims to deepen the understanding of the versatility of the PAL gene family and provide a valuable reference for further genetic improvement of the potato.
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- 2022
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26. Genome-Wide Analysis and Expression Profiling of the Phenylalanine Ammonia-Lyase Gene Family in
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Fangyu, Mo, Long, Li, Chao, Zhang, Chenghui, Yang, Gong, Chen, Yang, Niu, Jiaxin, Si, Tong, Liu, Xinxin, Sun, Shenglan, Wang, Dongdong, Wang, Qin, Chen, and Yue, Chen
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Gene Expression Regulation, Plant ,Gene Expression Profiling ,Humans ,Plants ,Phylogeny ,Phenylalanine Ammonia-Lyase ,Plant Proteins ,Solanum tuberosum - Abstract
Phenylalanine ammonia-lyase is one of the most widely studied enzymes in the plant kingdom. It is a crucial pathway from primary metabolism to significant secondary phenylpropanoid metabolism in plants, and plays an essential role in plant growth, development, and stress defense. Although PAL has been studied in many actual plants, only one report has been reported on potato, one of the five primary staple foods in the world. In this study, 14 StPAL genes were identified in potato for the first time using a genome-wide bioinformatics analysis, and the expression patterns of these genes were further investigated using qRT-PCR. The results showed that the expressions of StPAL1, StPAL6, StPAL8, StPAL12, and StPAL13 were significantly up-regulated under drought and high temperature stress, indicating that they may be involved in the stress defense of potato against high temperature and drought. The expressions of StPAL1, StPAL2, and StPAL6 were significantly up-regulated after MeJa hormone treatment, indicating that these genes are involved in potato chemical defense mechanisms. These three stresses significantly inhibited the expression of StPAL7, StPAL10, and StPAL11, again proving that PAL is a multifunctional gene family, which may give plants resistance to multiple and different stresses. In the future, people may improve critical agronomic traits of crops by introducing other PAL genes. This study aims to deepen the understanding of the versatility of the PAL gene family and provide a valuable reference for further genetic improvement of the potato.
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- 2022
27. A high‐precision and fast off‐line beamforming pattern estimation technique for active phased array antenna application
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Zicheng Zhou, Xiaopeng Lu, Yufan Yao, Yang Niu, Xin Fang, Xingwang Qiao, Guan‐Long Huang, and Changqing Gu
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Electrical and Electronic Engineering ,Computer Graphics and Computer-Aided Design ,Computer Science Applications - Published
- 2022
28. Modified donor blood flow-preserved cross-leg anterolateral thigh flap procedure for complex lower extremity reconstruction
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Hong-Xiang Zhou, Liang He, Dong Yin, Yang Niu, Zhe Jin, Jun-Jie Li, Qian-Kun Wang, and Tao Zhou
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Adult ,Leg ,Soft Tissue Injuries ,Adolescent ,Blood Loss, Surgical ,Middle Aged ,Plastic Surgery Procedures ,Myocutaneous Flap ,Young Adult ,Treatment Outcome ,Lower Extremity ,Thigh ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Child - Abstract
Background Complex lower limb reconstruction due to severe trauma remains a challenge for reconstructive surgeons. Here, we introduce a modified donor blood flow-preserved cross-leg anterolateral thigh flap procedure and evaluate its clinical efficacy. Methods Between January 2013 and December 2019, 22 patients (range 10 to 64 years old) with unilateral lower limb injury underwent modified donor blood flow-preserved cross-leg anterolateral thigh flap procedures. Among them, 16 cases were traffic accidents, 5 cases were persistent ulcers, and 1 case was a degloving injury. The arterial pedicle of the flap was prepared in a Y-shaped fashion and microanastomosed to the posterior tibial artery of intact leg in a flow-through style. A split-thickness skin graft was applied to wrap the vascular pedicle after anastomosis. The flap was designed in a single or bilobed fashion according to the shape of the tissue defect. The operation time, the intraoperative blood loss and the length of hospital stays were recorded. The vascular pedicle was divided 4 weeks after anastomosis. Doppler ultrasound was performed to evaluate the blood flow of the donor posterior tibial artery during postoperative follow-up. Results All 22 flaps survived. The tissue defects ranged from 12 × 6 to 21 × 18 cm2. The flap sizes ranged from 14 × 7.5 to 24 × 21 cm2. The average operation time, intraoperative blood loss and length of hospital stays were 6.73 ± 1.49 h, 280.95 ± 59.25 ml and 30.55 ± 2.52 days, respectively. Eighteen flaps were designed in a single fashion, while four were in bilobed fashion. Twenty patients underwent fasciocutaneous flap transplantations, while two underwent musculocutaneous flap transplantations. Two cases developed local lysis of the flap which healed after further debridement. Direct suture of the incision after flap harvest was performed in 16 cases, while additional full-thickness skin grafting was performed in the remaining 6 cases. Further bone transport procedures were performed in 15 patients who had severe tibia bone defects. The blood flow of donor posterior tibial artery was confirmed in all patients during follow-ups. All patients recovered flap sensation at the final follow-up. The postoperative follow-ups ranged from 18 to 84 months, and no long-term complications were observed. Conclusions The modified donor blood flow-preserved cross-leg anterolateral thigh flap procedure is an ideal method to repair severe lower limb trauma with tibial artery occlusion which avoids sacrificing the major artery of the uninjured lower limb.
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- 2022
29. Chimonobambusa sangzhiensis (Poaceae, Bambusoideae), a new combination supported by morphological and molecular evidence
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Zheng-Yang Niu, Zhuo-Yu Cai, Chun-Lin Liao, and Nian-He Xia
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Tracheophyta ,bamboo ,new combination ,Poales ,Liliopsida ,morphology ,Plant Science ,Plantae ,Poaceae ,phylogeny ,Biota ,Ecology, Evolution, Behavior and Systematics ,Chimonobambusa - Abstract
This study elucidates the taxonomic position of Indosasa sangzhiensis in considering whether it belongs to Indosasa or Chimonobambusa. Based on morphological and molecular phylogenetic evidence, our results explicitly indicated that I. sangzhiensis should be a member of Chimonobambusa, rather than Indosasa, and is a distinct species closely related to C. communis, C. opienensis and C. puberula. Thus, the new combination Chimonobambusa sangzhiensis (B.M.Yang) N.H.Xia & Z.Y.Niu is made. A detailed description as well as two color plates of this species are also provided.
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- 2022
30. Exploring the Dynamics and Regulatory Functions of Nuclear Lipids
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Yang Niu, Yeun Ju Kim, Joshua Pemberton, and Tamas Balla
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Genetics ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2022
31. The effect of different adiposity factors on insulin resistance in obese children and adolescents
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Jing Zou, Qingya Tang, Huijun He, Yang Niu, Xuelin Zhao, Xiaomeng Mao, Wei Cai, and Jinye Sheng
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Male ,Pediatric Obesity ,medicine.medical_specialty ,Waist ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Adipose tissue ,030209 endocrinology & metabolism ,Context (language use) ,Clinical nutrition ,Body fat percentage ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Internal medicine ,medicine ,Humans ,Child ,Adiposity ,Univariate analysis ,business.industry ,medicine.disease ,030220 oncology & carcinogenesis ,Female ,Insulin Resistance ,Waist Circumference ,business ,Body mass index - Abstract
Insulin resistance (IR) has been common in obese children, but the effect of different adiposity factors on IR is still unclear.To evaluate the associations between IR with body mass index (BMI), waist circumference (WC), body fat mass (BFM), and body fat percentage (BFP) in obese children and adolescents.A total of 224 simple obese children were included in this study, including 150 boys and 74 girls, aged 3-18 who were seen in the clinical nutrition outpatient of Xinhua Hospital from September 2012 to December 2019. Basic information, body composition and laboratory tests were collected.Compared with girls, boys had higher height, weight, BMI, WC, and BFM (P 0.05), but on the contrary, boys' FINS and HOMA- IR were lower than girls' (P 0.05). With the age increasing, height, weight, BMI, BFM, WC, HC, WHtR, FINS and HOMA-IR increased accordingly (P 0.05). The results from univariate analysis and multiple linear regression analysis showed that the impact of BMI on IR was slightly lower than BFM, WC and HC, but higher than BFP, with adjusting for the effects of age, sex and lipid metabolism (P 0.01).Overall adipose tissue, especially abdominal adipose tissue, is a powerful marker in inducing IR in obese children and adolescents. In addition, more attention should be paid to WC and BFM than BMI in obese people with IR.
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- 2021
32. Research Progress of Liquid Crystal Polymer Composites in Augmented and Virtual Reality
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Bing-Bing Zhang, Xiao-Min Liu, Su-Xiao Li, Zi-Yang Niu, and Mengzhu Du
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Materials science ,General Materials Science ,Composite material ,Virtual reality - Abstract
The three-dimensional (3D) display technology has always been a hot spot in the display field. The core of augmented reality (AR), virtual reality (VR), and naked-eye 3D display are to visually regulate the light entering the human eye to form a binocular parallax, that is, a visual deviation in the image of the two eyes, which produces a stereoscopic sense in the human brain. In the AR and VR display field, we always pursue a perfect immersive visual experience, which poses great challenges to the wide field of view (FOV) and high resolution of the system. As a new type of polymer material, liquid crystal polymers are widely used in AR and VR because of their unique optoelectronic properties, such as scattering or transparency with the change of an applied electric field. In this paper, we review some key challenges in the field of AR and VR display, such as the well-known vergence-accommodation conflict (VAC), and propose solutions that have been proven effective. We introduce the important functions and optoelectronic properties of liquid crystal (LC) materials by describing in detail the working principle of polymer dispersed liquid crystal (PDLC), doublet geometric phase (GP) lens, and polymer-stabilized liquid crystal (PSLC). Finally, we summarize and discuss the main uses and challenges of liquid crystal materials in the field of AR and VR displays.
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- 2021
33. Zoom Unit in Augmented Reality: Liquid Lens
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Bing-Bing Zhang, Xiao-Min Liu, Mengzhu Du, Zi-Yang Niu, and Pengbo Chen
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Materials science ,Liquid lens ,Computer graphics (images) ,General Materials Science ,Augmented reality ,Zoom ,Unit (housing) - Abstract
With the development of modern technology and people’s demand for improving living standards, the traditional 2D display cannot meet the needs of people, so the augmented reality (AR) technology which combines virtual objects with real environment arises at the historic moment. AR technology sprouted in the 1960 s, and ushered in rapid development in the 21st century through continuous technical iteration. However, the traditional AR system cannot solve the vergence-accommodation conflict (VAC), to solve which, researchers introduced liquid lens into the optical system of AR. The methods and materials of making liquid lens are different. In this paper, the research progress of liquid lens is summarized from three aspects. Firstly, the research progress of liquid lens is briefly reviewed. Secondly, the classification and typical preparation technology of liquid lens are introduced, and different requirements for performance are described. Finally, the performance and testing method of liquid lens is introduced.
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- 2021
34. Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity
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Dong-Mei Jiang, Ze-Long Wang, Jia-Di Yang, Xin Wang, Chun-Yang Niu, Cheng-Weng Ji, Wei-Kang Ling, Xiao-Guang An, Yong-Ni Guo, Qian Sun, Lin Bai, De-Bing Li, Xiao-Hui Si, and Bo Kang
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Nutrition and Dietetics ,spermidine ,metabolite ,intestinal morphology ,microorganisms ,intestine ,Food Science - Abstract
Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites, and microbial diversity in mice. We showed that 0.3 mmol/L of spermidine significantly promoted the growth of ileal villi (p < 0.05), and 3.0 mmol/L of spermidine significantly increased the body weight of mice and promoted the growth of jejunum villi (p < 0.05). The 16S rDNA sequencing results indicated that 3.0 mmol/L of spermidine affected the balance of the intestinal flora by increasing the abundance of intestinal Lactic acid bacteria and reducing the abundance of harmful bacteria (Turicibacter and Alistipes). Additionally, spermidine affects the levels of microbial metabolites such as succinic acid and Pantetheine. In summary, spermidine affects intestinal morphology and regulates intestinal flora and metabolites, and this study has provided a new understanding of spermidine’s effects on the intestinal tract.
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- 2023
35. Sexual conflict in protandrous flowers and the evolution of gynodioecy*
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Spencer C. H. Barrett, Yuan-Wen Duan, Xue-Yan Li, Hao Wang, Zhi-Qiang Zhang, Qing-Jun Li, and Yang Niu
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0106 biological sciences ,0301 basic medicine ,media_common.quotation_subject ,Zoology ,Fertility ,Flowers ,Gynodioecy ,Biology ,medicine.disease_cause ,010603 evolutionary biology ,01 natural sciences ,Sexual conflict ,03 medical and health sciences ,Hermaphrodite ,Pollinator ,Pollen ,Genetics ,medicine ,Hermaphroditic Organisms ,Pollination ,Ecology, Evolution, Behavior and Systematics ,media_common ,Longevity ,food and beverages ,Campanulaceae ,Biological Evolution ,Sexual dimorphism ,030104 developmental biology ,Seeds ,Genetic Fitness ,General Agricultural and Biological Sciences - Abstract
Sexual interference between male and female function in hermaphrodite plants is reduced by protandry. In environments with insufficient pollinator service, prolongation of male function owing to limited pollen removal could restrict the duration of female function and lower seed production. We provide evidence that this form of sexual conflict has played a role in the spread of females in gynodioecious populations of Cyananthus delavayi in the pollen-limited environments in which this subalpine species occurs. Using field experiments involving artificial pollen removal from the strongly protandrous flowers of hermaphrodites, we demonstrated a trade-off between male- and female-phase duration with no influence on overall floral longevity. Pollen removal at the beginning of anthesis resulted in hermaphrodite seed production matching that of females. In contrast, restricted pollen removal increased the duration of male function at the expense of female function lowering maternal fertility compared to females. This pattern was evident in five populations with females experiencing a twofold average seed fertility advantage compared to hermaphrodites. Gynodioecy often appears to evolve from protandrous ancestors and pollen limitation is widespread in flowering plants suggesting that sexual conflict may play an unappreciated role in the evolution of this form of sexual dimorphism.
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- 2020
36. Elucidation of the Reinforcing Spleen Effect of Jujube Fruits Based on Metabolomics and Intestinal Flora Analysis
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Yan-Ling, Yi, Yao, Li, Sheng, Guo, Hui, Yan, Xin-Fei, Ma, Wei-Wei, Tao, Er-Xin, Shang, Yang, Niu, Da-Wei, Qian, and Jin-Ao, Duan
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Microbiology (medical) ,Infectious Diseases ,Plant Extracts ,Fruit ,Immunology ,Animals ,Metabolomics ,Ziziphus ,Syndrome ,Microbiology ,Spleen ,Gastrointestinal Microbiome ,Rats - Abstract
Jujube (Ziziphus jujuba Mill.) fruit (JF) is widely consumed as food in Asian countries due to its potential effects for human health. As a traditional Chinese medicine, JF is often used to treat anorexia, fatigue and loose stools caused by spleen deficiency syndromes in China, but the mechanism underlying this effect has not been thoroughly elucidated. In this study, a rat model of spleen deficiency syndromes was adopted to investigate the therapeutic effect of JF extract and its possible mechanism by metabolomics analyses of plasma and urine as well as the intestinal flora analysis. The results showed that the changes in plasma and urine metabolites caused by spleen deficiency were reversed after administration of JF, and these changed endogenous metabolites were mainly involved in retinol metabolism, pentose and glucuronate interconversions, nicotinate and niacinamide metabolism pathways. The 16S rDNA sequencing results showed that JF could regulate intestinal flora imbalance caused by spleen deficiency. The covariance analysis of intestinal flora structure and metabolome indicated that Aerococcus may be a candidate strain for predicting and treating the metabolic pathways of spleen deficiency and related disorders. In summary, it can be revealed that spleen deficiency, which alters metabolic profiles and the intestinal flora, could be alleviated effectively by JF extract.
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- 2022
37. Intersexual mimicry and imperfect deceit of a threatened aquatic herb Ottelia acuminata
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Weibang Sun, Xiang-Hai Cai, Yang Niu, Jing Yang, and Gao Chen
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food.ingredient ,food ,Dioecy ,Herb ,Threatened species ,Mimicry ,Zoology ,Plant Science ,Biology ,Ottelia acuminata ,Ecology, Evolution, Behavior and Systematics ,Sex ratio - Published
- 2020
38. Milk Fat Globule Membrane Enhances Colonic–Mucus‐Barrier Function in a Rat Model of Short‐Bowel Syndrome
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Jiang Wu, Yang Niu, Qingya Tang, Ying Li, and Zhicai Yu
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Male ,Short Bowel Syndrome ,Receptors, Vasopressin ,medicine.medical_specialty ,030309 nutrition & dietetics ,Crypt ,Medicine (miscellaneous) ,Mucin 2 ,Gut flora ,digestive system ,Enteral administration ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Intestinal Mucosa ,Barrier function ,Glycoproteins ,0303 health sciences ,Receptors, Angiotensin ,Nutrition and Dietetics ,Intestinal permeability ,biology ,Chemistry ,Mucin ,Lipid Droplets ,medicine.disease ,Short bowel syndrome ,biology.organism_classification ,Rats ,Mucus ,Endocrinology ,030211 gastroenterology & hepatology ,Glycolipids - Abstract
BACKGROUND Clinical research reveals that colon plays an important role in mitigating the effects of short-bowel syndrome (SBS). Previously, we showed that the milk fat globule membrane (MFGM) had protective effects on gut barrier integrity in the rat SBS model. Here, we used the same rat model to investigate the effects of enteral MFGM supplementation on gut microbiota and colonic-mucus-barrier function and its related mechanisms. METHODS We randomly divided 24 male Sprague-Dawley rats into 3 groups: Sham, SBS (rats with massive small-bowel resection), and SBS+MFGM (SBS rats supplemented with 1.5 g/kg/d MFGM). We then evaluated gut permeability, crypt depth, goblet-cell count, mucin 1 (MUC1), mucin 2 (MUC2), microbiota, short-chain fatty acids, and protein expressions of nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 6 (NLRP6) pathway of the colon. RESULTS Compared with SBS rats, SBS+MFGM rats exhibited lower intestinal permeability, increased crypt depth, more goblet cells, and more MUC1/MUC2-positive cells. The SBS+MFGM group also had greater Firmicutes abundance and lower acetate concentration (P < .05). Sham rats had significantly lower Bacteroidetes abundance than SBS rats, but SBS+MFGM and SBS groups did not differ. Additionally, the SBS+MFGM group had higher NLRP6 and interleukin (IL)-18 expression but lower IL-1β and Caspase-1 (cysteinyl aspartate-specific protease-1) expression than the SBS group (P < .05). CONCLUSION Supplementation of MFGM modulates gut microbiota composition in SBS, possibly through strengthening the colonic mucus barrier and regulation of NLRP6 inflammasome.
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- 2020
39. Red flowers differ in shades between pollination systems and across continents
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Yang Niu, Zhe Chen, Chang-Qiu Liu, and Hang Sun
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bird ,Old World ,Pollination ,Color ,Zoology ,Flowers ,Plant Science ,Biology ,Pollination syndrome ,AcademicSubjects/SCI01080 ,Birds ,pollinator ,Pollinator ,Animals ,plant-animal interaction ,floral colour ,Bee ,colour vision ,pollination syndrome ,AcademicSubjects/SCI01210 ,Colour Vision ,Spectral properties ,AcademicSubjects/SCI01130 ,Original Articles ,Bees ,Attraction ,Reflectivity ,flower evolution - Abstract
Background and AimsFloral colour is a primary signal in plant–pollinator interactions. The association between red flowers and bird pollination is well known, explained by the ‘bee avoidance’ and ‘bird attraction’ hypotheses. Nevertheless, the relative importance of these two hypotheses has rarely been investigated on a large scale, even in terms of colour perception per se.MethodsWe collected reflectance spectra for 130 red flower species from different continents and ascertained their pollination systems. The spectra were analysed using colour vision models for bees and (three types of) birds, to estimate colour perception by these pollinators. The differences in colour conspicuousness (chromatic and achromatic contrast, purity) and in spectral properties between pollination systems and across continents were analysed.Key ResultsCompared with other floral colours, red flowers are very conspicuous to birds and much less conspicuous to bees. The red flowers pollinated by bees and by birds are more conspicuous to their respective pollinators. Compared with the bird flowers in the Old World, the New World ones are less conspicuous to bees and may be more conspicuous not only to violet-sensitive but also to ultraviolet-sensitive birds. These differences can be explained by the different properties of the secondary reflectance peak (SP). SP intensity is higher in red flowers pollinated by bees than those pollinated by birds (especially New World bird flowers). A transition from high SP to low SP in red flowers can induce chromatic contrast changes, with a greater effect on reducing attraction to bees than enhancing attraction to birds.ConclusionsShades of red flowers differ between pollination systems. Moreover, red bird flowers are more specialized in the New World than in the Old World. The evolution towards colour specialization is more likely to result in higher efficiency of bee avoidance than bird attraction
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- 2020
40. The ultraviolet colour component enhances the attractiveness of red flowers of a bee-pollinated plant
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Yang Niu, Hang Sun, Zhe Chen, and Chang-Qiu Liu
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0106 biological sciences ,Attractiveness ,Ecology ,Plant Science ,Biology ,medicine.disease_cause ,010603 evolutionary biology ,01 natural sciences ,Horticulture ,Component (UML) ,medicine ,Ecology, Evolution, Behavior and Systematics ,Ultraviolet ,010606 plant biology & botany - Abstract
AimsBee-pollinated flowers are rarely red, presumably because bees (which lack red receptors) have difficulty detecting red targets. Although the response of bees to red colour has been investigated in lab experiments, most stimuli have been pure red, while the subtle diversity of red as perceived by humans (human-red) has received very limited attention. Here we test the hypothesis that ultraviolet (UV) reflected from human-red flowers enhances their attractiveness to bees, through increased chromatic contrast.MethodsUsing Onosma confertum (Boraginaceae), a plant with UV-reflecting red flowers that are pollinated by bumblebees, we investigated the effects of UV reflection on pollinator responses by conducting phenotypic manipulation experiments in the field. Colour preferences of flower-naïve bumblebees were also examined. Colour perception by bumblebees was estimated in terms of chromatic and achromatic contrast, based on two different colour perception models.Important FindingsWe found that both natural and flower-naïve bumblebees strongly preferred visiting UV-reflecting targets compared with UV-absorbing ones. Colour models show that the UV-reflecting flowers exhibit higher spectral purity and higher chromatic contrast against the foliage background, whereas they have similar achromatic contrast in terms of green receptor contrast. These results indicate that the component of UV reflection increases chromatic contrast in O. confertum, enhancing the visual attractiveness of these red flowers to bumblebees. We further infer that the secondary reflectance might be a necessary component in human-red flowers that are primarily pollinated by animals without red receptors, such as bees.
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- 2020
41. The role of hepatocyte growth factor in mesenchymal stem cell-induced recovery in spinal cord injured rats
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Tianyu Han, Yang Niu, Huang Fang, Ying Wang, Cai-Liang Shen, Peiwen Song, and Xia Xiang
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Neurite ,Medicine (miscellaneous) ,SMAD ,Bone morphogenetic protein ,Mesenchymal Stem Cell Transplantation ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,lcsh:Biochemistry ,Bone morphogenetic proteins ,medicine ,Animals ,lcsh:QD415-436 ,Spinal Cord Injuries ,Neural stem cells ,Hepatocyte growth factor ,Inflammation ,lcsh:R5-920 ,Chemistry ,Regeneration (biology) ,Research ,Mesenchymal stem cell ,Cell Differentiation ,Cell Biology ,Neural stem cell ,Cell biology ,Rats ,Spinal Cord ,Culture Media, Conditioned ,Molecular Medicine ,Mesenchymal stem cells ,Stem cell ,lcsh:Medicine (General) ,medicine.drug - Abstract
Background Mesenchymal stem cells (MSCs) have become a promising treatment for spinal cord injury (SCI) due to the fact that they provide a favorable environment. Treatment using MSCs results in a better neurological functional improvement through the promotion of nerve cell regeneration and the modulation of inflammation. Many studies have highlighted that the beneficial effects of MSCs are more likely associated with their secreted factors. However, the identity of the factor that plays a key role in the MSC-induced neurological functional recovery following SCI as well as its molecular mechanism still remains unclear. Methods A conditioned medium (collected from the MSCs) and hepatocyte growth factor (HGF) were used to test the effects on the differentiation of neural stem cells (NSCS) in the presence of BMP4 with or without a c-Met antibody. In SCI rats, Western blot, ELISA, immunohistochemistry, and hematoxylin-eosin staining were used to investigate the biological effects of MSC-conditioned medium and HGF on nerve cell regeneration and inflammation with or without the pre-treatment using a c-Met antibody. In addition, the possible molecular mechanism (cross-talk between HGF/c-Met and the BMP/Smad 1/5/8 signaling pathway) was also detected by Western blot both in vivo and in vitro. Results The conditioned medium from bone marrow-derived MSCs (BMSCs) was able to promote the NSC differentiation into neurons in vitro and the neurite outgrowth in the scar boundary of SCI rats by inhibiting the BMP/Smad signaling pathway as well as reduces the secondary damage through the modulation of the inflammatory process. The supplementation of HGF showed similar biological effects to those of BMSC-CM, whereas a functional blocking of the c-Met antibody or HGF knockdown in BMSCs significantly reversed the functional improvement mediated by the BMSC-CM. Conclusions The MSC-associated biological effects on the recovery of SCI rats mainly depend on the secretion of HGF.
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- 2020
42. Different epitopes of Ralstonia solanacearum effector RipAW are recognized by two Nicotiana species and trigger immune responses
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Yue Chen, Xin Jin, Cuizhu Zhao, Mingxia Lu, Yong Zhang, Núria S. Coll, Haibin Lu, Yang Niu, Yizhe He, Jinxue Hu, Qin Chen, Dongdong Wang, Mancang Zhang, Marc Valls, Huijuan Wang, Yisa Wang, Shouyang Fu, Gong Chen, Natural Science Foundation of Shaanxi Province, Shaanxi Provincial Key Laboratory Project of Department of Education, Shaanxi Province, and National Natural Science Foundation of China
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Cell death ,Nicotiana ,viruses ,Nicotiana tabacum ,Bacterial diseases ,Soil Science ,Nicotiana benthamiana ,Plant cells and tissues ,Plant Science ,Effector-triggered immunity ,medicine.disease_cause ,Epitope ,Epitopes ,Protein Domains ,effector‐triggered immunity ,Tobacco ,medicine ,Plant Immunity ,Molecular Biology ,E3 ligase ,Plant Diseases ,Ralstonia solanacearum ,Mutation ,Malalties bacterianes ,biology ,Effector ,RipAW ,fungi ,food and beverages ,Original Articles ,biology.organism_classification ,Cèl·lules i teixits vegetals ,Cell biology ,cell death ,effector ,Immune system ,Sistema immunitari ,Original Article ,Agronomy and Crop Science - Abstract
Diverse pathogen effectors convergently target conserved components in plant immunity guarded by intracellular nucleotide-binding domain leucine-rich repeat receptors (NLRs) and activate effector-triggered immunity (ETI), often causing cell death. Little is known of the differences underlying ETI in different plants triggered by the same effector. In this study, we demonstrated that effector RipAW triggers ETI on Nicotiana benthamiana and Nicotiana tabacum. Both the first 107 amino acids (N1-107) and RipAW E3-ligase activity are required but not sufficient for triggering ETI on N. benthamiana. However, on N. tabacum, the N1-107 fragment is essential and sufficient for inducing cell death. The first 60 amino acids of the protein are not essential for RipAW-triggered cell death on either N. benthamiana or N. tabacum. Furthermore, simultaneous mutation of both R75 and R78 disrupts RipAW-triggered ETI on N. tabacum, but not on N. benthamiana. In addition, N. tabacum recognizes more RipAW orthologs than N. benthamiana. These data showcase the commonalities and specificities of RipAW-activated ETI in two evolutionally related species, suggesting Nicotiana species have acquired different abilities to perceive RipAW and activate plant defences during plant–pathogen co-evolution., This work was funded by the Nature Science Basic Research Plan of Shaanxi Province (2020JM-160), the Special Research project from Shaanxi province (F2020221001), the Program of Introducing Talents of Innovative Discipline to Universities (Project 111) from the State administration of Foreign Experts Affairs (B18042) and the External Science and Technology Cooperation Program of Ningxia Academy of Agriculture and Forestry Sciences (DW-X-2018012), the Start-up Funds of Northwest A&F University (Z111021601), the Fundamental Research Fund for the Central Universities of China (Z109021706), the Key Research and Development plan of Ningxia Province (2021BEF02033), and the National Natural Science Foundation of China for C.Z. (31901573).
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- 2022
43. Potential Therapeutic Effects of Mi-Jian-Chang-Pu Decoction on Neurochemical and Metabolic Changes of Cerebral Ischemia-Reperfusion Injury in Rats
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Jingjing Liu, Lingling Yang, Yang Niu, Chao Su, Yingli Wang, Ruru Ren, Jianyu Chen, and Xueqin Ma
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Aging ,Glutathione Disulfide ,Article Subject ,Cell Biology ,General Medicine ,Biochemistry ,Brain Ischemia ,Rats ,Rats, Sprague-Dawley ,Tandem Mass Spectrometry ,Reperfusion Injury ,Animals ,Humans ,Ischemic Stroke - Abstract
As a traditional Chinese medicine formula, Mi-Jian-Chang-Pu decoction (MJCPD) has been successfully used in patients with language dysfunction and hemiplegia after ischemic stroke (IS). Given the excellent protective effects of MJCPD against nerve damage caused by IS in clinical settings, the present investigation mainly focused on its underlying mechanism on ischemia-reperfusion (IR) injury. Firstly, by applying the MCAO-induced cerebral IR injury rats, the efficacy of MJCPD on IS was estimated using the neurological deficit score, TTC, HE, and IHC staining, and neurochemical measurements. Secondly, an UHPLC-QTOF-MS/MS-based nontargeted metabolomics was developed to elucidate the characteristic metabolites. MJCPD groups showed significant improvements in the neurological score, infarction volume, and histomorphology, and the changes of GSH, GSSG, GSH-PX, GSSG/GSH, LDH, L-LA, IL-6, TNF-α, and VEGF-c were also reversed to normal levels after the intervention compared to the MCAO model group. Metabolomics profiling identified 21 different metabolites in the model group vs. the sham group, 10 of which were significantly recovered after treatment of MJCPD, and those 10 metabolites were all related to the oxidative stress process including glucose, fatty acid, amino acid, glutamine, and phospholipid metabolisms. Therefore, MJCPD might protect against IS by inhibiting oxidative stress during IR.
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- 2022
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44. Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway
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Hongxia Jiang, Yang Niu, Yuanzhou He, Xiaochen Li, Yongjian Xu, and Xiansheng Liu
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Proteomics ,X-Box Binding Protein 1 ,Physiology ,MAP Kinase Signaling System ,Hypertension, Pulmonary ,Clinical Biochemistry ,Myocytes, Smooth Muscle ,Cell Biology ,Pulmonary Artery ,Vascular Remodeling ,Rats ,Rats, Sprague-Dawley ,Disease Models, Animal ,Animals ,Hypoxia ,Cell Proliferation - Abstract
Hypoxic pulmonary hypertension (HPH) is characterized by elevated pulmonary artery resistance and vascular remodeling. Endoplasmic reticulum stress (ERS) is reported to be involved in HPH, but the underlying mechanisms remain uncertain. We found that Xbp1s, a potent transcription factor during ERS, was elevated in hypoxic-cultured rat PASMCs and lung tissues from HPH rats. Our in vitro experiments demonstrated that overexpressing Xbp1s can promote proliferation, cell viability, and migration and inhibit the apoptosis of PASMCs, while silencing Xbp1s led to the opposite. Through data-independent acquisition (DIA) mass spectrometry, we identified extensive proteomic alterations regulated by hypoxia and Xbp1s. Further validation revealed that p-JNK, rather than p-ERK or p-p38, was the downstream effector of Xbp1s. p-JNK inhibition reversed the biological effects of Xbp1s overexpression in vitro. In the animal HPH model, rats were randomly assigned to five groups: normoxia, hypoxia, hypoxia+AAV-CTL (control), hypoxia+AAV-Xbp1s (prevention), and hypoxia+AAV-Xbp1s (therapy). Adeno-associated virus (AAV) serotype 1-mediated Xbp1s knockdown in the prevention and therapy groups significantly reduced right ventricular systolic pressure, total pulmonary resistance, right ventricular hypertrophy, and the medial wall thickness of muscularized distal pulmonary arterioles; AAV-Xbp1s also decreased proliferating cell nuclear antigen expression and increased apoptosis in pulmonary arterioles. Collectively, our findings demonstrated that the Xbp1s-p-JNK pathway is important in hypoxic vascular remodeling and that targeting this pathway could be an effective strategy to prevent and alleviate HPH development.
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- 2021
45. Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents
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Yang Niu, Qingya Tang, Xuan Zhao, Xuelin Zhao, Xiaomeng Mao, Jinye Sheng, Wei Cai, and Yi Feng
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Male ,Pediatric Obesity ,obesity ,Adolescent ,Endocrinology, Diabetes and Metabolism ,nutritional and metabolic diseases ,RC648-665 ,Diseases of the endocrine glands. Clinical endocrinology ,Body Mass Index ,Endocrinology ,uric acid ,children ,Child, Preschool ,insulin resistance ,Humans ,Insulin ,Female ,adolescents ,Child ,Original Research ,Retrospective Studies - Abstract
ObjectiveThis study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents.MethodsA total of 369 participants aged 4-17 years with obesity who attended the Nutrition Outpatient Clinic for Obesity at Xinhua Hospital from January 2012 to January 2019 were recruited for this retrospective study. We classified participants into two groups on the basis of HOMA-IR values: the low HOMA-IR group (< 3.16) (n = 222) and the high HOMA-IR group (≥ 3.16) (n = 147).ResultsThe univariate analysis found that the high HOMA-IR group had higher BMI, SUA, and fasting insulin (FINS) (P < 0.05). Multiple linear regression analysis and mediating effect analysis indicated that body mass index (BMI) could directly regulate FINS and HOMA-IR (both P < 0.05). The results from the mediating effect analysis found that UA partially played an indirect role in the link between BMI, FINS and HOMA-IR (both P < 0.05) but had no effect on fasting blood glucose (P > 0.05).ConclusionsSUA should be investigated in obesity and plays a partial mediating role in insulin resistance induced by obesity in obese children and adolescents.
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- 2021
46. Mystery revisited: Is nocturnal colored nectar a nonadaptive floral trait?
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Xiang‐Hai Cai, Bao‐Bao Shi, Yang Niu, Jia Ge, Guillaume Chomicki, and Gao Chen
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Phenotype ,Plant Nectar ,Flowers ,Pollination ,Ecology, Evolution, Behavior and Systematics - Published
- 2021
47. Modified Recipient Blood Flow-Preserved Cross-Leg Anterolateral Thigh Flap Procedure for Complex Lower Extremity Reconstruction
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Liang He, Jun-Jie Li, Hong-Xiang Zhou, Zhe Jin, Qian-Kun Wang, Dong Yin, Tao Zhou, and Yang Niu
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business.industry ,Medicine ,Anatomy ,Blood flow ,Anterolateral thigh ,business - Abstract
Background: Complex lower limb reconstruction following severe trauma remains a challenge for reconstructive surgeons. We here introduce a modified recipient blood flow-preserved cross-leg anterolateral thigh flap procedure and evaluate its clinical efficacy.Methods: Between January 2013 and December 2019, 22 patients (range 10 to 64 years old) with unilateral lower limb injuries underwent the modified recipient blood flow-preserved cross-leg anterolateral thigh flap procedures. Among them, 16 cases were traffic accidents, 5 cases were stubborn ulcers, and 1 case was degloving injury. The arterial pedicle of flap was prepared as Y-shaped fashion and microanastomosed to contralateral posterior tibial artery in a flow-through style. A split-thickness skin graft was applied to wrap the vascular pedicle after anastomosis. The flap was designed as single or bilobed fashions according to the shape of defects. The tissue defects ranged from 12 × 6 to 21 × 18 cm2. The vascular pedicle was divided 4 weeks after vascular anastomosis. Doppler ultrasound was performed to evaluate the blood flow of the recipient posterior tibial artery during postoperative follow-up.Results: All of 22 flaps survived. The flap sizes ranged from to 14 × 7.5 to 24 × 21 cm2. Eighteen flaps were designed as single fashion, and four flaps were bilobed fashion. Twenty patients underwent fasciocutaneous flap transplantation, and two underwent musculocutaneous flap transplantation. Two cases developed local lysis of the flap, and the wound healed after further debridement. Direct suture of the donor-site incision were performed in 16 cases, while additional full-thickness skin grafting were performed in remaining 6 cases. Further bone transport procedure was performed in 15 patients with severe tibia bone defects. Blood flow of recipient posterior tibial arteries were all confirmed during follow-up. The postoperative follow-up ranged 18 to 84 months, and no long-term complications were observed.Conclusions: The modified recipient blood flow-preserved cross-leg anterolateral thigh flap procedure is an ideal method to repair large tissue defects without sacrificing major artery of uninjured lower limb.
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- 2021
48. Correction to: Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles Modified with Transferrin for Antitumor
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Zonghua Tian, Shuang Li, Jianhong Yang, Jing Chen, Yang Niu, Guojing Gou, Jueshuo Guo, and Li Li
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chemistry.chemical_classification ,Ecology ,Chemistry ,Pharmacology toxicology ,Pharmaceutical Science ,Nanoparticle ,General Medicine ,Aquatic Science ,Pharmacology ,PLGA ,chemistry.chemical_compound ,Transferrin ,Piperine ,Drug Discovery ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2021
49. Skeletal Muscle Mass Has Stronger Association With the Risk of Hyperuricemia Than Body Fat Mass in Obese Children and Adolescents
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Luyao Xie, Phoenix K. H. Mo, Qingya Tang, Xuan Zhao, Xuelin Zhao, Wei Cai, Yi Feng, and Yang Niu
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Food Science - Abstract
BackgroundHyperuricemia has been increasing among children with obesity in recent years. However, few studies in such a study group had explored the relationship between obesity-anthropometric indexes and hyperuricemia. This study aimed to examine the associations between hyperuricemia and different body components in children and adolescents with obesity, and further explore gender differences in these associations.MethodsIn this cross-sectional study, a total of 271 obese children and adolescents (153 boys and 118 girls) aged 6–17 years were recruited from Shanghai Xinhua Hospital. Data about basic information, anthropometric assessments, body composition, and laboratory tests of participants were collected.ResultsIn this study, 73 boys (47.71%) and 57 girls (48.31%) were diagnosed to have hyperuricemia. The impacts of percentage of skeletal muscle (PSM) (OR = 1.221, P < 0.001) and skeletal muscle mass (SMM) (OR = 1.179, P < 0.001) on the risk of hyperuricemia was the largest, followed by hip circumference (HC) (OR = 1.109, P < 0.001), waist circumference (WC) (OR = 1.073, P < 0.001), and body fat mass (BFM) (OR = 1.056, P < 0.05) in whole sample, which was adjusted for age, gender and body mass index (BMI). After being stratified by gender, PSM (boys: OR = 1.309, P < 0.001) and SMM (boys: OR = 1.200, P < 0.001; girls: OR = 1.147, P < 0.05) were still the most predictors of hyperuricemia, followed by HC (boys: OR = 1.147, P < 0.001; girls: OR = 1.080, P < 0.05). WC showed a significant association with hyperuricemia only in boys (OR = 1.083, P < 0.05), while BFM showed no association with hyperuricemia in both gender groups after adjusting for age and BMI.ConclusionOur findings suggested that SMM was a stronger predictor of hyperuricemia than BFM in children and adolescents with obesity, especially in boys.
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- 2021
50. The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non‐volatile components in normal rats
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Yang Niu, Kaidi Huang, Jin-Ao Duan, Sheng Guo, Yiying Zhang, Fanshu Bu, Dawei Qian, Erxin Shang, Hui Ren, and Ting Zhang
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Male ,Coumaric Acids ,Clinical Biochemistry ,Herb-Drug Interactions ,Cmax ,Biochemistry ,Analytical Chemistry ,Rats, Sprague-Dawley ,Ferulic acid ,chemistry.chemical_compound ,Glucosides ,Pharmacokinetics ,Limit of Detection ,Tandem Mass Spectrometry ,In vivo ,Drug Discovery ,Oils, Volatile ,Caffeic acid ,Animals ,Molecular Biology ,Chromatography, High Pressure Liquid ,Pharmacology ,Chromatography ,Chemistry ,Reproducibility of Results ,General Medicine ,Paeoniflorin ,Rats ,Linear Models ,Monoterpenes ,Icariin ,Magnoflorine ,Drugs, Chinese Herbal - Abstract
Hui Medicine ZhaLi NuSi Prescription (ZLNS) is described in "Hui Hui Prescription," and it has been used to treat cerebral infarction in Hui Region, China. In this study, a rapid and reliable ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS) method was established and applied to simultaneously determine geniposidic acid, oxypaeoniflorin, hydroxysafflor yellow A, caffeic acid, magnoflorine, paeoniflorin, ferulic acid, β-ecdysterone, icariin, rhein, and baohuoside I in rat plasma. The pharmacokinetic parameters of these components and the influence of essential oils (EOs) on them were investigated in normal rats. The results showed that the pharmacokinetic parameters (AUC0 - t , AUC0 - ∞ , t1/2 , tmax , cmax ) of the aforementioned compounds were significantly changed after co-administering with ZLNS EO. The AUC values of oxypaeoniflorin, paeoniflorin, ferulic acid, and baohuoside I with EOs were decreased significantly. This is the first report for the comparative pharmacokinetic study of ZLNS bioactive components in normal rats, which may provide the basis for drug interaction study in vivo and insight into their clinical applications.
- Published
- 2021
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