1. A minimally invasive strategy to evacuate hematoma by synergy of an improved ultrasonic horn with urokinase: An in vitro study
- Author
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Junhui, Tang, Jiawei, Tang, Qiong, Zhu, Yiyi, Liao, Luhua, Bai, Tingting, Luo, Shuang, Feng, and Zheng, Liu
- Subjects
Hematoma ,Fibrinolytic Agents ,Ultrasonic Therapy ,Animals ,Cattle ,Thrombolytic Therapy ,General Medicine ,Urokinase-Type Plasminogen Activator - Abstract
In this study, Ultrasound Needle-an improved minimally invasive ultrasonic horn device was used to explore its potential of synergizing with urokinase in enhancing clots lysis in an in vitro intracranial hematoma model.Ten milliliter bovine blood was incubated for 3 h at 37℃, and coagulated into clot to mimic intracranial hematoma in vitro. Ultrasound Needle was an improved ultrasonic horn with a fine tip (1.80 mm) and metallic sheath, and had a frequency of 29.62 kHz. The 10,000 IU urokinase was injected through the metallic sheath during the vibration of Ultrasound Needle tip to lyse the clots for 8 min under different working parameter settings (n = 8) to explore the influence of parameters Amplitude (%) and Duty (%) on clot lysis weight (WThe clot lysis weight WUltrasound Needle, an improved ultrasonic horn device, can mechanically damage the clot tissues and exhibit an excellent synergistic lysis effect with thrombolytic drugs. Therefore, Ultrasound Needle has great potential in providing a new minimally invasive strategy for rapid intracranial hematoma evacuation.
- Published
- 2022
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