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1. Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Author

Bauer, Michael, Glenn, Tasha, Achtyes, Eric D., Alda, Martin, Agaoglu, Esen, Altınbaş, Kürsat, Andreassen, Ole A., Angelopoulos, Elias, Ardau, Raffaella, Aydin, Memduha, Ayhan, Yavuz, Baethge, Christopher, Bauer, Rita, Baune, Bernhard T., Balaban, Ceylan, Becerra-Palars, Claudia, Behere, Aniruddh P., Behere, Prakash B., Belete, Habte, Belete, Tilahun, Belizario, Gabriel O., Bellivier, Frank, Belmaker, Robert H., Benedetti, Francesco, Berk, Michael, Bersudsky, Yuly, Bicakci, Şule, Birabwa-Oketcho, Harriet, Bjella, Thomas D., Brady, Conan, Cabrera, Jorge, Cappucciati, Marco, Castro, Angela M. P., Chen, Wei-Ling, Cheung, Eric Y. W., Chiesa, Silvia, Crowe, Marie, Cuomo, Alessandro, Dallaspezia, Sara, Del Zompo, Maria, Desai, Pratikkumar, Dodd, Seetal, Etain, Bruno, Fagiolini, Andrea, Fellendorf, Frederike T., Ferensztajn-Rochowiak, Ewa, Fiedorowicz, Jess G., Fountoulakis, Kostas N., Frye, Mark A., Geoffroy, Pierre A., Gitlin, Michael J., Gonzalez-Pinto, Ana, Gottlieb, John F., Grof, Paul, Haarman, Bartholomeus C. M., Harima, Hirohiko, Hasse-Sousa, Mathias, Henry, Chantal, Hoffding, Lone, Houenou, Josselin, Imbesi, Massimiliano, Isometsä, Erkki T., Ivkovic, Maja, Janno, Sven, Johnsen, Simon, Kapczinski, Flávio, Karakatsoulis, Gregory N., Kardell, Mathias, Kessing, Lars V., Kim, Seong J., König, Barbara, Kot, Timur L., Koval, Michael, Kunz, Mauricio, Lafer, Beny, Landén, Mikael, Larsen, Erik R., Lenger, Melanie, Licht, Rasmus W., Lopez-Jaramillo, Carlos, MacKenzie, Alan, Madsen, Helle Ø., Madsen, Simone A. K. A., Mahadevan, Jayant, Mahardika, Agustine, Manchia, Mirko, Marsh, Wendy, Martinez-Cengotitabengoa, Monica, Martini, Julia, Martiny, Klaus, Mashima, Yuki, McLoughlin, Declan M., Meesters, Ybe, Melle, Ingrid, Meza-Urzúa, Fátima, Mikolas, Pavol, Mok, Yee M., Monteith, Scott, Moorthy, Muthukumaran, Morken, Gunnar, Mosca, Enrica, Mozzhegorov, Anton A., Munoz, Rodrigo, Mythri, Starlin V., Nacef, Fethi, Nadella, Ravi K., Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Omrani, Adel, Osher, Yamima, Ouali, Uta, Pantovic-Stefanovic, Maja, Pariwatcharakul, Pornjira, Petite, Joanne, Petzold, Johannes, Pfennig, Andrea, Ruiz, Yolanda P., Pinna, Marco, Pompili, Maurizio, Porter, Richard J., Quiroz, Danilo, Rabelo-da-Ponte, Francisco D., Ramesar, Raj, Rasgon, Natalie, Ratta-apha, Woraphat, Ratzenhofer, Michaela, Redahan, Maria, Reddy, M. S., Reif, Andreas, Reininghaus, Eva Z., Richards, Jenny G., Ritter, Philipp, Rybakowski, Janusz K., Sathyaputri, Leela, Scippa, Angela M., Simhandl, Christian, Smith, Daniel, Smith, José, Stackhouse, Paul W., Stein, Dan J., Stilwell, Kellen, Strejilevich, Sergio, Su, Kuan-Pin, Subramaniam, Mythily, Sulaiman, Ahmad H., Suominen, Kirsi, Tanra, Andi J., Tatebayashi, Yoshitaka, Teh, Wen L., Tondo, Leonardo, Torrent, Carla, Tuinstra, Daniel, Uchida, Takahito, Vaaler, Arne E., Vieta, Eduard, Viswanath, Biju, Yoldi-Negrete, Maria, Yalcinkaya, Oguz K., Young, Allan H., Zgueb, Yosra, and Whybrow, Peter C.

Abstract

Background Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

Published
2023
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2. A leaky umbrella has little value:evidence clearly indicates the serotonin system is implicated in depression

Author

Jauhar, Sameer, Arnone, Danilo, Baldwin, David S., Bloomfield, Michael, Browning, Michael, Cleare, Anthony J., Corlett, Phillip, Deakin, J.F. William, Erritzoe, David, Fu, Cynthia, Fusar-Poli, Paolo, Goodwin, Guy M., Hayes, Joseph, Howard, Robert, Howes, Oliver D., Juruena, Mario F., Lam, Raymond W., Lawrie, Stephen M., McAllister-Williams, Hamish, Marwaha, Steven, Matuskey, David, McCutcheon, Robert A., Nutt, David J., Pariante, Carmine, Pillinger, Toby, Radhakrishnan, Rajiv, Rucker, James, Selvaraj, Sudhakar, Stokes, Paul, Upthegrove, Rachel, Yalin, Nefize, Yatham, Lakshmi, Young, Allan H., Zahn, Roland, and Cowen, Philip J.

Abstract

A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this.

Published
2023
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3. Self-blame-selective hyper-connectivity between anterior temporal and subgenual cortices predicts prognosis in major depressive disorder

Author

Fennema, Diede, Barker, Gareth, O'Daly, Owen, Duan, Suqian, Carr, Ewan, Goldsmith, Kimberley, Young, Allan, Moll, Jorge, and Zahn, Roland

Subjects
self-blame, fMRI, depression, biomarker, prognosis
Abstract

Background: Self-blame-related fMRI measures were shown to predict subsequent recurrence in remitted major depressive disorder (MDD). Their role in current MDD, however, is unknown. We hypothesised that these neural signatures reflect a highly recurrent but remitting course of MDD and therefore predict favourable outcomes over a four-month follow-up period in current MDD. Methods: Forty-five participants with current MDD and non-responders to at least two serotonergic antidepressants, were encouraged to optimise their medication and followed up after receiving four months of primary care treatment-as-usual. Prior to their medication review, participants completed an fMRI paradigm in which they viewed self- and other-blame emotion-evoking statements. Thirty-nine participants met pre-defined fMRI data minimum quality thresholds. Psychophysiological interaction analysis was used to determine baseline connectivity of the right superior anterior temporal lobe (RSATL), with an a priori BA25 region-of-interest for self-blaming vs other-blaming emotions, using Quick Inventory of Depressive Symptomatology (16-item) percentage change as a covariate. Results: We corroborated our pre-registered hypothesis that a favourable clinical outcome was associated with higher self-blame-selective RSATL-BA25 connectivity (Family-Wise Error-corrected p s(34) = −0.47, p =.005). This generalised to the sample including participants with suboptimal fMRI quality (r s(39) = −0.32, p =.05). Conclusions: This study shows that neural signatures of overgeneralised self-blame are relevant for prognostic stratification of current treatment-resistant MDD. Future studies need to confirm whether this neural signature indeed represents a trait-like feature of a fully remitting subtype of MDD, or whether it is also modulated by depressive state and related to treatment effects.

Published
2023
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4. A leaky umbrella has little value:evidence clearly indicates the serotonin system is implicated in depression

Author

Jauhar, Sameer, Arnone, Danilo, Baldwin, David S, Bloomfield, Michael, Browning, Michael, Cleare, Anthony J, Corlett, Phillip, Deakin, J F William, Erritzoe, David, Fu, Cynthia, Fusar-Poli, Paolo, Goodwin, Guy M, Hayes, Joseph, Howard, Robert, Howes, Oliver D, Juruena, Mario F, Lawrie, Stephen M, McAllister-Williams, Hamish, Marwaha, Steven, Matuskey, David, McCutcheon, Robert A, Nutt, David J, Pariante, Carmine, Pillinger, Toby, Radhakrishnan, Rajiv, Rucker, James, Selvaraj, Sudhakar, Stokes, Paul, Upthegrove, Rachel, Yalin, Nefize, Yatham, Lakshmi, Young, Allan H, Zahn, Roland, and Cowen, Philip J

Published
2023
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5. Economic impact of reducing treatment gaps in depression

Author

McCrone, Paul, Young, Allan H., Zahn, Roland, Eberhard, Jonas, Wasserman, Danuta, Brambilla, Paolo, Balazs, Judit, Caldas-De-Almeida, Jose, Ulrichsen, Andrea, Baltzis, Spyridon, Carli, Vladmir, Antunes, Ana, Schiena, Giandomenico, Quoidbach, Vinciane, Boyer, Patrice, Strawbridge, Rebecca, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Psychiatry and Mental health, treatment gaps, SDG 3 - Good Health and Well-being, Economics, cost, depression
Abstract

Publisher Copyright: © 2023 Elsevier Masson SAS. All rights reserved. Background Major depressive disorder (MDD) is highly prevalent across Europe. While evidence-based treatments exist, many people with MDD have their condition undetected and/or untreated. This study aims to assess the cost-effectiveness of reducing treatment gaps using a modelling approach. Methods A decision tree model covering a 27-month time horizon was used. This followed a care pathway where MDD could be detected or not, and where different forms of treatment could be provided. Expected costs pertaining to Germany, Hungary, Italy, Portugal, Sweden and the UK were calculated and quality-adjusted life years (QALYs) were estimated. The incremental costs per QALY of reducing detect and treatment gaps were estimated. Results The expected costs with a detection gap of 69% and treatment gap of 50% were €1236 in Germany, €476 Hungary, €1413 Italy, €938 Portugal, €2093 Sweden, and €1496 in the UK. The incremental costs per QALY of reducing the detection gap to 50% ranged from €2429 in Hungary to €10,686 in Sweden. The figures for reducing the treatment gap to 25% ranged from €3146 in Hungary to €13,843 in Sweden. Conclusions Reducing detection and treatment gaps, and maintaining current patterns of care, is likely to increase healthcare costs in the short term. However, outcomes are improved and reducing these gaps to 50% and 25% respectively appears to be a cost-effective use of resources. authorsversion epub_ahead_of_print

Published
2023

6. Comparing measurements of lithium treatment efficacy in people with bipolar disorder: systematic review and meta-analysis

Author

Ulrichsen, Andrea, Hampsey, Elliot, Taylor, Rosie, Gadelrab, Romayne, Strawbridge, Becci, and Young, Allan

Abstract

BackgroundLithium has long been recognised as an effective treatment for bipolar disorder. Its relative efficacy has been measured with a diverse range of clinical outcomes, resulting in differences in efficacy reporting that have not been systematically reviewed.AimsWe aimed to identify and compare the various measures of lithium efficacy employed in interventional studies for people with bipolar disorder.MethodDatabase (PubMed, Web of Science) and hand searches were performed to identify studies that assessed a clinical response in patients with bipolar disorder who received lithium, up to the end of 2021. We included primary human interventional studies without excluding specific study designs, bipolar disorder subtypes, duration or dosage of lithium treatment. Continuous outcome effects were meta-analysed; binary outcomes were synthesised visually and narratively. The Cochrane risk-of-bias tool was used to assess study-level risk of bias.ResultsSeventy-one studies were included (N = 30 542). Approximately two-thirds of participants attained a clinically significant improvement in manic or depressive symptoms, and over 50% achieved remission. About a third required hospital admission (study length 2–12 years) and around 50% needed further treatment to stay well or had recurrence of symptoms; the latter two outcomes tended to be assessed over long-term maintenance periods.ConclusionsAn abundance of measurements have been used to assess lithium's clinical effects, across several study designs. Despite the resultant high heterogeneity, an overall picture of lithium's effects emerges that supports previous literature; between half and two-thirds of patients respond well to lithium across varying outcome measures, baseline mood states, study durations and bipolar disorder subtypes.

Published
2023

7. sj-docx-1-jop-10.1177_02698811231161627 – Supplemental material for A transdiagnostic systematic review and meta-analysis of ketamine’s anxiolytic effects

Author

Hartland, Hannah, Mahdavi, Kimia, Jelen, Luke A, Strawbridge, Rebecca, Young, Allan H, and Alexander, Laith

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231161627 for A transdiagnostic systematic review and meta-analysis of ketamine’s anxiolytic effects by Hannah Hartland, Kimia Mahdavi, Luke A Jelen, Rebecca Strawbridge, Allan H Young and Laith Alexander in Journal of Psychopharmacology

Published
2023
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8. NESPRED-Study 1| Prediction of recurrence risk in major depressive disorder

Author

Williams, Steven, Moll, Jorge, Sato, João R., Lawrence, Andrew J, Zahn, Roland, Dr Lars-Håkan Thorell, Nikkheslat, Naghmeh, Young, Allan H, Pariante, Carmine, O'Daly, Owen, Snowdon, Anita, Fennema, Diede, Dr Flavio Dell' Acqua, Valmaggia, Lucia, Stahl, Daniel, Suqian Duan, Spilling, Catherine, Marquand, Andre F., Barker, Gareth, and Tong, Amy

Subjects
Social Cognition, Medical Sciences, Mental and Social Health, Major Depressive Disorder, fMRI, Life Sciences, Psychiatry and Psychology, Diseases, Biomarker, Prognosis, Machine Learning, Psychological Phenomena and Processes, DTI, Medicine and Health Sciences, Physical Sciences and Mathematics, Psychiatric and Mental Health, EEG, Prediction
Abstract

Primary Aim: To provide definitive evidence and external validation for our previously identified prediction model of Major Depressive Disorder (MDD) recurrence risk (Lawrence et al., 2022, https://doi.org/10.1016/j.bpsc.2021.06.010) Secondary Aim: To determine whether fMRI could be replaced for individual risk prediction by either structural grey matter and diffusion white matter MRI or by adding further, more scalable clinical, psychological, physiological and neurochemical measures to the prediction model.

Published
2023
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9. sj-pptx-3-jop-10.1177_02698811231158232 – Supplemental material for Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology

Author

Rogers, Jonathan P, Oldham, Mark A, Fricchione, Gregory, Northoff, Georg, Ellen Wilson, Jo, Mann, Stephan C, Francis, Andrew, Wieck, Angelika, Elizabeth Wachtel, Lee, Lewis, Glyn, Grover, Sandeep, Hirjak, Dusan, Ahuja, Niraj, Zandi, Michael S, Young, Allan H, Fone, Kevin, Andrews, Simon, Kessler, David, Saifee, Tabish, Gee, Siobhan, Baldwin, David S, and David, Anthony S

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pptx-3-jop-10.1177_02698811231158232 for Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology by Jonathan P Rogers, Mark A Oldham, Gregory Fricchione, Georg Northoff, Jo Ellen Wilson, Stephan C Mann, Andrew Francis, Angelika Wieck, Lee Elizabeth Wachtel, Glyn Lewis, Sandeep Grover, Dusan Hirjak, Niraj Ahuja, Michael S Zandi, Allan Young, Kevin Fone, Simon Andrews, David Kessler, Tabish Saifee, Siobhan Gee, David S Baldwin and Anthony S David in Journal of Psychopharmacology

Published
2023
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10. sj-docx-2-jop-10.1177_02698811231158232 – Supplemental material for Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology

Author

Rogers, Jonathan P, Oldham, Mark A, Fricchione, Gregory, Northoff, Georg, Ellen Wilson, Jo, Mann, Stephan C, Francis, Andrew, Wieck, Angelika, Elizabeth Wachtel, Lee, Lewis, Glyn, Grover, Sandeep, Hirjak, Dusan, Ahuja, Niraj, Zandi, Michael S, Young, Allan H, Fone, Kevin, Andrews, Simon, Kessler, David, Saifee, Tabish, Gee, Siobhan, Baldwin, David S, and David, Anthony S

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-2-jop-10.1177_02698811231158232 for Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology by Jonathan P Rogers, Mark A Oldham, Gregory Fricchione, Georg Northoff, Jo Ellen Wilson, Stephan C Mann, Andrew Francis, Angelika Wieck, Lee Elizabeth Wachtel, Glyn Lewis, Sandeep Grover, Dusan Hirjak, Niraj Ahuja, Michael S Zandi, Allan Young, Kevin Fone, Simon Andrews, David Kessler, Tabish Saifee, Siobhan Gee, David S Baldwin and Anthony S David in Journal of Psychopharmacology

Published
2023
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11. sj-docx-1-jop-10.1177_02698811231158245 – Supplemental material for Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020

Author

Kopra, Emma I, Ferris, Jason A, Winstock, Adam R, Kuypers, Kim PC, Young, Allan H, and Rucker, James J

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231158245 for Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020 by Emma I Kopra, Jason A Ferris, Adam R Winstock, Kim PC Kuypers, Allan H Young and James J Rucker in Journal of Psychopharmacology

Published
2023
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12. sj-docx-1-jop-10.1177_02698811231158232 – Supplemental material for Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology

Author

Rogers, Jonathan P, Oldham, Mark A, Fricchione, Gregory, Northoff, Georg, Ellen Wilson, Jo, Mann, Stephan C, Francis, Andrew, Wieck, Angelika, Elizabeth Wachtel, Lee, Lewis, Glyn, Grover, Sandeep, Hirjak, Dusan, Ahuja, Niraj, Zandi, Michael S, Young, Allan H, Fone, Kevin, Andrews, Simon, Kessler, David, Saifee, Tabish, Gee, Siobhan, Baldwin, David S, and David, Anthony S

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231158232 for Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology by Jonathan P Rogers, Mark A Oldham, Gregory Fricchione, Georg Northoff, Jo Ellen Wilson, Stephan C Mann, Andrew Francis, Angelika Wieck, Lee Elizabeth Wachtel, Glyn Lewis, Sandeep Grover, Dusan Hirjak, Niraj Ahuja, Michael S Zandi, Allan Young, Kevin Fone, Simon Andrews, David Kessler, Tabish Saifee, Siobhan Gee, David S Baldwin and Anthony S David in Journal of Psychopharmacology

Published
2023
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13. sj-docx-1-jop-10.1177_02698811231173588 – Supplemental material for The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression

Author

Nettis, Maria Antonietta, Lombardo, Giulia, Hastings, Caitlin, Zajkowska, Zuzanna, Mariani, Nicole, Nikkheslat, Naghmeh, Sforzini, Luca, Worrell, Courtney, Begum, Amina, Brown, Mollie, Cleare, Anthony J, Young, Allan H, Pariante, Carmine M, and Mondelli, Valeria

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231173588 for The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression by Maria Antonietta Nettis, Giulia Lombardo, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Luca Sforzini, Courtney Worrell, Amina Begum, Mollie Brown, Anthony J Cleare, Allan H Young, Carmine M Pariante and Valeria Mondelli in Journal of Psychopharmacology

Published
2023
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14. sj-docx-1-jop-10.1177_02698811231158245 – Supplemental material for Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020

Author

Kopra, Emma I, Ferris, Jason A, Winstock, Adam R, Kuypers, Kim PC, Young, Allan H, and Rucker, James J

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811231158245 for Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020 by Emma I Kopra, Jason A Ferris, Adam R Winstock, Kim PC Kuypers, Allan H Young and James J Rucker in Journal of Psychopharmacology

Published
2023
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15. The association between sleep spindles and cognition in euthymic bipolar bipolar disorder patients

Author

Ritter, Philipp, Strawbridge, Becci, Tröger, Anna, and Young, Allan H

Subjects
FOS: Psychology, Neuroscience and Neurobiology, Cognitive Neuroscience, Medicine and Health Sciences, Psychology, Life Sciences, Psychiatry and Psychology, Social and Behavioral Sciences
Abstract

This project examines the relationship between sleep spindle density and various cognitive domains (e.g., attention, memory) in euthymic bipolar disorder patients.

Published
2023
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17. Is there a 'bipolar iceberg' in UK primary care psychological therapy services?

Author

Strawbridge, Rebecca, Alexander, Laith, Richardson, Thomas, Young, Allan, and Cleare, Anthony

Abstract

Background: Improving Access to Psychological Therapies (IAPT) is a primary care therapy service commissioned by England’s National Health Service (NHS) for people with unipolar depression and anxiety-related disorders. Its scope does not extend to ‘severe mental illness’, including bipolar disorders (BD), but evidence suggests there is a high BD prevalence in ostensibly unipolar major depressive disorder (uMDD) samples. This study aimed to indicate the prevalence and characteristics of people with BD in a naturalistic cohort of IAPT patients. Methods: 371 participants were assessed before initiating therapy. Participants were categorised by indicated diagnoses: BD type-I (BD-I) or type-II (BD-II) as defined using a DSM diagnostic interview, bipolar spectrum (BSp, not meeting diagnostic criteria but exceeding BD screening thresholds), lifetime uMDD or other. Information about psychiatric history and co-morbidities was examined, along with symptoms before and after therapy.Results: 10% of participants were grouped as having BD-I, 20% BD-II, 40% BSp, 25% uMDD and 5% other. BD and uMDD participants had similar demographic characteristics, but patients meeting criteria for BD-I/BD-II had more complex psychiatric presentations. All three ‘bipolar’ groups had particularly high rates of anxiety disorders. IAPT therapy receipt was comparable between groups, as was therapy response (F9,704=1.113, p=0.351). Conclusions: notwithstanding the possibility that bipolar diathesis was overestimated, findings illustrate a high prevalence of BD in groups of people notionally with uMDD or anxiety. As well as improving the detection of BD, further substantive investigation is required to establish whether individuals affected by BD should be eligible for primary care psychological intervention.

Published
2022

18. A European Brain Council Value of Treatment study

Author

Strawbridge, Rebecca, McCrone, Paul, Ulrichsen, Andrea, Zahn, Roland, Eberhard, Jonas, Wasserman, Danuta, Brambilla, Paolo, Schiena, Giandomenico, Hegerl, Ulrich, Balazs, Judit, Caldas De Almeida, Jose, Antunes, Ana, Baltzis, Spyridon, Carli, Vladimir, Quoidbach, Vinciane, Boyer, Patrice, Young, Allan H., Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Psychiatry and Mental health, care pathways, major depressive disorder, treatment, SDG 3 - Good Health and Well-being, diagnosis
Abstract

Funding: This work was supported by the European Brain Council (EBC). This work is also supported by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. Background: Despite well-established guidelines for managing major depressive disorder (MDD), its extensive disability burden persists. This Value of Treatment mission from the European Brain Council aimed to elucidate the nature and extent of 'gaps' between best-practice and current32 practice care, specifically to: 1. Identify current treatment gaps along the care pathway and determine the extent of these gaps in comparison with the stepped-care model. 2. Recommend policies intending to better meet patient needs (i.e., minimise treatment gaps). Methods: After agreement upon a set of relevant treatment gaps, data pertaining to each gap were gathered and synthesised from several sources across six European countries. Subsequently a modified-Delphi approach was undertaken to attain consensus amongst an expert panel on proposed recommendations for minimising treatment gaps. Results: 4 recommendations were made to increase the depression diagnosis 40 rate (from ~50% episodes), aiming to both increase the number of patients seeking help, and the likelihood of a practitioner to correctly detect depression. These should reduce time to treatment (from ~1-8 years after illness onset) and increase rates of treatment; 9 further recommendations aimed to increase rates of treatment (from ~25-50% of patients currently treated), mainly focused on targeting the best treatment to each patient. To improve follow-up after treatment initiation (from ~30-65% followed up within 3 months), 7 recommendations focused on increasing continuity of care. For those not responding, 10 recommendations focused on ensuring access to more specialist care (currently at rates of ~5-25% of patients). Conclusions: The treatment gaps in depression care are substantial and concerning, from the proportion of people not entering care pathways to those stagnating in primary care with impairing and persistent illness. A wide range of recommendations can be made to enhance care throughout the pathway. publishersversion epub_ahead_of_print

Published
2022

20. sj-docx-1-jop-10.1177_02698811221099650 – Supplemental material for Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD)

Author

Kopra, Emma I, Ferris, Jason A, Rucker, James J, McClure, Benjamin, Young, Allan H, Copeland, Caroline S, and Winstock, Adam R

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221099650 for Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD) by Emma I Kopra, Jason A Ferris, James J Rucker, Benjamin McClure, Allan H Young, Caroline S Copeland and Adam R Winstock in Journal of Psychopharmacology

Published
2022
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21. sj-docx-1-jop-10.1177_02698811221104058 – Supplemental material for Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression

Author

Scott, Fraser, Hampsey, Elliot, Gnanapragasam, Sam, Carter, Ben, Marwood, Lindsey, Taylor, Rachael W, Emre, Cansu, Korotkova, Lora, Martín-Dombrowski, Jonatan, Cleare, Anthony J, Young, Allan H, and Strawbridge, Rebecca

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221104058 for Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression by Fraser Scott, Elliot Hampsey, Sam Gnanapragasam, Ben Carter, Lindsey Marwood, Rachael W Taylor, Cansu Emre, Lora Korotkova, Jonatan Martín-Dombrowski, Anthony J Cleare, Allan H Young and Rebecca Strawbridge in Journal of Psychopharmacology

Published
2022
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22. sj-docx-1-jop-10.1177_02698811221084063 – Supplemental material for Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms

Author

Kopra, Emma I, Ferris, Jason A, Winstock, Adam R, Young, Allan H, and Rucker, James J

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221084063 for Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms by Emma I Kopra, Jason A Ferris, Adam R Winstock, Allan H Young and James J Rucker in Journal of Psychopharmacology

Published
2022
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23. sj-docx-1-jop-10.1177_02698811221089042 – Supplemental material for Patient perspectives of lithium and quetiapine augmentation treatment in treatment-resistant depression: A qualitative assessment

Author

McKeown, Lucas, Taylor, Rachael W, Day, Elana, Shah, Rupal, Marwood, Lindsey, Tee, Helena, Kerr-Gaffney, Jess, Oprea, Emanuella, Geddes, John R, McAllister-Williams, R Hamish, Young, Allan H, and Cleare, Anthony J

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221089042 for Patient perspectives of lithium and quetiapine augmentation treatment in treatment-resistant depression: A qualitative assessment by Lucas McKeown, Rachael W Taylor, Elana Day, Rupal Shah, Lindsey Marwood, Helena Tee, Jess Kerr-Gaffney, Emanuella Oprea, John R Geddes, R Hamish McAllister-Williams, Allan H Young and Anthony J Cleare in Journal of Psychopharmacology

Published
2022
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24. sj-pdf-1-jop-10.1177_02698811211064720 – Supplemental material for The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation

Author

Rucker, James J, Marwood, Lindsey, Ajantaival, Riikka-Liisa J, Bird, Catherine, Eriksson, Hans, Harrison, John, Lennard-Jones, Molly, Mistry, Sunil, Saldarini, Francesco, Stansfield, Susan, Tai, Sara J, Williams, Sam, Weston, Neil, Malievskaia, Ekaterina, and Young, Allan H

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-jop-10.1177_02698811211064720 for The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation by James J Rucker, Lindsey Marwood, Riikka-Liisa J Ajantaival, Catherine Bird, Hans Eriksson, John Harrison, Molly Lennard-Jones, Sunil Mistry, Francesco Saldarini, Susan Stansfield, Sara J Tai, Sam Williams, Neil Weston, Ekaterina Malievskaia and Allan H Young in Journal of Psychopharmacology

Published
2022
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25. Morally Particular Fictions: Narrative Framings of Moral Judgements

Author

Young, Allan

Subjects
Philosophy, Literature, 190402 Creative Writing (incl. Playwriting), FOS: Languages and literature, FOS: Arts (arts, history of arts, performing arts, music), 200599 Literary Studies not elsewhere classified, 220305 Ethical Theory, FOS: Philosophy, ethics and religion
Abstract

Submitted in total fulfilment of the requirements for the degree of Master of Arts to the School of Humanities & Social Sciences, La Trobe University, Victoria, Australia.

Published
2022
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26. sj-docx-1-jop-10.1177_02698811221115762 – Supplemental material for The effects of reserpine on depression: A systematic review

Author

Strawbridge, Rebecca, Javed, Rahila R, Cave, Jeremy, Jauhar, Sameer, and Young, Allan H

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221115762 for The effects of reserpine on depression: A systematic review by Rebecca Strawbridge, Rahila R Javed, Jeremy Cave, Sameer Jauhar and Allan H Young in Journal of Psychopharmacology

Published
2022
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27. sj-docx-1-jop-10.1177_02698811221084063 – Supplemental material for Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms

Author

Kopra, Emma I, Ferris, Jason A, Winstock, Adam R, Young, Allan H, and Rucker, James J

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221084063 for Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms by Emma I Kopra, Jason A Ferris, Adam R Winstock, Allan H Young and James J Rucker in Journal of Psychopharmacology

Published
2022
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28. sj-docx-1-jop-10.1177_02698811221099650 – Supplemental material for Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD)

Author

Kopra, Emma I, Ferris, Jason A, Rucker, James J, McClure, Benjamin, Young, Allan H, Copeland, Caroline S, and Winstock, Adam R

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_02698811221099650 for Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD) by Emma I Kopra, Jason A Ferris, James J Rucker, Benjamin McClure, Allan H Young, Caroline S Copeland and Adam R Winstock in Journal of Psychopharmacology

Published
2022
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29. Understanding the Impact of the COVID-19 Pandemic, Lockdowns and Social Isolation on Sleep Quality

Author

O'Regan,David, Jackson,Melinda L, Young,Allan H, and Rosenzweig,Ivana

Subjects
Nature and Science of Sleep
Abstract

David O’Regan,1,2 Melinda L Jackson,3 Allan H Young,4 Ivana Rosenzweig1,5 1Sleep Disorders Centre, Guy’s and St Thomas’ Hospital, GSTT NHS, London, UK; 2Faculty of Life and Sciences Medicine, King’s College London, London, UK; 3Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia; 4School of Academic Psychiatry, IoPPN, King’s College London, London, UK; 5Sleep and Brain Plasticity Centre, CNS, IoPPN, King’s College London, London, UKCorrespondence: Ivana RosenzweigSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, Box 089, De Crespigny Park, London, SE5 8AF, UKEmail ivana.1.rosenzweig@kcl.ac.ukAbstract: The uncertain, ever-changing and an ongoing nature of the COVID-19 pandemic means that it may take some time before we can fully appreciate the negative effect of the pandemic and lockdown on our sleep and mental health. It is increasingly recognised that in the aftermath of pandemic, several persistent sleep, neuropsychiatric and physical sequelae may continue long after the pandemic is over. A body of evidence to date also highlights a significant disparity in sleep and mental health difficulties in specific vulnerable groups in the community, with different temporal profiles and sleep issues that are reported. In this perspective, we argue for a possible mechanistic impact of the COVID-19 pandemic, with its imposed restrictions and social isolation on sleep quality. We similarly discuss some of the potential international differences, as well as similarities, behind reported idiosyncratic biological vulnerabilities that may have contributed to the genesis of sleep issues. Lastly, we propose some possible implementations and innovations that may be needed in restructuring of sleep disorders services in order to benefit recovering COVID-19 patients.Keywords: sleep, insomnia, hypersomnia, lockdown, COVID-19 pandemic, social isolation

Published
2021

30. COVID-19 UK family carers and policy implications

Author

Onwumere, Juliana, Cresswell, Cathy, Livingston, Gill, Shiers, David, Tantchuria, Kate, Charman, Tony, Russell, Ailsa, Tresaure, Janet, Di Forti, Marta, Wildman, Emilie, Minnis, Helen, Young, Allan, Davis, Annette, and Kuipers, Elizabeth

Subjects
SDG 3 - Good Health and Well-being, health care facilities, manpower, and services, social sciences, human activities, health care economics and organizations, humanities
Abstract

Informal (unpaid) carers are an integral part of all societies and the health and social care systems in the UK depend on them. Despite the valuable contributions and key worker status of informal carers, their lived experiences, wellbeing, and needs have been neglected during the COVID-19 pandemic. In this Health Policy, we bring together a broad range of clinicians, researchers, and people with lived experience as informal carers to share their thoughts on the impact of the COVID-19 pandemic on UK carers, many of whom have felt abandoned as services closed. We focus on the carers of children and young people and adults and older adults with mental health diagnoses, and carers of people with intellectual disability or neurodevelopmental conditions across different care settings over the lifespan. We provide policy recommendations with the aim of improving outcomes for all carers.

Published
2021
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31. Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Author

Bauer, Michael, Glenn, Tasha, Achtyes, Eric D., Agaoglu, Esen, Altınbaş, Kürşat, Andreassen, Ole A., Angelopoulos, Elias, Ardau, Raffaella, Arrua Vares, Edgar, Aydin, Memduha, Ayhan, Yavuz, Baethge, Christopher Jan, Bauer, Rita, Baune, Bernhard T., Balaban, Ceylan, Becerra-Palars, Claudia, Behere, Aniruddh P., Behere, Prakash B., Belete, Habte, Belete, Tilahun, Belizario, Gabriel Okawa, Bellivier, Frank, Belmaker, Robert H., Benedetti, Francesco, Berk, Michael, Bersudsky, Yuly, Bicakci, Şule, Birabwa-Oketcho, Harriet, Bjella, Thomas D., Brady, Conan, Cabrera, Jorge, Cappucciati, Marco, Castro, Angela Marianne Paredes, Chen, Wei-Ling, Cheung, Eric Y. Wo, Chiesa, Silvia, Crowe, Marie, Cuomo, Alessandro, Dallaspezia, Sara, Del Zompo, Maria, Desai, Pratikkumar, Dodd, Seetal, Donix, Markus, Etain, Bruno, Fagiolini, Andrea, Fellendorf, Frederike T., Ferensztajn-Rochowiak, Ewa, Fiedorowicz, Jess G., Fountoulakis, Kostas N., Frye, Mark A., Geoffroy, Pierre A., Gonzalez-Pinto, Ana, Gottlieb, John F., Grof, Paul, Haarman, Bartholomeus C. M., Harima, Hirohiko, Hasse-Sousa, Mathias, Henry, Chantal, Høffding, Lone, Houenou, Josselin, Imbesi, Massimiliano, Isometsä, Erkki T., Ivkovic, Maja, Janno, Sven, Johnsen, Simon, Kapczinski, Flávio, Karakatsoulis, Gregory N., Kardell, Mathias, Kessing, Lars Vedel, Kim, Seong Jae, König, Barbara, Kot, Timur L., Koval, Michael, Kunz, Mauricio, Lafer, Beny, Landén, Mikael, Larsen, Erik R., Lenger, Melanie, Lewitzka, Ute, Licht, Rasmus W., Lopez-Jaramillo, Carlos, MacKenzie, Alan, Madsen, Helle Østergaard, Madsen, Simone Alberte Kongstad A., Mahadevan, Jayant, Mahardika, Agustine, Manchia, Mirko, Marsh, Wendy, Martinez-Cengotitabengoa, Monica, Martiny, Klaus, Mashima, Yuki, McLoughlin, Declan M., Meesters, Ybe, Melle, Ingrid, Meza-Urzúa, Fátima, Ming, Mok Yee, Monteith, Scott, Moorthy, Muthukumaran, Morken, Gunnar, Mosca, Enrica, Mozzhegorov, Anton A., Munoz, Rodrigo, Mythri, Starlin V., Nacef, Fethi, Nadella, Ravi K., Nakanotani, Takako, Nielsen, René Ernst, O‘Donovan, Claire, Omrani, Adel, Osher, Yamima, Ouali, Uta, Pantovic-Stefanovic, Maja, Pariwatcharakul, Pornjira, Petite, Joanne, Pfennig, Andrea, Pica Ruiz, Yolanda, Pilhatsch, Maximilian, Pinna, Marco, Pompili, Maurizio, Porter, Richard, Quiroz, Danilo, Rabelo-da-Ponte, Francisco Diego, Ramesar, Raj, Rasgon, Natalie, Ratta-apha, Woraphat, Ratzenhofer, Michaela, Redahan, Maria, Reddy, M. S., Reif, Andreas, Reininghaus, Eva Z., Richards, Jenny Gringer, Ritter, Philipp, Rybakowski, Janusz K., Sathyaputri, Leela, Scippa, Ângela M., Simhandl, Christian, Severus, Emanuel, Smith, Daniel, Smith, José, Stackhouse Jr., Paul W., Stein, Dan J., Stilwell, Kellen, Strejilevich, Sergio, Su, Kuan-Pin, Subramaniam, Mythily, Sulaiman, Ahmad Hatim, Suominen, Kirsi, Tanra, Andi J., Tatebayashi, Yoshitaka, Teh, Wen Lin, Tondo, Leonardo, Torrent, Carla, Tuinstra, Daniel, Uchida, Takahito, Vaaler, Arne E., Veeh, Julia, Vieta, Eduard, Viswanath, Biju, Yoldi-Negrete, Maria, Yalcinkaya, Oguz Kaan, Young, Allan H., Zgueb, Yosra, and Whybrow, Peter C.

Subjects
ddc:150, ddc:610
Abstract

Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p

Published
2021

32. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Author

Mullins, Niamh, Forstner, Andreas J., O'Connell, Kevin S., Coombes, Brandon, Coleman, Jonathan R.I., Qiao, Zhen, Als, Thomas D., Bigdeli, Tim B., Børte, Sigrid, Bryois, Julien, Charney, Alexander W., Drange, Ole Kristian, Gandal, Michael J., Hagenaars, Saskia P., Ikeda, Masashi, Kamitaki, Nolan, Kim, Minsoo, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Steinberg, Stacy, Trubetskoy, Vassily, Winsvold, Bendik S., Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Agerbo, Esben, Al Eissa, Mariam, Albani, Diego, Alliey-Rodriguez, Ney, Anjorin, Adebayo, Antilla, Verneri, Antoniou, Anastasia, Awasthi, Swapnil, Hyun Baek, Ji, Bækvad-Hansen, Marie, Bass, Nicholas, Bauer, Michael, Beins, Eva C., Bergen, Sarah E., Birner, Armin, Bøcker Pedersen, Carsten, Bøen, Erlend, Boks, Marco P., Bosch, Rosa, Brum, Murielle, Brumpton, Ben M., Brunkhorst-Kanaan, Nathalie, Budde, Monika, Bybjerg-Grauholm, Jonas, Byerley, William, Cairns, Murray, Casas, Miquel, Cervantes, Pablo, Clarke, Toni-Kim, Cruceanu, Cristiana, Cuellar-Barboza, Alfredo, Cunningham, Julie, Curtis, David, Czerski, Piotr M., Dale, Anders M., Dalkner, Nina, David, Friederike S., Degenhardt, Franziska, Djurovic, Srdjan, Dobbyn, Amanda L., Douzenis, Athanassios, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Nicol Ferrier, I., Fiorentino, Alessia, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Frei, Oleksandr, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Garnham, Julie, Gelernter, Joel, Marianne Giørtz Pedersen, Marianne, Gizer, Ian R., Gordon, Scott D., Gordon-Smith, Katherine, Greenwood, Tiffany A., Grove, Jakob, Guzman-Parra, José, Ha, Kyooseob, Haraldsson, Magnus, Hautzinger, Martin, Heilbronner, Urs, Hellgren, Dennis, Herms, Stefan, Hoffmann, Per, Holmans, Peter A., Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Kalman, Janos L., Kamatani, Yoichiro, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koromina, Maria, Kranz, Thorsten M., Kranzler, Henry R., Kubo, Michiaki, Kupka, Ralph, Kushner, Steven A., Lavebratt, Catharina, Lawrence, Jacob, Leber, Markus, Lee, Heon-Jeong, Lee, Phil H., Levy, Shawn E., Lewis, Catrin, Liao, Calwing, Lucae, Susanne, Lundberg, Martin, MacIntyre, Donald J., Maier, Wolfgang, Maihofer, Adam, Malaspina, Dolores, Maratou, Eirini, Martinsson, Lina, Mattheisen, Manuel, McGregor, Nathaniel W., McGuffin, Peter, McKay, James D., Medeiros, Helena, Medland, Sarah E., Millischer, Vincent, Montgomery, Grant W., Moran, Jennifer L., Morris, Derek W., Mühleisen, Thomas W., O'Brien, Niamh, O'Donovan, Claire, Olde Loohuis, Loes M., Oruc, Lilijana, Papiol, Sergi, Pardiñas, Antonio F., Perry, Amy, Pfennig, Andrea, Porichi, Evgenia, Potash, James B., Quested, Digby, Raj, Towfique, Rapaport, Mark H., DePaulo, J Raymond, Regeer, Eline J., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roth, Julian, Roussos, Panos, Ruderfer, Douglas M., Sánchez-Mora, Cristina, Schulte, Eva C., Senner, Fanny, Sharp, Sally, Shilling, Paul D., Sigurdsson, Engilbert, Sirignano, Lea, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Søholm, Artigas, Maria Soler, Spijker, Anne T., Stein, Dan J., Strauss, John S., Beata Świątkowska, Beata, Terao, Chikashi, Thorgeirsson, Thorgeir E., Toma, Claudio, Tooney, Paul, Tsermpini, Evangelia-Eirini, Vawter, Marquis P., Vedder, Helmut, Walters, James T.R., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Hannah, Young, Allan H., Zandi, Peter P., Zhou, Hang, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Alfredsson, Lars, Babadjanova, Gulja, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Bengesser, Susanne, Berrettini, Wade H., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Breen, Gerome, Carr, Vaughan J., Catts, Stanley, Corvin, Aiden, Craddock, Nicholas, Dannlowski, Udo, Dikeos, Dimitris, Esko, Tõnu, Etain, Bruno, Ferentinos, Panagiotis, Frye, Mark, Fullerton, Janice M., Gawlik, Micha, Gershon, Elliot S., Goes, Fernando, Green, Melissa J., Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Henskens, Frans, Hillert, Jan, Hong, Kyung Sue, Hougaard, David M., Hultman, Christina M., Hveem, Kristian, Iwata, Nakao, Jablensky, Assen V., Jones, Ian, Jones, Lisa A., Kahn, René S., Kelsoe, John R., Kirov, George, Mikael Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Lochner, Christine, Loughland, Carmel, Martin, Nicholas G., Mathews, Carol A., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Michie, Patricia, Milani, Lili, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Bo Mortensen, Preben, Mowry, Bryan, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nievergelt, Caroline M., Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C., Smith, Daniel, Oedegaard, Ketil J., Olsson, Tomas, Owen, Michael J., Paciga, Sara A., Pantelis, Chris, Pato, Carlos, Pato, Michele T., Patrinos, George P., Perlis, Roy H., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Reininghaus, Eva Z., Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Ripke, Stephan, Saito, Takeo, Schall, Ulrich, Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Scott, Rodney J., Scott, Laura J., Serretti, Alessandro, Weickert, Cynthia Shannon, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Streit, Fabian, Turecki, Gustavo, Sullivan, Patrick F., Vaaler, Arne E, Vieta, Eduard, Vincent, John B., Waldman, Irwin D., Weickert, Thomas W., Werge, Thomas, Wray, Naomi R., Zwart, John-Anker, Biernacka, Joanna M., Nurnberger, John I., Cichon, Sven, Edenberg, Howard J., Stahl, Eli A., McQuillin, Andrew, Di Florio, Arianna, Ophoff, Roel A., and Andreassen, Ole A.

Abstract

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.

Published
2021

33. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Author

Andlauer, Till F M, Guzman-Parra, Jose, Orozco Diaz, Guillermo, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, de Diego-Otero, Yolanda, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Moreno-Küstner, Berta, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L, Auburger, Georg, Kittel-Schneider, Sarah, Knowles, James A, Kogevinas, Manolis, Koller, Anna C, Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B, Leber, Markus, Lee, Phil H, Degenhardt, Franziska, Levy, Shawn E, Li, Jun Z, Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J, Mahon, Pamela B, Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, Heilmann-Heimbach, Stefanie, McGuffin, Peter, McInnis, Melvin G, McKay, James D, Medeiros, Helena, Medland, Sarah E, Meng, Fan, Milani, Lili, Montgomery, Grant W, Morris, Derek W, Mühleisen, Thomas W, Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M, Adolfsson, Annelie Nordin, Nwulia, Evaristus A, O'Donovan, Claire, Loohuis, Loes M Olde, Ori, Anil P S, Oruc, Lilijana, Ösby, Urban, Perlis, Roy H, Perry, Amy, Pfennig, Andrea, Potash, James B, Purcell, Shaun M, Regeer, Eline J, Reif, Andreas, Reinbold, Céline S, Rice, John P, Richards, Alexander L, Frank, Josef, Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M, Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F, Scheftner, William A, Schork, Nicholas J, Weickert, Cynthia Shannon, Foo, Jerome C, Shehktman, Tatyana, Shilling, Paul D, Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B, Sobell, Janet L, Hansen, Christine Søholm, Spijker, Anne T, Clair, David St, Steffens, Michael, Streit, Fabian, Treutlein, Jens, Strauss, John S, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C, EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J, Witt, Stephanie H, Weickert, Thomas W, Xi, Simon, Xu, Wei, Young, Allan H, Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Cichon, Sven, Alda, Martin, Backlund, Lena, Baune, Bernhard T, Bellivier, Frank, Berrettini, Wade H, Biernacka, Joanna M, Blackwood, Douglas H R, Boehnke, Michael, Børglum, Anders D, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J, Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M, Gershon, Elliot S, Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M, Hultman, Christina M, Jones, Ian, Jones, Lisa A, Kahn, René S, Kirov, George, Landén, Mikael, Leboyer, Marion, Mayoral, Fermín, Lewis, Cathryn M, Li, Qingqin S, Lissowska, Jolanta, Martin, Nicholas G, Mayoral, Fermin, McElroy, Susan L, McIntosh, Andrew M, McMahon, Francis J, Melle, Ingrid, Metspalu, Andres, Müller-Myhsok, Bertram, Mitchell, Philip B, Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Myers, Richard M, Neale, Benjamin M, Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M, Forstner, Andreas J, O'Donovan, Michael C, Oedegaard, Ketil J, Owen, Michael J, Paciga, Sara A, Pato, Carlos, Pato, Michele T, Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A, Schalling, Martin, Schofield, Peter R, Schulze, Thomas G, Serretti, Alessandro, Smoller, Jordan W, Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F, Turecki, Gustavo, Vaaler, Arne E, Vieta, Eduard, Vincent, John B, Werge, Thomas, Nurnberger, John I, Wray, Naomi R, Florio, Arianna Di, Edenberg, Howard J, Stahl, Eli A, Ophoff, Roel A, Scott, Laura J, Andreassen, Ole A, Kelsoe, John, Sklar, Pamela, Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M, Breen, Gerome, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T F, Bigdeli, Tim B, Binder, Elisabeth B, Bryois, Julien, Buttenschøn, Henriette N, Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R I, Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, McQuillin, Andrew, Craddock, Nick, Crawford, Gregory E, Davies, Gail, Deary, Ian J, Derks, Eske M, Direk, Nese, Dolan, Conor V, Dunn, Erin C, Eley, Thalia C, Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K, Gaspar, Héléna A, Goes, Fernando S, Trubetskoy, Vassily, Hall, Lynsey S, Hansen, Thomas F, Hickie, Ian B, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Howard, David M, Ising, Marcus, Jansen, Rick, Jorgenson, Eric, Kohane, Isaac S, Kraft, Julia, Wang, Yunpeng, Kretzschmar, Warren W, Kutalik, Zoltán, Li, Yihan, Lind, Penelope A, MacKinnon, Dean F, Maier, 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Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Wu, Yang, Xi, Hualin S, Yang, Jian, Holmans, Peter A, Zhang, Futao, Arolt, Volker, Berger, Klaus, Boomsma, Dorret I, de Geus, E. J. C., DePaulo, J Raymond, Domenici, Enrico, Abbott, Liam, Domschke, Katharina, Grabe, Hans J, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Kendler, Kenneth S, Kloiber, Stefan, Lewis, Glyn, Madden, Pamela A F, Magnusson, Patrik K, Akil, Huda, Pedersen, Nancy L, Penninx, Brenda W J H, Porteous, David J, Preisig, Martin, Albani, Diego, Schaefer, Catherine, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M, Gil Flores, Susana, Alliey-Rodriguez, Ney, Levinson, Douglas F, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Cabaleiro Fabeiro, Francisco J, Belliveau, Richard, Bergen, Sarah E, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Del Río Noriega, Francisco, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Coryell, William, Perez, Fermin Perez, Craig, David W, Cruceanu, Cristiana, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, Del-Favero, Jurgen, Djurovic, Srdjan, Dobbyn, Amanda L, Haro González, Jesus, Dumont, Ashley, Elvsåshagen, Torbjørn, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forty, Liz, Fraser, Christine, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Complex Trait Genetics, Epidemiology and Data Science, APH - Digital Health, Andlauer T.F.M., Guzman-Parra J., Streit F., Strohmaier J., Gonzalez M.J., Gil Flores S., Cabaleiro Fabeiro F.J., del Rio Noriega F., Perez F.P., Haro Gonzalez J., Orozco Diaz G., de Diego-Otero Y., Moreno-Kustner B., Auburger G., Degenhardt F., Heilmann-Heimbach S., Herms S., Hoffmann P., Frank J., Foo J.C., Treutlein J., Witt S.H., Cichon S., Kogevinas M., Stahl E.A., Breen G., Forstner A.J., McQuillin A., Ripke S., Trubetskoy V., Mattheisen M., Wang Y., Coleman J.R.I., Gaspar H.A., de Leeuw C.A., Steinberg S., Pavlides J.M.W., Trzaskowski M., Pers T.H., Holmans P.A., Abbott L., Agerbo E., Akil H., Albani D., Alliey-Rodriguez N., Als T.D., Anjorin A., Antilla V., Awasthi S., Badner J.A., Baekvad-Hansen M., Barchas J.D., Bass N., Bauer M., Belliveau R., Bergen S.E., Pedersen C.B., Boen E., Boks M., Boocock J., Budde M., Bunney W., Burmeister M., Bybjerg-Grauholm J., Byerley W., Casas M., Cerrato F., Cervantes P., Chambert K., Charney A.W., Chen D., Churchhouse C., Clarke T.-K., Coryell W., Craig D.W., Cruceanu C., Czerski P.M., Dale A.M., de Jong S., Del-Favero J., DePaulo J.R., Djurovic S., Dobbyn A.L., Dumont A., Elvsashagen T., Escott-Price V., Fan C.C., Fischer S.B., Flickinger M., Foroud T.M., Forty L., Fraser C., Freimer N.B., Frisen L., Gade K., Gage D., Garnham J., Giambartolomei C., Pedersen M.G., Goldstein J., Gordon S.D., Gordon-Smith K., Green E.K., Green M.J., Greenwood T.A., Grove J., Guan W., Parra J.G., Hamshere M.L., Hautzinger M., Heilbronner U., Hipolito M., Holland D., Huckins L., Jamain S., Johnson J.S., Jureus A., Kandaswamy R., Karlsson R., Kennedy J.L., Kittel-Schneider S., Knowles J.A., Koller A.C., Kupka R., Lavebratt C., Lawrence J., Lawson W.B., Leber M., Lee P.H., Levy S.E., Li J.Z., Liu C., Lucae S., Maaser A., MacIntyre D.J., Mahon P.B., Maier W., Martinsson L., McCarroll S., McGuffin P., McInnis M.G., McKay J.D., Medeiros H., Medland S.E., Meng F., Milani L., Montgomery G.W., Morris D.W., Muhleisen T.W., Mullins N., Nguyen H., Nievergelt C.M., Adolfsson A.N., Nwulia E.A., O'Donovan C., Loohuis L.M.O., Ori A.P.S., Oruc L., Osby U., Perlis R.H., Perry A., Pfennig A., Potash J.B., Purcell S.M., Regeer E.J., Reif A., Reinbold C.S., Rice J.P., Richards A.L., Rivas F., Rivera M., Roussos P., Ruderfer D.M., Ryu E., Sanchez-Mora C., Schatzberg A.F., Scheftner W.A., Schork N.J., Weickert C.S., Shehktman T., Shilling P.D., Sigurdsson E., Slaney C., Smeland O.B., Sobell J.L., Hansen C.S., Spijker A.T., Clair D.S., Steffens M., Strauss J.S., Szelinger S., Thompson R.C., EThorgeirsson T., Vedde H., Wang W., Watson S.J., Weickert T.W., Xi S., Xu W., Young A.H., Zandi P., Zhang P., Zollner S., Adolfsson R., Agartz I., Alda M., Backlund L., Baune B.T., Bellivier F., Berrettini W.H., Biernacka J.M., Blackwood D.H.R., Boehnke M., Borglum A.D., Corvin A., Craddock N., Daly M.J., Dannlowski U., Esko T., Etain B., Frye M., Fullerton J.M., Gershon E.S., Gill M., Goes F., Grigoroiu-Serbanescu M., Hauser J., Hougaard D.M., Hultman C.M., Jones I., Jones L.A., Kahn R.S., Kirov G., Landen M., Leboyer M., Lewis C.M., Li Q.S., Lissowska J., Martin N.G., Mayoral F., McElroy S.L., McIntosh A.M., McMahon F.J., Melle I., Metspalu A., Mitchell P.B., Morken G., Mors O., Mortensen P.B., Muller-Myhsok B., Myers R.M., Neale B.M., Nimgaonkar V., Nordentoft M., Nothen M.M., O'Donovan M.C., Oedegaard K.J., Owen M.J., Paciga S.A., Pato C., Pato M.T., Posthuma D., Ramos-Quiroga J.A., Ribases M., Rietschel M., Rouleau G.A., Schalling M., Schofield P.R., Schulze T.G., Serretti A., Smoller J.W., Stefansson H., Stefansson K., Stordal E., Sullivan P.F., Turecki G., Vaaler A.E., Vieta E., Vincent J.B., Werge T., Nurnberger J.I., Wray N.R., Florio A.D., Edenberg H.J., Ophoff R.A., Scott L.J., Andreassen O.A., Kelsoe J., Sklar P., Byrne E.M., Abdellaoui A., Adams M.J., Air T.M., Bacanu S.-A., Beekman A.T.F., Bigdeli T.B., Binder E.B., Bryois J., Buttenschon H.N., Cai N., Castelao E., Christensen J.H., Colodro-Conde L., Couvy-Duchesne B., Crawford G.E., Davies G., Deary I.J., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Kiadeh F.F.H., Finucane H.K., Goes F.S., Hall L.S., Hansen T.F., Hickie I.B., Homuth G., Horn C., Hottenga J.-J., Howard D.M., Ising M., Jansen R., Jorgenson E., Kohane I.S., Hill, Kraft J., Kretzschmar W.W., Kutalik Z., Li Y., Lind P.A., MacKinnon D.F., Maier R.M., Marchini J., Mbarek H., McGrath P., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Mondimore F.M., Mostafavi S., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Painter J.N., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Quiroz J.A., Qvist P., Riley B.P., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sinnamon G.C.B., Smit J.H., Smith D.J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Berger K., Boomsma D.I., de Geus E.J.C., Domenici E., Domschke K., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Kendler K.S., Kloiber S., Lewis G., Madden P.A.F., Magnusson P.K., Pedersen N.L., Penninx B.W.J.H., Porteous D.J., Preisig M., Schaefer C., Tiemeier H., Uher R., Volzke H., Weissman M.M., Levinson D.F., Child and Adolescent Psychiatry / Psychology, Epidemiology, Internal Medicine, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, APH - Methodology, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Complex Trait Genetics, and Adult Psychiatry

Subjects
Netherlands Twin Register (NTR), Genetic variants, Bipolar Disorder, Specific risk, Disease, 0302 clinical medicine, Multiplex, Genetic risk, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Depression (differential diagnoses), 0303 health sciences, Depression, ddc, 3. Good health, Geðraskanir, Psychiatry and Mental health, Schizophrenia, Cohort, Major depressive disorder, Case-Control Studie, Human, medicine.medical_specialty, Bipolar disorder, Article, Cellular and Molecular Neuroscience, 03 medical and health sciences, Geðklofi, SDG 3 - Good Health and Well-being, medicine, Humans, Genetic Predisposition to Disease, ddc:610, Psychiatry, Þunglyndi, Molecular Biology, 030304 developmental biology, Depressive Disorder, Major, Geðhvarfasýki, business.industry, Psychiatric disorder, medicine.disease, Genarannsóknir, Case-Control Studies, Multiple comparisons problem, business, 030217 neurology & neurosurgery
Abstract

Publisher's version, Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development., The study was supported by the German Federal Ministry of Education and Research (BMBF), through the Integrated Network IntegraMent, under the auspices of the e:Med programme (grants 01ZX1314A to MMN and SC; 01ZX1314G to MR; 01ZX1614J to BMM) through grants 01EE1406C to MR and 01EE1409C to MR and SHW, and through ERA-NET NEURON, “SynSchiz—Linking synaptic dysfunction to disease mechanisms in schizophrenia—a multilevel investigation” (01EW1810 to MR) and BMBF grants 01EE1409C and 01EE1406C to MR and SHW; by the German Research Foundation (DFG grants FOR2107; RI908/11-2 to MR; NO246/10-2 to MMN; MU1315/8-2 to BMM; WI 3439/3-2 to SHW), by the Andalusian regional Health and Innovation Government (grants PI-0060-2017, RC-0006-2015 the Nicolas Monarde Programme for YDO and CTS-546) and by the Swiss National Science Foundation (SNSF grant 156791 to SC). MMN is a member of the DFG-funded cluster of excellence ImmunoSensation. The PGC has received major funding from the US National Institute of Mental Health and the US National Institute of Drug Abuse (U01 MH109528 and U01 MH1095320). We thank the research participants and employees of 23andMe, Inc. for their contribution to the MDD meta-analysis published in [14]. We thank the International Genomics of Alzheimer's Project (IGAP) for providing summary results data for the present analyses. See the Supplementary Data for extended Acknowledgements.

Published
2021
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34. Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Author

Bauer, Michael, Glenn, Tasha, Achtyes, Eric, Alda, Martin, Agaoglu, Esen, Altınbaş, Kürşat, Andreassen, Ole, Angelopoulos, Elias, Ardau, Raffaella, Vares, Edgar Arrua, Aydin, Memduha, Ayhan, Yavuz, Baethge, Christopher, Bauer, Rita, Baune, Bernhard, Balaban, Ceylan, Becerra-Palars, Claudia, Behere, Aniruddh, Behere, Prakash, Belete, Habte, Belete, Tilahun, Belizario, Gabriel Okawa, Bellivier, Frank, Belmaker, Robert, Benedetti, Francesco, Berk, Michael, Bersudsky, Yuly, Bicakci, Şule, Birabwa-Oketcho, Harriet, Bjella, Thomas, Brady, Conan, Cabrera, Jorge, Cappucciati, Marco, Castro, Angela Marianne Paredes, Chen, Wei-Ling, Cheung, Eric, Chiesa, Silvia, Crowe, Marie, Cuomo, Alessandro, Dallaspezia, Sara, del Zompo, Maria, Desai, Pratikkumar, Dodd, Seetal, Donix, Markus, Etain, Bruno, Fagiolini, Andrea, Fellendorf, Frederike, Ferensztajn-Rochowiak, Ewa, Fiedorowicz, Jess, Fountoulakis, Kostas, Frye, Mark, Geoffroy, Pierre, Gonzalez-Pinto, Ana, Gottlieb, John, Grof, Paul, Haarman, Bartholomeus, Harima, Hirohiko, Hasse-Sousa, Mathias, Henry, Chantal, Høffding, Lone, Houenou, Josselin, Imbesi, Massimiliano, Isometsä, Erkki, Ivkovic, Maja, Janno, Sven, Johnsen, Simon, Kapczinski, Flávio, Karakatsoulis, Gregory, Kardell, Mathias, Kessing, Lars Vedel, Kim, Seong Jae, König, Barbara, Kot, Timur, Koval, Michael, Kunz, Mauricio, Lafer, Beny, Landén, Mikael, Larsen, Erik, Lenger, Melanie, Lewitzka, Ute, Licht, Rasmus, Lopez-Jaramillo, Carlos, Mackenzie, Alan, Madsen, Helle Østergaard, Madsen, Simone Alberte Kongstad A, Mahadevan, Jayant, Mahardika, Agustine, Manchia, Mirko, Marsh, Wendy, Martinez-Cengotitabengoa, Monica, Martiny, Klaus, Mashima, Yuki, Mcloughlin, Declan, Meesters, Ybe, Melle, Ingrid, Meza-Urzúa, Fátima, Ming, Mok Yee, Monteith, Scott, Moorthy, Muthukumaran, Morken, Gunnar, Mosca, Enrica, Mozzhegorov, Anton, Munoz, Rodrigo, Mythri, Starlin, Nacef, Fethi, Nadella, Ravi, Nakanotani, Takako, Nielsen, René Ernst, O'Donovan, Claire, Omrani, Adel, Osher, Yamima, Ouali, Uta, Pantovic-Stefanovic, Maja, Pariwatcharakul, Pornjira, Petite, Joanne, Pfennig, Andrea, Ruiz, Yolanda Pica, Pilhatsch, Maximilian, Pinna, Marco, Pompili, Maurizio, Porter, Richard, Quiroz, Danilo, Rabelo-Da-Ponte, Francisco Diego, Ramesar, Raj, Rasgon, Natalie, Ratta-Apha, Woraphat, Ratzenhofer, Michaela, Redahan, Maria, Reddy, M., Reif, Andreas, Reininghaus, Eva, Richards, Jenny Gringer, Ritter, Philipp, Rybakowski, Janusz, Sathyaputri, Leela, Scippa, Ângela, Simhandl, Christian, Severus, Emanuel, Smith, Daniel, Smith, José, Stackhouse, Paul, Stein, Dan, Stilwell, Kellen, Strejilevich, Sergio, Su, Kuan-Pin, Subramaniam, Mythily, Sulaiman, Ahmad Hatim, Suominen, Kirsi, Tanra, Andi, Tatebayashi, Yoshitaka, Teh, Wen Lin, Tondo, Leonardo, Torrent, Carla, Tuinstra, Daniel, Uchida, Takahito, Vaaler, Arne, Veeh, Julia, Vieta, Eduard, Viswanath, Biju, Yoldi-Negrete, Maria, Yalcinkaya, Oguz Kaan, Young, Allan, Zgueb, Yosra, Whybrow, Peter, Madsen, Simone Alberte Kongstad A., Bauer, M., Glenn, T., Achtyes, E. D., Alda, M., Agaoglu, E., Altinbas, K., Andreassen, O. A., Angelopoulos, E., Ardau, R., Vares, E. A., Aydin, M., Ayhan, Y., Baethge, C., Bauer, R., Baune, B. T., Balaban, C., Becerra-Palars, C., Behere, A. P., Behere, P. B., Belete, H., Belete, T., Belizario, G. O., Bellivier, F., Belmaker, R. H., Benedetti, F., Berk, M., Bersudsky, Y., Bicakci, S., Birabwa-Oketcho, H., Bjella, T. D., Brady, C., Cabrera, J., Cappucciati, M., Castro, A. M. P., Chen, W. -L., Cheung, E. Y. W., Chiesa, S., Crowe, M., Cuomo, A., Dallaspezia, S., Del Zompo, M., Desai, P., Dodd, S., Donix, M., Etain, B., Fagiolini, A., Fellendorf, F. T., Ferensztajn-Rochowiak, E., Fiedorowicz, J. G., Fountoulakis, K. N., Frye, M. A., Geoffroy, P. A., Gonzalez-Pinto, A., Gottlieb, J. F., Grof, P., Haarman, B. C. M., Harima, H., Hasse-Sousa, M., Henry, C., Hoffding, L., Houenou, J., Imbesi, M., Isometsa, E. T., Ivkovic, M., Janno, S., Johnsen, S., Kapczinski, F., Karakatsoulis, G. N., Kardell, M., Kessing, L. V., Kim, S. J., Konig, B., Kot, T. L., Koval, M., Kunz, M., Lafer, B., Landen, M., Larsen, E. R., Lenger, M., Lewitzka, U., Licht, R. W., Lopez-Jaramillo, C., Mackenzie, A., Madsen, H. O., Madsen, S. A. K. A., Mahadevan, J., Mahardika, A., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Martiny, K., Mashima, Y., Mcloughlin, D. M., Meesters, Y., Melle, I., Meza-Urzua, F., Ming, M. Y., Monteith, S., Moorthy, M., Morken, G., Mosca, E., Mozzhegorov, A. A., Munoz, R., Mythri, S. V., Nacef, F., Nadella, R. K., Nakanotani, T., Nielsen, R. E., O'Donovan, C., Omrani, A., Osher, Y., Ouali, U., Pantovic-Stefanovic, M., Pariwatcharakul, P., Petite, J., Pfennig, A., Ruiz, Y. P., Pilhatsch, M., Pinna, M., Pompili, M., Porter, R., Quiroz, D., Rabelo-da-Ponte, F. D., Ramesar, R., Rasgon, N., Ratta-apha, W., Ratzenhofer, M., Redahan, M., Reddy, M. S., Reif, A., Reininghaus, E. Z., Richards, J. G., Ritter, P., Rybakowski, J. K., Sathyaputri, L., Scippa, A. M., Simhandl, C., Severus, E., Smith, D., Smith, J., Stackhouse, P. W., Stein, D. J., Stilwell, K., Strejilevich, S., Su, K. -P., Subramaniam, M., Sulaiman, A. H., Suominen, K., Tanra, A. J., Tatebayashi, Y., Teh, W. L., Tondo, L., Torrent, C., Tuinstra, D., Uchida, T., Vaaler, A. E., Veeh, J., Vieta, E., Viswanath, B., Yoldi-Negrete, M., Yalcinkaya, O. K., Young, A. H., Zgueb, Y., Whybrow, P. C., Etain, Bruno, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), GHU Paris Psychiatrie et Neurosciences, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Fondation FondaMental [Créteil], Clinical Cognitive Neuropsychiatry Research Program (CCNP), Department of Pathology, and Faculty of Health Sciences

Subjects
Neurophysiology and neuropsychology, Psychiatry, Bipolar disorder, QP351-495, Research, Seasonal variation, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Circadian, Neurosciences. Biological psychiatry. Neuropsychiatry, Solar insolation, Suicide, Sunlight, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, RC321-571
Abstract

Background Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p

Published
2021
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35. Additional file 11 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 11.

Published
2021
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36. Additional file 4 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 4.

Published
2021
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37. Additional file 13 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 13.

Published
2021
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39. Additional file 7 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 7.

Published
2021
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40. Additional file 2 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2021
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42. Additional file 6 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 6.

Published
2021
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43. sj-docx-1-jop-10.1177_0269881121991827 – Supplemental material for Efficacy of onabotulinumtoxinA in the treatment of unipolar major depression: Systematic review, meta-analysis and meta-regression analyses of double-blind randomised controlled trials

Author

Arnone, Danilo, Galadari, Hassan, Rodgers, Carl J, Östlundh, Linda, Aziz, Karim Abdel, Stip, Emmanuel, and Young, Allan H

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-jop-10.1177_0269881121991827 for Efficacy of onabotulinumtoxinA in the treatment of unipolar major depression: Systematic review, meta-analysis and meta-regression analyses of double-blind randomised controlled trials by Danilo Arnone, Hassan Galadari, Carl J Rodgers, Linda Östlundh, Karim Abdel Aziz, Emmanuel Stip and Allan H Young in Journal of Psychopharmacology

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2021
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44. Additional file 1 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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45. Additional file 10 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 10.

Published
2021
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46. Additional file 3 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2021
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47. Antidepressant and antipsychotic treatment of Psychotic Major Depression in a British mental healthcare setting

Author

Jami, Eshim S., Pritchard, Megan, Shetty, Hitesh, Stewart, Robert, Young, Allan H., and Heslin, Margaret

Abstract

Evidence from treatment trials shows that the most effective pharmacological treatment for Psychotic Major Depression (PMD) is combined antidepressant and antipsychotic pharmacotherapy. This study investigates the use of antidepressant and antipsychotic treatment for PMD in clinical practice and examines how treatment profiles correlate with demographic and clinical symptoms. Anonymised electronic health records of 2,837 individuals with PMD were followed up for 12-months post-diagnosis in a historic open cohort design. The use of antidepressants and antipsychotics, alone or in combination, were described using frequency statistics. Demographic and clinical characteristics associated with each treatment were assessed using logistic regression analyses. Antidepressant and antipsychotic combination pharmacotherapy was the most used treatment for PMD with 69.9% users, compared to antidepressant monotherapy (10.9%) and antipsychotic monotherapy (10.3%). The remaining 8.9% of individuals did not receive antidepressant or antipsychotic treatment. The presence of delusions was strongly associated with the use of antipsychotics, both alone (odds ratio =3.99, 95% confidence intervals = 2.72–5.83, pp

Published
2021
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48. Additional file 12 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 12.

Published
2021
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49. Additional file 5 of Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)

Author

Azim, Lumbini, Hindmarch, Paul, Browne, Georgiana, Chadwick, Thomas, Clare, Emily, Courtney, Paul, Dixon, Lyndsey, Duffelen, Nichola, Fouweather, Tony, Geddes, John R., Goudie, Nicola, Harvey, Sandy, Helter, Timea, Holstein, Eva-Maria, Martin, Garry, Mawson, Phil, McCaffery, Jenny, Morriss, Richard, Simon, Judit, Smith, Daniel, Stokes, Paul R. A., Walker, Jenn, Weetman, Chris, Wolstenhulme, Faye, Young, Allan H., Watson, Stuart, and McAllister-Williams, R. Hamish

Subjects
Data_FILES
Abstract

Additional file 5.

Published
2021
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