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Additional file 1: Fig. S1. Spatio-temporal distributions of contents of fluorescence components in Lake Shahu.

High heterogeneity and nonuniformly distributed multiscale pore systems are two characteristics of the unconventional reservoirs, which lead to very complex transport mechanisms. Limited by inadequate computational capability and imaging field of view, flow simulation cannot be directly performed on complex pore structures. The traditional methods usually coarsen the grid to reduce the computational load but will lead to the missing microstructure information and inaccurate simulation results. To develop a better understanding of flow properties in unconventional reservoirs, this study proposed a new upscaling method integrated gray lattice Boltzmann method (GLBM) and pore network model (PNM), accounting for the fluid flow in heterogeneous porous media. This method can reasonably reduce the computational loads while preserving certain micropore characteristics. Verifications are conducted by comparing the simulation and experimental results on tight sandstones, and good agreements are achieved. The proposed method is proven to be capable of estimating bulk properties in highly heterogenous unconventional reservoirs. This method could contribute to the development of multiscale pore structure characterizations and enhance the understandings of fluid flow mechanisms in unconventional reservoirs.

We synthesize lipophilic, highly efficient, and pH-insensitive oleic acid-modified quantum dots (QDs) with maximum emission at a wavelength of 628 nm. The pH sensing film is fabricated by encapsulating 5-hexadecanoylamino-fluorescein and QDs as the reference in D4-hydromed and plasticized polystyrene. Using a light-emitting diode with a central wavelength of 410 nm as an excitation source, it is shown that the emission wavelengths of the pH sensitive indicator and reference dye have no spectral overlap and match respectively the channels of a 3CCD (RGB) camera with low cross-talk. A series of validation experiments shows that this ratiometric pH optode has good properties of high sensitivity, long-term stability, and photostability. It had a fast response time of

A certain degree of private ownership of military human capital determines the uncertainty of its supply. simply by the efforts of monitoring that can not completely solve the problem of the owners of military human capital, as well as really solve the moral hazard existing in the military. By setting up a general parameterized commission-agent model to discuss the game between the military and the owner of military human capital, we design the contract that the military human capital is remunerated as the factor of production so as to find the Ways of self-supervised incentive for the owner of the military human capital.

Immobilized metal ion affinity adsorbents have been widely used in separation technique to purify proteins. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion has been applied to clinical trial. In this study, in order to prevent the leakage of Zn2+ loaded from cellulose beads based adsorbent, improve its stability and adsorption capacity for testosterone, Freeze-drying method was used to enhance the porosity of cellulose beads, improve the surface area of the cellulose beads and adsorption capacity for testosterone. Chitosan was used to coat the adsorbents for preventing the leakage of Zn2+ loaded and improve the adsorbent’s stability. Moreover, the factors affecting adsorption ability and some components in plasma were also investigated. The results indicate the adsorption ability of the adsorbent can be significantly improved by freeze-drying. After the adsorbent was coated with 0.02% chitosan solution, the highest adsorption percentage reached 48%. During adsorption, the Zn2+ concentration in plasma did not rise. In addition, the adsorption percentage for total proteins was below 15%. The results may be caused by the pore size and surface area of the adsorbent enlarged via freeze-drying, and the chitosan solution went into the pores and coated the outer and inner surface of the adsorbent. The adsorbent has a potential clinical application to remove testosterone in patients with recurrent and metastatic prostate cancer.