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Branched flow is an interesting phenomenon that can occur in diverse systems. It is usually linear in the sense that the flow does not alter the medium properties. Branched flow of light on thin films was recently discovered. A question of interest is thus if nonlinear branched flow of light can also occur. Here we found using particle-in-cell simulations that with intense laser propagating in plasma with randomly uneven density distribution, photoionization by the laser can locally enhance the density variations along the laser paths and thus the branching of the laser. However, too-intense lasers can smooth the uneven electron density and suppress branching. The observed branching properties agree well with an analysis based on a Helmholtz equation for the laser electric field. Branched flow of intense laser in uneven plasma potentially opens up a new realm of intense laser-matter interaction., 6 pages, 5 figures

Imposing an external magnetic field in short-pulse intense laser-plasma interaction is of broad scientific interest in related plasma research areas. We propose a simple method using a virtual current layer by introducing an extra current density term to simulate the external magnetic field, and demonstrate it with three-dimensional particle-in-cell simulations. The field distribution and its evolution in sub-picosecond time scale are obtained. The magnetization process takes a much longer time than that of laser-plasma interaction due to plasma diamagnetism arising from collective response. The long-time evolution of magnetic diffusion and diamagnetic current can be predicted based on a simplified analytic model in combination with simulations., Comment: 5 pages, 5 figures

A scheme for controlling the direction of energetic proton beam driven by intense laser pulse is proposed. Simulations show that a precisely directed and collimated proton bunch can be produced by a sub-picosecond laser pulse interacting with a target consisting of a thin solid-density disk foil with a solenoid coil attached to its back at the desired angle. It is found that two partially overlapping sheath fields are induced. As a result, the accelerated protons are directed parallel to the axis of the solenoid, and their spread angle is also reduced by the overlapping sheath fields. The proton properties can thus be controlled by manipulating the solenoid parameters. Such highly directional and collimated energetic protons are useful in the high-energy-density as well as medical sciences., Comment: 5 pages, 5 figures

We have investigated the polarization of attosecond light bursts generated by nanobunches of electrons from relativistic few-cycle laser pulse interaction with the surface of overdense plasmas. Particle-in-cell simulation shows that the polarization state of the generated attosecond burst depends on the incident-pulse polarization, duration, carrier envelope phase, as well as the plasma scale length. Through laser and plasma parameter control, without compromise of generation efficiency, a linearly polarized laser pulse with azimuth $\theta^i=10^\circ$ can generate an elliptically polarized attosecond burst with azimuth $|\theta^r_{\rm atto}|\approx61^\circ$ and ellipticity $\sigma^r_{\rm atto}\approx0.27$; while an elliptically polarized laser pulse with $\sigma^i\approx0.36$ can generate an almost circularly polarized attosecond burst with $\sigma^r_{\rm atto}\approx0.95$. The results propose a new way to a table-top circularly polarized XUV source as a probe with attosecond scale time resolution for many advanced applications.

Alfv��nic turbulent cascade perpendicular and parallel to the background magnetic field is studied accounting for anisotropic dispersive effects and turbulent intermittency. The perpendicular dispersion and intermittency make the perpendicular-wavenumber magnetic spectra steeper and speed up production of high ion-cyclotron frequencies by the turbulent cascade. On the contrary, the parallel dispersion makes the spectra flatter and decelerate the frequency cascade above the ion-cyclotron frequency. Competition of the above factors results in spectral indices distributed in the interval [-2,-3], where -2 is the index of high-frequency space-filling turbulence, and -3 is the index of low-frequency intermittent turbulence formed by tube-like fluctuations. Spectra of fully intermittent turbulence fill a narrower range of spectral indices [-7/3,-3], which almost coincides with the range of indexes measured in the solar wind. This suggests that the kinetic-scale turbulent spectra are shaped mainly by dispersion and intermittency. A small mismatch with measured indexes of about 0.1 can be associated with damping effects not studied here., 9 Pages, 3 Figures, and 2 Tables

Random excitation of intense periodic highly-localized single-cycle light pulses in a stochastic background by continuous-wave stimulated Brillouin scattering in long optical fibers with weak feedback is found experimentally. Events with low period numbers are dominant and the optical feedback is crucial for the phenomenon. A three-wave coupling model for the phenomenon is proposed. The results are in good qualitative agreement with the observed phenomenon. The latter should be relevant to the understanding of similar rogue wave events in other nonlinear dissipative systems., 9 pages, 3 figures

It is shown that the transverse Rayleigh Taylor like instability can be well stabilized by using elliptically polarized laser in the hole boring radiation pressure acceleration regime. The $\bm{J}\times\bm{B}$ effect of the laser will thermalize the local electrons and support a transverse diffusion mechanism of the ions, resulting in the stabilization of the short wavelength perturbations, which is quite similar to the ablative Rayleigh Taylor instability in the initial confinement fusion research. The proper range of polarization ratio is obtained from a theoretical model for the given laser intensity and plasma density. The stabilization mechanism is well confirmed by two dimensional Particle-in-Cell simulations, and the ion beam driven by the elliptically polarized laser is more concentrated and intense compared with that of the circularly polarized laser., Comment: 6 pages, 5 figures

BACKGROUND AND OBJECTIVES: The aim of the collaborative study was to evaluate a panel of plasma samples containing different genotypes of parvovirus B19 (B19V) for use in nucleic acid amplification technology (NAT)-based assays. MATERIALS AND METHODS: The panel of samples [Center for Biologics Evaluation and Research Parvovirus B19 Genotype Panel 1; National Institute for Biological Standards and Control (NIBSC) code number 09/110] comprises four different members, i.e. Member 1, Member 2, Member 3, and Member 4 (M1-M4); these represent genotypes 1, 2, 3a B19V, and a negative plasma control, respectively. Thirty-five laboratories from 13 different countries participated in the study. Participants assayed the panel members concurrently with the 2nd World Health Organization (WHO) International Standard for B19V DNA (NIBSC code 99/802) on four separate occasions. RESULTS: A total of 44 sets of data were returned, 34 from quantitative assays and 10 from qualitative assays. The majority of assays used were in-house and based on real-time PCR. The results showed that all three genotypes were detected consistently by the majority of participants, although a small number of assays detected genotypes 2 and 3 less efficiently, or not at all. Real-time stability studies have indicated that the panel of B19V samples is stable under normal conditions of storage, i.e. ≤-70°C. CONCLUSIONS: The four-member panel is intended for use in evaluating the ability of NAT assays to detect different B19V genotypes (M1-M3). Based on the results of the collaborative study, the panel was established as the 1st WHO International Reference Panel for parvovirus B19 genotypes.

Proton acceleration by ultra-intense laser pulse irradiating a target with cross-section smaller than the laser spot size and connected to a parabolic density channel is investigated. The target splits the laser into two parallel propagating parts, which snowplow the back-side plasma electrons along their paths, creating two adjacent parallel wakes and an intense return current in the gap between them. The radiation-pressure pre-accelerated target protons trapped in the wake fields now undergo acceleration as well as collimation by the quasistatic wake electrostatic and magnetic fields. Particle-in-cell (PIC) simulation shows that stable long-distance acceleration can be realized, and a 30 fs monoenergetic ion beam of > 10 GeV peak energy and < 2degree divergence can be produced by a 9.8 *10^21 W/cm2 circularly polarized laser pulse., 9page,4figures

A two-dimensional generalized cubic nonlinear Schr��dinger equation with complex coefficients for the group dispersion and nonlinear terms is used to investigate the evolution of a finite-amplitude localized initial perturbation. It is found that modulation of the latter can lead to side-band formation, wave condensation, collapse, turbulence, and inverse cascade, although not all together nor in that order., 12 pages, 5 figures

Evolution of the single-mode ablative Rayleigh-Taylor instability in the presence of preheating is investigated numerically. It is found that the instability evolution depends strongly on the preheating length $L$ in front of the ablation-front interface. For weak preheating ($L/L_{\rm SH}\leq f_0$, where $L_{\rm SH}$ is the Spitzer-Harm length and $f_0\sim 20$ is a critical value), the linear growth rate has a sharp maximum and a secondary spike-bubble structure is generated. Interaction of this growing structure with the master spike-bubble leads to rupture of the latter. However, for strong preheating ($L/L_{\rm SH}>20$), the linear growth rate has no sharp maximum and no secondary spike-bubble is generated. Instead, the master spike-bubble evolves into an elongated jet. These results are interpreted in terms of the evolution and interaction of the instability-generated harmonic modes., 5 pages, 4 figures

BACKGROUND AND OBJECTIVES: A collaborative study, involving 26 laboratories from 14 countries, was carried out in order to establish a World Health Organization (WHO) International Standard for human parvovirus B19 (B19) DNA nucleic acid amplification techniques (NAT). MATERIALS AND METHODS: Four samples: AA, BB (which were lyophilized), CC and DD (which were liquid preparations) were analysed using several different NAT assays. The mean B19 DNA content of each sample was determined for each laboratory using an end-point dilution method. RESULTS: There was good agreement between the overall mean 'equivalents'/ml obtained by the different assays. The mean log(10) 'equivalents'/ml were 5.76 for sample AA, 5.73 for sample BB, 5.82 for sample CC and 7.70 for sample DD. The differences in titre among samples AA, BB and CC were not statistically significant, but the titre of DD was significantly higher. CONCLUSIONS: Despite the range of NAT assays used in the study, it was possible to calculate the mean B19 DNA concentrations in the four preparations. Lyophilized preparation AA was established as the first International Standard for B19 DNA NAT assays and was assigned a concentration of 10(6) international units (IU)/ml.