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4. Correlation between polymorphism of endothelial nitric oxide synthase and avascular necrosis of femoral head

Author

Zhang, Guo-Ping, Sun, Jing-Na, Wang, Jian, Zhang, Hai-Jing, Zhu, Chao-Hua, Lin, Lei, Li, Quan-Hai, Zhao, Zhen-Shuan, Yu, Xiao-Guang, Liu, Guo-Bin, and Dong, Wei

Subjects
Original Article
Abstract

Objective: We analyzed the correlation between mutation in intron 4 and exon 7 of endothelial nitric oxide synthase (eNOS) and avascular necrosis of femoral head (ANFH). Method: A total of 260 ANFH cases without history of hip joint injuries were diagnosed and subject to staging according to Ficat standard, with 262 health subjects as control. Venous blood was collected to extract genome DNA, which was then amplified by PCR. The polymorphism of 27 bp repeat sequence in intron 4 and G894T polymorphism in exon 7 of eNOS gene was detected. Results: The b/b, b/a and a/a genotype frequency of intron 4 was 77.7%, 19.2% and 3.1% in ANFH group, respectively, and that in the control group was 58.0%, 32.8% and 9.2%, respectively. The b allele frequency in ANFH group was obviously higher than that in the control (P

Published
2015

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