Search

EMUs play an important role in the rapid development of China’s economy, so ensuring the safety of high-speed EMUs has been a research issue for relevant experts and scholars. Because the defect change of the motor car apron will lead to the stability of the whole motor car running on the side, this paper takes the motor car apron defect as the recognition object, and proposes to add feature reasoning module to the typical convolutional network model to improve the ability to identify occlusion defects by solving the problem that the traditional recognition model cannot identify the features of occlusion and stacking and the status quo that cannot be identified under a small number of samples, Then the meta learning mechanism is incorporated into the model to realize the recognition under the condition of few samples in the dataset. Through experimental comparison, it is proved that the performance of the improved recognition network algorithm in recognition accuracy and recognition speed is improved as a whole. &nbsp

Following results of recent studies, Huperzia myriophyllifolia (Huperziaceae), Lycopodium subinundatum (Lycopodiaceae), and Polystichum pseudodeltodon, P. pseudostenophyllum, P. subapiciflorum, and P. subobliquum (Dryopteridaceae) are recognized/reinstated. A new combination, Pseudolycopodiella subinundata, is made based on L. subinundatum. Spinulum lioui (Lycopodiaceae) is reported as a new record for most part of China and other Asian countries.

Following a recent phylogenetic study, we here review the circumscription of the grammitid fern genus Oreogrammitis (Polypodiaceae: Grammitidoideae). We propose three new genera Calligrammitis, Devolia, and Glabrigrammitis, to accommodate the three clades resolved outside of the core Oreogrammitis. The taxonomic treatment is presented, and the morphology of each new genus is shown with a color plate.

A new species of Hymenasplenium (Aspleniaceae), H. hovenkampii, from the Lesser Sunda Islands of Indonesia is described. This species was preliminarily identified as H. unilaterale, but can be easily distinguished by its bipinnatisect laminae (vs. 1-pinnate lamina) and reddish brown (vs. dark brown to black) stipes and rachises. In fact, all species known so far in the genus have simple or 1-pinnate laminae, whereas the new species is the only one in the genus with bipinnatisect laminae.

With the rapid development of "Silk Road E-commerce", the cross-border e-commerce cooperation between China and countries along the "Belt and Road" is gradually deepening. As a major e-commerce country and the initiator of "Silk Road E-Commerce", China has rich experience and a good material foundation. As the largest economy of ASEAN and one of the partner countries of "Silk Road E-Commerce", Indonesia has a broad market and a huge consumer base. The cross-border e-commerce sector between China and Indonesia has shown strong complementary and synergistic development capabilities. This paper first analyzes the basic situation of "Silk Road E-commerce", followed by an in-depth analysis of the current situation, development pain points and cooperation space of cross-border e-commerce in China and Indonesia, and puts forward six suggestions for the development of cross-border e-commerce in China and Indonesia, which provide strong academic support for scholars in this field.

BACKGROUND: The inflammatory response caused by the NLRP3 is closely related to the formation of myocardial ischemia-reperfusion injury. Costimulatory receptor CD137 and its ligand play a crucial role in regulating the inflammatory immune response in atherosclerosis, which is the fundamental cause of cardiovascular diseases. However, the roles of CD137 signaling in the process of myocardial ischaemia-reperfusion (IR) injury remain unknown. METHODS: Genetic ablation was used to determine the functional significance of CD137 in myocardial IR injury. Expression of CD137 was examined by Western-blot, quantitative real-time polymerase chain reaction, and immunohistochemistry in a murine IR model by coronary artery ligation. Even’s blue-TTC staining and echocardiography to evaluate the severity of myocardial IR injury. Furthermore, HL-1 cardiomyocytes treated with agonist-CD137 recombinant protein were used to explore the underlying mechanism in CD137 signaling-induced NLRP3 inflammasome activation in response to hypoxia/reoxygenation or LPS/ATP. RESULTS: We demonstrated that CD137 knockout significantly improved cardiac function, accompanied by a markedly reduced NLRP3-mediated inflammatory response and IA/AAR which were reversed by mitophagy inhibitor Mdivi-1. Activating CD137 signaling significantly inhibited mitophagy and provoked NLRP3-mediated inflammatory response in H/R-injured or LPS-primed and ATP-stimulated HL-1 cardiomyocytes, the effects of which could be abolished by either anti-CD137 or mitophagy activator FCCP. Besides, mitochondrial ROS was augmented by activating CD137 signaling through the suppression of mitophagy. CONCLUSIONS: Our results reveal that activating CD137 signaling aggravates myocardial IR injury by upregulating NLRP3 inflammasome activation via suppressing mitophagy and promoting mtROS generation.

Hong-Fu Li,1,2,&ast; Li-Xia Zhang,2,&ast; Wen-Lan Zhang,2,&ast; Jing Li,2,&ast; Ya-Qian Li,2,&ast; Tong-Ping Hu2 1Department of Clinical Laboratory, Zhuhai Third People’s Hospital, Zhuhai, People’s Republic of China; 2Department of Clinical laboratory, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Inner Mongolia, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tong-Ping Hu, Department of Clinical laboratory, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, No. 41, of Linyin Road, Kundulun District, Baotou City, Baotou, 014000, People’s Republic of China, Tel +86 13296922365, Email hutongping1976@126.comObjective: The purpose of this study was to analyse the clinical, microbiological and molecular epidemiological characteristics of patients with pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae (KPN) in Inner Mongolia, China.Methods: The KPN isolates from 78 KPN-PLA cases admitted to a tertiary teaching hospital in Baotou, Inner Mongolia, from 2016 to 2019 were studied systematically and described comprehensively. The virulence factors, drug resistance and sequence types of KPN in different samples were identified by a wire-drawing test, polymerase chain reaction, a drug susceptibility test and multi-site sequence typing.Results: There were more male than female KPN-PLA patients (P< 0.05). The mortality rate was 2.5%, and KPN-PLA was significantly associated with diabetes mellitus (P< 0.05). Most of the KPN isolates in the puncture fluid of patients with KPN-PLA were hypervirulent KPN (HvKP). The positive rate of the KPN-PLA specimens was higher than that of the blood and urine specimens. The KPN isolates of the urine specimens had higher drug resistance than the other two (P< 0.05). The hypermucoviscous KPN, aerobic actin (aero) (+), K1 and K2 serotypes accounted for 80.8%, 89.7%, 56.4% and 26.9%, respectively. In addition to ironB (3.8%), the detection rates of virulence factors rmpA, irp2, entB, iucD, aero, wcaG, iutA, kfu, ybtA, iron, fimH and mrkD were higher (69.2%– 100.0%). The positive rate of KPN isolates of the KPN-PLA puncture fluid was higher than that of the blood and urine samples (P< 0.05). In addition, ST23 was found to be the dominant ST (32.1%) of KPN-PLA in the Baotou region.Conclusion: In the KPN-PLA specimens, the KPN isolates were more virulent than those in the blood and urine specimens, and a carbapenem-resistant HvKP strain emerged. This research will help improve the understanding of HvKP and provide useful suggestions for KPN-PLA treatments.Keywords: Klebsiella pneumoniae, virulence factor, capsular serotype, bacterial drug resistance, multilocus sequence typing

Poor prenatal sleep quality is associated with increased risk for depressive symptoms but may go undetected in brief, busy prenatal care visits. Among non-depressed pregnant participants, we evaluated whether 1) the endorsement of sleep disturbance on a depression questionnaire predicted postpartum depressive symptoms, 2) the strength of these associations was higher than other somatic symptoms of pregnancy and depression (i.e., fatigue, appetite disturbance), and 3) the endorsement of prenatal sleep disturbance varied by participant characteristics. In this retrospective cohort study, participants had a live birth and completed Patient Health Questionnaire (PHQ-9) during pregnancy and within 8 weeks postpartum between 2012 and 2017. Participants who were non-depressed during pregnancy (PHQ-9 < 10) were included (n = 3619). We operationalized sleep disturbance, fatigue, and appetite disturbance as endorsement of item 3, 4, and 5 on the PHQ-9, respectively, and postpartum depressive symptoms as PHQ-9 total score ≥ 10. Participant characteristic variables included age, race, ethnicity, parity, gestational age at delivery, and preterm birth. Prenatal sleep disturbance was associated with higher odds of postpartum depressive symptoms (aORs 1.9, 95% CI 1.2–3.1 for first trimester; 3.7, 95% CI 1.5–11.5 for second trimester; 3.4, 95% CI 1.9–6.8 for third trimester). Fatigue and appetite disturbance in the first and third trimesters were associated with higher odds of postpartum depressive symptoms. Sleep disturbance varied by race during the first and second trimesters (p < 0.05) and was highest among Black or African American participants (61.8–65.1%). A routinely administered single-item measure of sleep disturbance could identify otherwise lower-risk pregnant individuals who may benefit from depression prevention efforts.

Herein, we demonstrate that dichloromethanol but not difluoromethanol is a viable surrogate of carbon monoxide for prodrug design.

A 1D chain Zn coordination polymer was successfully designed and synthesized to detect V2O74− ions, Fe3+ ions, and nitrotoluene, demonstrating that it could behave as a functional probe with high selectivity, sensitivity, and recyclability.

Ning Yan,1,&ast; Dapeng Chen,1,&ast; Ruiping Pan,2 Li Zhang,3 Juan Ma,4 Zhengjun Zhang,1 Yuqi Dang,5 Liqun Wang,6 Xueping Ma,1,7 Shaobin Jia1,7 1Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2Department of Chinese Medicine, The Second People’s Hospital of Shizuishan, Shizuishan, 753000, People’s Republic of China; 3Department of Endocrinology, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 4Clinical Medical College, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 5Department of Endocrinology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, 750001, People’s Republic of China; 6Department of Epidemiology and Statistics, School of Public Health and Management, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 7Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xueping Ma; Shaobin Jia, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China, Tel +8613519290991 ; +8613995078969, Email maxueping4033@126.com; jsbxn@163.comPurpose: This study aimed to evaluate the relationship between social capital (SC) and hypertension among type 2 diabetes mellitus (T2DM) patients, considering the moderation effects of depressive symptoms.Patients and Methods: A total of 1761 Chinese T2DM patients completed measure scales of social capital and epidemiological survey depression scale (CES-D). The Bootstrap methods PROCESS program is employed to test the moderation model.Results: The prevalence of hypertension among T2DM patients was 39.3%. The SC was negatively correlated with the CES-D score (r=− 0.18, P< 0.01); the SC was also negatively correlated with diastolic blood pressure (r=− 0.05, P< 0.05); and the CES-D score was positively correlated with systolic blood pressure (r=0.05, P< 0.05). Both logistic regression analysis and the Bootstrap method showed that depressive symptoms weakened the protective effect of SC on hypertension, there existed a moderating effect of depressive symptoms on the relationship between SC and hypertension among T2DM patients.Conclusion: Depressive symptoms may be one crucial moderator of the relationship between SC and hypertension in a representative sample of Chinese diabetes patients. The findings indicate that improving SC and mental health may help manage hypertension among T2DM patients.Keywords: social capital, depressive symptoms, hypertension, moderation, type 2 diabetes mellitus

Li-Li Zhang,&ast; Wen-Hao Wang,&ast; Yong-Li Hou Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, Taiyuan, 030000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yong-Li Hou, Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, No. 382 of Wuyi Road, Xinghualing District, Taiyuan, 030000, People’s Republic of China, Tel +86 03513382151, Email houyonglihyl@126.comObjective: To investigate the risk factors of intraoperative massive hemorrhage in patients with pernicious placenta previa (PPP) and analyze the value of bilateral internal iliac artery balloon occlusion in Cesarean section for these patients.Methods: The clinical data of 134 patients with PPP admitted to the Second Hospital of Shanxi Medical University from January 2012 to January 2019 were analyzed. A logistic regression analysis was used to analyze the risk factors for intraoperative massive hemorrhage in PPP. The study subjects were divided into the intervention group (38 cases) and the routine group (96 cases) according to whether bilateral internal iliac artery balloon occlusion was conducted during the operation. The differences in some clinical indicators were compared between the two groups.Results: The risk factors for intraoperative massive hemorrhage in PPP were age ≥ 35 years, gestational age ≥ 34 weeks, complete placenta previa, and the presence of placenta accreta. The differences in the operation time, postoperative transfer to the intensive care unit, postoperative length of the hospital stay, and neonatal weight and score were not statistically significant between the intervention group and the routine group (P > 0.05 for all). While the intraoperative blood loss and the transfusion volume in the intervention group were lower than in the routine group, the hospitalization cost was higher in the former than in the latter, and the differences were statistically significant (P < 0.05 for all). Moreover, there was no case of hysterectomy in the intervention group, while there were two cases of hysterectomies in the routine group.Conclusion: The risk factors for intraoperative massive hemorrhage in PPP were age ≥ 35 years, gestational age ≥ 34 weeks, complete placenta previa, and the presence of placenta accreta. Internal iliac artery balloon occlusion during PPP could reduce intraoperative blood loss and the hysterectomy rate.Keywords: pernicious placenta previa, internal iliac artery balloon occlusion, intraoperative bleeding, risk factor

Ling-Ling Xu,1– 4,&ast; Yao Yan,1– 3,&ast; Yu-Min Yuan,1– 3 Ying Li,1– 3 Jun Jiang,1– 3 Li-Cai Zhang1– 3 1Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, People’s Republic of China; 3NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou, People’s Republic of China; 4Department of Anesthesiology, Nanjing Gaochun People’s Hospital, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Li-Cai Zhang, Email licaizhang001@163.comObjective: To assess the receptors of TRPV1 and GABAB1 receptors that were colocalized in cerebrospinal fluid contacting nucleus (CSF-contact nucleus) of chronic inflammatory pain (CIP) rats bringing inspiration for reducing chronic pain.Methods: A rat model of CIP was constructed by plantar injection of complete Freund’s adjuvant (CFA), and the paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured 1, 3, 5, 7, 10, and 14 days after plantar injection. In the first part of the experiment, rats with CIP were divided into the immunofluorescence group and the coimmunoprecipitation (Co-IP) group (n = 6). Rats in the immunofluorescence group were injected with the retrograde tracer CB conjugated with Alexa Fluor 594 into the lateral ventricle two days before the injection of CFA into the plantar surface of the left paw. Three days later, rats that exhibited hyperalgesia were perfused, and their brains were extracted and used for double immunofluorescence staining of the CSF-contacting nucleus. Rats in the Co-IP group were anesthetized and dissected 3 days after CFA injection, and fresh brain segments containing the CSF-contacting nucleus were collected for Co-IP to assess the colocalization of TRPV1 and GABAB1 in the CSF-contacting nucleus (n = 6). In the second part of the experiment, SD rats were divided into the normal saline group (control group) and the CFA group. Fresh CSF-contacting nucleus-containing tissues were collected for Western blot analysis 3 days after plantar injection to observe the changes in TRPV1 and GABAB1 expression in the CSF-contacting nucleus.Results: TRPV1 and GABAB1 were co-expressed in the CSF-contacting nucleus in rats with CIP, and their expression was upregulated.Conclusion: TRPV1 and GABAB1 in the CSF-contacting nucleus are jointly involved in CIP in rats, and there is a direct or indirect link between TRPV1 and GABAB1.Keywords: cerebrospinal fluid-contacting nucleus, TRPV1 receptor, GABAB1 receptor, chronic inflammatory pain

Non-small-cell lung cancer (NSCLC) remains the major cause of cancer-related death. Immune checkpoint inhibition has become the cornerstone treatment for NSCLC. Cuproptosis is a newly identified form of cell death relying on mitochondrial respiration that might play a role in shaping tumor immune microenvironment (TIME). The clinical significance of cuproptosis-related genes (CRGs) remains unclear and warrant investigation. The current study extracted RNA sequencing profiles and corresponding clinical information from six aggregated datasets from the Gene Expression Omnibus (GEO) repository as the training set, and from The Cancer Genome Atlas (TCGA) database as the testing set. Cuproptosis-related immune genes (CRIMGs) were obtained through coexpression analysis, univariate Cox regression analysis, and LASSO analysis for overall survival (OS) association analysis. Consensus clustering was employed to divide the subjects into clusters. Stepwise multivariate Cox regression was used to establish the prognostic CRIMG_score from the CRIMGs. A 17-gene prediction signature was established that informed patients' OS both in the training and testing datasets (p 0.001). The predictive value of the signature in terms of immunotherapeutic responses was assessed in two publicly available NSCLC immunotherapy datasets (POPLAR and OAK studies) and an internal dataset from Sun Yat-sen University Cancer Center (ORIENT-11 study). Patients in the high-risk group displayed worse survival, a characteristic suppressive tumor immune microenvironment, and low immunotherapeutic benefits compared to those in the low-risk group. Collectively, the CRIMG_score established herein could serve as a promising indicator of prognosis and immunotherapeutic response in patients with NSCLC.

Bamboo filament decorated board is a new kind of bamboo and wood composite material. In this material, melamine-urea-formaldehyde (MUF) modified resin impregnated paper is used as the bonding material between bamboo filament decoration material and finger joint plate. This research investigated the effects of hot pressing temperature, time, and pressure on surface bonding properties of bamboo filament decorated board, and the optimum process parameters were determined. With the surface bonding strength as the evaluation index, the response surface analysis was used to optimize the design of the optimal hot pressing process. The optimum surface bonding strength of 1.13 MPa was achieved with the process parameters of 130 s (hot pressing time), 148 °C (hot pressing temperature), and 2.00 MPa (hot pressing pressure). The experimental values were in good agreement with the predicted ones, and the relative error was less than 5%, showing the optimized result.

Easter, 1916 is a classic work of Irish poet Yeats, describing four leaders in Irish raising and expressing Yeats’ complicated attitudes toward the rebellion. Being different from the traditional view of history, the study interprets the poem by analyzing its clauses from the perspective of functional grammar. It is concluded that a large amount of material process are used to represent the experiences of the characters, which realizes the narrative function of a poem. Relational process, the identifying one particularly, highlights the beliefs of revolutionaries and Yeats’ suspicion of their sacrifice. But finally, the mental, verbal and behavioural processes rebuild his support for the uprising and the nationalism represented by it.

“O Captain! My Captain!”, written by Walt Whitman, one of the most talented poets in American history, is an elegy on the death of Pres. Abraham Lincoln. It portrays Lincoln as the captain of a sea-worn ship, which implies the Union triumphant after the American Civil War. By drawing on multimodal discourse analysis and its theoretical framework of Halliday’s systemic functional grammar, this paper seeks to explore its meaning from both literary and non-literary aspects. The ideational function of the poem presents readers largely material processes, which post a whole dynamic scene. Whitman calls the captain “captain”, “my captain” and “father”. The change indicates that the author’s mourning seems to transcend the sorrow of a citizen for the assassination of a leader to become more like that of a son for his father. Cohesive markers of conjunction glue everything together and make the poem ship-like. To connect literature with linguistics and multimodal discourse analysis provides a new way to interpret Whitman’s poem and helps to understand the poem better.

With the development of information technology, cold chain logistics monitoring systems are widely used in transportation of fresh food to detect the quality parameters in real time. Poor network transmission performance, high packet loss rate and high maintenance cost are the main problems in the current cold chain logistics monitoring. To solve these problems, the paper presents a low-power monitoring system based on Narrow Band Internet of Things (NB-IoT). Considering the characteristics of the moving carriage, the polling mode of Bluetooth is proposed for the communication of one sink node to three sensor nodes. An improved working sequence is designed to reduce the power consumption of Bluetooth modules. Subsequently, analyzing the standard NB-IoT terminal state transition diagram, combining with the practical applications of cold chain logistics, an improved terminal state transition diagram is proposed and its terminal power consumption is analyzed. In the experimental test, the packet loss rate is less than 1% within 8 km. And the battery life of improved Bluetooth module is 143 times of that of traditional one. The power consumption of main service of NB-IoT is discussed, the formula is given which includes the transmission quality, random access times, number of concurrent users, sleep interval and other parameters. Through simulation and calculate, the battery life of terminal is up to 17 years. These improvements will greatly reduce the cost of cold chain logistics monitoring system. In addition, the packet loss rate test experiment proves the high reliability of the communication system. &nbsp

Polystichum suiyangense (Dryopteridaceae), a new species from Suiyang County, Guizhou, China, is described and illustrated. It is a member of P. sect. Sphaenopolystichum and similar to P. auriculum, P. bifidum, and P. martinii, but differs from them in its frond texture, leaf color, scales on petiole and rachis, pinna shape, and pinna apex. The new species is currently known only from the type locality and is classified as CR (critically endangered) following the IUCN criteria.

Northanger Abbey is one of Jane Austen's six novels which contains rich connotation and profound implication. Female education is the theme of the novel. With the help of Gothic novels, Austen interprets the theme of female education in the framework of Catherine and Henry's love and marriage story, and explores how young men and women find their own marriage partners under the pressure of society and the times. Jane Austen expressed her progressive view of female education. She thinks that only relying on parents' education at home can not cultivate mature and rational qualified women. They also need to step into the society and read novels to get personal growth in these activities of communicating with others. In Austen's time, a popular educational concept strongly advocates that women should receive family education to ensure their physical and mental purity, and believes that novels will corrupt their hearts and lead them astray. Austen's view is progressive and positive at that time. She points out the importance of rationality to emotion and imagination, and defends the art of fiction including Gothic novels.

Aims: To enhance the cytotoxicity of natural killer (NK) cells against prostate cancer cells via NKG2D agonist, with 4-1BB antibody and IL-27 combination. Materials & methods: FACS was used to detect degranulation and cell surface receptors in NK cells isolated from healthy donors. Cytokine concentrations were measured using ELISA. NK-cell cytotoxicity was analyzed using Cell Counting Kit-8. Results: NKG2D agonist, 4-1BB antibody and IL-27 combination treatment improved the activating receptor expression and IFN-γ and TNF-α secretion but decreased the suppressive receptor CD158a expression and IL-10 secretion in NK cells. The combined treatment enhanced NK-cell cytotoxicity against both PC3 and DU145 cells with concurrent enhanced STAT3 activation. Conclusion: 4-1BB antibody and IL-27 improved NKG2D agonist function in NK cells against prostate cancer cells.

Zhen Qin,1– 3 Shuai Xu,1– 3 Ruixia Yuan,4 Zeyu Wang,1– 3 Yongzheng Lu,1– 3 Yanyan Xu,1– 3 Yan Lv,1– 3 Fengyi Yu,1– 3 Jing Bai,1– 3 Hui Zhang,1– 3 Li Zhang,1– 3 Jinying Zhang,1– 3 Junnan Tang1– 3 1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 2Henan Province Key Laboratory of Cardiac Injury and Repair, Zhengzhou, Henan, 450052, People’s Republic of China; 3Henan Province Clinical Research Center for Cardiovascular Diseases, Zhengzhou, Henan, 450018, People’s Republic of China; 4Clinical Big Data Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of ChinaCorrespondence: Junnan Tang, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China, Tel +86 15890696166, Email fcctangjn@zzu.edu.cn Jinying Zhang, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China, Tel +86 13503830283, Email jyzhang@zzu.edu.cnObjective: We aimed to investigate the prognostic value of the triglyceride-glucose (TyG) index combined the with Global Registry of Acute Coronary Events (GRACE) score in adult acute coronary syndrome (ACS) patients with type 2 diabetes mellitus (T2DM) who underwent percutaneous coronary intervention (PCI).Methods: The study enrolled total 899 ACS patients with T2DM who underwent PCI. TyG index and the GRACE risk score were calculated and assessed by median. The correlation was analyzed by Spearman’s rank correlation coefficient. The cumulative major adverse cardiovascular event (MACE) curve was generated using the Kaplan–Meier method. Multivariate Cox regression was used to identify predictors of MACEs. Additionally, the receiver operating characteristic curve (ROC), net reclassification index (NRI) and Integrated Discrimination Improvement (IDI) were applied to analyze the performance of each single factor index and combined multivariate index in predicting MACE.Results: In the ACS patients with T2DM after PCI, there were significant differences in the TyG index and GRACE risk score between the MACE group and the MACE-free group (P < 0.001). Kaplan–Meier analysis showed that the TyG index combined with the GRACE risk score was positively correlated with the occurrence of MACEs (log rank P < 0.001). Multivariate Cox regression analyses showed that the TyG index, the GRACE risk score, and the TyG index combined with the GRACE risk score were independent predictors of long-term MACEs (adjusted HR: 1.805; 95% CI: 1.479– 2.203, P < 0.001; adjusted HR: 1.012; 95% CI: 1.009– 1.016, P < 0.001; and adjusted HR: 2.337; 95% CI: 1.805– 3.025, P < 0.001, respectively). Correlation analysis indicated that the TyG index was positively correlated with the GRACE risk score (R = 0.140, P < 0.001). The analysis of AUC, NRI and IDI revealed that the combined multivariate index performed better prognostic role than each single factor index in predicting the occurrence of MACE.Conclusion: Both the GRACE risk score and the TyG index could be significant and independent predictors of clinical outcomes in ACS patients with T2DM after PCI. A combination of them could be enhanced predictions of clinical outcomes in these patients.Keywords: triglyceride-glucose index, GRACE risk score, predictive biomarker, acute coronary syndrome, type 2 diabetes mellitus, percutaneous coronary intervention

Qianting Yang, Jiao Xie, Yan Cai, Na Wang, Yan Wang, Li Zhang, Youjia Li, Jingjie Yu, Ya Li, Haitao Wang, Kanghuai Zhang Department of Pharmacy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaCorrespondence: Kanghuai Zhang, Department of Pharmacy, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an, 710004, People’s Republic of China, Tel +86-29-87679282, Email zhangkanghuai12@163.comPurpose: To determine whether combinations of antifungal drugs are effective and safe for patients in intensive-care units.Methods: This study compared the efficacy and safety of caspofungin (CAS), voriconazole (VOR), amphotericin B liposome (L-AmB), CAS+VOR, and CAS+L-AmB as empirical, preemptive, and targeted therapies for invasive fungal infection (IFI).Results: Comparing the CAS, VOR, and CAS+VOR groups revealed that there were no differences in response rates between all therapy types, IFI-associated death within 90 days was less common in the CAS+VOR group (1.8%) than the VOR group (14.3%), and there were more adverse events in the VOR group than in the CAS group (P < 0.05). For empirical or preemptive therapy, the CAS group had a better response rate (80.0%) than the CAS+VOR group (47.1%), and there were more adverse events in the VOR group than in the CAS group (P < 0.05). For targeted therapy, no differences were found for efficacy and safety. There were no differences among the CAS, L-AmB, and CAS+L-AmB groups in efficacy and safety.Conclusion: Patients who received CAS monotherapy as an empirical or preemptive therapy could achieve good outcomes. Patients who received CAS+VOR or CAS+L-AmB achieved almost the same outcomes when compared with those who received CAS, VOR, and L-AmB monotherapy as targeted therapies, but those who received CAS+VOR had a lower IFI mortality rate than did those who received VOR monotherapy.Keywords: caspofungin, voriconazole, amphotericin B liposome, combination therapy, invasive fungal infection, intensive-care units

The range and speed of a moving object can be ascertained using the sensing technique known as light detection and ranging (LiDAR). It has recently been suggested that quantum LiDAR, which uses entangled states of light, can enhance the capabilities of LiDAR. Entangled pulsed light is used in prior quantum LiDAR approaches to assess both range and velocity at the same time using the pulses' time of flight and Doppler shift. The entangled pulsed light generation and detection, which are crucial for pulsed quantum LiDAR, are often inefficient. Here, we study a quantum LiDAR that operates on a frequency-modulated continuous wave (FMCW), as opposed to pulses. We first outline the design of the quantum FMCW LiDAR using entangled frequency-modulated photons in a Mach-Zehnder interferometer, and we demonstrate how it can increase accuracy and resolution for range and velocity measurements by $\sqrt{n}$ and $n$, respectively, with $n$ entangled photons. We also demonstrate that quantum FMCW LiDAR may perform simultaneous measurements of the range and velocity without the need for quantum pulsed compression, which is necessary in pulsed quantum LiDAR. Since the generation of entangled photons is the only inefficient nonlinear optical process needed, the quantum FMCW LiDAR is better suited for practical implementations. Additionally, most measurements in the quantum FMCW LiDAR can be carried out electronically by down-converting optical signal to microwave region.

Selaginella subchaetoloma X.M.Zhou, Li Bing Zhang & Z.R.He, sp. nov. (Figs. 1, 3) Type: — CHINA. Yunnan: Zhaotong City, Qiao Jia County, Yao Shan Town, Jionglonggou, elev. ca. 1650 m, on ditch wall in Yunnan pine (Pinus yunnanensis Franch.) forest, 16 August 2002, Zhao-Rong He & Xing-Long Liu 29625 (holotype PYU-01001254!; isotype PYU-01001255!). Diagnosis: — Selaginella subchaetoloma is extremely similar to S. chaetoloma, but S. subchaetoloma has creeping sterile part and ascending fertile part (Figs. 1A, 2A, B) (vs. nearly creeping in S. chaetoloma) (Fig. 3D), apex of dorsal leaves abruptly short-acuminate to submucronate (Fig. 1D, J) (vs. long aristate in S. chaetoloma) (Fig. 3G), and ventral leaves slightly involute when dry (Fig. 1C, E, I) (vs. not involute when dry in S. chaetoloma) (Fig. 3I). Plants terrestrial, evergreen, ascending from decumbent base up to 12 cm (Figs. 1A, 3A, B). Rhizophores present only at middle and lower part of the main stem, borne on ventral side in axils of branches, 0.16–0.27 mm in diam. (Fig. 1A & C). Main stem pinnately branched, 0.25–0.46 mm in diam., terete; primary leafy branches 7 or 9 pairs, 3 times pinnately branched, adjacent primary branches on main stem 0.5–1.1 cm apart (Figs. 1A, 3A, B); ultimate branches of leafy portion of main stem 1.8–3.1 mm wide. Axillary leaves on branches symmetrical, ovate, 1.1–1.3 × 0.6–0.7 mm, base broadly cuneate, margin sparsely long ciliolate (Fig. 1H). Dorsal leaves asymmetrical, those on main stems not obviously larger than those on branches; dorsal leaves on branches not approximate or contiguous, obliquely oval, 1.2–1.6 × 0.9–1.0 mm, strongly carinate, base shallowly cordate, outside margin sparsely long ciliolate at base, denticulate upwards, inside basal margin entire below middle, ciliolate-denticulate to denticulate upwards, apex abruptly short-acuminate to submucronate (Fig. 1D, J). Ventral leaves asymmetrical, those on main stem not obviously larger than those on branches; ventral leaves on branches spreading or deflexed, ovate to broadly ovate, 1.5–2.2 × 0.9–1.2 mm, apex obtuse, base nearly rounded; basiscopic margin subentire or entire; acroscopic base enlarged, broader, slightly overlapping stem and branches, margin long ciliolate, cilia 0.10–0.50 mm; apical margin denticulate (Fig. 1C, E, I). Strobili solitary or binate, terminal, compact, dorsiventrally complanate, 4.0–6.4 × 1.5– 2.0 mm (Figs. 1B, 3C). Sporophylls dimorphic, indistinctly white-margined (Fig. 1F, G); dorsal sporophylls ovatetriangular, carinate, margin long ciliolate, apex acuminate, with sporophyll-pteryx complete and ciliolate (Fig. 1K); ventral sporophylls ovate, carinate, margin ciliolate; megasporophylls in basal portion on lower side of strobilus (Fig. 1L). Megaspores slightly yellow, spherical, 284–360 μm in diam., prominent laesurae extend 1/2–2/3 of the distance to the equator, both proximal and laesurae surfaces verrucate or vermiculate ornamentation covered with the reticulate microstructure (Fig. 1M, N). Microspores orange, hemispherical, 29.7–42.7 μm in diam., both the proximal and distal surfaces densely verrucate, without obvious microstructures (Fig. 1O, P). Additional specimens examined (paratypes):— CHINA. Yunnan: Kunming City, Luquan County, Zehei Township, Guicheng Village, elev. ca. 1550 m, 6 May 1964, W.- M. Chu et al. 1527 (PYU); Wumeng Township, elev. ca. 2150 m, 7 May 1964, W.- M. Chu, et al. 1649 (PYU); Wumeng Mountain, elev. ca. 1900 m, 15 October 1964, W.- M. Chu & J.-L. Wu 2411 (PYU); Wumeng Mountain, elev. ca. 2300 m, 15 October 1964, W.- M. Chu & J.-L. Wu 2436 (PYU); Lezuoni Village, elev. ca. 1900 m, November 1964, W.- M. Chu & J.-L. Wu 3051 (PYU); Zhaotong City, Qiaojia County, Chongxi Township, Mahong Village, elev. ca. 1500 m, 16 October 1991, W.- M. Chu & H.-Z. Yan 24404 (PYU); Qiaojiaying Township, Hetao Village, elev. ca. 2200 m, 5 August 2002, W.- M. Chu & Z.-R. He 29610 (PYU); Xiaohe Town, Yaoshan, Jionglonggou, elev. ca. 1650 m, 16 August 2002, Z.- R. He & X.-L. Liu 29625 (PYU); Sichuan: Ya’an City, Lushan County, elev. ca. 2000 m, 15 November 1963, S-H. Kung 3502 (PYU); elev. ca. 1900 m, 15 November 1963, S-H. Kung 3503 (PYU); elev. ca. 1800 m, 15 November 1963, S-H. Kung 3521 (PYU); elev. ca. 1780 m, 18 November 1963, S .- H. Kung 3522 (PYU); elev. ca. 1750 m, 18 November 1963, S .- H. Kung 3524 (PYU); Luding County, Xinglong Town, Shima Village, Zhaizigou, elev. ca. 1700 m, 8 September 1981, S .- H. Kung 6282 (PYU); Shimian County, Anshun Town, Xiaoshui Village, elev. ca. 1300 m, 11 November 1991, L .- B. Zhang & X.- S. Guo 2609 (CDBI); Shimian County, elev. ca. 1200 m, 20 November 1991, L .- B. Zhang & X.- S. Guo 2697 (CDBI). Habitat and geographical distribution: — This species is distributed from Central Yunnan to West Sichuan in China. It was observed to grow on ground and ditch wall in Yunnan pine forest or conifer-broadleaf forest at elevations between 1200–2300 m. Etymology: —The specific epithet subchaetoloma derives from the Latin prefix sub-, somewhat, and chaetoloma, referring to the similarities between the new species and Selaginella chaetoloma. Vernacular name: —áfṅǐ&lstrok; (jin mao bian juan bai).

Fang, Shao-Li, Li, Yu-Xin, Zhang, Li-Bing, He, Zhao-Rong, Zhou, Xin-Mao (2023): Selaginella subchaetoloma (Sect. Heterostachys; Selaginellaceae), a new species from Southwest China. Phytotaxa 603 (3): 224-234, DOI: 10.11646/phytotaxa.603.3.2, URL: http://dx.doi.org/10.1094/PDIS-04-22-0755-PDN

Ji-Lang Zeng,1– 3,&ast; Yi-Fei Xiang,1– 3,&ast; Li-Wei Zhang,1– 3,&ast; Li-Chuan Chen,1– 3 Jun-Han Chen,1– 3 Wen-Jia Liang,1– 3 Zhebin You,2– 4 Chang-Xi Wang,1– 3 Zhi-Jie Lin,1– 3 Kai-Yang Lin,1– 3 Yansong Guo1– 3 1Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, People’s Republic of China; 2Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, People’s Republic of China; 3Fujian Heart Failure Center Alliance, Fuzhou, People’s Republic of China; 4Fujian Key Laboratory of Geriatrics, Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yansong Guo; Kai-Yang Lin, Fujian Provincial Hospital, Dongjie Street 134, Fuzhou, Fujian, 350001, People’s Republic of China, Tel +86-13559355708, Fax +86-591-87557768, Email ysguo1234@126.com; lky7411@sina.comPurpose: Prior research has demonstrated a key role of systemic inflammatory state in the pathogenesis and progression of contrast-associated acute kidney injury (CA-AKI). Recently, the systemic inflammation score (SIS) has been introduced to evaluate the inflammatory status, utilizing the lymphocyte-to-monocyte ratio (LMR) and albumin. The primary objective of this study was to determine whether the SIS can predict CA-AKI and long-term prognosis in patients undergoing elective percutaneous coronary intervention (PCI).Patients and Methods: A total of 5726 patients who underwent elective PCI were included from January 2012 to December 2018. The primary outcome was CA-AKI, defined as an increase in serum creatinine (SCr) ≥ 0.3 mg/dl or ≥ 50% than baseline SCr within 48 h after the PCI procedure. The secondary outcome was long-term mortality. All patients were classified into low- and high-SIS groups.Results: During hospitalization, 349 (6.1%) patients developed CA-AKI. Multivariate logistic regression analysis showed that patients in the high SIS group had a 1.47-fold higher risk of developing CA-AKI than those in the low SIS group [odds ratio (OR): 1.50, 95% confidence interval (CI): 1.12– 2.01, P =0.006]. Furthermore, the SIS showed the greatest prediction performance for CA-AKI compared with other inflammatory hematological ratios. In the multivariate Cox regression analysis, the high SIS group was found to be closely associated with long-term mortality [hazard ratio (HR): 1.58, 95% CI: 1.26– 1.97, P < 0.001, vs low SIS group]. The Kaplan-Meier curve analysis also demonstrated a difference in long-term mortality between the two groups (Log rank test, P < 0.001).Conclusion: The SIS was closely associated with CA-AKI and long-term mortality in patients after elective PCI. Thus, more attention should be paid to exploring the potential benefits of anti-inflammatory strategies in preventing CA-AKI and improving the prognosis of patients undergoing PCI.Keywords: contrast-associated acute kidney injury, mortality, percutaneous coronary intervention, systemic inflammation score

3D object detection from LiDAR point cloud is of critical importance for autonomous driving and robotics. While sequential point cloud has the potential to enhance 3D perception through temporal information, utilizing these temporal features effectively and efficiently remains a challenging problem. Based on the observation that the foreground information is sparsely distributed in LiDAR scenes, we believe sufficient knowledge can be provided by sparse format rather than dense maps. To this end, we propose to learn Significance-gUided Information for 3D Temporal detection (SUIT), which simplifies temporal information as sparse features for information fusion across frames. Specifically, we first introduce a significant sampling mechanism that extracts information-rich yet sparse features based on predicted object centroids. On top of that, we present an explicit geometric transformation learning technique, which learns the object-centric transformations among sparse features across frames. We evaluate our method on large-scale nuScenes and Waymo dataset, where our SUIT not only significantly reduces the memory and computation cost of temporal fusion, but also performs well over the state-of-the-art baselines., Accepted to IROS 2023

Baohu Zhang,1,&ast; Jie Zhou,1,&ast; Guancong Xie,2,&ast; Li Zhang,1 Yang Zhang,1 Kangli Xu,1 Tianyuan Feng,1 Shucai Yang1 1Department of Clinical Laboratory, Pingshan General Hospital, Southern Medical University (Pingshan District People’s Hospital of Shenzhen), Shenzhen, Guangdong, People’s Republic of China; 2Department of Cardiovascular Medicine, Pingshan General Hospital, Southern Medical University (Pingshan District People’s Hospital of Shenzhen), Shenzhen, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shucai Yang; Tianyuan Feng, Email shucaiyang@link.cuhk.edu.hk; psyyfty@sina.comAbstract: S. mitis/oralis has been previously reported in isolated cases of bacterial endocarditis and liver abscesses. Its presence in urine is generally considered a contaminant. A 66-year-old male patient was admitted to the hospital due to recurrent chest tightness and four-year history of exertional dyspnea. On the second day of admission, the patient presented with urgent and frequent urination, as well as dysuria. Both initial and subsequent urine cultures showed S. mitis/oralis infection, with polymorphonuclear leukocyte phagocytosis observed in the second sample. MALDI-TOF results confirmed the isolated strain as S. mitis/oralis. Drug susceptibility testing revealed multidrug resistance to penicillin, ceftriaxone, cefepime, levofloxacin, ofloxacin, and tetracycline, but sensitivity to quinupristin/dalfopristin, vancomycin, and linezolid. The clinician then prescribed vancomycin for anti-infective treatment, which proved effective. Keywords: S. mitis/oralis, UTI, MDR, phagocytosisKeywords: Streptococcus mitis/oralis, UKI, multidrug resistant, phagocytosis

Xiao-Ru Liang,1,&ast; Yan-Fei Liu,1,&ast; Feng Chen,2 Zhi-Xia Zhou,3 Li-Jie Zhang,1 Zhi-Juan Lin1 1Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Weifang Medical University, Weifang, People’s Republic of China; 2Department of General Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong, People’s Republic of China; 3Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhi-Juan Lin; Li-Jie Zhang, Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Weifang Medical University, Weifang, People’s Republic of China, Tel +86-536-8462530, Email eva1949@163.com; zhanglj@wfmc.edu.cnAbstract: Long non-coding RNAs (lncRNAs) are non-coding RNAs (ncRNAs) longer than 200nt. They have complex biological functions and take part in multiple fundamental biological processes, such as cell proliferation, differentiation, survival and apoptosis. Recent studies suggest that lncRNAs modulate critical regulatory proteins involved in cancer cell cycle, such as cyclin, cell cycle protein-dependent kinases (CDK) and cell cycle protein-dependent kinase inhibitors (CKI) through different mechanisms. To clarify the role of lncRNAs in the regulation of cell cycle will provide new ideas for design of antitumor therapies which intervene with the cell cycle progression. In this paper, we review the recent studies about the controlling of lncRNAs on cell cycle related proteins such as cyclin, CDK and CKI in different cancers. We further outline the different mechanisms involved in this regulation and describe the emerging role of cell cycle-related lncRNAs in cancer diagnosis and therapy.Keywords: cyclin, cyclin-CDK, CDK inhibitors, lncRNA