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Additional file 1. Figure S1. Synthesis process of hollow MnO2. Figure S2. UV–vis-NIR spectra of MnO2-Ce6-HA and MnO2-MTZ-HA. Figure S3. Physiological stability evaluation: Digital images of H-MnO2 and MnO2-C/M-HA dispersed in H2O, PBS and DMEM solution for 24 h. Figure S4. TEM image of H-MnO2 at pH 7.4 and pH 5.5. Figure S5. Fluorescence microscopic images of 4T1 cells incubated with Free Ce6 or MnO2-Ce6-HA at different time points. Scale bar: 50 μm. Figure S6. Cell viability of 4T1 with different concentrations of MTZ with or without 660 nm (1.0 W·cm-2, 15 min) for 24 h. Figure S7. Cell viability of 4T1 with different concentrations of MnO2-HA for 24 h. Figure S8. Cell viability of 4T1 with different concentrations of MnO2-C/M-HA with or without 660 nm (1.0 W·cm-2, 15 min) for 24 h. Figure S9. The cytotoxicity of 4T1 cells of varying formulations with or without 660 nm (1.0 W·cm-2, 15 min) for 24 h in hypoxia. Figure S10. Fluorescence microscope images of ROS generation by DCFH-DA staining in cells in hypoxia. Scale bar: 100 μm. Figure S11. Intracellular ATP level after various treatments. Figure S12. Schematic diagram of co-culture by non-contact communication cell chip. Figure S13. Local structure of non-contact communication cell chip. Figure S15. Immunofluorescence of CD11c in 3D-cell cultures of BMDCs. Scale bar: 50 μm. Figure S15. Immunofluorescence of CD80/CD86 in 3D-cell cultures of BMDCs. Scale bar: 50 μm. Figure S16. Ex vivo fluorescence images (12 h post-injection) of 4T1 tumor-bearing mice organs or tissue treated with free Ce6 and MnO2-C/M-HA. Figure S17. H&E staining of heart, liver, spleen, lung, and kidney at the end of antitumor study. Scale bar: 100 μm. Figure S18. Hemolysis rate by incubating RBCs with MnO2-HA and MnO2-C/M-HA at different concentrations (25-100 µg/mL) for 4 h. Figure S19. Blood biochemical indices of healthy mice at day 1, 4 and 7 after intravenous injection of MnO2-C/M-HA. Figure S20. The whole tumor staining of TUNEL. Scale bar: 1000 μm. Figure S21. Immunohistochemical assay of CRT and HMGB1 in the tumor tissues after various treatments. Scale bar: 200 µm. Figure S22. Representative flow cytometry plots showing mature DCs (CD11c+CD80+CD86+) after various treatments. Figure S23. Representative flow cytometry plots showing cytotoxic T lymphocytes (CD3+CD8+) after various treatments. Table S1. Antibodies were used for WB, FC or IF/IHC in this study.

The experimental course is an indispensable teaching link in the teaching activities of colleges and universities, which is conducive to cultivating students' practical innovation ability. With the rapid development of market economy, the teaching mode of colleges and universities is facing more opportunities and challenges. It also needs to take experimental courses more seriously. From the perspective of craftsman spirit, this paper discusses the importance of craftsman spirit to students' development and the development status of craftsman spirit in the current experimental courses, as well as how to integrate the craftsman spirit into the ideological and political teaching of experimental courses, so as to provide some help for improving the quality of experimental courses.

Constrained layer damping treatment is widely used to suppress the vibration and noise of thin-walled structures. However, full coverage of constrained damping layer will increase unnecessary additional mass, resulting in material waste and cannot effectively improve the damping performance of the composite structure. In this article, a topology optimization approach is proposed to realize the optimal distribution of constrained damping layer. The design objective is to maximize modal loss factors solved by the modal strain energy method under the constraint of volume. Taking the relative density of the finite element of the constrained damping layer as design variable, the solid isotropic material with penalization method is used to realize the optimal topological distribution of the damping material on the surface of the metal substrate. Then the moving asymptote method is adopted as an optimizer to search the optimal layout of the constrained damping layer. Based on a modified modal superposition method, the sensitivities of the objective function with respect to the design variables are obtained. Numerical examples and experiments are presented for illustrating the validity and efficiency of this approach. The results show that the objective function converges to the optimal value smoothly, and the optimized modal loss factors have been significantly improved. The layouts of the constrained damping layer after optimization are clear and reasonable, and its distributions are affected by both the damping layer and the constraining layer. Each part of the constrained damping layer after optimizing can greatly improve the damping performance of the structure.

To effectively minimize the launch mass and physical size constrained by the launch vehicles, the space experiment facilities are compactly designed using thin frame and shell structures to house high-precision and delicate instruments and experiment apparatuses, which are typical shock sensitive. When the construction of these facilities is completed, they need to be transported to the launch site to be integrated into the launch vehicles. Due to uneven and sometime rough road terrains, poor shock suspension system of the transportation vehicles, and high travel speed, the vibration excited between the road surfaces and vehicle wheels will be directly transmitted to the scientific experiment facilities via the vehicle bodies, which may potentially damage the delicate instruments or deviate the calibrations. Therefore, a vibration isolation system is needed to prevent the experiment facilities from being affected by the vibrations and shocks during the transportation. This paper will present the design of an effective vibration/shock isolation system for such applications. A six degree-of-freedom dynamic model of the vibration isolation system is established using ADAMS, and the vibration isolation efficiency and shock responses in Cartesian space are calculated. The simulation results show that the vibration isolation system is effective to attenuate high frequency vibrations and shocks in all three axes of the Cartesian space.

Force sensing including collision position, force direction and force size makes robots smoothly interact with environment to strongly adapt to outside world. Skin sensing imitates principle of human skin using special material and physical structure with disadvantages of complex design, low sampling rate, and poor generality and so on. In this paper, the method of using fore/torque sensor to calculate collision position, force direction and force size is provided. We detail elaborate algorithm based on physical principle, and unified modeling method for basic geometric surface. Considering algorithm solvability and uniqueness, three constraints are proposed, which are joint constraint, contour constraint and force direction constraint. In order to solve conflict solution of algorithm in redundant constraints, we propose compatibility and method. In addition, gravity compensation and dynamic compensation are also described for working manipulator in gravity and dynamic environment. As a result of our simulation experiment, we would find that this method is effective for manipulator to measure collision position.

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