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В статье описывается случай проведения перитонеального диализа проточной методикой у недоношенного ребенка с очень низкой массой тела. Описывается течение заболевания у ребенка до развития острого почечного повреждения, используемое техническое оснащение и расходные материалы. Также представлено документальное оформление при проведении перитонеального диализа. Несмотря на неблагоприятный исход заболевания, обусловленный тяжелым внутрижелудочковым кровоизлиянием, перитонеальный диализ признан успешным. У ребенка купирована гиперкалиемия и достигнут отрицательный жидкостный баланс. Требуется проведение широкого ряда исследований для изучения различных аспектов применения перитонеального диализа у недоношенных детей., The article describes a case of continuous flow peritoneal dialysis in a premature baby with a very low body weight. It describes the course of the disease in a newborn before the acute renal damage onset, the technical equipment and consumables. Documentation of peritoneal dialysis is also presented. Despite the unfavorable outcome of the disease due to severe intraventricular hemorrhage, peritoneal dialysis was evaluated as successful. The child has stopped hyperkalemia and achieved a negative fluid balance. A wide range of studies are required to investigate various aspects of the use of peritoneal dialysis in premature infants.

A system for sorbent‐assisted peritoneal dialysis (SAPD) has been developed that continuously recirculates dialysate via a tidal mode using a single‐lumen peritoneal catheter with the regeneration of spent dialysate by means of sorbents. SAPD treatment may improve plasma clearance by the maintenance of a high plasma‐to‐dialysate concentration gradient and by increasing the mass transfer area coefficient (MTAC) of solutes. The system is designed for daily 8‐hr treatment (12 kg, nighttime system). A wearable system (2.3 kg, daytime system) may further enhance the clearance of phosphate and organic waste solutes during the day. Uremic pigs (n = 3) were treated with the day‐ (n = 3) and nighttime system (n = 15) for 4–8 hr per treatment. Plasma clearance (Cl), MTAC, and total mass transport (MT) of urea, creatinine, phosphate, and potassium were compared with a static dwell (n = 28). Cl, MTAC, and MT of urea, creatinine, phosphate, and potassium were low in the pig as compared to humans due to the pig's low peritoneal transport status and could be enhanced only to a limited extent by SAPD treatment compared with a static dwell (nighttime system: Cl urea: ×1.5 (p = .029), Cl creatinine: ×1.7 (p = .054), Cl phosphate: ×1.5 (p = .158), Cl potassium: ×1.6 (p = .011); daytime system: Cl creatinine: ×2.7 (p = .040), Cl phosphate: ×2.2 (p = .039)). Sorbent‐assisted peritoneal dialysis treatment in a uremic pig model is safe and enhances small solute clearance as compared to a static dwell. Future studies in humans or animal species with higher peritoneal transport should elucidate whether our SAPD system enhances clearance to a clinically relevant extent as compared to conventional PD., A system for sorbent‐assisted peritoneal dialysis (SAPD) has been developed that continuously recirculates dialysate via a tidal mode using a single lumen peritoneal catheter with regeneration of spent dialysate by means of sorbents. SAPD treatment may improve plasma clearance by maintenance of a high plasma‐to‐dialysate concentration gradient and by increasing the mass transfer area coefficient (MTAC) of solutes. The system is designed for daily 8‐hr treatment (12 kg, nighttime system). A wearable system (2.3 kg, daytime system) may further enhance clearance of phosphate and organic waste solutes during the day.

В статье представлена сравнительная характеристика методов заместительной почечной терапии, применяемых у новорожденных различного гестационного возраста и массы тела, обсуждается клинический случай применения проточной модификации перитонеального диализа у новорожденного с массой тела при рождении 660 г и острым почечным повреждением., The article presented the comparative characteristics of methods of kidney replacement therapy in newborns. We present the clinical case of continuous flow peritoneal dialysis in a newborn with extremely low birth weight (660 g birth weight) with acute renal injury.