1. Six New Phragmalin Limonoids from the Stems of Chukrasia tabularis A. Juss
- Author
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Shou-Bai Liu, Wen-Li Mei, Hao Wang, You-Xing Zhao, Fan-Dong Kong, Yan-Cui Wang, and Hao-Fu Dai
- Subjects
Limonins ,Stereochemistry ,α-glucosidase inhibition activity ,Pharmaceutical Science ,010402 general chemistry ,01 natural sciences ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,lcsh:Organic chemistry ,Phragmalin ,Drug Discovery ,Meliaceae ,Physical and Theoretical Chemistry ,Nuclear Magnetic Resonance, Biomolecular ,acetylcholinesterase inhibitory activity ,Molecular Structure ,Plant Stems ,biology ,Plant Extracts ,010405 organic chemistry ,Chemistry ,Chukrasia tabularis A. Juss ,Organic Chemistry ,Chukrasia tabularis ,biology.organism_classification ,0104 chemical sciences ,Chemistry (miscellaneous) ,phragmalin limonoid ,Molecular Medicine ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
Six new phragmalin limonoids, named moluccensin Z1 (1), moluccensin Z2 (2), carapanolide Y (3), tabulalin N (4), chukvelutilide A1 (5), and velutinasin J (6), as well as two known compounds, chukvelutilide A (7) and velutinasin D (8) were isolated from the stems of Chukrasia tabularis A. Juss. The structures of the new compounds 1&ndash, 6 were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for &alpha, glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against &alpha, glucosidase and acetylcholinesterase in vitro.
- Published
- 2018
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