1. Curcumin supplementation, exercise, Nrf2/NFkB activity
- Author
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Clifford, Tom and Thorley, Josh
- Subjects
physiology ,Life Sciences ,exercise science ,redox biology - Abstract
Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kB) are two important transcription factors which regulate cellular responses towards oxidative and inflammatory stress, respectively. Interventions such as exercise and curcumin supplementation have been reported to modulate Nrf2 and NF-kB activity in order to gain a more favourable balance between redox and inflammatory processes, in turn enhancing cellular adaptation and defence. Indeed, previous animal knockout studies have suggested that there is functional cross-talk between Nrf2 and KF-kB, whereby activation of Nrf2 may lead to inhibition of NF-kB activity, consequently blunting the associated inflammatory processes and reducing cellular damage. Previous research has suggested that combining such interventions may further augment Nrf2 activity, thereby attenuating NF-kB activity, although such findings in humans are limited. In addition, emerging evidence suggests that females may have greater circulating antioxidant enzymes compared to males, possibly due enhanced affinity for Nrf2 activation. It is not yet clear however whether Nrf2 activity is gender specific. The aim of this study will address these gaps in knowledge by examining the influence of eccentric exercise and curcumin supplementation on Nrf2 and NF-kB activity in males and females.
- Published
- 2023
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