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3 results on '"van Gerven, Nicole M. F."'

1. Additional file 1 of Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial

Author

Snijders, Romée J. A. L. M., Stoelinga, Anna E. C., Gevers, Tom J. G., Pape, Simon, Biewenga, Maaike, Verdonk, Robert C., de Jonge, Hendrik J. M., Vrolijk, Jan Maarten, Bakker, Sjoerd F., Vanwolleghem, Thomas, de Boer, Ynto S., Pronk, Martine A. M. C. Baven, Beuers, Ulrich H. W., van der Meer, Adriaan J., van Gerven, Nicole M. F., Sijtsma, Marijn G. M., Verwer, Bart J., Gisbertz, Ingrid A. M., Bartelink, Maartje, van den Brand, Floris F., Sebib Korkmaz, Kerem, van den Berg, Aad P., Guichelaar, Maureen M. J., Soufidi, Khalida, Levens, Amar D., van Hoek, Bart, and Drenth, Joost P. H.

Abstract

Additional file 1. Spirit checklist.

Published
2023
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3. Seroprevalence of Hepatitis E Virus in Autoimmune Hepatitis Patients in the Netherlands

Author

van Gerven, Nicole M. F., van der Eijk, Annemiek A., Pas, Suzan D., Zaaijer, Hans L., de Boer, Ynto S., Witte, Birgit I., van Nieuwkerk, Carin M. J., Mulder, Chris J. J., Bouma, Gerd, de Man, Robert A., AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Gastroenterology and Hepatology

Subjects
immune system diseases, viruses, virus diseases, digestive system diseases
Abstract

In recent years chronic courses of hepatitis E virus (HEV) infection have been described in immunosuppressed individuals. This may implicate a potential role for HEV in the development of autoimmune diseases, including autoimmune hepatitis (AIH). Here we investigated the prevalence of HEV-antibodies in AIH patients in an endemic Central European country. HEV-specific immunoglobulin G (IgG) and HEV RNA were determined in 354 and 377 AIH patients, respectively. Clinical characteristics and disease outcome parameters were retrospectively collected. No HEV viraemic patients were identified in this cohort. A total of 106 AIH patients (29.9%) tested positive for anti-HEV IgG, and this figure was slightly higher compared to the prevalence in a reference cohort including 5,329 healthy Dutch blood donors (26.7%; P>0.05). This is the largest study on the association between HEV infection and AIH. Apparently silent HEV infection is present in a significant proportion of AIH patients, yet appears not to have significant clinical repercussions in this immune compromised group of patients. Nevertheless, since acute hepatitis E may present with histological and biochemical features of AIH, the possibility of a (concomitant) HEV infection should be considered in this category of patients

Published
2016

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