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Scope and Method of Study: This cross-sectional study investigated the extent and severity of protein energy malnutrition and deficiencies of vitamin A, iron, iodine and zinc nutrition in 10 - 15 year old school girls from Tigray, Northern Ethiopia using anthropometric, biochemical and clinical indicators. A structured questionnaire was used to collect sociodemographic information. Serum retinol was analyzed by High Pressure Liquid Chromatography (HPLC); Urinary iodine (UI) concentrations were determined by chemical and spectroscopic methods; ferritin was analyzed by immunoradiometric assay (IRMA); serum zinc was analyzed using an inductively coupled plasma mass spectrometer (ICPMS); soluble transferrin receptors (sTfR) and C- Reactive Protein (hsCRP) were determined using enzyme linked immunosorbent assays (ELISA).