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This study is generally concerned with the assumption that the contemporary global flows of people, capital, and commodities, which accelerated dramatically in the age of globalization, have significant impacts on the land use patterns of global cities. With this assumption, the study further questions in the context of polycentric US metropolis, whether or not the distribution of transnational advanced producer service firms define a new form of centrality, in which the traditional central business districts and suburban centers differ from each other in terms of spatial clustering patterns and sectoral distributions of transnational advanced producer service firms. Spatial clustering patterns of advanced producer service firms are evaluated according to high-rise and high-density criteria. In ten selected cities, clusters of advanced producer service firms and high-rise office buildings are identified through the Nearest Neighbor Hierarchical Clustering Method in CrimeStat. To define the polycentric US metropolis, the research employs Lang et al's (2006) classification of metropolitan office space. The results show significant differences between former manufacturing belt cities and Sunbelt cities.