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Chemotherapy drugs such as a DOX is a common method for cancer treatment. However, severe side effects can limit the administration of these drugs. To ameliorate detrimental side-effects of chemotherapeutic agents, one approach is to implement a capturing device to intake residues of chemotherapy before spreading to the blood circulation. Here we introduced a packed mesh of Silk Fibroin and Nanocellulose microbeads that can effectively bind to the DOX through negatively charged carboxylic group of ENCC and positively charged nitrogen in DOX. Step emulsification microfluidic device with the scale-up capability used to fabricate homogenous microbeads that were placed into a porous mesh. The represented device can capture 800 g of DOX with 200g of microbeads only after two pass flow. In addition, the in vitro experiment demonstrates the effect of the SF and ENCC microbeads on NIH-3T3 fibroblast cell on reducing toxicity of DOX.