51 results on '"Blobel, Gerd A."'
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2. let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching
3. Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
4. Molecular basis of polycomb group protein–mediated fetal hemoglobin repression
5. Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression
6. Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression
7. Robust erythroid differentiation system for rhesus hematopoietic progenitor cells allowing preclinical screening of genetic treatment strategies for the hemoglobinopathies
8. A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages
9. Erythropoiesis provides a BRD's eye view of BET protein function
10. Functions of BET proteins in erythroid gene expression
11. Analysis of disease-causing GATA1 mutations in murine gene complementation systems
12. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment
13. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
14. Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing
15. Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)
16. Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation
17. Let-7 Inhibits HIC2 to Control BCL11A Transcription and Hemoglobin Switching
18. Global regulation of erythroid gene expression by transcription factor GATA-1
19. Short Hairpin RNA Screen Reveals Bromodomain Proteins as Novel Targets in Acute Myeloid Leukemia
20. Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers
21. A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells
22. GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression
23. Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation
24. GATA-1 caught in the AKT
25. Charting a noncoding gene for γ-globin activation
26. Comparison of Fetal and Adult Erythroid Chromosomal Architectures Identifies a Novel Fetal Hemoglobin Regulatory Region
27. Domain-Focused CRISPR-Cas9 Screen Identifies Hri Kinase As a Regulator of Fetal Hemoglobin in Adult Human Erythroid Cells
28. Deep Mining of Natural Genetic Variation in Erythroid Cells Reveals New Insights about In Vivo Transcription Factor Binding and Chromatin Accessibility
29. A Dynamic Intron Retention Program in the Mammalian Megakaryocyte and Erythrocyte Lineages
30. A Novel Regulatory Region of the p27 Locus Is Required for Normal Erythroid p27 Expression, and Produces a Long Noncoding RNA with No Detectable Function
31. Genome Editing Recreates Hereditary Persistence of Fetal Hemoglobin in Primary Human Erythroblasts
32. A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit
33. Epigenetics of Cellular Memory: Insights from the Chromatin Accessibility Landscape of the Mitotic Genome
34. Hematopoietic Transcriptional Regulation At The Mitosis-G1 Transition
35. Controlling Long-Range Genomic Interactions to Reprogram the β-Globin Locus
36. GATA1 and the BET Family Protein Brd3 Form a Mitotic Bookmarking Complex
37. Linking Transcription Factor Pathways to Disease-Causing GATA1 Mutations
38. Lineage-Specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1
39. Low frequency of MLL3 mutations in colorectal carcinoma
40. Graded Repression of PU.1 Expression by GATA Factors Influence Hematopoietic Progenitor Cell Fate
41. SCL and Associated Proteins Distinguish Active from Repressive GATA Transcription Factor Complexes.
42. The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression.
43. GATA-1 Represses PU.1/Sfpi-1 Gene Transcription in Erythro-Megakaryocytic Progenitors.
44. The GATA-1/FOG-1/NuRD Axis Is Essential for Normal Hematopoiesis.
45. Segregating regulatory steps in β-globin locus activation
46. Cyclin D/CDK4/6 kinase activity, regulated by GATA1, is required for megakaryocyte polyploidization
47. Maturation Stage-Specific Regulation of Megakaryocytic Genes by Pointed-Domain Ets Proteins.
48. Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin.
49. Genetic Modeling of Chemical Antagonists: Genome Scale Validation of Hematopoietic Disease Drug Targets by In Vivo Functional Analysis.
50. Identification of Cyclin D3 as a Direct Transcriptional Target of E2A Using Damid.
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