105 results on '"Chibale, Kelly"'
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2. Thwarting protein synthesis leads to malaria parasite paralysis
3. The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
4. MalDA, Accelerating Malaria Drug Discovery
5. Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes
6. Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
7. Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents
8. The quest for the holy grail: new antitubercular chemical entities, targets and strategies
9. A preformulation co-crystal screening case study: Polymorphic co-crystals of an imidazopyridazine antimalarial drug lead with the coformer succinic acid
10. Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery
11. Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties
12. Cocrystal and Salt Forms of an Imidazopyridazine Antimalarial Drug Lead
13. Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles
14. Pyrimidine-chloroquinoline hybrids: Synthesis and antiplasmodial activity
15. Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis
16. Synthesis and biological evaluation of 4 arylcoumarin analogues as tubulin-targeting antitumor agents
17. Preparation and Physicochemical Characterization of an Inclusion Complex Between Dimethylated β-Cyclodextrin and a Drug Lead From a New Class of Orally Active Antimalarial 3,5-Diaryl-2-Aminopyridines
18. Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization
19. Antimalarial benzoheterocyclic 4-aminoquinolines: Structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies
20. Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity
21. Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids
22. Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities
23. Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity
24. Synthesis and structure–activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2
25. Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery
26. Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor
27. Tetrazole-based deoxyamodiaquines: Synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents
28. Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies
29. Synthesis, characterization and antiplasmodial evaluation of cyclopalladated thiosemicarbazone complexes
30. Structure–activity relationships for ferriprotoporphyrin IX association and β-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods
31. Heteroleptic Rh(III) phenylpyridyl complexes based on an aminoquinoline-benzimidazole hybrid scaffold: Antiplasmodial evaluation and mechanistic insights
32. Keystone Malaria Symposium 2022: a vibrant discussion of progress made and challenges ahead from drug discovery to treatment
33. The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
34. Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
35. 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
36. A new approach for anthelmintic discovery for humans
37. Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents
38. Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity
39. Linear free energy relationships predict coordination and π-stacking interactions of small molecules with ferriprotoporphyrin IX
40. Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores
41. Synthesis and in vitro evaluation of palladium(II) salicylaldiminato thiosemicarbazone complexes against Trichomonas vaginalis
42. Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands
43. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity
44. Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity
45. Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
46. Synthetic medicinal chemistry of selected antimalarial natural products
47. Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery
48. Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum
49. Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum
50. Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ- and δ-lactams via a ‘catch and release’ protocol
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