98 results on '"Denu, John M."'
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2. Catalysis by protein acetyltransferase Gcn5
3. Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity
4. A practical guide for analysis of histone post-translational modifications by mass spectrometry: Best practices and pitfalls
5. Metabolism and the Epigenome: A Dynamic Relationship
6. Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators
7. Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence
8. Mechanism of activation for the sirtuin 6 protein deacylase
9. Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells
10. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions
11. General method for rapid purification of native chromatin fragments
12. Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys
13. Using comparative biology to understand how aging affects mitochondrial metabolism
14. Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin
15. Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?
16. Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells
17. Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis
18. A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics
19. Mechanisms and Dynamics of Protein Acetylation in Mitochondria
20. Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies
21. SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching
22. Stoichiometry of Site-specific Lysine Acetylation in an Entire Proteome
23. Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression
24. Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1
25. NAD+ Deficiency in Age-Related Mitochondrial Dysfunction
26. Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
27. Quantification of Mitochondrial Acetylation Dynamics Highlights Prominent Sites of Metabolic Regulation
28. Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome
29. The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis
30. Sirtuin Catalysis and Regulation
31. SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status
32. Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
33. Orphan Macrodomain Protein (Human C6orf130) Is an O-Acyl-ADP-ribose Deacylase: SOLUTION STRUCTURE AND CATALYTIC PROPERTIES
34. Autoacetylation of the Histone Acetyltransferase Rtt109
35. Hydrolysis of O-Acetyl-ADP-ribose Isomers by ADP-ribosylhydrolase 3
36. Structure and Biochemical Functions of SIRT6
37. Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases
38. Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9
39. Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction
40. Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
41. SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production
42. Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
43. A continuous microplate assay for sirtuins and nicotinamide-producing enzymes
44. Hydrolase Regulates NAD+ Metabolites and Modulates Cellular Redox
45. Chemical mechanisms of histone lysine and arginine modifications
46. Ure(k)a! Sirtuins Regulate Mitochondria
47. Mechanisms and Molecular Probes of Sirtuins
48. Acetylation-dependent ADP-ribosylation by Trypanosoma brucei Sir2
49. The Sirtuin family: therapeutic targets to treat diseases of aging
50. Catalysis and substrate selection by histone/protein lysine acetyltransferases
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