92 results on '"Hubbuch, Jürgen"'
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2. Predicting multimodal chromatography of therapeutic antibodies using multiscale modeling
3. Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors
4. Antibody sequence-based prediction of pH gradient elution in multimodal chromatography
5. Modeling of biopharmaceutical UF/DF from laboratory to manufacturing scale
6. Connected mechanistic process modeling to predict a commercial biopharmaceutical downstream process
7. Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation
8. Bio-based material formulation for extrusion printing by dityrosine crosslinking of unmodified casein
9. Automated and dynamic extrusion pressure adjustment based on real-time flow rate measurements for precise ink dispensing in 3D bioprinting
10. Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps
11. Steric exclusion chromatography of lentiviral vectors using hydrophilic cellulose membranes
12. Modeling the Gibbs–Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model
13. Exploration of fiber-based cation exchange adsorbents for the removal of monoclonal antibody aggregates
14. Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model
15. Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach
16. High throughput screening of fiber-based adsorbents for material and process development
17. Image analysis as PAT-Tool for use in extrusion-based bioprinting
18. On the analysis of chromatographic biopharmaceutical data by curve resolution techniques in the framework of the area of feasible solutions
19. Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design
20. Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation
21. Time-Dependent Multi-Light-Source Image Classification Combined With Automated Multidimensional Protein Phase Diagram Construction for Protein Phase Behavior Analysis
22. Kinetic reaction modeling for antibody-drug conjugate process development
23. Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography
24. Prediction uncertainty assessment of chromatography models using Bayesian inference
25. Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment
26. Monitoring of antibody-drug conjugation reactions with UV/Vis spectroscopy
27. 3D bioprinting – Flow cytometry as analytical strategy for 3D cell structures
28. Application of Empirical Phase Diagrams for Multidimensional Data Visualization of High-Throughput Microbatch Crystallization Experiments
29. Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates
30. Packing characteristics of winged shaped polymer fiber supports for preparative chromatography
31. In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography
32. Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression
33. An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration
34. Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process
35. Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks
36. Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure–activity relationship modeling approach
37. Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
38. Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks
39. An orientation sensitive approach in biomolecule interaction quantitative structure–activity relationship modeling and its application in ion-exchange chromatography
40. Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure–activity relationship models
41. A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases
42. Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography
43. High-throughput downstream process development for cell-based products using aqueous two-phase systems
44. Concentration-dependent changes in apparent diffusion coefficients as indicator for colloidal stability of protein solutions
45. Prediction of salt effects on protein phase behavior by HIC retention and thermal stability
46. Quantification of PEGylated proteases with varying degree of conjugation in mixtures: An analytical protocol combining protein precipitation and capillary gel electrophoresis
47. Impact of polymer surface characteristics on the microrheological measurement quality of protein solutions – A tracer particle screening
48. Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography
49. High-throughput characterization of virus-like particles by interlaced size-exclusion chromatography
50. High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli
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