106 results on '"Kinase Inhibitors"'
Search Results
2. Exploring the potential of EphA2 receptor signaling pathway: a comprehensive review in cancer treatment
3. Tyrosine kinase inhibitors (TKIs) for ovarian cancer treatment: from organic to inorganic chemotherapeutics towards selectivity—a perspective overview
4. Integration of fingerprint-based similarity searching and kernel-based partial least squares analysis to predict inhibitory activity against CSK, HER2, JAK1, JAK2, and JAK3
5. Potential protein kinase inhibitors that target G-quadruplex DNA structures in the human telomeric regions
6. Novel Bipyrazole Targeting Dual CDK-2 and VEGFR-2 Kinases: Synthesis, Anticancer Evaluation, and In Silico Studies
7. Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts
8. A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov
9. An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma
10. Structure-based optimization of aminothiadiazole inhibitors of AKT
11. In vitro and in vivo evaluation of kinase and protease inhibitors against Trypanosoma evansi
12. Non-hippo kinases: indispensable roles in YAP/TAZ signaling and implications in cancer therapy
13. In Vitro and In Silico Studies of Kinase Inhibitor of MAPK3 Protein to Determine Leishmania martiniquensis Treatment
14. Hematologic side effects of biologics and kinase inhibitors used in rheumatologic diseases: a review of the current evidence
15. Novel Approaches for the Treatment of Patients with Richter’s Syndrome
16. Prioritizing the Catalytic Gatekeepers through Pan- Inhibitory Mechanism of Entrectinib against ALK, ROS1 and TRKA Tyrosine Kinases
17. Safety of direct oral anticoagulants in patients with advanced solid tumors receiving anti-VEGF agents: a retrospective study
18. Differential in vitro effects of targeted therapeutics in primary human liver cancer: importance for combined liver cancer
19. PI3K signalling at the intersection of cardio-oncology networks: cardiac safety in the era of AI
20. Artificial intelligence to guide precision anticancer therapy with multitargeted kinase inhibitors
21. Identification of kinase inhibitors that rule out the CYP27B1-mediated activation of vitamin D: an integrated machine learning and structure-based drug designing approach
22. New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome
23. Discovery of moiety preference by Shapley value in protein kinase family using random forest models
24. Kinase gene fusions: roles and therapeutic value in progressive and refractory papillary thyroid cancer
25. Development and validation of a sensitive liquid chromatography tandem mass spectrometry assay for the simultaneous determination of ten kinase inhibitors in human serum and plasma
26. Combating drug resistance in acute myeloid leukaemia by drug rotations: the effects of quizartinib and pexidartinib
27. Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ) inhibitors discovered by virtual screening using free energy models
28. Identification of Novel Small-Molecule Kinase Modulators for the Treatment of Neuroblastoma
29. Data structures for computational compound promiscuity analysis and exemplary applications to inhibitors of the human kinome
30. Vemurafenib may overcome TNF-related apoptosis-inducing ligand (TRAIL) resistance in anaplastic thyroid cancer cells
31. Phenylethanoid glycosides as a possible COVID-19 protease inhibitor: a virtual screening approach
32. Pancreatic Cancer: Recent Progress of Drugs in Clinical Trials
33. Systematic computational identification of promiscuity cliff pathways formed by inhibitors of the human kinome
34. Novel Targets and Drug Development in Portal Hypertension
35. Repurposing of Kinase Inhibitors for Treatment of COVID-19
36. Chemical space exploration based on recurrent neural networks: applications in discovering kinase inhibitors
37. Assessing the information content of structural and protein–ligand interaction representations for the classification of kinase inhibitor binding modes via machine learning and active learning
38. Inhibitors of the p21 Activated Kinases
39. Re-evaluation of protein kinase CK2 pleiotropy: new insights provided by a phosphoproteomics analysis of CK2 knockout cells
40. Integrating phosphoproteomics into the clinical management of prostate cancer
41. An in silico design of bioavailability for kinase inhibitors evaluating the mechanistic rationale in the CYP metabolism of erlotinib
42. Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins
43. Nanotechnology for the treatment of melanoma skin cancer
44. A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells
45. Neue Aspekte in der Therapie von Schilddrüsenkarzinomen: Highlights des ASCO-Kongresses 2016
46. Emerging Therapies for Rheumatoid Arthritis
47. Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma
48. Cardiovascular drugs and triazole based kinase inhibitors as a new strategies for the treatment of Alzheimer disease
49. Neue Therapiekonzepte bei der chronisch-lymphatischen Leukämie
50. Groebke–Blackburn–Bienaymé multicomponent reaction: emerging chemistry for drug discovery
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