40 results on '"van der Graaf, P H"'
Search Results
2. Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases
3. QSPRpred: a Flexible Open-Source Quantitative Structure-Property Relationship Modelling Tool
4. Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
5. Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model
6. Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling
7. Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations
8. A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis
9. A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability
10. Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1
11. Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling
12. Correction to: Mathematical Modelling of Alternative Pathway of Complement System
13. Design principles of collateral sensitivity-based dosing strategies
14. FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective
15. Model reduction in mathematical pharmacology: Integration, reduction and linking of PBPK and systems biology models
16. Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
17. How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review
18. Mathematical Modelling of Alternative Pathway of Complement System
19. Optimization of Cancer Treatment in the Frequency Domain
20. Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
21. A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
22. A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds
23. A mathematical analysis of rebound in a target-mediated drug disposition model: II. With feedback
24. Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends
25. Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae
26. Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy
27. Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling
28. Topics in Mathematical Pharmacology
29. Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid
30. Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans
31. Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling
32. A mathematical analysis of rebound in a target-mediated drug disposition model: I.Without feedback
33. Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
34. Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
35. Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans
36. A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat
37. Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
38. Allometric Scaling of Pharmacodynamic Responses: Application to 5-Ht1A Receptor Mediated Responses from Rat to Man
39. Pharmacokinetic-Pharmacodynamic Analysis of the EEG Effect of Alfentanil in Rats Followingβ-Funaltrexamine-Induced μOpioid Receptor “Knockdown”In Vivo
40. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for α1-adrenoceptor-mediated pressor activity
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