177 results on '"A. Silva Lopes"'
Search Results
2. Molecular investigation in individuals with orofacial clefts and microphthalmia-anophthalmia-coloboma spectrum
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Atique Tacla, Milena, de Mello Copelli, Matheus, Pairet, Eleonore, Monlleó, Isabella Lopes, Ribeiro, Erlane Marques, Lustosa Mendes, Elaine, Helaers, Raphaël, Vieira, Tarsis Paiva, Vikkula, Miikka, and Gil-da-Silva-Lopes, Vera Lúcia
- Abstract
This study describes genomic findings among individuals with both orofacial clefts (OC) and microphthalmia/anophthalmia/coloboma (MAC) recorded in the Brazilian Database on Craniofacial Anomalies (BDCA). Chromosomal microarray analysis (CMA) and Whole Exome Sequencing (WES) were performed in 17 individuals with OC-MAC. Clinical interpretation of molecular findings was based on data available at the BDCA and on re-examination. No copy number variants (CNVs) classified as likely pathogenic or pathogenic were detected by CMA. WES allowed a conclusive diagnosis in six individuals (35.29%), two of them with variants in the CHD7gene, and the others with variants in the TFAP2A, POMT1, PTPN11, and TP63genes with the following syndromes: CHARGE, CHD7-spectrum, Branchiooculofacial, POMT1-spectrum, LEOPARD, and ADULT. Variants of uncertain significance (VUS) possibly associated to the phenotypes were found in six other individuals. Among the individuals with VUSes, three individuals presented variants in genes associated to defects of cilia structure and/or function, including DYNC2H1, KIAA0586, WDR34, INTU, RPGRIP1L, KIF7, and LMNA. These results show that WES was the most effective molecular approach for OC-MAC in this cohort. This study also reinforces the genetic heterogeneity of OC-MAC, and the importance of genes related to ciliopathies in this phenotype.
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- 2024
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3. Analysis of fractal dimension of lymphocytes exposed to different doses of ionizing radiation through box counting method
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de Oliveira Filho, Jonas Sérgio, de Oliveira Barbosa, Anna Beatriz, de Lima, Maria Eduarda Beatriz, de Souza, Ivone Antônia, de Salazar e Fernandes, Thiago, and da Silva Lopes, Isvânia Maria Serafim
- Abstract
Objective: The aim of this study was to develop software to estimate the fractal dimensions of lymphocyte nuclei irradiated with doses of gamma radiation in order to evaluate its usability as a morphometric biomarker of human exposures to ionizing radiation. Methods: A software based on Python language was developed to estimate the fractal dimensions of irradiated and non-irradiated lymphocyte nuclei. The method applied was the well-established box-counting. Results: Known mathematical fractals from the literature were used to validate the software, which presented the expected values of fractal dimensions for such objects. In the experimental group, irradiated with gamma radiation, it was observed changes in values of fractal dimensions, some with statistical significance (p < 0.05). However, these differences became more pronounced only for doses as high as 4 Gy. Conclusion: The developed software here proved to be a promising tool for analyzing changes in chromatin roughness of irradiated lymphocytes. This is of potential use as a morphometric biomarker of ionizing radiation, as a quick and easy method to perform especially in cases of large amounts of samples to be analyzed, such as in mass casualties..
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- 2024
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4. Stigmatization and Mental Health Impact of Chronic Pediatric Skin Disorders
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Paller, Amy S., Rangel, Stephanie M., Chamlin, Sarah L., Hajek, Aleena, Phan, Sheshanna, Hogeling, Marcia, Castelo-Soccio, Leslie, Lara-Corrales, Irene, Arkin, Lisa, Lawley, Leslie P., Funk, Tracy, Castro Porto Silva Lopes, Fabiana, Antaya, Richard J., Ramien, Michele L., Vivar, Karina L., Teng, Joyce, Coughlin, Carrie C., Rehmus, Wingfield, Gupta, Deepti, Bercovitch, Lionel, Stein, Sarah L., Boull, Christina, Tom, Wynnis L., Liang, Marilyn G., Hunt, Raegan, Luu, Minnelly, Holland, Kristen E., Schoch, Jennifer J., Cella, David, Lai, Jin-Shei, and Griffith, James W.
- Abstract
IMPORTANCE: Chronic skin disorders in children frequently are visible and can cause stigmatization. However, the extent of stigmatization from chronic skin disease and association with mental health needs further study. OBJECTIVE: To examine the extent of stigma, dependence on disease visibility and severity, and association with mental health and quality of life (QOL) in chronic pediatric skin disease. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional, single-visit study was conducted at 32 pediatric dermatology centers in the US and Canada from November 14, 2018, to November 17, 2021. Participants included patients aged 8 to 17 years with chronic skin disease and 1 parent. MAIN OUTCOMES AND MEASURES: Using the Patient-Reported Outcomes Measurement Instrumentation System (PROMIS) Stigma-Skin, the extent of stigma with child-, caregiver-, and physician-assessed disease visibility (primary outcome) and severity was compared, as well as reduced QOL (assessed by Skindex-Teen), depression, anxiety, and poor peer relationships (PROMIS child and proxy tools) (secondary outcomes). RESULTS: The study included 1671 children (57.9% female; mean [SD] age, 13.7 [2.7] years). A total of 56.4% participants had self-reported high disease visibility and 50.5% had moderate disease severity. Stigma scores significantly differed by level of physician-assessed and child/proxy-assessed disease visibility and severity. Among children with chronic skin disorders, predominantly acne, atopic dermatitis, alopecia areata, and vitiligo, only 27.0% had T scores less than 40 (minimal or no stigma) and 43.8% had at least moderate stigma (T score ≥45) compared with children with a range of chronic diseases. Stigma scores correlated strongly with reduced QOL (Spearman ρ = 0.73), depression (ρ = 0.61), anxiety (ρ = 0.54), and poor peer relationships (ρ = −0.49). Overall, 29.4% of parents were aware of bullying of their child, which was strongly associated with stigma (Cohen d = −0.79, with children who were not bullied experiencing lower levels of stigma). Girls reported more stigma than boys (Cohen d = 0.26). Children with hyperhidrosis and hidradenitis suppurativa were most likely to have increased depression and anxiety. CONCLUSIONS AND RELEVANCE: The findings of this study suggest that physician assessment of disease severity and visibility is insufficient to evaluate the disease impact in the patient/caregiver. Identifying stigmatization, including bullying, and tracking improvement through medical and psychosocial interventions may be a key role for practitioners.
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- 2024
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5. On activism and knowledge: the experience of cannabis associations in Brazil.
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Lopes da Silva Rodrigues, Ana Paula, da Silva Lopes, Ivonete, and Alves Mourão, Victor Luiz
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RIGHT to health ,ACTIVISM ,SOCIAL networks ,SCIENTIFIC knowledge ,SOCIAL & economic rights ,PATIENTS' families ,PETROLEUM distribution ,MARIJUANA growing ,SOCIAL media ,WEEDS - Abstract
The emergence of civil associations in favor of cannabis began in the 2010s. Faced with the inertia of the State, these organizations have acted in the reception, support, information, training, and facilitation of access for patients and their families to the medicine produced from marijuana, a prohibited substance in Brazil. This study aims to analyze how cannabis activism promoted by Brazilian associations is based on scientific knowledge or knowledge acquired through the experience of members. The methodology included interviews with participants from the ACuCa, Ama+me, and Apepi associations, as well as the Content Analysis of the profiles of these institutions on Instagram. It was found that cannabis activism on Instagram is similar to that practiced in person; however, activism on social media prioritizes the dissemination of knowledge through information and training of its followers, being careful to treat the content in order to suit the guidelines of the platform. In addition, the main lines of action of cannabis associations (reception and distribution of medicinal oils) appear in a veiled way in the publications, most of which occur through private conversations in the media with the associations. [ABSTRACT FROM AUTHOR]
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- 2024
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6. A última catástrofe planetária? História ambiental e história do tempo presente, uma aproximação necessária.
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Malta Pereira, Elenita and Silva Lopes, Alfredo Ricardo
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Copyright of Tempo (1413-7704) is the property of Universidade Federal Fluminense, Departamento de Historia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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7. Forest road density in flat and sloping site conditions in Brazil
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Faria, Felipe Nascimento de, da Silva Lopes, Eduardo, Sampietro, Jean Alberto, and Correia, Reinaldo José
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ABSTRACTForest road densities which are too high increase production costs, planting area loss, and environmental impacts. To solve this problem and plan an adequate forest road density, it is necessary to analyze and consider the topography, road network-related costs, and the type and number of machines to meet the required wood production. The aim of this study was to determine the current road density (RD), the optimal economic road density (ORD) and operational road density (OD) in flat and sloping site conditions for the full tree harvesting system in Southern Brazil. The RD was determined by the ratio of total road lengthand the total productive area. ORD was determined based on the transport geometry model, considering the minimization of the sum of unit costs of road construction and maintenance, loss of productive area, mitigation of road impacts, and wood extraction. The OD was determined considering the minimum number of extraction machines necessary to meet the annual demand for wood. All forest road densities were lower in flat site conditions than in sloping areas. In both conditions (flat and sloping), RDs (126 and 180 m ha−1, respectively) were higher than ORDs (53 and 65 m ha−1, respectively), which were lower than ODs (92 and 123 m ha−1, respectively). Therefore, OD can be an alternative parameter for managers to use in forest road network planning, mainly in conditions where ORD is not feasible to adopt.
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- 2024
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8. Four putative pathogenic ARHGAP29variants in patients with non-syndromic orofacial clefts (NsOFC)
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Ranji, Peyman, Pairet, Eleonore, Helaers, Raphael, Bayet, Bénédicte, Gerdom, Alexander, Gil-da-Silva-Lopes, Vera Lúcia, Revencu, Nicole, and Vikkula, Miikka
- Abstract
The pathophysiological basis of non-syndromic orofacial cleft (NsOFC) is still largely unclear. However, exome sequencing (ES) has led to identify several causative genes, often with reduced penetrance. Among these, the Rho GTPase activating protein 29 (ARHGAP29) has been previously implicated in 7 families with NsOFC. We investigated a cohort of 224 NsOFCs for which no genetic pathogenic variant had been identified by diagnostic testing. We used ES and bioinformatic variant filtering and identified four novel putative pathogenic variants in ARHGAP29in four families. One was a missense variant leading to the substitution of the first methionine with threonine, two were heterozygous frameshift variants leading to a premature termination codon, and one was a nonsense variant. All variants were predicted to result in loss of function, either through mRNA decay, truncated ARHGAP29, or abnormal N-terminal initiation of translation of ARHGAP29. The truncated ARHGAP29 proteins would lack the important RhoGAP domain. The variants were either absent or rare in the control population databases, and the loss of intolerance score (pLI) of ARHGAP29 is 1.0, suggesting that ARHGAP29 haploinsufficiency is not tolerated. Phenotypes ranged from microform cleft lip (CL) to complete bilateral cleft lip and palate (CLP), with one unaffected mutation carrier. These results extend the mutational spectrum of ARHGAP29and show that it is an important gene underlying variable NsOFC phenotypes. ARHGAP29should be included in diagnostic genetic testing for NsOFC, especially familial cases, as it may be mutated in ∼4% of them (4/97 in our cohort) with high penetrance (89%).
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- 2024
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9. Hesitação da vacina da febre amarela e sua relação com influências contextuais, individuais ou de grupo e questões específicas da vacina: uma revisão de escopo.
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da Silva Lopes, Vanessa, Cristiano de Souza, Pablo, Marvila Garcia, Érica, and Costa Lima, Jaqueline
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VACCINATION complications ,VACCINE hesitancy ,VACCINATION coverage ,YELLOW fever ,SCIENTIFIC literature ,VACCINE safety - Abstract
Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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10. A experimentação e o currículo: Concepções e teorias entrelaçadas.
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da Silva Lopes, Eduarda, Santo Hermel, Erica Do Espirito, and de Andrade Leite, Fabiane
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TEACHER training courses ,BIOLOGY teachers ,SCIENCE education ,COLLEGE curriculum ,SCIENCE teachers ,LIFE sciences ,CURRICULUM - Abstract
Copyright of Revista Electrónica de Enseñanza de las Ciencias is the property of Revista Electronica de Ensenanza de las Ciencias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
11. Percepção/Processamento da variação sociolinguística: considerações sobre contribuições e desafios da pesquisa experimental.
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Abreu Gomes, Christina and Silva Lopes de Melo, Marcelo Alexandre
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SOCIOLINGUISTICS ,SPEECH perception ,COGNITION ,GRAMMAR - Abstract
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- 2023
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12. Um olhar para a disciplina curricular Cultura Digital do Novo Ensino Médio: a relação das Tecnologias Digitais de Informação e Comunicação e o Ensino de Física.
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José Testa, Maurício, da Silva Lopes, Eduarda, Pyetro Vidmar, Muryel, and Paulo Pastorio, Dioni
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Copyright of Caderno Brasileiro de Ensino de Física is the property of Caderno Brasileiro de Ensino de Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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13. Okra (Abelmoschus esculentus L. moench) fruit powder standardized in flavonoids improves glycemic control and metabolic memory in acute and chronic hyperglycemia.
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Apolinário da Silva, Ana Paula, Xavier da Silva Neto, João, Wemmenson Gonçalves Moura, Luiz Francisco, de Lima Rebouças, Emanuela, Flávio da Silva Lopes, Francisco, Barbosa da Silva, Wildson Max, Maia de Morais, Selene, Bezerra da Silva, Bruno, and Florindo Guedes, Maria Izabel
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TYPE 2 diabetes ,GLYCEMIC control ,BLOOD sugar ,DRIED fruit ,HEAT shock proteins ,OKRA - Abstract
Type 2 diabetes mellitus (T2DM) is a chronic disease with high global prevalence characterized by persistent hyperglycemia. Elevated blood glucose levels are associated with constant oxidative stress and increased protein glycation, establishing a metabolic memory state. Therefore, the efficacy of the Okra (Abelmoschus esculentus L. moench) Fruit Powder Standardized in Flavonoids (OFP-SF) was evaluated in glucose homeostasis, oxidative stress, and metabolic memory, using zebrafish models of acute and chronic hyperglycemia. The OFP-SF was produced from dried fresh fruits and subsequently subjected to characterization regarding its antioxidant potential and chemical composition. Finally, the product was standardized to contain 1.6% flavonoids. In acute hyperglycemia, OFP-SF at doses of 125 μg and 250 μg demonstrated the ability to normalize blood glucose levels, reaching levels of 94.56 ± 5.9 mg/dL and 76.88 ± 8.9 mg/dL, respectively, when administered prior to glucose overload. The same doses were tested in a chronic hyperglycemia model, where after a seven-day treatment, animals receiving 125 and 250 μg of OFP-SF exhibited glycemic values of 73.45 ± 15.67 mg/dL and 33.96 ± 5.31 mg/dL, respectively, comparable to those observed in the Control group (49.48 ± 2.77 mg/dL). Furthermore, OFP-SF was able to mitigate metabolic memory by reducing oxidative stress and protein glycation in the brain, liver, and eye tissues of hyperglycemic zebrafish. These findings provide a basis for developing new products that utilize the phytochemical potential of A. esculentus fruits for the prevention and adjunctive treatment of T2DM. [ABSTRACT FROM AUTHOR]
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- 2024
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14. A Systematic Review With Pairwise and Network Meta-analysis of Closed Reduction Methods for Anterior Shoulder Dislocation
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Gonai, Shiro, Yoneoka, Daisuke, Miyoshi, Takahiro, and da Silva Lopes, Katharina
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To review closed reduction methods for anterior shoulder dislocation and perform the first comprehensive comparison of the individual methods in terms of success rate, pain, and reduction time.
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- 2023
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15. Análise do ambiente térmico urbano e áreas potencialmente expostas ao calor extremo no município do Porto (Portugal).
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Silva Lopes, Hélder, Remoaldo, Paula C., Ribeiro, Vítor, and Martin-Vide, Javier
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LAND surface temperature ,URBAN heat islands ,EVAPORATIVE cooling ,RADIATION absorption ,URBAN density ,REMOTE-sensing images ,LAND cover - Abstract
Copyright of Cuadernos de Geografia: Revista Colombiana de Geografía is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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16. Impact of urban morphology on the intensity of nocturnal heat islands: Analysis through the validation of simulation models in central-west Brazil.
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da Silva Lopes, Estéfane and Hora, Karla Emmanuela Ribeiro
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Urban morphology is one of the factors that influence the intensity of urban heat islands. Studying urban morphology means studying the factors that influence the formation of the urban environment, such as urban canyons and the ratio between building height and street width. The aim of this article is to verify the errors of heat island prediction models with respect to data obtained from measurements for the city of Goiânia/Brazil. Air temperature surveys were carried out in the field and the heat island intensity values were compared with the numerical model by Oke (1982) and by Nakata-Osaki et al. (2016). A simulation of an urban scenario was applied, represented by various types of urban canyons. The results showed that two numerical models correlated well with the values measured on site. The errors of the models used were determined using the Root Mean Square Error, which showed an error of around 5 °C for the Oke model and 2 °C for the Nakata-Osaki model. It is hoped that the research will be an analytical tool for public authorities, such Municipal Environment Agency, providing support for legislation and municipal plans based on the results obtained, contributing to the wellbeing of the population. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Volume, biomass, carbon stock and efficiency of water use in irrigated eucalyptus.
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da Silva Lopes, Adriano, Vinicius Folegatti, Marcos, Duarte Fanaya Júnior, Eder, Queiroz de Oliveira, Gabriel, Lopes de Oliveira, Jean Carlos, Melgar Rosalvo Brito, Kelvin, and Hayd Rego, Norton
- Abstract
Copyright of Ciência Florestal (01039954) is the property of Ciencia Florestal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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18. Outcomes between different validated questionnaires to assess the level of physical activity in cardiac patients adhering to a rehabilitation program.
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Loch Gomes, Rayana, Silva Lopes, Jaqueline Santos, Luiz de Marco, Rafael, Gardim de Almeida, Camila Balsamo, Marques Vanderlei, Luiz Carlos, and Regueiro Lorençoni, Roselene Modolo
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- 2022
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19. Coordenação do cuidado na Atenção Primária: gravidez, câncer de colo uterino e de mama como marcadores .
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Nogueir Rezende, Cecilia a, Xavier de Abreu, Daisy Maria, Silva Lopes, Érica Araújo, de Fátima Santos, Alaneir, and Gonzaga da Matta Machado, Antônio Thomaz
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MEDICAL personnel ,PRIMARY health care ,INTEGRATED health care delivery ,BREAST cancer ,MATERNAL health ,CANCER patient care - Abstract
Copyright of Interface - Comunicação, Saúde, Educação is the property of Fundacao UNI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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20. EFFECT OF SEQUENTIAL NEPHRON BLOCKADE X DUAL RENIN-ANGIOTENSIN SYSTEM BLOCKADE + BISOPROLOL IN THE TREATMENT OF RESISTANT HYPERTENSION, A RANDOMIZED CONTROLLED TRIAL (RESHYPOT)
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Cestario, Elizabeth Do Esp, Vilela-martin, José Fernando, Cosenso-martin, Luciana Neves, Rubio, Tatiane Azevedo, Uyemura, Jessica Rodrigue Roma, Da Silva Lopes, Valquiria, Fernandes, Letícia Aparecid Barufi, Tacito, Lucia Helena Bonalume, Junior, Heitor Moreno, and Yugar-toledo, Juan Carlos
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- 2024
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21. Electrodeposited Zn-soybean nanocrystal composite coatings: an effective strategy to produce cheaper and corrosion resistant Zn composite coatings
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da Silva Lopes, Carolina, Della Rovere, Carlos Alberto, Rigoli, Isabel Cristina, Fanezi da Rocha, Claudia Lisiane, and Caldas de Souza, Carlos Alberto
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Zn-soybean nanocrystal composite coating was produced through electrodeposition. The coatings were obtained in the absence and presence of different concentrations of soybean nanocrystals obtained through the bleaching process with a sodium hypochlorite (NaClO) solution and hydrolysis in a sulfuric acid solution. The effect of nanocrystal addition on the coating characteristics was analyzed through scanning electron microscopy (SEM), roughness measurements, hardness measurements, corrosion resistance evaluation and current efficiency determination. Corrosion resistance was evaluated at 0.5 wt% NaCl solution through mass loss and electrochemical measurements. The results obtained indicate that the presence of soybean nanocrystal reduces the hardness, but increases the corrosion resistance of the Zn coating and this effect is related to the decrease in the roughness of the coating.
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- 2022
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22. Physical therapy interventions for the treatment of delayed onset muscle soreness (DOMS): Systematic review and meta-analysis.
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Nahon, Roberto Lohn, Silva Lopes, Jaqueline Santos, and Monteiro de Magalhães Neto, Aníbal
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To evaluate the impact of interventions on pain associated with DOMS. PubMed, EMBASE, PEDro, Cochrane, and Scielo databases were searched, from the oldest records until May/2020. Search terms used included combinations of keywords related to "DOMS" and "intervention therapy". Healthy participants (no restrictions were applied, e.g., age, sex, and exercise level). To be included, studies should be: 1) Randomized clinical trial; 2) Having induced muscle damage and subsequently measuring the level of pain; 3) To have applied therapeutic interventions (nonpharmacological or nutritional) and compare with a control group that received no intervention; and 4) The first application of the intervention had to occur immediately after muscle damage had been induced. One hundred and twenty-one studies were included. The results revealed that the contrast techniques (p = 0,002 I
2 = 60 %), cryotherapy (p = 0,002 I2 = 100 %), phototherapy (p = 0,0001 I2 = 95 %), vibration (p = 0,004 I2 = 96 %), ultrasound (p = 0,02 I2 = 97 %), massage (p < 0,00001 I2 = 94 %), active exercise (p = 0,0004 I2 = 93 %) and compression (p = 0,002 I2 = 93 %) have a better positive effect than the control in the management of DOMS. Low quality evidence suggests that contrast, cryotherapy, phototherapy, vibration, ultrasound, massage, and active exercise have beneficial effects in the management of DOMS-related pain. • Contrast techniques, cryotherapy, phototherapy, vibration, ultrasound, massage, active exercise, and compression clothing are more effective than no intervention for the treatment of pain associated with late pain DOMs. • In comparison to no intervention, no statistically significant effect on DOMs related pain was demonstrated for the techniques of kinesiotaping, acupuncture, foam roller, stretching, electro-stimulation, and magnetic therapy. • The low quality of the included studies should be considered, for futures clinical trial improve the fragile methodological points highlighted. • The outcomes demonstrate the impact of interventions for pain associated with DOMS, which can be used both in the preparation of futures clinical trials and to support timely practical action. [ABSTRACT FROM AUTHOR]- Published
- 2021
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23. Covid-19 pandemic: profile of the affected and protagonism of computerized tomography in sars-cov-2 pneumonia.
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SOARES DIEGO, REGINA PAULA, BARBOSA AGUIAR, LINDENBERG, DA SILVA LOPES, ISABELLE BERNARDINA, ARAÚJO COELHO DO NASCIMENTO, EVEANIA, RODRIGUES DE ALMEIDA, JEFESSON, and RÁDIS BAPTISTA, GANDHI
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COVID-19 pandemic ,COMPUTED tomography ,PNEUMONIA ,CHEST (Anatomy) ,PLEURAL effusions - Abstract
Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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24. Popular education, youth and peasant agroecology in Brazil.
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Goris, M.B., Silva Lopes, I., Verschoor, G., Behagel, J., and Botelho, M.I.V.
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PEASANTS ,AGRICULTURAL ecology ,PARENTS ,TRANSFORMATIVE learning ,ACTIVISM ,POPULAR literature ,SCHOOL administration ,FARMERS' attitudes - Abstract
Most young people engaged in agroecology in Zona da Mata Mineira, Brazil, participate in popular education. Popular education is a Latin-American concept that entails transformative learning, among others. Despite the large body of literature on popular education, there is little knowledge about how it supports reflection, enhances situated abilities, and affects relationships between young farmers and nature. This article looks at popular education practices in Zona da Mata in three different places: a family farming high school, a youth organization, and a workers' union school. Each place gives special attention to agroecology. Based on participatory observations, video recordings, films made by youth, interviews and analysis of educational materials this article visualizes how young people become engaged in peasant agroecology through the use of affective experiences, relationship-building, and reflection in popular education. Our findings show that the pedagogic method of alternation used at the family farming high school fosters on-farm learning experiences between young farmers and their parents. At the workers' union school and at the youth organization intentional leisure activities promoted joy, spirituality, activism and peasant culture, with joy becoming an explicit organizing force. We conclude that, in our cases, popular education positively supports, often in unexpected ways, relations young agroecological farmers have with their parents, nature, and youth from conventional farms. • The pedagogy of alternation engages both students and parents in agroecology. • Joy is a mobilizing force that engages youth from conventional farms in agroecology. • Popular education supports ungendering agricultural and domestic work. • Participatory video methods help study learning experiences without being present. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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25. VULNERABILIDADE COSTEIRA A DERRAMES DE ÓLEO E À INUNDAÇÃO DE UMA ILHA FLUVIO-ESTUARINA AMAZÔNICA -- ILHA DE MOSQUEIRO (BELÉM-PARÁ-BRASIL).
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Yguara Parente, Yago, Carvalho Mendes, Amilcar, Oliveira de Miranda, Artur Gustavo, and da Silva Lopes, Karina
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- 2021
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26. Watermelon and others plant foods that trigger headache in migraine patients.
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Silva-Néto, Raimundo Pereira, de Almeida Soares, Adriana, Augusto Carvalho de Vasconcelos, Carlos, and da Silva Lopes, Luciano
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FERTILIZERS ,MIGRAINE ,EDIBLE plants ,WATERMELONS ,HEADACHE ,MIGRAINE aura ,SPREADING cortical depression ,PRIMARY headache disorders - Abstract
Background: Food is already recognized as a trigger for migraine, but its mechanism of action has not been fully clarified. There is evidence that they act on the pathogenesis of migraine, interfering with meningeal inflammation, vasodilation and cerebral glucose metabolism. Aim: The aim of this study was to know which plant foods are triggers for migraine and the latency time for the onset of pain. Method: We interviewed patients with migraine and tension-type headache about plant foods that trigger headache and onset time of the headache. We studied 3,935 migraine patients and 1,163 with tension-type headache. Results: There were headaches triggered by plant foods after 90.5 ± 7.9 minutes of ingestion in 40.3% (1,584/3,935) of migraine patients and none with tension-type headache. Headaches triggered by plant foods intake are distributed in the following order of frequency: watermelon (29.5%), passion fruit (3.73%), orange (2.01%), pineapple (1.52%), grape (0.51%), banana (0.46%), cucumber (0.43%), acerola (0.25%) and papaya (0.25%). Conclusions: Many plant foods, especially watermelon, may trigger headache attacks in migraine patients within a few minutes. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
27. Produção de mudas de Senegalia bahiensis Benth. em diferentes volumes de tubetes.
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Soares de Freitas, Teresa Aparecida, Silva Lopes, Emile Caroline, Ferreira Graham de Araujo, Jamille, Barbosa dos Santos, Lucas, and Vita Reis Mendonça, Andrea
- Abstract
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- Published
- 2021
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28. LITERATURA E CIRCULAÇÃO DE AFETOS: PROMESSAS DE FELICIDADE, ILUSÃO E DESAMPARO EM A CASA NA FLORESTA, DE BERNHARD SCHLINK.
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de SOUZA, César Martins and da Silva LOPES, Raquel
- Subjects
HAPPINESS ,COUPLES ,PREJUDICES ,SOCIAL pressure ,INTIMACY (Psychology) ,GENDER inequality ,MODERNITY ,DILEMMA - Abstract
Copyright of Revista de Letras is the property of Revista de Letras and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
29. Fractal signature of coronaviruses related to severe acute respiratory syndrome
- Author
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de Salazar e Fernandes, Thiago, de Oliveira Filho, Jonas Sérgio, and da Silva Lopes, Isvania Maria Serafim
- Abstract
Purpose: The aim of this work was to investigate the genome of SARS-CoV, MERS-CoV, and SARS-CoV-2 by the paradigm of chaos theory and fractal geometry. Coronavirus is the agent that causes the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) and emergent infections such as the present pandemic of COVID-19. Understanding its genome pattern is important for developing new and faster ways of testing for identifying the genome of the virus and also for better understanding of its origin and evolution. Methods: For that, it was calculated the alpha coefficient by detrended fluctuation analysis (DFA) for the sequences of these genomes converted to binary numbers in order to determine if it is a chaotic or a random series of data. Also, it applied the random walking for obtaining a fractal map of the whole genome and calculated the fractal dimension (FD) by box-counting of this map by two different software. Results: With this, it was found that the alpha coefficient of the first SARS viruses was > 0.5, indicating that the series is chaotic or fractal, and has a persistent long-range memory or self-similarity along its sequence. This is not the case for MERS virus, which showed to have a completely random sequence (α< 0.5). For the fractal dimension, SARS viruses presented a FD around 1.5, and for MERS the fractal dimension decreases (FD < 1.5). Conclusion: The images generated by random walking of the entire RNA genome are by itself a fractal signature of the virus, which may be applied for studying its origin and for faster diagnostic of COVID-19.
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- 2022
- Full Text
- View/download PDF
30. Watermelon and others plant foods that trigger headache in migraine patients
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Silva-Néto, Raimundo Pereira, de Almeida Soares, Adriana, Augusto Carvalho de Vasconcelos, Carlos, and da Silva Lopes, Luciano
- Abstract
ABSTRACTBackground: Food is already recognized as a trigger for migraine, but its mechanism of action has not been fully clarified. There is evidence that they act on the pathogenesis of migraine, interfering with meningeal inflammation, vasodilation and cerebral glucose metabolism.Aim: The aim of this study was to know which plant foods are triggers for migraine and the latency time for the onset of pain.Method: We interviewed patients with migraine and tension-type headache about plant foods that trigger headache and onset time of the headache. We studied 3,935 migraine patients and 1,163 with tension-type headache.Results: There were headaches triggered by plant foods after 90.5 ± 7.9 minutes of ingestion in 40.3% (1,584/3,935) of migraine patients and none with tension-type headache. Headaches triggered by plant foods intake are distributed in the following order of frequency: watermelon (29.5%), passion fruit (3.73%), orange (2.01%), pineapple (1.52%), grape (0.51%), banana (0.46%), cucumber (0.43%), acerola (0.25%) and papaya (0.25%).Conclusions: Many plant foods, especially watermelon, may trigger headache attacks in migraine patients within a few minutes.
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- 2021
- Full Text
- View/download PDF
31. Is there a common pathophysiological mechanism between COVID-19 and depression?
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da Silva Lopes, Luciano, Silva, Raquel Oliveira, de Sousa Lima, Guilherme, de Araújo Costa, Arthur Caminha, Barros, Daniela França, and Silva-Néto, Raimundo Pereira
- Abstract
COVID-19 is a disease caused by SARS-CoV-2 and was initially considered to cause serious damage to the respiratory system. Over time, it has been found to affect other organs due to its ability to bind to the ACE2 receptor (type 2 angiotensin-converting enzyme), which can be found in various tissues, including the central nervous system. In addition, a large formation of pro-inflammatory cytokines responsible for various lesions was observed during the evolution of this disease. Our objective was to demonstrate the molecular mechanisms involved in the infection that may demonstrate the relationship between COVID-19 and the development of depressive conditions. Based on the main medical databases (LiLacs, SciELO, Bireme, Scopus, EBSCO, and PubMed) and using the terms 'coronavirus infections' AND 'Inflammation' AND 'depression' AND 'cytokines', we conducted an integrative review of articles published in 2020. Considering this stage of Covid-19 and the inflammatory component of depression, this review showed a relationship between these two conditions based on common pathophysiological mechanisms indicating possible depressive disorders in surviving patients, especially in the most severe cases. The role of inflammatory cytokines and the presence of ACE-2 receptors on the cell surface appear to be the common pathophysiological mechanism between COVID-19 and depression.
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- 2021
- Full Text
- View/download PDF
32. Validity and reliability of an instrument to measure factors associated with screen time in Brazilian students.
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Barbosa Filho, Valter Cordeiro, Silva Bandeira, Alexsandra, Ricardo Rech, Cassiano, Silva Lopes, Adair, Mota, Jorge, and Samara Silva, Kelly
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SELF-efficacy ,MEASURING instruments ,FACTOR analysis ,SCHOOL supplies ,CROSS-sectional method ,BEDROOMS - Abstract
Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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33. Geomorfologia no livro didático: clareza, linguagem e concepção em Sene e Moreira (2018), 6° ano do ensino fundamental.
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Silva Lopes, Jaelson and Sabóia de Aquino, Claudia Maria
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GEOMORPHOLOGY ,NATURAL landscaping ,SCHOOL year ,PHYSICAL geography ,ELEMENTARY schools ,TEXTBOOKS - Abstract
Copyright of Boletim de Geografia is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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34. PSYCHOSOCIAL ASPECTS OF PHYSICAL ACTIVITY: DATA ON BRAZILIAN ADOLESCENTS.
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Bertuol, Cecília, Samara da Silva, Kelly, Miranda Tassitano, Rafael, da Silva Lopes, Adair, and Vinicius Nahas, Markus
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BRAZILIANS ,PHYSICAL activity ,WOMEN'S employment ,SOCIODEMOGRAPHIC factors ,LOGISTIC regression analysis - Abstract
Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
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35. MEMÓRIAS COLETIVAS, TRAUMAS INDIVIDUAIS: AS MEMÓRIAS DOS DESASTRES SOCIOAMBIENTAIS NO SUL DE SANTA CATARINA (1974-2004).
- Author
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Silva Lopes, Alfredo Ricardo
- Abstract
Copyright of Historia: Questoes & Debates is the property of Universidade Federal do Parana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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36. Structure-based virtual screening of mangiferin derivatives with antidiabetic action: a molecular docking and dynamics study and MPO-based drug-likeness approach
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da Silva Lopes, Francisco Flávio, Lúcio, Francisco Nithael Melo, da Rocha, Matheus Nunes, de Oliveira, Victor Moreira, Roberto, Caio Henrique Alexandre, Marinho, Márcia Machado, Marinho, Emmanuel Silva, and de Morais, Selene Maia
- Abstract
Extracts from Mangifera indicaleaves and its main component, mangiferin, have proven antidiabetic activity. In this study, mangiferin and its natural derivatives Homomangiferin (HMF), Isomangiferin (IMF), Neomangiferin (NMF), Glucomangiferin (GMF), Mangiferin 6’-gallate (MFG), and Norathyriol (NRT) were compared regarding their action on Diabetes mellitus(DM), employing docking and molecular dynamics (MD) simulations to analyze interactions with the aldose reductase enzyme, the precursor to the conversion of glucose into sorbitol. Notably, HMF showed significant affinity to residues in the active site of the enzyme, including Trp 79, His 110, Trp 111, Phe 122, and Phe 300, with an energy of − 7.2 kcal/mol, observed in the molecular docking simulations. MD reinforced the formation of stable complexes for HMF and MFG with the aldose reductase, with interaction potential energies (IPE) in the order of − 300.812 ± 52 kJ/mol and − 304.812 ± 52 kJ/mol, respectively. The drug-likeness assessment, by multiparameter optimization (MPO), highlighted that HMF and IMF have similarities with polyphenols and glycosidic flavonoids recently patented as antidiabetics, revealing that high polarity (TPSA > 180 Å2) is a favorable property for subcutaneous administration, especially because of the gradual passive cell permeability values in biological tissues, with Pappvalues estimated at < 10 × 10−6cm/s. These compounds are metabolically stable against metabolic enzymes, resulting in a low toxic incidence by metabolic activation, corroborating with a lethal dose (LD50) greater than 2000 mg/kg. In this way, HMF showed a systematic alignment between predicted pharmacokinetics and pharmacodynamics, characterizing it as the most favorable substance for inhibiting aldose reductase.
- Published
- 2024
- Full Text
- View/download PDF
37. Metabolic syndrome impact on nutritional deficiencies and metabolic status 1 year after sleeve gastrectomy.
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de Sousa Paredes, Silvia Cristina, de Lurdes Fernandes Alves, Marta, da Silva Lopes Pereira, Maria Ramires, and Ribeiro, Laura Virgínia Pereira Teixeira
- Abstract
A paucity of information is available on the comparative nutritional deficiencies considering the presence of metabolic syndrome (MetS) and nutritional changes after vertical sleeve gastrectomy (SG). To compare the nutritional status in patients with and without MetS before and 1 year after SG and to investigate its association with metabolic status. A tertiary referral center. Retrospective study, including all patients submitted to SG between January 2011 and July 2015. Patients were evaluated before and 12 months after surgery. MetS presence was classified using the International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute 2009 definition. Univariate and multivariate analyses were applied to find associations between MetS, nutritional, anthropometric, and metabolic parameters. A total of 330 patients were included and MetS was present in 47%. Preoperatively, patients without MetS presented a higher percentage of folate deficiency (12% versus 2%, P <.001). Follow-up data were available for 202 patients. In the 1-year evaluation, MetS patients presented significantly lower body mass index and percent excess weight loss (70.96 ± 20.4 versus 79.55 ± 23.0, P <.001). These patients also presented lower homocysteine (11.76 ± 4.3 versus 13.66 ± 7.6, P =.027) and magnesium (19.41 ± 2.1 versus 20.22 ± 1.9, P =.004) levels but higher calcium (9.27 ±.3 versus 9.16 ±.4, P =.031) and vitamin B12 (396, P 312–504.5 versus 329, P 255–433, P =.002) levels comparing with those without MetS. Multiple linear regression evidenced that higher preoperative albumin and postoperative ferritin and homocysteine were predictors of a lower body mass index after surgery, and higher postoperative folate levels were associated with lower insulin-resistance. The impact of SG on nutritional parameters is affected by MetS. If not treated, preoperative deficiencies can impair postoperative metabolic status and weight loss. MetS should be considered when evaluating bariatric surgery candidates, and preoperative supplementation and long-term nutritional follow-up are required to prevent further nutritional deficiencies. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
38. Conhecimento da Oximetria de Pulso na Triagem da Cardiopatia Congênita.
- Author
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Staff Zanquetta, Márcia, da Silva Lopes, Valquiria, and Fernandes de Godoy, Moacir
- Abstract
Copyright of Saúde Coletiva is the property of MPM Comunicacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
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39. Pobreza e vulnerabilidade: uma história social dos desastres de 1974 na Bacia do Rio Tubarão (SC-Brasil).
- Author
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Silva Lopes, Alfredo Ricardo
- Subjects
ENVIRONMENTAL disasters ,WATERSHEDS ,RULING class ,WORKING class ,SOCIAL history ,DISASTERS - Abstract
Copyright of Estudos Ibero-Americanos is the property of EDIPUCRS - Editora Universitaria da PUCRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
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40. Características clínicas de pacientes atendidos pela equipe de fisioterapia na enfermaria de um hospital de pequeno porte na região Litoral Norte do Rio Grande do Sul.
- Author
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da Silva Lopes da Silva, Tainara, da Silva Silveira, Tais, Castilho da Silveira, Cibele, da Silva Rafael, Marjorie, de Oliveira Sena, Cristiane Helena, and Heinzmann-Filho, João Paulo
- Published
- 2020
- Full Text
- View/download PDF
41. SATISFAÇÃO DO USUÁRIO COM OS SERVIÇOS DE SAÚDE DE ATENÇÃO BÁSICA: PERCEPÇÃO MASCULINA.
- Author
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Pereira Pavan, Isabella, da Silva Lopes Baptista, Angeline, Pupin Rosa, Caio, da Silva Cabral, Danusa, Bittencourt, Flavio, and Albino da Silva, Simone
- Subjects
MEN'S health ,HEALTH facilities ,HEALTH services accessibility ,RESEARCH methodology ,CROSS-sectional method ,WAITING rooms ,PATIENT satisfaction ,FAMILY health ,INTERVIEWING ,FISHER exact test ,PATIENTS' attitudes ,PRIMARY health care ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,MEDICAL referrals ,PATIENT-professional relations ,MEDICAL appointments ,FAMILY services - Abstract
Copyright of Ciencia, Cuidado e Saude is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
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42. Identification of genomic imbalances in oral clefts
- Author
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Lustosa-Mendes, Elaine, Santos, Ana P. dos, Vieira, Társis P., Ribeiro, Erlane M., Rezende, Adriana A., Fett-Conte, Agnes C., Cavalcanti, Denise P., Félix, Têmis M., Monlleó, Isabella L., and Gil-da-Silva-Lopes, Vera Lúcia
- Abstract
This article presents a clinical and cytogenomic approach that focuses on the diagnosis of syndromic oral clefts (OCs).
- Published
- 2021
- Full Text
- View/download PDF
43. Improving fatigue life of cold forging dies by finite element analysis: A case study
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Dalbosco, Misael, da Silva Lopes, Gabriel, Schmitt, Pedro David, Pinotti, Luciano, and Boing, Denis
- Abstract
•Optimization of a cold forging die by means of finite element analyses.•Changes in the preloading profile dropped principal stress from 597 to 170 MPa.•Average number of parts produced per tool increased fourfold.•Analysis also predicted crack nucleation spot and propagation direction.
- Published
- 2021
- Full Text
- View/download PDF
44. Brazil's Craniofacial Project: Different approaches on orofacial clefts and 22q11.2 deletion syndrome
- Author
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Gil‐da‐Silva‐Lopes, Vera Lúcia, Tacla, Milena Atique, Sgardioli, Ilária Cristina, Vieira, Társis Paiva, and Monlleó, Isabella Lopes
- Abstract
This article reports the present situation of Brazilian health care in genetics for Orofacial Cleft (OFC) and 22q11.2 Deletions Syndrome (22q11.2 DS) based on research conducted by Brazil's Craniofacial Project (BCFP). Established in 2003, BCFP is a voluntary and cooperative network aiming to investigate the health care of people with these diseases and other craniofacial anomalies. The initiatives and research results are presented in four sections: (a) a comprehensive report of the Brazilian public health system in craniofacial genetics; (b) multicentric studies developed on OFC and 22q11.2 DS; (c) education strategies focused on addressing these conditions for both population and health‐care professionals; and (d) the nosology through the Brazilian Database on Craniofacial Anomalies (BDCA). Since 2006, BDCA uses a standardized method with detailed clinical data collection, which allows for conducting studies on nosology, genotype–phenotype correlations, and natural history; data can also contribute to public policies. Currently, the BDCA stores data on 1,724 individuals, including 1,351 (78.36%) who were primarily admitted due to OFC and 373 (21.63%) with clinical suspicion of 22q11.2 DS. Chromosomal abnormalities/genomic imbalances were represented by 92/213 (43.19%) individuals with syndromic OFC, including 43 with 22q11.2 DS, which indicates the need for chromosomal microarray analysis in this group. The nosologic diversity reinforces that monitoring clinical is the best strategy for etiological investigation. BCFP's methodology has introduced the possibility of increasing scientific knowledge and genetic diagnosis of OFC and 22q11.2 DS to in turn improve health care and policies for this group of diseases.
- Published
- 2020
- Full Text
- View/download PDF
45. Genomic imbalances in craniofacial microsomia
- Author
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Spineli‐Silva, Samira, Sgardioli, Ilária C., Santos, Ana P., Bergamini, Luna L., Monlleó, Isabella L., Fontes, Marshall I. B., Félix, Têmis M., Ribeiro, Erlane M., Xavier, Ana C., Lustosa‐Mendes, Elaine, Gil‐da‐Silva‐Lopes, Vera L., and Vieira, Tarsis P.
- Abstract
The aim of this study was to perform 22q11.2 deletion screening and chromosomal microarray analysis (CMA) in individuals clinically diagnosed with craniofacial microsomia (CFM) and review previously published cases of CFM with genomic imbalances. It included 54 individuals who were evaluated by a clinical geneticist. Copy number variants (CNVs) in the 22q11.2 region were investigated by multiplex ligation‐dependent probe amplification (MLPA) for all individuals. The CMA was performed only for individuals with additional major features. MLPA revealed pathogenic CNVs at the 22q11 region in 3/54 (5.6%) individuals. CMA revealed pathogenic CNVs in 4/17 (23.5%) individuals, including the three CNVs at the 22q11 region also detected by MLPA, and CNVs classified as variants of unknown significance (VOUS) in 4/17 (23.5%) individuals. Pathogenic alterations were found at the 2p12, 5p15, 13q13, and 22q11 regions. VOUS were found at 3q29, 5q22.2, 5q22.1, and 9p22 regions. All individuals with pathogenic alterations presented additional major features, including congenital heart disease (CHD). The literature review revealed pathogenic CNVs in 17/193 (8.8%) individuals and most of them also presented additional major features, such as CHD, renal anomalies, or developmental delay. In conclusion, CNVs should be investigated in patients with CFM and additional major features.
- Published
- 2020
- Full Text
- View/download PDF
46. IRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate
- Author
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Bezerra, João Felipe, Silva, Heglayne Pereira Vital da, Bortolin, Raul Hernandes, Luchessi, André Ducati, Ururahy, Marcela Abbott Galvão, Loureiro, Melina Bezerra, Gil-da-Silva-Lopes, Vera Lúcia, Almeida, Maria das Graças, Amaral, Viviane Souza do, and Rezende, Adriana Augusto de
- Abstract
Non-syndromic orofacial clefts have a complex etiology due to the contribution from both genetic and environmental risk factors, as well as the interaction between them. Among the more than 15 susceptibility loci for non-syndromic orofacial clefts with considerable statistical and biological support, the IRF6 is the most validated gene by the majority of studies. Nonetheless, in genetically heterogeneous populations such as Brazilian, the confirmation of association between non-syndromic orofacial clefts and IRF6 common variants is not a consolidated fact and unrecognized IRF6 variants are poorly investigated.
- Published
- 2020
- Full Text
- View/download PDF
47. Familial Aggregation of Childhood‐ and Adulthood‐Onset Systemic Lupus Erythematosus
- Author
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Sinicato, Nailú Angélica, Oliveira, Luciana, Lapa, AlineTamires, Postal, Mariana, Peliçari, Karinade Oliveira, Costallat, Lilian T. L., Marini, Roberto, Gil‐da‐Silva‐Lopes, Vera Lúcia, Niewold, Timothy B., and Appenzeller, Simone
- Abstract
To assess the familial occurrence of systemic lupus erythematosus (SLE) in a large Brazilian cohort. Consecutive patients with SLEwere recruited and stratified according to age at disease onset into childhood‐onset SLEor adult‐onset SLE. Each patient was personally interviewed regarding the history of SLEacross 3 generations (first‐, second‐, and third‐degree relatives). Recurrence rates were analyzed for each degree of relation. We included 392 patients with SLE(112 with childhood‐onset SLEand 280 with adult‐onset SLE). We identified 2,574 first‐degree relatives, 5,490 second‐degree relatives, and 6,805 third‐degree relatives. In the combined overall SLEcohort, we observed a familial SLErecurrence rate of 19.4 in first‐degree relatives, 5.4 in second‐degree relatives, and 3.0 in third‐degree relatives. Recurrence rates were higher for first‐ and second‐degree relatives of patients with childhood‐onset SLEthan for first‐ and second‐degree relatives of patients with adult‐onset SLE(25.2 versus 18.4 for first‐degree, and 8.5 versus 4.5 for second‐degree), while in third‐degree relatives, recurrence rates were higher in adult‐onset SLEthan in childhood‐onset SLE(P= 2.2 × 10–4for differences in recurrence proportions between childhood‐onset SLEand adult‐onset SLE). There were no phenotypic differences in patients from multicase versus single‐case families, and there was no sex‐skewing observed in the offspring of patients with SLE. The greater decline in SLErecurrence rate by generation in childhood‐onset SLEversus adult‐onset SLEsuggests a more polygenic and epistatic inheritance and suggests that adult‐onset SLEmay be characterized by fewer risk factors that are individually stronger. This finding suggests a higher genetic load in childhood‐onset SLEversus adult‐onset SLEand a difference in the genetic architecture of the disease based on age at onset.
- Published
- 2020
- Full Text
- View/download PDF
48. Intraperitoneal cannabidiol attenuates neonatal germinal matrix hemorrhage-induced neuroinflamation and perilesional apoptosis.
- Author
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Abrantes De Lacerda Almeida, Timóteo, Santos, Marcelo Volpon, Da Silva Lopes, Luiza, Goel, Gunjan, Leonardo De Freitas, Renato, De Medeiros, Priscila, Crippa, José Alexandre, and Machado, Hélio Rubens
- Subjects
CANNABIDIOL ,PREMATURE infants ,CEREBRAL edema ,INTRAVENTRICULAR hemorrhage ,NEUROPROTECTIVE agents ,NEURAL development - Abstract
Background. As the survival of preterm infants has increased significantly, germinal matrix hemorrhage (GMH) has become an important public health issue. Nevertheless, treatment strategies for the direct neuronal injury are still scarce. The present study aims to analyze the neuroprotective properties of cannabidiol in germinal matrix hemorrhage. Methods. 112 Wistar rat pups (P7) were submitted to an experimental collagenase induced model of GMH. Inflammatory response and neuronal death were analyzed both at the perilesional area as at the distant ipsilateral CA1 hippocampal area. Immunohistochemistry for GFAP and caspase 3 was used. The ipsilateral free water content was assessed for stimation of cerebral edema, and neurodevelopment and neurofunctional tests were conducted. Results. Reduction of reactive astrocytosis was observed both in the perilesional area 24 hours and 14 days after the hemorrhage lesion (p < 0.001) and in the Stratum oriens of the ipsilateral hippocampal CA1 14 days after the hemorrhage lesion (p < 0.05) in the treated groups. Similarly, there was a reduction in the number of Caspase 3-positive astrocytes in the perilesional area in the treated groups 24 hours after the hemorrhage lesion (p < 0.001). Finally, we found a significant increase in the weight of the rats treated with cannabidiol. Conclusion. The treatment of GMH with cannabidiol significantly reduced the number of apoptotic cells and reactive astrocytes in the perilesional area and the ipsilateral hippocampus. In addition, this response was sustained 14 days after the hemorrhage. These results corroborate our hypothesis that cannabidiol is a potential neuroprotective agent in the treatment of germinal matrix hemorrhage. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
49. Change in overweight and obesity over a decade according to sociodemographic factors in Brazilian adolescents.
- Author
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dos Santos, Priscila Cristina, da Silva, Kelly Samara, da Silva, Jaqueline Aragoni, dos Santos, Carla Elane Silva, Del Duca, Giovani Firpo, da Silva Lopes, Adair, and Nahas, Markus Vinícius
- Subjects
SOCIODEMOGRAPHIC factors ,OBESITY ,TEENAGERS ,AGE groups ,CHILDHOOD obesity ,INCOME ,CITIES & towns - Abstract
Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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50. Irrigação e fertirrigação no desenvolvimento de eucalipto.
- Author
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Marinho de Faria Pereira, Vitor Gabriel, da Silva Lopes, Adriano, Braga Belchior, Isabela, Fanaya Júnior, Eder Duarte, Pacheco, Arthur, and Melgar Brito, Kelvin Rosalvo
- Abstract
Copyright of Ciência Florestal (01039954) is the property of Ciencia Florestal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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