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The article reports on the study which investigates the association of the tumor suppressor genes (TSG) methylation in benign breast epithelium and to breast cancer risk. The study conducted univariate, multivariate and unsupervised cluster analysis to establish relationship between TSG methylation and a personal history of breast cancer, predicted breast cancer risk and specific cancer risk factors. It is concluded that TSG methylation increases in benign breast epithelium with increasing age.