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• Z-Ajoene modulates Hedgehog/Gli pathway by reducing Gli transcriptional activity. • Z-Ajoene inhibits expressions of Gli- and FoxM1-target proteins in PANC-1 cells. • Z-Ajoene inhibits growth of PANC-1 cells via cell cycle arrest at G2/M phase. Overexpression of glioma-associated oncogene (Gli), a transcription factor at the final step of Hedgehog (Hh) pathway, is involved in pancreatic cancer development. Therefore, inhibition of Gli can be a therapeutic strategy to treat pancreatic cancer. The objective of this study was to determine effects of Z-ajoene from garlic, on Gli-mediated transcription and proliferation of pancreatic cancer cells. We found that Z-ajoene could inhibit Gli transcriptional activity in Sonic Hedgehog (Shh) stimulated C3H10T1/2 mesenchymal stem cells. Z-Ajoene suppressed Gli transcriptional activity and Gli-target protein expressions in PANC-1 human pancreatic cancer cells. Z-Ajoene also reduced expression of FoxM1, one of Gli-target proteins, and subsequently down-regulated expressions of cell cycle-related proteins. Moreover, Z-ajoene reduced cell proliferation and increased G2/M phase of PANC-1 cells. These results suggest that Z-ajoene can repress pancreatic cancer cell proliferation by inhibiting Gli signaling. Thus, Z-ajoene might be a lead compound for the development of anti-pancreatic cancer agent. [ABSTRACT FROM AUTHOR]

The article focuses on a study that discusses effects of ajoene, garlic compound on intestinal Immunoglobin A (IgA) production. Topics discussed include oil-macerated garlic extract enhances intestinal IgA production, garlic is used against cardiovascular diseases, cancer, and infection, and effects of administrating Oil-Macerated Garlic Extract (OMGE) on Fecal IgA Production. It also mentions lactic acid bacterial polysaccharides and polyphenols immunostimulants.

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The article reports on the thermostability of allicin determined by chemical and biological assays. It states that allicin in an aqueous extract of garlic was degraded stoichiometricaly in proportion to the temperature. The thermostablity of allicin can be determined by a systematic analyses employing chemical quantification and an antibacterial activity assay.

Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)