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Background: Cardiovascular diseases (CVDs) are the leading cause of global morbidity often overlooked. Much of the population risk of CVD is attributable to modifiable risk factors, and the gaps in knowledge of cardiovascular risk factors (CRF) are barriers to the effective prevention and treatment of CVDs. Aim: To assess the knowledge, awareness, and CVD risk among the staff of the college of health science. Methods: A cross-sectional study of 70 academic and non-academic staff who consented were given questionnaires for cardiovascular risk factor (CRF) knowledge level, cardiovascular risk awareness (CRA), international physical activity questionnaire (IPAQ), and international stress management association questionnaire (ISMAQ). Selected anthropometric indices, blood pressure, and fasting blood sugar (FBG) were also measured. Results: The mean knowledge level of CVDs was 23.21 ± 3.230, and the mean CRA was 42.61 ± 4.237. The study participants demonstrated moderate-to-high stress (48%), physical inactivity of 18.9%, overweight/obesity of 62.48%, abdominal obesity of 21.4%, hypertensive (systole and diastole) of 27.2%, hyperglycemic of 7.2%, and smokers of 7.2%. There was a significant relationship between the participants’ knowledge level and awareness of CVDs (p< 0.003) and knowledge of CRFs also increased with an increase in educational level. Participants > 40 years had a 3–9% risk of having a CVD event within 10 years. Conclusions: The knowledge and awareness of CRFs among the participants was high, and some exhibited risk factors. The staff of the university could improve their risk score by practicing health-promoting behaviors like increased physical activity, blood pressure control, and smoking cessation.