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Supplemental Digital Content is Available in the Text. This article describes a surgical approach using intraoperative optical coherence tomography and endoscopy for Argus II retinal prosthesis system explantation. Purpose: To describe a surgical approach using intraoperative optical coherence tomography and endoscopy for successful Argus II retinal prosthesis system removal. Methods: Retrospective review of a patient undergoing Argus II explantation 8 months after initial implantation. Results: Successful explantation of the Argus II device was performed in this patient. Conclusion: Explantation of the Argus II device can be a difficult surgery, and intraoperative optical coherence tomography and endoscopy can be used to help avoid potential complications. [ABSTRACT FROM AUTHOR]