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Background: Mucous membrane pemphigoid (MMP) is an autoimmune disease that can lead to fibrosis of mucous membranes and functional impairment. Biologic agents should be explored as alternative treatment options to improve outcomes.Objective: To conduct a systematic review of biologic treatment outcomes in patients with MMP.Methods: A MEDLINE and Embase search was conducted on July 23, 2020, to include 63 studies using Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.Results: Use of intravenous immunoglobulin (n = 154), rituximab (n = 112), tumor necrosis factor α inhibitors (n = 7), and combination treatments (n = 58) were reported in 331 patients with MMP. Intravenous immunoglobulin led to complete resolution in 61.7% (n = 95/154) of patients within 26.0 months, with a recurrence rate of 22.7% (n = 35/154) and headache as the most common adverse effect (8.4%, n = 13/154). Rituximab led to complete resolution in 70.5% (n = 79/112) of patients within 8.7 months, with a recurrence rate of 35.7% (n = 40/112). The most commonly reported adverse effects were urinary tract infections (4.5%, n = 5/112), leukocytopenia (2.7%, n = 3/112), and death due to severe infections (1.8%, n = 2/112). Tumor necrosis factor α inhibitors led to complete resolution in 71.4% (n = 5/7) of patients within 3.9 months of treatment without reported adverse events.Conclusions: Randomized clinical trials with long-term follow-up are required to conclude the promising safety and efficacy of biologic agents in patients with MMP. [ABSTRACT FROM AUTHOR]

Abstract In the paper, the methods of reused yarn processing are analyzed, considering the issue of maintenance reliability of the proposed auxiliary equipment for garment and knitting production waste processing. The estimation of implementation possibility is given for the developed technology by means of introduction of oiling device at the stage of yarn winding on a spool after backwinding on auxiliary equipment that will allow reducing the treated yarn’s fluffiness and removing its glassy state giving elasticity. [ABSTRACT FROM AUTHOR]

In the paper the analysis of technologies for processing of wastes of sewing and knitted production is carried out. Issues of development of ecologically expedient methods and devices for processing of wastes of sewing and knitted production are considered. Approbation of the developed universal auxiliary equipment for processing of wastes from sewing and knitting production has been carried out. The effect of humidity and temperature on the physical and mechanical properties of recycled yarn fibers has been studied. The estimation of the possibility of implementing the developed technology with the mathematical modeling is given. [ABSTRACT FROM AUTHOR]

The article investigates the sources of sewing and knitting production waste, analysis types and characteristics of knitted waste, the current state of waste treatment technologies and their impact on the environment. It is proved that the technological production processes are accompanied by intense release of harmful substances that contaminate the work area and the environment, causing deterioration of working conditions for people and equipment. On the basis of technology analysis of recycling sewing and knitting production waste was designed and presented a model for the processing of knitting yarn waste. [ABSTRACT FROM AUTHOR]