31 results on '"Bertora P"'
Search Results
2. Prestroke Cognitive Impairment: Frequency and Association With Premorbid Neuropsychiatric, Functional, and Neuroimaging Features
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Mele, Francesco, Cova, Ilaria, Nicotra, Alessia, Maestri, Giorgia, Salvadori, Emilia, Cucumo, Valentina, Masserini, Federico, Martelli, Martina, Pomati, Simone, Bertora, Pierluigi, and Pantoni, Leonardo
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- 2024
- Full Text
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3. The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction
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Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Mosconi, Maria Giulia, Giustozzi, Michela, Tsivgoulis, Georgios, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna M., Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, De Magistris, Ilaria Leone, Cancelloni, Virginia, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Moci, Marco, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Morotti, Andrea, Magoni, Mauro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Halvatsiotis, Panagiotis, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Baronello, Mario Maimone, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and De Marchis, Gian Marco
- Abstract
Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF.Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding).Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77).Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability.
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- 2023
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4. Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy
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Caliandro, Pietro, Cancelloni, Virginia, Marco, Moci, Reale, Giuseppe, Zauli, Aurelia, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Calabresi, Paolo, Giulia Mosconi, Maria, Giustozzi, Michela, Tsivgoulis, Georgios, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Marco De Marchis, Gian, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Maria Lotti, Enrico, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Leone De Magistris, Ilaria, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Emanuele Saggese, Carlo, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Chiara Caselli, Maria, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Halvatsiotis, Panagiotis, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Poli, Loris, Magoni, Mauro, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Girardi, Laura, Maimone Baronello, Mario, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and Paciaroni, Maurizio
- Abstract
Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.Patients and methods: We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemic and haemorrhagic events considered separately. A multivariable logistic regression analysis was performed to identify independent predictors for outcome events. To compare the risk of outcome events between the two cohorts, the relation between the survival function and the set of explanatory variables were calculated by Cox proportional hazard models and the results were reported as adjusted hazard ratios (HR). Finally another analysis was performed to compare the overall risk of outcome events in both OAC/AP and OAC cohorts after propensity score matching (PSM).Results: During a mean follow-up time of 7.5 ± 9.1 months (median follow-up time 3.5 months, interquartile range ±3), 2284 stroke patients were on oral anticoagulants and 215 were on combined therapy. The multivariable model demonstrated that the composite outcome is associated with age (OR: 1.03, 95% CI: 1.01–1.04 for each year increase) and concomitant antiplatelet therapy (OR: 2.2, 95% CI: 1.48–3.27), the ischaemic outcome with congestive heart failure (OR: 1.55, 95% CI: 1.02–2.36) and concomitant antiplatelet therapy (OR: 1.93, 95% CI: 1.19–3.13) and the haemorrhagic outcome with age (OR: 1.03, 95% CI: 1.01–1.06 for each year increase), alcoholism (OR: 2.15, 95% CI: 1.06–4.39) and concomitant antiplatelet therapy (OR: 2.22, 95% CI: 1.23–4.02). Cox regression demonstrated a higher rate of the composite outcome (hazard ratio of 1.93 [95% CI, 1.35–2.76]), ischaemic events (HR: 2.05 [95% CI: 1.45–2.87]) and bleeding outcomes (HR: 1.90 [95% CI, 1.06–3.40]) in OAC/AP cohort. After PSM analysis, the composite outcome remained more frequent in people treated with OAC + AP (RR: 1.70 [95% CI, 1.05–2.74]).Discussion: Secondary prevention with combination of oral anticoagulant and antiplatelet therapy after ischaemic stroke was associated with worse outcomes in our cohort.Conclusion: Further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischaemic stroke in patients with atrial fibrillation.
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- 2023
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5. Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study
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Paciaroni, Maurizio, Caso, Valeria, Agnelli, Giancarlo, Mosconi, Maria Giulia, Giustozzi, Michela, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Kriemler, Lilian, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Grory, Brian Mac, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Traballi, Laura, Urbini, Chiara, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Tsivgoulis, Georgios, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, and De Marchis, Gian Marco
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- 2022
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6. Left atrial reservoir strain during acute heart failure: A prospective cohort study.
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Bateau, J., Kraemer, J., Bertora, D., Baudouy, D., Bun, S.-S., Squara, F., Ferrari, E., and Moceri, P.
- Abstract
Acute heart failure is the most frequent reason for hospitalization in people over 65-years-old. The burden on public health justifies the development of tools relevant to diagnose and optimize its treatment. Left atrial reservoir peak strain (PALS) has shown an excellent correlation with left ventricular filling pressures (LVFP) measured invasively but its evolution during hospitalization for heart failure has never been studied. The aim of our study is to investigate the evolution of PALS in patients hospitalized for acute heart failure and its correlation with the usual clinical and biological ultrasound parameters. We included in this study 19 patients hospitalized for acute heart failure in the cardiology department of the Nice University Hospital. Clinical, biological and echocardiographic data were collected daily during the hospitalization. PALS was measured using the 4 chambers view (Tomtec 2D STRAIN, Unterschleissheim, Germany). Our results show that PALS is feasible and reproducible. The average PALS over the first two days was low, below 15% (threshold previously established as best correlated with increased LVFP) and exceeded this threshold by the third day of treatment. No correlation was found between PALS and other ultrasound parameters on admission or during the hospital course. PALS is the only ultrasound marker whose evolution is correlated to the evolution of BNP. The threshold of 12.5%, determined by a ROC curve, was the most discriminating for the prediction of clinically increased LVFP (AUC: 0.680). Using this threshold in the 68% of patients in the grey area of the E/E' ratio and the 41% of patients with low or indeterminate LVFP according to the current algorithm, we reduce the inaccuracy rate by respectively 5 and 20%. The results obtained in the determination of PALS on admission and during hospitalization are consistent with previous studies. In our study, PALS is an independent marker of clinically increased LVFP. PALS allowed to increase the sensitivity of echo to detect increased LVFP and remain useful throughout the acute heart failure hospitalization as it is correlated with BNP and could help monitoring the therapy efficacy. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Causes and Risk Factors of Cerebral Ischemic Events in Patients With Atrial Fibrillation Treated With Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention
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Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Silvestrelli, Giorgio, Seiffge, David Julian, Engelter, Stefan, De Marchis, Gian Marco, Polymeris, Alexandros, Zedde, Maria Luisa, Yaghi, Shadi, Michel, Patrik, Eskandari, Ashraf, Antonenko, Kateryna, Sohn, Sung-Il, Cappellari, Manuel, Tassinari, Tiziana, Tassi, Rossana, Masotti, Luca, Katsanos, Aristeidis H., Giannopoulos, Sotirios, Acciarresi, Monica, Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Pierini, Patrizia, Giustozzi, Michela, Lotti, Enrico Maria, Ntaios, George, Kargiotis, Odysseas, Monaco, Serena, Lochner, Piergiorgio, Bandini, Fabio, Liantinioti, Chrysoula, Palaiodimou, Lina, Abdul-Rahim, Azmil H., Lees, Kennedy, Mancuso, Michelangelo, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Galliazzo, Silvia, Ageno, Walter, Toso, Elisabetta, Angelini, Filippo, Chiti, Alberto, Orlandi, Giovanni, Denti, Licia, Flomin, Yuriy, Marcheselli, Simona, Mumoli, Nicola, Rimoldi, Alexandra, Verrengia, Elena, Schirinzi, Erika, Del Sette, Massimo, Papamichalis, Panagiotis, Komnos, Apostolos, Popovic, Nemanja, Zarkov, Marija, Rocco, Alessandro, Diomedi, Marina, Giorli, Elisa, Ciccone, Alfonso, Mac Grory, Brian C., Furie, Karen L., Bonetti, Bruno, Saia, Valentina, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Grifoni, Elisa, Padroni, Marina, Karagkiozi, Efstathia, Perlepe, Kalliopi, Makaritsis, Konstantinos, Mannino, Marina, Maccarrone, Miriam, Ulivi, Leonardo, Giannini, Nicola, Ferrari, Elena, Pezzini, Alessandro, Doronin, Boris, Volodina, Vera, Baldi, Antonio, D’Amore, Cataldo, Deleu, Dirk, Corea, Francesco, Putaala, Jukka, Santalucia, Paola, Nardi, Katiuscia, Risitano, Angela, Toni, Danilo, and Tsivgoulis, Georgios
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- 2019
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8. Italian women who did not intend to breastfeed: A descriptive study.
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Agnese Mauri, Paola, Soldi, Marta, Cortinovis, Ivan, Bertora, Francesca, and Guerrini Contini, Norma Nilde
- Abstract
The aim of this study is to identify some characteristics of women who, before having delivered their babies, decide not to breastfeed. To date there are no Italian studies trying to understand characteristics and reasons of mothers who do not want to breastfeed. In Italy at the time of discharge from hospitals 2-3% of women have already made the decision to inhibit the onset of lactation. In this descriptive study women suppressed their milk supply with some medication straight after delivery as they did not wish to breastfeed. One hundred and ninety-two mothers from a hospital in Northern Italy, taking Cabergoline 1 mg by mouth after delivery, were studied with Multiple Correspondence Analysis and Cluster Analysis. Variables analysed were taken from clinical records and by interviewing each woman once. Five clusters were found: each group describes a different profile of women who intended not to breastfeed. This study revealed that variables linked to the choice of inhibiting the onset of lactation are complex. Each woman is unique and some factors, which have emerged from clusters, can help health professionals to target appropriate interventions, as it is very important to counsel mothers about the best way of feeding newborns. [ABSTRACT FROM AUTHOR]
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- 2017
9. ULTRASOUND TRANSDUCERS.
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Lemoigne, Yves, Caner, Alessandra, Rahal, Ghita, and BERTORA, FRANCO
- Abstract
Ultrasound imaging modality has the major advantage, as compared to other medical imaging modes, to provide real-time acquisitions. It is a cheap modality compared to MRI and others, and it is non-invasive. One interest in using ultrasound imaging is to study the dynamic behaviour of various organs such as arteries, liver, heart. Today's scanners allow the visualization of the structures in gray scale images and the visualization of the flow information in color Doppler mode images. Both information can be acquired simultaneously. In this chapter we will present the basic principles leading to the design of probes. [ABSTRACT FROM AUTHOR]
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- 2007
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10. Highly Magneto-Responsive Elastomeric Films Created by a Two-Step Fabrication Process
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Marchi, Sophie, Casu, Alberto, Bertora, Franco, Athanassiou, Athanassia, and Fragouli, Despina
- Abstract
An innovative method for the preparation of elastomeric magnetic films with increased magneto-responsivity is presented. Polymeric films containing aligned magnetic microchains throughout their thickness are formed upon the magnetophoretic transport and assembly of microparticles during polymer curing. The obtained films are subsequently magnetized at a high magnetic field of 3 T directed parallel to the orientation of the microchains. We prove that the combination of both alignment of the particles along a favorable direction during curing and the subsequent magnetization of the solid films induces an impressive increase of the films’ deflection. Specifically, the displacements reach few millimeters, up to 85 times higher than those of the nontreated films with the same particle concentration. Such a process can improve the performance of the magnetic films without increasing the amount of magnetic fillers and, thus, without compromising the mechanical properties of the resulting composites. The proposed method can be used for the fabrication of magnetic films suitable as components in systems in which large displacements at relatively low magnetic fields are required, such as sensors and drug delivery or microfluidic systems, especially where remote control of valves is requested to achieve appropriate flow and mixing of liquids.
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- 2015
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11. Score for the targeting of atrial fibrillation (STAF): a new approach to the detection of atrial fibrillation in the secondary prevention of ischemic stroke.
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Suissa L, Bertora D, Lachaud S, Mahagne MH, Suissa, Laurent, Bertora, David, Lachaud, Sylvain, and Mahagne, Marie Hélène
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- 2009
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12. Ischemic stroke caused by giant cell arteritis associated with pulmonary adenocarcinoma.
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Scopelliti, Giuseppe, Bertora, Pierluigi, Bortolami, Cristina, Rosa, Silvia, and Pantoni, Leonardo
- Abstract
• Giant cell arteritis may manifest in patients with cancer. • Stroke caused by a vasculitic process requires a vigorous therapeutic approach. • In stroke patients with giant cell arteritis an uncovered neoplasm should be searched for. Giant cell arteritis (GCA) is the most common vasculitis in patients older than 50 years, and it is occasionally a cause of ischemic stroke. GCA as a paraneoplastic manifestation has been rarely described. We describe a 77-year-old man with a sudden onset of dizziness, vomiting, and gait disturbances. Following imaging studies, a diagnosis of bulbar ischemic stroke with left vertebral artery stenosis was made. Based on a history of polymyalgia rheumatica, on laboratory tests, and brain digital subtraction angiography, a diagnosis of GCA was advanced and the patient underwent high-dose steroidal therapy. After a total body 18-FGD PET imaging, a pulmonary adenocarcinoma was found. Vertebral artery involvement is a rare but important occurrence in GCA as it carries a high mortality rate, and may require a vigorous therapeutic approach. The association of lung cancer and GCA is infrequent, and the relationship between malignancy and GCA remains unclear. Whereas the search for a malignancy in the setting of a GCA is not routinely performed, the use of total body PET when a large vessel vasculitis is suspected may provide useful information on disease and help recognize occult neoplasms. [ABSTRACT FROM AUTHOR]
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- 2020
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13. Patent Foramen Ovale and Stroke in Intermediate-Risk Pulmonary Embolism
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Doyen, Denis, Castellani, Mathieu, Moceri, Pamela, Chiche, Olivier, Lazdunski, Rémi, Bertora, David, Cerboni, Pierre, Chaussade, Claire, and Ferrari, Emile
- Abstract
Patent foramen ovale (PFO) in pulmonary embolism (PE) is associated with an increased risk of complications. However, little is known about PFO and ischemic stroke prevalence, particularly in acute intermediate-risk PE. In addition, in this context, the so-called “gold standard” method of PFO diagnosis remains unknown. We aimed to evaluate PFO and ischemic stroke prevalence and determine which of transesophageal echocardiography (TEE) or transthoracic echocardiography (TTE) is the best PFO diagnostic method in this context.
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- 2014
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14. Transesophageal Ecocardiography: The Correct Intraoperative Way to Detect the Source of Peripheral Embolism in an Emergency
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Blangetti, Ilaria, Fenoglio, Lorena, Avallato, Carla, Bertora, Marco, Novali, Claudio, Peinetti, Flavio, and Locatelli, Alessandro
- Abstract
Arterial thromboembolism in patients with an unknown source of embolization is associated with significant morbidity and mortality. Once the acute process has been treated, a search of the offending embolic source must be conducted to prevent additional episodes. The most common sources of peripheral embolism include intracardiac thrombi (85%), thrombus within arterial aneurysm, thrombus overlying complex atherosclerotic plaques, and paradoxical embolization from deep venous thrombus. A strong association has been shown between protruding, noncalcified plaques 4 cm in the aorta detected by transesophageal echocardiography and the risk of embolism. Moreover, as many as 25–50% of protruding plaques may have superimposed mobile thrombi ranging from one to several centimeters, and this imparts a high embolic risk. The formation of thrombi in morphologically normal aorta is a rare event. We report a case of peripheral embolization in a young man caused by a thrombus in the descending aorta detected by transesophageal echocardiography.
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- 2013
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15. A New Modifier for Silica in Reinforcing SBR Elastomers for the Tyre Industry
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Bertora, Alessandro, Castellano, Maila, Marsano, Enrico, Alessi, Matteo, Conzatti, Lucia, Stagnaro, Paola, Colucci, Giovanna, Priola, Aldo, and Turturro, Antonio
- Abstract
A new alkoxysilane was used to reduce the hydrophilic character of the silica used in reinforcing styrene/butadiene elastomers for the tyre industry. The surface properties of silica modified with 17 wt.‐% of this silane were estimated by inverse GC. A clear change from hydrophilic to hydrophobic character was observed. Styrene/butadiene copolymers loaded with modified silicas were characterized were characterized using vulcanization tests, stress/strain measurements and morphological analysis. The best tensile properties were obtained with TESPT‐modified silica. The properties of the compound loaded with sb1‐pre‐grafted silica are scantily lower that the ones of the other compounds. This difference must be ascribed to a higher crosslink density given by the sulfur deriving from the TESPT decomposition during the vulcanization process.
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- 2011
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16. Nitrous Oxide and Carbon Dioxide Emissions Following Green Manure and Compost Fertilization in Corn
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Alluvione, Francesco, Bertora, Chiara, Zavattaro, Laura, and Grignani, Carlo
- Abstract
Alternative N fertilizers that stimulate low greenhouse gas emissions from soil are needed to reduce the impact of agriculture on global warming. Corn (Zea maysL.) grown in a calcareous silt loam soil in northwestern Italy was fertilized with a municipal solid waste compost and vetch (Vicia villosaRoth.) green manure. Their potential to reduce N2O and CO2emissions was compared with that of urea (130 kg N ha−1). Gaseous fluxes were measured for 2 yr in the spring (after soil incorporation of fertilizers) and in summer. In spring, the slow mineralization of compost reduced N2O emissions (0.11% of supplied N) relative to urea (3.4% of applied N), without an increase in CO2fluxes. Nitrous oxide (2.31% of fixed N) and CO2emissions from rapid vetch decomposition did not differ from urea. When N2O and CO2fluxes were combined, compost reduced by 49% the CO2equivalent emitted following urea application. Vetch did not show such an effect. In summer, no fertilizer effect was found on N2O and CO2emissions. Compost proved to be potentially suitable to reduce the CO2equivalent emitted after soil incorporation while vetch did not. For a thorough evaluation, net greenhouse gas emissions assessment should be extended to the entire N life cycle. Differences between calculated N2O emission factors and the default Tier 1 value of the Intergovernmental Panel on Climate Change (1%) confirmed the need for site‐ and fertilizer‐specific estimations.
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- 2010
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17. Left ventricular non-compaction associated with Wolff-Parkinson-White syndrome: Echo, contrast-echo and cardiovascular magnetic-resonance data.
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Moceri, Pamela, Bertora, David, Cerboni, Pierre, and Gibelin, Pierre
- Published
- 2008
- Full Text
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18. Interaction of Selected Vasodilating βBlockers with Adrenergic Receptors in Human Cardiovascular Tissues
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Monopoli, A., Forlani, A., Bevilacqua, M., Vago, T., Norbiato, G., Bertora, P., Biglioli, P., Alamanni, F., and Ongini, E.
- Abstract
β- And α1-adrenoceptor antagonist properties of bufuralol, carvedilol, celiprolol, dilevalol, labetalol, and pindolol were investigated in human myocardium and mammary artery using binding techniques and functional studies. In myocardial membranes, β-adrenoceptor antagonists showed monophasic competition isotherms for [l25I]pindolol binding with high affinity (Kifrom 1–100 nM), except for celiprolol which displayed a bi-phasic competition isotherm (pKi= 6.4 ± 0.06 for prand 4.8 ± 0.07 for β2-adrenoceptors). Drug interactions with α1-adrenoceptors were evaluated in human mammary artery by [3H]prazosin binding and by measuring contractile responses to norepinephrine (NE). Labetalol and carvedilol showed a moderate affinity for a,-adreno-ceptors (pKi = 6.2 ± 0.01 and 6.1 ± 0.06, respectively), and inhibited NE-induced contractions (pA2= 6.93 ± 0.23 and 8.64 ± 0.24, respectively). Dilevalol, bufuralol, and pindolol displayed weak effect both in binding (Kiin micromolar range) and functional experiments (pA2= 5.98, 5.54, and 6.23, respectively). Celiprolol did not show antagonist properties up to 100 μ.Min functional studies, but displayed a slight affinity for a,-adrenoceptors in binding studies. The data indicate that the vasodilating activity of these p-adrenoceptor antagonists is caused in some instances by an α1adrenoceptor antagonism (labetalol, carvedilol), whereas for the others alternative mechanisms should be considered.
- Published
- 1989
19. Prevalence of subclinical neuropathy in diabetic patients: assessment by study of conduction velocity distribution within motor and sensory nerve fibres
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Bertora, P., Valla, Pierluigi, Dezuanni, Elisabetta, Osio, Maurizio, Mantica, Davide, Bevilacqua, Maurizio, Norbiato, Guido, Caccia, Mario Riccardo, and Mangoni, Alfonso
- Abstract
Abstract: Nerve conduction velocity distribution (CVD) study is a newly-developed electrodiagnostic method for detecting alterations in the composition of nerve fibres according to their conduction velocity. The presence of subclinical neuropathy was evaluated in 138 diabetic patients by CVD study of four motor nerves (external popliteal and ulnar nerves bilaterally) and two sensory nerves (median nerve bilaterally), and the data obtained were compared with standard electrophysiological parameters in the same nerve segments. CVD studies revealed an altered distribution pattern in 106 of 129 evaluable patients for motor nerves (82%) and in 67 of 115 evaluable patients for sensory nerves (58%), while standard examination gave abnormal findings in 92 of 137 patients (67%) and in 33 of 118 patients (11%), respectively. Of the patients adequately evaluated by both techniques, 21 of 129 patients (16%) revealed altered CVD data unaccompanied by slowing of maximum nerve conduction velocity, and 37 patients of 101 (37%) showed similar findings for sensory nerves. Subclinical alterations of motor and sensory nerve CVD were not significantly related to age or to metabolic control expressed as glycated haemoglobin levels; a significantly longer duration of disease was found in patients with motor and mixed subclinical neuropathy with respect to non-neuropathic patients. The CVD study allowed us to detect subclinical abnormalities of motor and sensory nerve fibres; often this is a more sensitive method than the standard electrodiagnostic study. This method can be very useful as a diagnostic tool and in research in the study of the progression of diabetic neuropathy.
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- 1998
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20. βAdrenergic Receptors and Reflex Tachycardia After Single and Repeated Felodipine Administration in Essential Hypertension
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Savonitto, Stefano, Bevilacqua, Maurizio, Chebat, Enrica, Vago, Tarcisio, Bertora, Pierluigi, Baldi, Gabriella, Renesto, Elio, Peruzzi, Elena, Sardina, Marco, and Norbiato, Guido
- Abstract
To verify the possible contribution of β-adrenergic receptor down-regulation to the reversal of reflex tachycardia during chronic treatment with a dihydropyridine calcium antagonist. 11 hypertensive patients were studied with noninvasive blood pressure (BP) and heart rate (HR) monitoring after a placebo period, and on the first and seventh day of felodipine administration. 5 mg twice daily. Plasma catecholamines and neutrophil β-adrenergic receptors were measured on the first and seventh day of treatment, immediately before and 2 h after drug administration. The first administration of felodipine was followed by a significant drop in BP (peakreduction in mean BP 24 $$ 7 mm Hg). lasting 6 h and mirrored by reflex tachycardia (peak increase in HR 14 $$ 9 beats/min). On the mornin go the seventh day. 12 gafter the previous felodipine administration, mean BP (MBP) was 16 mm Hg lower than on the last placebo day. while HR was unchanged. The next administration of felodipine was followed by a smaller drop in BP (MBP – 15 $$ 7 mm Hg; NS vs. placebo), while reflex tachycardia was the same as after acute felodipine (HR 13 $$ 8 beats/min; p < 0.05 vs. placebo. NS vs. acute administration). Plasma noradrenaline concentration increased after both acute and chronic administration (p < 0.0001), and preadministration values were highest on day 7 (p < 0.05). Neutrophil β-adrenergic receptor density and affinity did not change either acutely or chronically. This study gives both indirect and direct evidence that β-adrenoceptor down-regulation does not occur during repeated felodipine administration in hypertension. Reflex tachycardia is not abolished, but is reset to lower BP levels
- Published
- 1991
21. Cortical Responses of Vestibular Reactions Measured by Topographic Brain Mapping and Vestibular Evoked Potentials
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Bertora, Guillermo and Bergmann, Julia
- Abstract
With the brain electrical activity mapping. we started to create typical patterns of potentials distributions on the scalp during various neurootological experiments. We are applying this technique for spatiotemporal analysis of cerebral evoked potentials due to vestibular stimulation. We obtain the vestibular evoked potentials (VbEP) using for the stimulation, the rotatory chair. We control it, with an external computer. that by means of an interactive program builds different sort of stimuli varying each one of the stimulus components. The electrodes are distributed on the scalp in agreement with the international system 10/20. We recognize with security, 4 positive-negative waves in a period among 70 to 490 ms. We designate the waves N1, N2, P2, N3 and N4. Vestibular evoked potentials is a newly developed tool, which we also can utilize for differentiating central and peripheral vestibular diseases.
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- 1995
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22. Score for the Targeting of Atrial Fibrillation (STAF)
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Suissa, Laurent, Bertora, David, Lachaud, Sylvain, and Mahagne, Marie Hélène
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The high risk of recurrence and comorbidity after a stroke associated with atrial fibrillation (AF) justifies an aggressive diagnostic approach so that anticoagulant treatment can be initiated.
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- 2009
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23. 111 “New” echocardiographic isovolumetric parameters combined with standard parameters for the assessment of left ventricular filling pressures.
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Tho, Aurélia, Moceri, Pamela, Bertora, David, Scarlatti, Didier, Camous, Jean-Pierre, and Gibelin, Pierre
- Abstract
Left ventricular filling pressures’ evaluation is still challenging. The ratio of the transmitral and myocardial early diastolic velocities (E/E’) can be used to estimate LV filling pressures (LVFP), but between 8 and 15 it remains unclear. Additionally, the time difference between the onset of E and E’ (Δ (RE-E’)), the time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity (Δ (IVRT-IVRT’)) and the mitral early diastolic velocity (E)/Strain rate ratio during the isovolumetric relaxation period also correlate to LVFP. The aim of this study was to evaluate the incremental value of those indices to evaluate LVFP (as measured by left ventricular end diastolic pressure (LVEDP)) in a heterogeneous group of patients during a simultaneous invasive procedure. Simultaneous cardiac catheterization, BNP dosage and doppler echocardiography were performed in 30 patients. LVEDP was elevated (>16mm Hg) in 14 patients (46,7%). The 3 previously described “new” parameters are significantly correlated to LVEDP, but particularly highly significant correlation was found between Δ (IVRT-IVRT’) and LVEDP (r=−0,74, p<0,005). ROC curves predict a 80% sensibility and specificity of Δ (IVRT-IVRT’). Δ (RE-E’) sensibility and specificity at lateral site are 87% and 93% respectively. E/SRivr has a 71% sensibility and a specificity. The incremental diagnostic value of each parameter and BNP in combination with “classic” parameters (E/A, E/E’) was evaluated by kappa coefficient. Δ (IVRT-IVRT’) at septal site (k=0,777) and Δ (RE-E’) (k=0,73) are the most accurate parameters, whereas additional use of E/SRivr (k=0,41) isn’t more useful than “classic” echocardiographic strategy (k=0,478) such as BNP (k=0,533). Δ (IVRT-IVRT’) and Δ (RE-E’) can predict LV filling pressures with reasonable accuracy. [Copyright &y& Elsevier]
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- 2011
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24. 130 Interest of tricuspid annular displacement “TAD” in evaluation of right ventricular ejection fraction.
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Hugues, Thomas, Ducreux, Dorothée, Bertora, David, Lemoigne, Franck, Berthier, Frederic, and Gibelin, Pierre
- Abstract
The ultrasound assessment of right ventricular (RV) function is often sub-optimal. The range of excursions of the mitral or tricuspid annulus measured in mm by 2D or TM mode echocardiography has been shown to reflect the systolic function of both ventricles. Methods: We studied a new technique based on a tissue tracking algorithm that is ultrasound beam angle independent for automated detection of tricuspid annular displacement (TAD) (QLAB, Philips Medical Imaging). Twenty six patients (pts) with pulmonary arterial hypertension (n= 13), heart failure (n= 9), valvulopathy (n= 3) or myocarditis (n= 1) were reffered for magnetic resonance imaging (MRI) and underwent a complete transthoracic echocardiography (TTE). MRI was performed on a 1.5 T MR scanner. MRI RV ejection fraction (RVEF) was correlated by linear regression with TAD, peak systolic tricuspid annular velocity (Sa) and RV fractional area change (FAC). Sixteen pts (61.5%) exhibited right ventricular systolic dysfunction (RVEF < 40%). TTE was performed in 44 healthy subjects in order to assess normal TAD value. Results: In the pts group, MRI RVEF was positively correlated with TAD (R
2 = 0,65; p< 0,0001), Sa (R2 = 0,56; p< 0,0001) and FAC (R2 = 0,39 p=0,0025). The strongest relation was observed with TAD. A value of TAD< 14 mm predicted right ventricular dysfunction with a sensitivity of 87.5% and a specificity of 90%. Most of (90%) healthy subjects exhibited TAD values exceeding this cut-off point (mean 16,9 +/- 1,64 mm, range 13,3 to 24,8 mm). Negative correlation was found between TAD and age (R2 =0,36 ; p<0,0001). Limitations: The echocardiographic and MRI parameters were not obtained simultaneously but at an interval of 24 hours. Our study is the first to correlate TAD with MRI RVEF. We conclude that TAD provides a simple, rapid, and non-invasive tool for assessing right ventricular systolic function. [Copyright &y& Elsevier]- Published
- 2010
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25. 144 Real-time three-dimensional echocardiography assessment of left ventricular function: left ventricular volumes underestimation increase with the dilatation degree.
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Moceri, Pamela, Bertora, David, Camous, Jean-Pierre, and Gibelin, Pierre
- Abstract
Aims: Accurate quantification of left ventricular (LV) volumes and ejection fraction (EF) is important, especially in heart failure patients. Cardiac magnetic resonance imaging (MRI) is considered as the reference and then we sought to compare three-dimensional echocardiography (3DE) for LV volumes and EF estimation, relative to MRI in heart failure patients. Methods: We studied 24 patients (17 men, age 58±15 years) with history of heart failure who underwent 3DE (Full volume real-time 3DE – iE33 (Philips Medical system) QLAB workstation) and MRI in a 48-hour delay. No patient was excluded from the study due to poor image quality. Results/Discussion: The heart failure etiology was: 41,7% (n=10) ischemic cardiomyopathy, 50% (n=12) dilated idiopathic cardiomyopathy and 8,3% (n=2) of patients suffered from heart failure with preserved EF. Mean LV end-diastolic volume (LVEDV) evaluated by MRI was 208±108mL (121±64 mL/m
2 ), mean EF 31±13% and mean LV end-systolic volume (LVESV) was 149±97 mL. 3DE data sets highly correlated with MRI, especially concerning EF (r : 0.86, 0.88, and 0.96 for LVEDV, LVESV, and EF, respectively) with small biases (-55 mL, -44 mL, 1,1%) and acceptable limits of agreement, but LV volumes are significantly underestimated by 3DE particularly in our patients with severe LV dysfunction, and 3DE data sets do not correlate as well as expected. We then determined that with a LVEDV below 120 mL/m2 , 3D was more accurate for volumes and EF evaluation. The degree of underestimation of LV volumes is significatively correlated with the LV dilatation degree (r=0,60 p=0,01). Conclusion: Compared with MRI, 3DE is a good method to evaluate LVEF, but 3DE appears to underestimate significantly LV volumes, with the problem of foreshortened apical views in heart failure patients. As the LVEDV increase, 3D accuracy simultaneously decrease. [Copyright &y& Elsevier]- Published
- 2010
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26. P1-177: Total folate levels in Alzheimer disease and other forms of degenerative cognitive decline.
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Lovati, Carlo, Bertora, Pierluigi, Galimberti, Daniela, Suardelli, Massimo, Mailland, Enrico, Rosa, Silvia, Capiluppi, Elisa, Vanotti, Alessandra, Pomati, Simone, and Mariani, Claudio
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- 2006
- Full Text
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27. P1-177: Total folate levels in Alzheimer disease and other forms of degenerative cognitive decline.
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Lovati, Carlo, Bertora, Pierluigi, Galimberti, Daniela, Suardelli, Massimo, Mailland, Enrico, Rosa, Silvia, Capiluppi, Elisa, Vanotti, Alessandra, Pomati, Simone, and Mariani, Claudio
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- 2006
- Full Text
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28. Response to Letter by Stahrenberg et al
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Suissa, Laurent, Bertora, David, Lachaud, Sylvain, and Mahagne, Marie Hélène
- Published
- 2010
- Full Text
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29. Carotid Endarterectomy and Cognitive Functions
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Pomati, Simone, Suardelli, Massimo, Bertora, Pierluigi, Pisacreta, Massimo, Di Maio, Stefania, Osio, Maurizio, Porretta, Tiziano, Pelucchi, Angelo, Bortolami, Cristina, Brambilla, Ari-anna, Borgo, Francesca M., Louati, Carlo, and Mariani, Claudio
- Published
- 2006
30. A Dedicated MRI Apparatus for Medical and Industrial Applications
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Bertora, F., Biglieri, E., Borgia, G. C., and Fantazzini, P.
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- 1994
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31. Special Purpose MRI Equipment for Medical and Industrial Applications
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Bertora, F. E. and Abele, M. G.
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- 1992
- Full Text
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