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2 results on '"Blum, Bethania"'

1. Drug-Drug Interaction Study of Benznidazole and E1224 in Healthy Male Volunteers

Author

Ribeiro, Isabela, Blum, Bethania, Fernandes, Jayme, Santina, Glaucia, Asada, Makoto, Everson, Michael, Schuck, Edgar, Feleder, Ethel, Evene, Eric, and Gualano, Virginie

Abstract

E1224 is a prodrug of ravuconazole (RVZ), an antifungal drug with promising anti-Trypanosoma cruziactivity, the causative organism of Chagas disease (CD). This study was designed to assess the pharmacokinetics (PK) and safety interactions of benznidazole (BNZ), the drug of choice for treatment of CD, and E1224 in healthy volunteers.

Published
2021
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2. Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment

Author

Galindo Bedor, Danilo César, Tavares Cavalcanti Bedor, Noely Camila, Viturino da Silva, José Wellithom, Damasceno Sousa, Giovana, Pereira de Santana, Davi, Garcia-Bournissen, Facundo, Altcheh, Jaime, Blum, Bethania, Alves, Fabiana, and Ribeiro, Isabela

Abstract

Chagas disease (CD) is recognized as one of the major neglected global tropical diseases. Benznidazole (BNZ) is the drug of choice for the treatment of adults, young infants, and newborns with CD.

Published
2018
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