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ObjectiveA number of studies have demonstrated the anti-aggressive properties of clozapine in schizophrenia and its positive effect in borderline personality disorder. There is no published literature on the treatment of antisocial personality disorder (ASPD) with clozapine. We present a case series of 7 patients with primary ASPD and high psychopathic traits treated with clozapine, having a significant history of serious violence and currently detained in a UK based high-security hospital.MethodsA retrospective review of case notes was carried out to formulate Clinical Global Impression (CGI) scores and record incidents of violence and aggression. Effect on specific symptom domains (cognitive-perceptual, impulsive-behavioural dyscontrol, affective dysregulation) was also noted. Metabolic parameters and serum clozapine levels were also sampled.ResultsAll 7 patients showed significant improvement on clozapine. It was shown to benefit all symptom domains, especially impulsive behavioral dyscontrol and anger. The number of violent incidents committed by 6 of the 7 patients reduced significantly, and all patients’ risk of violence reduced. Clozapine serum levels for 6 of the 7 patients were in the range 150–350 ng/mL.ConclusionClozapine is of benefit in reducing the clinical severity of ASPD. It improved all symptom domains, especially impulsive-behavioral dyscontrol and anger, and reduced levels of aggression and violence, especially at lower doses (serum levels <350 ng/m). To our knowledge, this is the first account of clozapine treatment in patients with ASPD and high psychopathy.

Presents a collection of activities, literature suggestions and reproducibles about ponds. How to capture students' interest in ponds; Comparison between a pond and an ocean or another body of water.

Presents some character building activities which focuses on ways to understand citizenship and promoting its importance in our country and the world. Description of a citizen; Reference to citizens in the United States; Information on a writing activity for creating a citizen journal; How a teacher can expand a students' understanding of citizens an citizenship in the community; Reference to the book `It Takes A Village.'

Presents a collection of activities on science experiments. Description of the activities; Identification of equipment needed; Results of the experiments.

Presents activities for children to encourage them to make trustworthy decisions. Activities including `What Would You Do?' `Honesty Acrostic Poems' and `As Honest as George Washington!'; Materials needed; Method for each activity.

Presents various activities based on pumpkins for elementary students. Using the growth cycle of pumpkins in teaching; Recommended literature for students.

Focuses on how respect can be incorporated in children's learning activities. Introduction of the meaning of respect; Promotion of student dignity and self-respect; How to help students understand that showing respect is the first step towards practicing it.

Offers creative character-building activities to give students a clear picture of responsibility, for use by primary teachers in their classrooms. Details on each activity. INSET: Books about responsiblity.

Presents a selection of activities for children to assist with character development. Information on the chain of caring program; Instruction for the receipt for a caring student program; How to make the caring crown.

Presents an art activity for children published in the June/July 2004 issue of "The Mailbox."