Search

The Yahuarcaca lake system in Leticia, Amazonas, Colombia has been affected by a socio-environmental conflict due to overexploitation of fishing resources and changes in the management of the floodable forest and lakes linked to the Yahuarcaca stream. In 2003, a knowledge-sharing dialogue was initiated between traditional ecological indigenous people and scientists to find solutions to the problem. This research aims to demonstrate how the La Tika organization serves as an environmental and territorial governance strategy for the Tikuna, Kokama, and Yagua indigenous communities. Through community and co-management of common-use fishing resources with state institutions such as the National Aquaculture and Fishing Authority (AUNAP), the organization has positively impacted the aquatic ecosystem and social welfare. The study is based on the Social-Ecological Systems (SES) and the Institutional Analysis and Development (IAD) framework by Elinor Ostrom and traditional knowledge of Fikret Berkes. As a result, the indigenous fishermen's organization was established and recognized nationally for its role in environmental governance and its impact on territorial identity, marking a significant milestone in the Colombian Amazon. [ABSTRACT FROM AUTHOR]

Reading is linked to numerous positive outcomes, including academic achievement, reduced stress, and enhanced life expectancy. However, a significant portion of Chilean adolescents engage in limited reading. Notably, male students tend to exhibit lower levels of reading motivation compared to their female counterparts, with declining reading self‐concept over time. To address this challenge, this study explores the impact of a 9‐month‐long pilot reading program aimed at increasing students' reading motivation and volume in an all‐boys rural school in southern Chile (N= 120), guided by Self‐Determination Theory and adapted from Atwell's reading workshop. The program included four pillars: access to high‐interest print books, 90 min per week of in‐class independent choice, and peer interactions around reading. t‐Tests showed a significant increase in students' reading volume but not in their reading motivation. Nevertheless, multiple regression analyses revealed that, when controlling for students' pre‐program reading motivation, achievement, and volume, post‐program reading motivation and time allocated for independent reading were significantly associated with the number of pages read during the program. Implications for practice and future research avenues are discussed.

The intensification of global governance activities in the area of international taxation has raised the question of the democratic legitimacy of the process since decisions in multilateral institutions are typically made by members of the executive alone and predominantly those from developed countries. There are opportunities to influence discussions at the global level for non-state actors, but the capacity to do so is unequally distributed. Yet, the results of global standard-setting processes need to be implemented domestically which affords opportunities for a wider range of constituencies to influence the outcome, among them elected parliamentarians, businesses, and local civil society. On the one hand, this two-stage process mitigates the lack of inclusiveness in global governance; on the other hand, it may jeopardize the effectiveness of global standards in achieving harmonization.In practice, opportunities for stakeholders to influence the implementation process and the interest to actually do so vary across countries. The purpose of this article is to chart this variation and discuss what it means for the global governance process. This is sourced from interviews on the implementation of the BEPS project’s standards with different tax policy stakeholders in Australia, Colombia, India, Mexico, the Netherlands, Nigeria, Senegal and Spain. With this data it is identified which non-governmental constituencies exist in each country, what are their interest vis-à-vis different elements of the BEPS Project, and what means they have at their disposal to influence the implementation process.The findings indicate variation across countries regarding the direction in which governmental and non-governmental stakeholders try to influence the outcomes as well as regarding their opportunities to effectively influence implementation processes. This entails that the level of implication of stakeholders will be context-dependent and so will be the answer to the question on whether the participation in the implementation process can ‘compensate’ for a lack of participation in standard setting processes.

The intensification of global governance activities in the area of international taxation has raised the question of the democratic legitimacy of the process since decisions in multilateral institutions are typically made by members of the executive alone and predominantly those from developed countries. There are opportunities to influence discussions at the global level for non-state actors, but the capacity to do so is unequally distributed. Yet, the results of global standard-setting processes need to be implemented domestically which affords opportunities for a wider range of constituencies to influence the outcome, among them elected parliamentarians, businesses, and local civil society. On the one hand, this two-stage process mitigates the lack of inclusiveness in global governance; on the other hand, it may jeopardize the effectiveness of global standards in achieving harmonization.In practice, opportunities for stakeholders to influence the implementation process and the interest to actually do so vary across countries. The purpose of this article is to chart this variation and discuss what it means for the global governance process. This is sourced from interviews on the implementation of the BEPS project’s standards with different tax policy stakeholders in Australia, Colombia, India, Mexico, the Netherlands, Nigeria, Senegal and Spain. With this data it is identified which non-governmental constituencies exist in each country, what are their interest vis-à-vis different elements of the BEPS Project, and what means they have at their disposal to influence the implementation process.The findings indicate variation across countries regarding the direction in which governmental and non-governmental stakeholders try to influence the outcomes as well as regarding their opportunities to effectively influence implementation processes. This entails that the level of implication of stakeholders will be context-dependent and so will be the answer to the question on whether the participation in the implementation process can ‘compensate’ for a lack of participation in standard setting processes.

The intensification of global governance activities in the area of international taxation has raised the question of the democratic legitimacy of the process since decisions in multilateral institutions are typically made by members of the executive alone and predominantly those from developed countries. There are opportunities to influence discussions at the global level for non-state actors, but the capacity to do so is unequally distributed. Yet, the results of global standard-setting processes need to be implemented domestically which affords opportunities for a wider range of constituencies to influence the outcome, among them elected parliamentarians, businesses, and local civil society. On the one hand, this two-stage process mitigates the lack of inclusiveness in global governance; on the other hand, it may jeopardize the effectiveness of global standards in achieving harmonization.In practice, opportunities for stakeholders to influence the implementation process and the interest to actually do so vary across countries. The purpose of this article is to chart this variation and discuss what it means for the global governance process. This is sourced from interviews on the implementation of the BEPS project’s standards with different tax policy stakeholders in Australia, Colombia, India, Mexico, the Netherlands, Nigeria, Senegal and Spain. With this data it is identified which non-governmental constituencies exist in each country, what are their interest vis-à-vis different elements of the BEPS Project, and what means they have at their disposal to influence the implementation process.The findings indicate variation across countries regarding the direction in which governmental and non-governmental stakeholders try to influence the outcomes as well as regarding their opportunities to effectively influence implementation processes. This entails that the level of implication of stakeholders will be context-dependent and so will be the answer to the question on whether the participation in the implementation process can ‘compensate’ for a lack of participation in standard setting processes.

The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1–9. Deep learning approaches have aided in exploring chemical spaces1,10–15; these typically use black box models and do not provide chemical insights. Here we reasoned that the chemical substructures associated with antibiotic activity learned by neural network models can be identified and used to predict structural classes of antibiotics. We tested this hypothesis by developing an explainable, substructure-based approach for the efficient, deep learning-guided exploration of chemical spaces. We determined the antibiotic activities and human cell cytotoxicity profiles of 39,312 compounds and applied ensembles of graph neural networks to predict antibiotic activity and cytotoxicity for 12,076,365 compounds. Using explainable graph algorithms, we identified substructure-based rationales for compounds with high predicted antibiotic activity and low predicted cytotoxicity. We empirically tested 283 compounds and found that compounds exhibiting antibiotic activity against Staphylococcus aureuswere enriched in putative structural classes arising from rationales. Of these structural classes of compounds, one is selective against methicillin-resistant S. aureus(MRSA) and vancomycin-resistant enterococci, evades substantial resistance, and reduces bacterial titres in mouse models of MRSA skin and systemic thigh infection. Our approach enables the deep learning-guided discovery of structural classes of antibiotics and demonstrates that machine learning models in drug discovery can be explainable, providing insights into the chemical substructures that underlie selective antibiotic activity.

ABSTRACTArts-based peacebuilding has gained attention, but evidence and research of its impact is fragmented and, in particular, the relationship between photography and peace is underexplored. This article examines photovoice as a tool for supporting everyday and community peace in conflict-affected communities. It identifies four ways that everyday peace indicator photovoice projects in Colombia bolstered community peace: by engendering healing, building territorial identity, enabling intergenerational dialogue, and catalysing action. These impacts emerged as photovoice built on enabling factors, extending existing community peacebuilding capacities, concerns and interventions. Reflecting on the constraints and tensions around working with photography in security-sensitive environments, we propose that participatory photography makes up a vital component of the peace photography genre. We argue that the careful, strategic harnessing of photovoice, and the visualisation of everyday peace, creates opportunities for raising the voices of conflict-affected communities, building shared imaginaries and nurturing dialogue, healing and action.

Mounting effective immunity against pathogens and tumours relies on the successful metabolic programming of T cells by extracellular fatty acids1–3. Fatty-acid-binding protein 5 (FABP5) has a key role in this process by coordinating the efficient import and trafficking of lipids that fuel mitochondrial respiration to sustain the bioenergetic requirements of protective CD8+T cells4,5. However, the mechanisms that govern this immunometabolic axis remain unexplored. Here we report that the cytoskeletal organizer transgelin 2 (TAGLN2) is necessary for optimal fatty acid uptake, mitochondrial respiration and anticancer function in CD8+T cells. TAGLN2 interacts with FABP5 to facilitate its cell surface localization and function in activated CD8+T cells. Analyses of ovarian cancer specimens revealed that endoplasmic reticulum (ER) stress responses induced by the tumour microenvironment repress TAGLN2 in infiltrating CD8+T cells, thereby enforcing their dysfunctional state. Restoring TAGLN2 expression in ER-stressed CD8+T cells increased their lipid uptake, mitochondrial respiration and cytotoxic capacity. Accordingly, chimeric antigen receptor T cells overexpressing TAGLN2 bypassed the detrimental effects of tumour-induced ER stress and demonstrated therapeutic efficacy in mice with metastatic ovarian cancer. Our study establishes the role of cytoskeletal TAGLN2 in T cell lipid metabolism and highlights the potential to enhance cellular immunotherapy in solid malignancies by preserving the TAGLN2–FABP5 axis.

TCF1highprogenitor CD8+T cells mediate the efficacy of immunotherapy; however, the mechanisms that govern their generation and maintenance are poorly understood. Here, we show that targeting glycolysis through deletion of pyruvate kinase muscle 2 (PKM2) results in elevated pentose phosphate pathway (PPP) activity, leading to enrichment of a TCF1highprogenitor-exhausted-like phenotype and increased responsiveness to PD-1 blockade in vivo. PKM2KOCD8+T cells showed reduced glycolytic flux, accumulation of glycolytic intermediates and PPP metabolites and increased PPP cycling as determined by 1,2-13C glucose carbon tracing. Small molecule agonism of the PPP without acute glycolytic impairment skewed CD8+T cells toward a TCF1highpopulation, generated a unique transcriptional landscape and adoptive transfer of agonist-treated CD8+T cells enhanced tumor control in mice in combination with PD-1 blockade and promoted tumor killing in patient-derived tumor organoids. Our study demonstrates a new metabolic reprogramming that contributes to a progenitor-like T cell state promoting immunotherapy efficacy.

We provide updated diagnoses for the senex-, burtoni-and dimorphus-groups of Camponotus(Myrmobrachys). Dichotomous keys for the C.(Myrmobrachys) groups and species of the dimorphus-group, based on type-specimens are provided. Two new species of the dimorphus-group are described, Camponotus cameloidessp. nov. and Camponotus hyalussp. nov. We classified C. dolabratusand C. lanciferas members of the dimorphus-group and C. crassicornis, C. subcircularis, and C. championias members of the senex-group. Scanning Electron Microscopy was used to describe the branched pilosity of C. cameloidesand this is the first description of it for adult workers of Camponotini tribe.

The recent inference of sulfur dioxide (SO2) in the atmosphere of the hot (approximately 1,100 K), Saturn-mass exoplanet WASP-39b from near-infrared JWST observations1–3suggests that photochemistry is a key process in high-temperature exoplanet atmospheres4. This is because of the low (<1 ppb) abundance of SO2under thermochemical equilibrium compared with that produced from the photochemistry of H2O and H2S (1–10 ppm)4–9. However, the SO2inference was made from a single, small molecular feature in the transmission spectrum of WASP-39b at 4.05 μm and, therefore, the detection of other SO2absorption bands at different wavelengths is needed to better constrain the SO2abundance. Here we report the detection of SO2spectral features at 7.7 and 8.5 μm in the 5–12-μm transmission spectrum of WASP-39b measured by the JWST Mid-Infrared Instrument (MIRI) Low Resolution Spectrometer (LRS)10. Our observations suggest an abundance of SO2of 0.5–25 ppm (1σrange), consistent with previous findings4. As well as SO2, we find broad water-vapour absorption features, as well as an unexplained decrease in the transit depth at wavelengths longer than 10 μm. Fitting the spectrum with a grid of atmospheric forward models, we derive an atmospheric heavy-element content (metallicity) for WASP-39b of approximately 7.1–8.0 times solar and demonstrate that photochemistry shapes the spectra of WASP-39b across a broad wavelength range.

OSA has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored.

This study estimates job creation from Costa Rica's transition to net-zero emissions by 2050, contrasting it with a business-as-usual scenario (BAU) using employment multipliers from Costa Rica’s input–output matrix. The model is soft-linked with a bottom-up technology‒rich regional model of the CLEW sectors in Costa Rica. A robust decision-making-inspired approach is taken to assess the effects of uncertainty on the estimations. The study addresses a literature gap in modeling subnational employment while accounting for long-term uncertainty and allows to identify economic activities affected by the transformation, so that policies regarding a just transition can be properly developed and stakeholders incentivized to take active participation in the process. Under baseline assumptions, a net-zero economy would have 135 thousand more jobs by 2050 than the BAU, equivalent to 7% of the employed population in 2017. Energy-related jobs would triple by mid-21st century, and regions capitalizing on renewables would perceive the highest gain. When considering uncertainty, the net jobs range between 35‒750 thousand. Since net positive outcomes in terms of jobs are feasible, global governance should focus efforts on policies that enhance these.

Planets with radii between that of the Earth and Neptune (hereafter referred to as ‘sub-Neptunes’) are found in close-in orbits around more than half of all Sun-like stars1,2. However, their composition, formation and evolution remain poorly understood3. The study of multiplanetary systems offers an opportunity to investigate the outcomes of planet formation and evolution while controlling for initial conditions and environment. Those in resonance (with their orbital periods related by a ratio of small integers) are particularly valuable because they imply a system architecture practically unchanged since its birth. Here we present the observations of six transiting planets around the bright nearby star HD 110067. We find that the planets follow a chain of resonant orbits. A dynamical study of the innermost planet triplet allowed the prediction and later confirmation of the orbits of the rest of the planets in the system. The six planets are found to be sub-Neptunes with radii ranging from 1.94R⊕to 2.85R⊕. Three of the planets have measured masses, yielding low bulk densities that suggest the presence of large hydrogen-dominated atmospheres.

Neptune-sized planets exhibit a wide range of compositions and densities, depending on factors related to their formation and evolution history, such as the distance from their host stars and atmospheric escape processes. They can vary from relatively low-density planets with thick hydrogen–helium atmospheres1,2to higher-density planets with a substantial amount of water or a rocky interior with a thinner atmosphere, such as HD 95338 b (ref. 3), TOI-849 b (ref. 4) and TOI-2196 b (ref. 5). The discovery of exoplanets in the hot-Neptune desert6, a region close to the host stars with a deficit of Neptune-sized planets, provides insights into the formation and evolution of planetary systems, including the existence of this region itself. Here we show observations of the transiting planet TOI-1853 b, which has a radius of 3.46 ± 0.08 Earth radii and orbits a dwarf star every 1.24 days. This planet has a mass of 73.2 ± 2.7 Earth masses, almost twice that of any other Neptune-sized planet known so far, and a density of 9.7 ± 0.8 grams per cubic centimetre. These values place TOI-1853 b in the middle of the Neptunian desert and imply that heavy elements dominate its mass. The properties of TOI-1853 b present a puzzle for conventional theories of planetary formation and evolution, and could be the result of several proto-planet collisions or the final state of an initially high-eccentricity planet that migrated closer to its parent star.

The aim of this study was to investigate the relationship between parents' reading motivation and leisure reading frequency and their children's reading motivation. Secondary data analysis was used to examine a sample of almost 330,000 Chilean adolescents. The results of multilevel regression models revealed that parents' reading motivation and frequency were significantly and positively associated with adolescents' reading motivation, even after controlling for their classmates' and their own previous reading achievement. Furthermore, the negative and significant association found between students' reading motivation and their socioeconomic status was smaller in effect size than that of parents' reading motivation and frequency combined. The implications and limitations of these findings are also discussed. The aim of this study was to investigate the relationship between parents' reading motivation and leisure reading frequency and their children's reading motivation. Secondary data analysis was used to examine a sample of almost 330,000 Chilean adolescents. The results of multilevel regression models revealed that parents' reading motivation and frequency were significantly and positively associated with adolescents' reading motivation, even after controlling for their classmates' and their own previous reading achievement.

Initiating and maintaining optimal immune responses requires high levels of protein synthesis, folding, modification and trafficking in leukocytes, which are processes orchestrated by the endoplasmic reticulum. Importantly, diverse extracellular and intracellular conditions can compromise the protein-handling capacity of this organelle, inducing a state of ‘endoplasmic reticulum stress’ that activates the unfolded protein response (UPR). Emerging evidence shows that physiological or pathological activation of the UPR can have effects on immune cell survival, metabolism, function and fate. In this Review, we discuss the canonical role of the adaptive UPR in immune cells and how dysregulation of this pathway in leukocytes contributes to diverse pathologies such as cancer, autoimmunity and metabolic disorders. Furthermore, we provide an overview as to how pharmacological approaches that modulate the UPR could be harnessed to control or activate immune cell function in disease.

Photochemistry is a fundamental process of planetary atmospheres that regulates the atmospheric composition and stability1. However, no unambiguous photochemical products have been detected in exoplanet atmospheres so far. Recent observations from the JWST Transiting Exoplanet Community Early Release Science Program2,3found a spectral absorption feature at 4.05 μm arising from sulfur dioxide (SO2) in the atmosphere of WASP-39b. WASP-39b is a 1.27-Jupiter-radii, Saturn-mass (0.28 MJ) gas giant exoplanet orbiting a Sun-like star with an equilibrium temperature of around 1,100 K (ref. 4). The most plausible way of generating SO2in such an atmosphere is through photochemical processes5,6. Here we show that the SO2distribution computed by a suite of photochemical models robustly explains the 4.05-μm spectral feature identified by JWST transmission observations7with NIRSpec PRISM (2.7σ)8and G395H (4.5σ)9. SO2is produced by successive oxidation of sulfur radicals freed when hydrogen sulfide (H2S) is destroyed. The sensitivity of the SO2feature to the enrichment of the atmosphere by heavy elements (metallicity) suggests that it can be used as a tracer of atmospheric properties, with WASP-39b exhibiting an inferred metallicity of about 10× solar. We further point out that SO2also shows observable features at ultraviolet and thermal infrared wavelengths not available from the existing observations.

This paper establishes the determinants of professionals’ postgraduate training needs. A quantitative survey of a sample of 492 professionals from Valle del Cauca, Colombia was conducted. The data were analyzed using structural equation modeling to verify the research hypotheses. The results show that the factors affecting the need for postgraduate training are individuals’ perceptions about their level of skill development and about the benefits of professional development. The findings suggest that career advancement is the most valued outcome of postgraduate training. Fieldwork was conducted with a sample of professionals located in the Valle del Cauca in Colombia, so it is important to continue validating the hypotheses in other regions to enable a comparison of results from different contexts. The study contributes to an understanding of the relationship between the variables and the explanation of the determinants of professionals’ perceptions of the need for postgraduate training. It also provides elements for decision-making in the strategic design of postgraduate training offerings. Considering the scarcity of research on the variables that determine the need for postgraduate training, this study provides one of the first theoretical and empirical validations of a perceptual measurement scale of professional training needs in Latin America.

Close-in giant exoplanets with temperatures greater than 2,000 K (‘ultra-hot Jupiters’) have been the subject of extensive efforts to determine their atmospheric properties using thermal emission measurements from the Hubble Space Telescope (HST) and Spitzer Space Telescope1–3. However, previous studies have yielded inconsistent results because the small sizes of the spectral features and the limited information content of the data resulted in high sensitivity to the varying assumptions made in the treatment of instrument systematics and the atmospheric retrieval analysis3–12. Here we present a dayside thermal emission spectrum of the ultra-hot Jupiter WASP-18b obtained with the NIRISS13instrument on the JWST. The data span 0.85 to 2.85 μm in wavelength at an average resolving power of 400 and exhibit minimal systematics. The spectrum shows three water emission features (at >6σconfidence) and evidence for optical opacity, possibly attributable to H−, TiO and VO (combined significance of 3.8σ). Models that fit the data require a thermal inversion, molecular dissociation as predicted by chemical equilibrium, a solar heavy-element abundance (‘metallicity’, M/H=1.03−0.51+1.11times solar) and a carbon-to-oxygen (C/O) ratio less than unity. The data also yield a dayside brightness temperature map, which shows a peak in temperature near the substellar point that decreases steeply and symmetrically with longitude towards the terminators.

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Transmission spectroscopy1–3of exoplanets has revealed signatures of water vapour, aerosols and alkali metals in a few dozen exoplanet atmospheres4,5. However, these previous inferences with the Hubble and Spitzer Space Telescopes were hindered by the observations’ relatively narrow wavelength range and spectral resolving power, which precluded the unambiguous identification of other chemical species—in particular the primary carbon-bearing molecules6,7. Here we report a broad-wavelength 0.5–5.5 µm atmospheric transmission spectrum of WASP-39b8, a 1,200 K, roughly Saturn-mass, Jupiter-radius exoplanet, measured with the JWST NIRSpec’s PRISM mode9as part of the JWST Transiting Exoplanet Community Early Release Science Team Program10–12. We robustly detect several chemical species at high significance, including Na (19σ), H2O (33σ), CO2(28σ) and CO (7σ). The non-detection of CH4, combined with a strong CO2feature, favours atmospheric models with a super-solar atmospheric metallicity. An unanticipated absorption feature at 4 µm is best explained by SO2(2.7σ), which could be a tracer of atmospheric photochemistry. These observations demonstrate JWST’s sensitivity to a rich diversity of exoplanet compositions and chemical processes.

The Saturn-mass exoplanet WASP-39b has been the subject of extensive efforts to determine its atmospheric properties using transmission spectroscopy1–4. However, these efforts have been hampered by modelling degeneracies between composition and cloud properties that are caused by limited data quality5–9. Here we present the transmission spectrum of WASP-39b obtained using the Single-Object Slitless Spectroscopy (SOSS) mode of the Near Infrared Imager and Slitless Spectrograph (NIRISS) instrument on the JWST. This spectrum spans 0.6–2.8 μm in wavelength and shows several water-absorption bands, the potassium resonance doublet and signatures of clouds. The precision and broad wavelength coverage of NIRISS/SOSS allows us to break model degeneracies between cloud properties and the atmospheric composition of WASP-39b, favouring a heavy-element enhancement (‘metallicity’) of about 10–30 times the solar value, a sub-solar carbon-to-oxygen (C/O) ratio and a solar-to-super-solar potassium-to-oxygen (K/O) ratio. The observations are also best explained by wavelength-dependent, non-grey clouds with inhomogeneous coverageof the planet’s terminator.

Measuring the metallicity and carbon-to-oxygen (C/O) ratio in exoplanet atmospheres is a fundamental step towards constraining the dominant chemical processes at work and, if in equilibrium, revealing planet formation histories. Transmission spectroscopy (for example, refs. 1,2) provides the necessary means by constraining the abundances of oxygen- and carbon-bearing species; however, this requires broad wavelength coverage, moderate spectral resolution and high precision, which, together, are not achievable with previous observatories. Now that JWST has commenced science operations, we are able to observe exoplanets at previously uncharted wavelengths and spectral resolutions. Here we report time-series observations of the transiting exoplanet WASP-39b using JWST’s Near InfraRed Camera (NIRCam). The long-wavelength spectroscopic and short-wavelength photometric light curves span 2.0–4.0 micrometres, exhibit minimal systematics and reveal well defined molecular absorption features in the planet’s spectrum. Specifically, we detect gaseous water in the atmosphere and place an upper limit on the abundance of methane. The otherwise prominent carbon dioxide feature at 2.8 micrometres is largely masked by water. The best-fit chemical equilibrium models favour an atmospheric metallicity of 1–100-times solar (that is, an enrichment of elements heavier than helium relative to the Sun) and a substellar C/O ratio. The inferred high metallicity and low C/O ratio may indicate significant accretion of solid materials during planet formation (for example, refs. 3,4,) or disequilibrium processes in the upper atmosphere (for example, refs. 5,6).

Measuring the abundances of carbon and oxygen in exoplanet atmospheres is considered a crucial avenue for unlocking the formation and evolution of exoplanetary systems1,2. Access to the chemical inventory of an exoplanet requires high-precision observations, often inferred from individual molecular detections with low-resolution space-based3–5and high-resolution ground-based6–8facilities. Here we report the medium-resolution (R≈ 600) transmission spectrum of an exoplanet atmosphere between 3 and 5 μm covering several absorption features for the Saturn-mass exoplanet WASP-39b (ref. 9), obtained with the Near Infrared Spectrograph (NIRSpec) G395H grating of JWST. Our observations achieve 1.46 times photon precision, providing an average transit depth uncertainty of 221 ppm per spectroscopic bin, and present minimal impacts from systematic effects. We detect significant absorption from CO2(28.5σ) and H2O (21.5σ), and identify SO2as the source of absorption at 4.1 μm (4.8σ). Best-fit atmospheric models range between 3 and 10 times solar metallicity, with sub-solar to solar C/O ratios. These results, including the detection of SO2, underscore the importance of characterizing the chemistry in exoplanet atmospheres and showcase NIRSpec G395H as an excellent mode for time-series observations over this critical wavelength range10.

This study aimed to scale the process of encapsulation in clay of the heavy metals Ni, Cr, and Cu, traditionally carried out at the laboratory level, up to industrial conditions. For this purpose, sludge from the galvanic industry, considered highly polluting, was mixed with the clay used to make traditional ceramics. The sludge concentrations were 2%, 5%, and 8% by weight. Two shaping processes traditionally used in the ceramic industry were used: extrusion and dry pressing, and the sintering was carried out in industrial gas kilns at 2 firing cycles: fast, lasting 34min in a roller gas kiln, and slow, lasting 42h in a tunnel gas kiln. The specimens thus obtained were characterized in terms of mechanical and esthetic properties. In the first case, the following characteristics were evaluated: flexural strength at three points, shrinkage, calcination losses, and water absorption. In the second, the color change obtained in the finished product generated by the presence of sludge was evaluated. Additionally, by means of the toxicity characteristic leaching procedure (TCLP) method, the impact that the finished product would have on the environment by leaching was determined. The results showed that the two processes of forming and sintering are viable for the treatment of galvanic sludge contaminant.

The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein response (UPR). The IRE1α-XBP1 arm of the UPR could also be activated by viral RNA via Toll-like receptors. Based on these premises, a study to gain insight into the pathogenesis of COVID-19 disease was conducted using nasopharyngeal exudates and bronchioloalveolar aspirates. The presence of the mRNA of spliced XBP1 and a high expression of cytokine mRNAs were observed during active infection. TLR8 mRNA showed an overwhelming expression in comparison with TLR7 mRNA in bronchioloalveolar aspirates of COVID-19 patients, thus suggesting the presence of monocytes and monocyte-derived dendritic cells (MDDCs). In vitro experiments in MDDCs activated with ssRNA40, a synthetic mimic of SARS-CoV-2 RNA, showed induction of XBP1 splicing and the expression of proinflammatory cytokines. These responses were blunted by the IRE1α inhibitor MKC8866, the TLR8 antagonist CU-CPT9a, and knockdown of TLR8 receptor. In contrast, the IRE1α-XBP1 activator IXA4 enhanced these responses. Based on these findings, the TLR8/IRE1α system seems to play a significant role in the induction of the proinflammatory cytokines associated with severe COVID-19 disease and might be a druggable target to control cytokine storm.

This study critically examines the socio-environmental conflict surrounding the Churimo Small Hydropower Station (SHPS) in Antioquia, Colombia, within the context of the region's armed conflict legacy. The Churimo project, while contributing to Colombia's renewable energy goals, has faced intense resistance from local communities due to ecological, cultural, and socio-political concerns. Utilizing an energy justice framework, we conducted in-depth interviews, analyzed public hearing records, and reviewed media coverage to uncover the multidimensional factors fueling opposition. The findings highlight six primary drivers of resistance: ecological impacts on the Churimo River, procedural injustices in stakeholder engagement, informational transparency deficits, adverse effects on local tourism, historical grievances related to hydropower development, and unresolved land restitution issues exacerbated by the region's violent past. The study reveals how these factors, compounded by a history of armed conflict, have intensified opposition and hindered the project's social legitimacy. We argue that achieving a just energy transition in Colombia requires addressing both the immediate and historical injustices faced by affected communities, ensuring that energy projects do not perpetuate existing vulnerabilities.

Protecting the health of migrants and refugees during the pandemic was a significant challenge in the Latin American region. We aimed to describe and contrast the response of the health systems of Mexico, Colombia and Perú to migrants' and refugees’ health needs during the COVID-19 pandemic, and to situate the response in the context of the migration and health policies of each country.

Surgical care holds significant importance in healthcare, especially in low and middle-income countries, as at least 50% of the 4.2 million deaths within the initial 30 days following surgery take place in these countries. The Lancet Commission on Global Surgery proposed six indicators to enhance surgical care. In Colombia, studies have been made using secondary data. However, strategies to reduce perioperative mortality have not been implemented. This study aims to describe the fourth indicator, perioperative mortality rate (POMR), with primary data in Colombia.

Objectives: This study analyzed the physical–chemical properties of three different brands of acupuncture needle, classified by acupuncturists as high (A), medium (B) and low (C) quality.Methods: Experienced acupuncturists, rated, in terms of perceived needling quality, three acupuncture needle brands as high (A), medium (B) and low (C) quality. Next, scanning electron microscopy (SEM) images of the tip and surface finish of the needles of each brand were analyzed. A mechanical test was developed and performed to evaluate the compressive force required to insert the needles through a smooth surface (silicon). In addition, X-ray fluorescence spectroscopy (XRF) and dispersive energy spectroscopy (DES) were conducted to analyze the material composition of the needles and presence of oxidation.Results: SEM images revealed that needle brands A and B presented a sharper tip and a more regular surface finish in comparison to brand C. In the insertion test, needle brands A and B had similar performance characteristics, with A requiring less force to penetrate the silicon device when compared to B, while C failed to penetrate the silicon and complete the test. The XRF analysis did not reveal any differences in material composition between the three brands. However, brand C exhibited particles embedded on the needle surface and DES confirmed oxidation.Conclusion: This study demonstrates that perceived needling quality by acupuncturists can be correlated with physical–chemical properties of the needles, especially those related to finishing quality of the tip and the surface of the needles.

Los trastornos del neurodesarrollo presentan una gran diversidad entre ellos, pudiendo generar dificultades funcionales o alguna discapacidad que requiera de asistencia tecnológica. Hoy, sin embargo, solo 1 de cada 10 personas que la necesitan, acceden a ella. Estas tecnologías de apoyo se definen como cualquier producto, equipo, software, o tecnología adaptada o especialmente diseñada, para mantener o incrementar las capacidades funcionales de niños, niñas y adolescentes en situación de discapacidad, convirtiéndose en un facilitador para la participación en actividades cotidianas en contexto educativo, de juego, y familiar. Lo anterior, permite generar oportunidades en la mejora en las habilidades de procesamiento, de comunicación y de interacción, siendo en la actualidad las tecnologías herramientas fundamentales en los procesos de inclusión. Existen diferentes tipos de tecnologías de apoyo, dependiendo de su naturaleza, nivel tecnológico y lógicas de operación. Este artículo comenta una gama de tecnologías utilizables en la clínica, como lo son las tecnologías de la información, sistemas de comunicación alternativas aumentativas, dispositivos tecnológicos de música, realidad virtual, juegos serios, relojes inteligentes, tableros electrónicos y Kinect, todos con evidencia científica de su efectividad en personas con trastornos del neurodesarrollo.

The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in malignant cells and infiltrating immune populations. Sensing and responding to ER stress is coordinated by the unfolded protein response (UPR), an integrated signaling pathway governed by three ER stress sensors: activating transcription factor (ATF6), inositol-requiring enzyme 1α (IRE1α), and protein kinase R (PKR)-like ER kinase (PERK). Persistent UPR activation modulates malignant progression, tumor growth, metastasis, and protective antitumor immunity. Hence, therapies targeting ER stress signaling can be harnessed to elicit direct tumor killing and concomitant anticancer immunity. We highlight recent findings on the role of the ER stress responses in onco-immunology, with an emphasis on genetic vulnerabilities that render tumors highly sensitive to therapeutic UPR modulation.