125 results on '"Chen, Weihong"'
Search Results
2. Metalloborospherenes with a Stabilized Classical Fullerene-like Borospherene B40 Act as Nonlinear Optical Switches, Electron Reservoirs, Molecular Capacitors, and Molecular Reactors.
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Chen, Weihong, Liu, Jiayuan, Sun, Weiming, Yu, Shansheng, Li, Ying, and Li, Zhiru
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- 2023
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3. Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures.
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Wang, Bin, Liu, Wei, Yu, Linling, Ye, Zi, Cheng, Man, Qiu, Weihong, Zhou, Min, Ma, Jixuan, Wang, Xing, Yang, Meng, Song, Jiahao, and Chen, Weihong
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- 2023
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4. Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures
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Wang, Bin, Liu, Wei, Yu, Linling, Ye, Zi, Cheng, Man, Qiu, Weihong, Zhou, Min, Ma, Jixuan, Wang, Xing, Yang, Meng, Song, Jiahao, and Chen, Weihong
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Acrolein is an identified high-priority hazardous air pollutant ubiquitous in daily life and associated with cardiometabolic risk that attracts worldwide attention. However, the etiology role of acrolein exposure in glucose dyshomeostasis and type 2 diabetes (T2D) is unclear. This repeated-measurement prospective cohort study included 3522 urban adults. Urine/blood samples were repeatedly collected for determinations of acrolein metabolites (N-acetyl-S-(3-hydroxypropyl)-l-cysteine, N-acetyl-S-(2-carboxyethyl)-l-cysteine; acrolein exposure biomarkers), glucose homeostasis, and T2D at baseline and a three-year follow-up. We found that each 3-fold increment in acrolein metabolites was cross-sectionally associated with 5.91–6.52% decrement in homeostasis model assessment-insulin sensitivity (HOMA-IS) and 0.07–0.14 mmol/L, 4.02–4.57, 5.91–6.52, 19–20, 18–19, and 23–31% increments in fasting glucose (FPG), fasting insulin (FPI), HOMA-insulin resistance (HOMA-IR), risks of prevalent IR, impaired fasting glucose (IFG), and T2D, respectively; longitudinally, participants with sustained-high acrolein metabolite levels had increased risks of incident IR, IFG, and T2D by 63–80, 87–99, and 120–154%, respectively (P< 0.05). In addition, biomarkers of heme oxygenase-1 activity (exhaled carbon monoxide), lipid peroxidation (8-iso-prostaglandin-F2α), protein carbonylation (protein carbonyls), and oxidative DNA damage (8-hydroxy-deoxyguanosine) mediated 5.00–38.96% of these associations. Our study revealed that acrolein exposure may impair glucose homeostasis and increase T2D risk via mediating mechanisms of heme oxygenase-1 activation, lipid peroxidation, protein carbonylation, and oxidative DNA damage.
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- 2023
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5. The emerging role of epigenetic regulation in the progression of silicosis.
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Yin, Haoyu, Xie, Yujia, Gu, Pei, Li, Wei, Zhang, Yingdie, Yao, Yuxin, Chen, Weihong, and Ma, Jixuan
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- 2022
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6. Epidemics and diversity of norovirus variants with acute gastroenteritis outbreak in Hongshan District, Wuhan City, China, 2021-2023.
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Xu, Dandan, Li, Jing, Han, Lingyan, Chen, Ding, Bao, Wubo, Li, Li, Wang, Huawei, Shui, Jinglin, Liang, Ruyi, Liu, Yang, Liu, Yingle, Cai, Kun, and Chen, Weihong
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Norovirus is the predominant pathogen causing foodborne illnesses and acute gastroenteritis (AGE) outbreaks worldwide, imposing a significant disease burden. This study aimed to investigate the epidemiological characteristics and genotypic diversity of norovirus outbreaks in Hongshan District, Wuhan City. A total of 463 AGE cases from 39 AGE-related outbreaks in Hongshan District between January 1, 2021, and June 30, 2023, were included in the study. Reverse transcription-polymerase chain reaction (RT-PCR) was used to identify norovirus types GI and GII in anal swab samples from all cases. Norovirus-positive samples were sequenced and analyzed for the open reading frame (ORF) 1/ORF2 hinge region. 26 norovirus infectious outbreaks were reported among 39 acute diarrheal outbreaks, including 14 outbreaks in kindergartens, 8 in elementary schools, and 4 in universities. Based on clinical symptoms and epidemiological investigations, a total of 1295 individuals were identified as having been exposed to norovirus, yielding an attack rate of 35.75 %. A higher proportion of outbreaks was observed during the winter and spring seasons (38.46 %). Additionally, norovirus-positive samples were subjected to sequencing and analysis of the open reading frame (ORF) 1/ORF2 hinge region. Genotypic data for norovirus was successfully obtained from 18 (69.23 %) of the infectious outbreaks, revealing 10 distinct recombinant genotypes. GII.4 Sydney 2012 [P31] and GII.17[P17] were the predominant strains in 2021 and 2022, GII.3 [P12] emerged as the dominant strain in 2023. Norovirus outbreaks in Hongshan District predominantly occurred in crowded educational institutions, with peaks in the cold season and a high attack rate in universities. GII.3 [P12] has become the locally predominant strain. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Bioinformatics analysis and identification of cuproptosis-related long non-coding RNAs in colorectal cancer
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Chen, Weihong, Huang, Dongqin, Su, Xiaoping, Su, Yuchao, and Li, Shaobin
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Objective Identifying precise biomarkers for colorectal cancer (CRC) detection and management remains challenging. Here, we developed an innovative prognostic model for CRC using cuproptosis-related long non-coding RNAs (lncRNAs).Methods In this retrospective study, CRC patient transcriptomic and clinical data were sourced from The Cancer Genome Atlas database. Cuproptosis-related lncRNAs were identified and used to develop a prognostic model, which helped categorize patients into high- and low-risk groups. The model was validated through survival analysis, risk curves, independent prognostic analysis, receiver operating characteristic curve analysis, decision curves, and nomograms. In addition, we performed various immune-related analyses. LncRNA expression levels were examined in normal human colorectal epithelial cells (FHC) and CRC cells (HCT-116) using quantitative polymerase chain reaction (qPCR).Results Six cuproptosis-related lncRNAs were identified: ZKSCAN2-DT, AL161729.4, AC016394.1, AC007128.2, AL137782.1, and AC099850.3. The prognostic model distinguished between high-/low-risk populations, demonstrating excellent predictive ability for survival outcomes. Immunocorrelation analysis showed significant differences in immune cell infiltration and functions, immune checkpoint expression, and m6A methylation-related genes. The qPCR results showed significant upregulation of ZKSCAN2-DT, AL161729.4, AC016394.1, AC007128.2 in HCT-116 cells, while AL137782.1 and AC099850.3 expression patterns were significantly downregulated.Conclusion Cuproptosis-related lncRNAs can potentially serve as reliable diagnostic and prognostic biomarkers for CRC.
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- 2024
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8. Serum metabolome perturbation in relation to noise exposure: Exploring the potential role of serum metabolites in noise-induced arterial stiffness.
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Chen, Zhaomin, Li, Wenzhen, Zhang, Haozhe, Huang, Xuezan, Tao, Yueqing, Lang, Kaiji, Zeng, Qiang, Chen, Weihong, and Wang, Dongming
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ARTERIAL diseases ,OCCUPATIONAL exposure ,METABOLITES ,NOISE pollution ,PUBLIC health - Abstract
Noise pollution has grown to be a major public health issue worldwide. We sought to profile serum metabolite expression changes related to occupational noise exposure by untargeted metabolomics, as well as to evaluate the potential roles of serum metabolites in occupational noise-associated arterial stiffness (AS). Our study involved 30 noise-exposed industrial personnel (Lipo group) and 30 noise-free controls (Blank group). The untargeted metabolomic analysis was performed by employing a UPLC-HRMS. The associations of occupational noise and significant differential metabolites (between Blank/Lipo groups) with AS were evaluated using multivariable-adjusted generalized linear models. We performed the least absolute shrinkage and selection operator regression analysis to further screen for AS's risk metabolites. We explored 177 metabolites across 21 categories significantly differentially expressed between Blank/Lipo groups, and these metabolites were enriched in 20 metabolic pathways. Moreover, 15 metabolites in 4 classes (including food, glycerophosphocholine, sphingomyelin [SM] and triacylglycerols [TAG]) were adversely associated with AS (all P < 0.05). Meanwhile, five metabolites (homostachydrine, phosphatidylcholine (PC) (32:1e), PC (38:6p), SM (d41:2) and TAG (45:1) have been proven to be useful predictors of AS prevalence. However, none of these 15 metabolites were found to have a mediating influence on occupational noise-induced AS. Our study reveals specific metabolic changes caused by occupational noise exposure, and several metabolites may have protective effects on AS. However, the roles of serum metabolites in noise-AS association remain to be validated in future studies. [Display omitted] • Serum metabolite expression changes were profiled by untargeted metabolomics. • Occupational noise exposure causes significant changes in serum metabolites. • Some metabolites were statistically significantly associated with both noise exposure and arterial stiffness. • Metabolites might be useful predictors of arterial stiffness prevalence. • The role of metabolites in noise-induced arterial stiffness needs to be confirmed. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Helvine-danalite mineralogy of the Dulong Sn-Zn polymetallic deposit in southeast Yunnan, China
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Liu, Shiyu, Liu, Yuping, Ye, Lin, Wei, Chen, and Chen, Weihong
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Southeastern (SE) Yunnan is a major Sn polymetallic province of China, with the Dulong large Sn-Zn polymetallic deposit (in the Laojunshan orefield) being one of the most representative deposits. Our recent work had first identified helvine- group minerals in this deposit. These minerals mainly occur in massive sphalerite ores, and coexist with sphalerite, pyrrhotite, biotite, talc, cassiterite, and fluorite. Raman spectroscopic, X‑ray difraction (XRD), scanning electron microscopic (SEM), and electron probe microanalysis (EPMA) analyses indicate that these helvine-group minerals are oscillatory-zoned helvine-danalite. Both the helvine and danalite zones are mixed with varying proportion of the other helvine-group end-member, and our studies indicate that the oscillatory zoning was formed mainly by periodic fluctuations of the fluid physicochemical conditions (notably fS2and fO2), but less related to the variation of the fluid Mn, Fe, and Zn contents. The helvine zone was likely formed in a higher fS2but lower fO2environment than the danalite zone. In this study, we present the first LA-ICP-MS in situ trace element data for the helvine-danalite minerals from Dulong, and the results indicate that the helvine has considerably high contents and a wide range of trace elements. The helvine is rich in Ca, Al, Sc, and Y, while the danalite is rich in Sn and P (reaching thousands of parts per million). Such trace element enrichments are likely controlled by their respective ionic size and chalcophile behavior.
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- 2022
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10. 口腔癌病人术后吞咽障碍评估及康复证据 总结.
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XIA Jialin, HOU Lili, LI Li, XING Weijie, GUO Xingtong, PENG Xuepei, and CHEN Weihong
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- 2022
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11. Study on the adsorptive property of HNO3-modified almond shell biochar for methylene blue
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Zuo, Chao, Qi, Baochuan, Feng, Dan, Shang, Jiangwei, and Chen, Weihong
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- 2022
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12. Multiple performance pressure inconsistency, resource slack, and the firm’s R&D investment: A behavioral agency theory perspective
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Diwei Lv, David, Chen, Weihong, and Lan, Hailin
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In the process of operation, firms will face different types of performance pressure. The inconsistency among multiple performance pressure signals has an important impact on resource allocation and R&D investment. However, at present, studies on the impact of multiple performance pressures on the firm’s resource allocation and R&D investment are very limited, and few studies have analyzed the impact of inconsistencies among multiple performance pressure signals on the firm’s R&D investment. Given this research gap, this article empirically tested a model from the perspective of behavioral agency theory, in which inconsistency in long- and short-term performance pressure facilitates the accumulation of organizational slack. We further test the impact of an increase in organizational slack on the firms’ R&D investment intensity and find that this effect is stronger when the level of managerial ownership is comparatively low. These results together indicate that high inconsistency in performance pressure and low managerial ownership jointly facilitate the accumulation of organizational slack, enabling firms to go beyond local search and have more slack searches in the face of multiple performance pressure, which is conducive to an increase in R&D investment.JEL CLASSIFICATION: M10.
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- 2022
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13. Condition monitoring of disconnecting switch opening and closing motor based on electromagnetic transient
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Khan, Zeashan Hameed, Zhang, Junxing, Zeng, Pengfei, You, Situ, Liu, Shuan, Liu, Hong, Fei, Hongyun, and Chen, Weihong
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- 2024
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14. Progressive collapse performance of shear strengthened RC frames by nano CFRP
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Chen, Weihong, Lin, Boxu, Li, Dong, Zhang, Jinwen, and Cui, Shuangshuang
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To investigate the effect of nano carbon-fiber-reinforced polymer (nano CFRP) on retrofitting reinforced concrete (RC) structures, this article presented the progressive collapse performance of two half-scale four-bay RC frames including one control specimen S1 and specimen S2 with nano CFRP retrofitting beam ends. The progressive collapse performance was discussed by comparing crack patterns, failure mode, load–displacement curves, horizontal displacement, strains, and rotational and energy dissipation capacity. The test results demonstrated that nano CFRP did not change the ductile beam-hinge failure mode, but improved the load-bearing capacity and ductility efficiently, and postpone shear failure of the joint core region obviously. Due to the insufficient development of plastic hinges limited by nano CFRP, S2 failed to enter catenary action, which revealed its own defects in anti-progressive collapse. It was shown that the retrofitting strategy using nano CFRP can substantially improve the mechanical characteristics and implement the strong column-weak beam failure mode.
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- 2022
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15. Longitudinal association of polycyclic aromatic hydrocarbons and genetic risk with lung function.
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Zhou, Min, Yang, Shijie, Cao, Limin, Dai, Wencan, Nie, Xiuquan, Mu, Ge, Zhang, Xiaokang, Wang, Bin, Ma, Jixuan, Wang, Dongming, Shi, Tingming, Wang, Chaolong, Hao, Xingjie, and Chen, Weihong
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POLYCYCLIC aromatic hydrocarbons ,LUNGS ,VITAL capacity (Respiration) ,FORCED expiratory volume ,DISEASE risk factors ,MONOGENIC & polygenic inheritance (Genetics) - Abstract
To quantify the association of polycyclic aromatic hydrocarbons (PAHs) and the polygenic risk score (PRS) with lung function decline, we developed a repeated-measures study with 4681 observations from baseline and 6-year follow-up of the Wuhan–Zhuhai cohort. Lung function and urinary monohydroxylated PAH metabolites (OH-PAHs) were measured for each observation. The PRS was derived from 246 lung function-associated genetic variants weighted by the effect size of the decreasing ratio of forced expiratory volume in 1 s by forced vital capacity (FEV1/FVC). Linear mixed models were used to estimate the longitudinal exposure–response relationships between OH-PAHs and lung function, and to evaluate the interactions between OH-PAHs and PRS on the longitudinal change of lung function. We found that each 1-unit increase in log-transformed values of 9-hydroxyfluorene, 2-hydroxyfluorene, 4-hydroxyphenanthrene, 9-hydroxyphenanthrene, 2-hydroxyphenanthrene, 1-hydroxyphenanthrene, 1-hydroxypyrene, low molecular weight OH-PAHs (ΣLMW–OH–PAHs), and total OH-PAHs (ΣOH-PAHs) was associated with an annual change in FEV1/FVC of −0.140, −0.112, −0.260, −0.300, −0.159, −0.220, −0.145, −0.156, and −0.177 %/year, respectively. Interactions on the annual decline of FEV1/FVC were detected between ΣLMW–OH–PAHs and PRS (−0.010 %/year, 95% confidence interval −0.018 to −0.001, P int = 0.0228), and between ΣOH-PAHs and PRS (−0.010 %/year, −0.018 to −0.001, P int = 0.0203). These results indicated that specific and total urinary OH-PAHs were associated with the longitudinal FEV1/FVC decline, and ΣLMW–OH–PAHs as well as ΣOH-PAHs interacted with PRS on the annual decline of FEV1/FVC. [Display omitted] • Positive longitudinal association between PAHs and lung function among general population. • The longitudinal lung function decline associated with PAHs enhanced across increased PRS. • Repeated-measures study was conducted to assess individual PAH exposure from varied sources over a long period. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome.
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Long, Pinpin, Wang, Qiuhong, Zhang, Yizhi, Zhu, Xiaoyan, Yu, Kuai, Jiang, Haijing, Liu, Xuezhen, Zhou, Min, Yuan, Yu, Liu, Kang, Jiang, Jing, Zhang, Xiaomin, He, Meian, Guo, Huan, Chen, Weihong, Yuan, Jing, Cheng, Longxian, Liang, Liming, and Wu, Tangchun
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- 2021
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17. Secondhand smoking and neurological disease: a meta-analysis of cohort studies
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Liu, Wei, Wang, Bin, Xiao, Yang, Wang, Dongming, and Chen, Weihong
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- 2021
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18. Extracellular signal-regulated kinase signaling pathway and silicosis
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Xie, Yujia, Ma, Jixuan, Yang, Meng, Fan, Lieyang, and Chen, Weihong
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Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace of many industries. Due to the lack of effective treatment and management, the continued high incidence of silicosis remains a major public health concern worldwide, especially in the developing countries. Till now, related molecular mechanisms underlying silicosis are still not completely understood. Multiple pathways have been reported to be participated in the pathological process of silicosis, and more complex signaling pathways are receiving attention. The activated extracellular signal-regulated kinase (ERK) signaling pathway has been recognized to control some functions in the cell. Recent studies have identified that the ERK signaling pathway contributes to the formation and development of silicosis through regulating the processes of oxidative stress, inflammatory response, proliferation and activation of fibroblasts, epithelial–mesenchymal transformation, autophagy, and apoptosis of cells. In this review article, we summarize the latest findings on the role of ERK signaling pathway in silica-induced experimental models of silicosis, as well as clinical perspectives.
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- 2021
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19. Drugs associated with a risk of supraventricular tachycardia: analysis using the OpenVigil database
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Chen, Weihong, Li, Shaobin, Huang, Dongqin, and Su, Yuchao
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Objective The OpenVigil database can be used to assess medications that may cause supraventricular tachycardia (SVT) and to produce a reference for their safe use in clinical settings.Methods We analyzed first-quarter data from 2004 to 2023, obtained by searching the OpenVigil database using the keyword “supraventricular tachycardia.” Trade names and generic names were obtained by querying the RxNav database, and the proportions were summarized. The proportionate reporting ratio (PRR), reporting odds ratio, and chi-square values were also summarized. We created Asahi diagrams and set the screening criteria to drug events ≥30, PRR >2, and chi-square >4. Outcomes were evaluated using the Side Effect Resource database, several scientific literature databases, and the Hangzhou Yiyao Rational Medication System.Results A total of 2435 distinct medications were found to induce SVT between the first quarter of 2004 and 2023, leading to 22,375 documented adverse events related to SVT. Further investigation revealed that salbutamol, paroxetine, formoterol, paclitaxel, venlafaxine, and theophylline were most likely to cause SVT.Conclusion We conducted signal mining of adverse drug events using the OpenVigil database and evaluated the six drugs most likely to cause SVT. The results of this research can serve as a drug safety reference in the clinic.
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- 2024
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20. Deformation Behavior of Eutectic Gallium–Indium under Electric Fields
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Zhang, Haibo, Ding, Qiong, Li, Ruohan, Chen, Weihong, and Wang, Peng
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Liquid metals are widely applied in various fields, including chemistry, catalysis, energy storage, chemical sensing, and stretchable electronics, due to their unique deformabilities. However, their behavior under a rod or ring electrode has never been analyzed. Furthermore, research on the deformation behavior of eutectic Ga–In (EGaIn), the most commonly used Ga-based liquid metal, under electric fields of varying intensities and shapes is lacking. Therefore, investigating the deformation behavior of liquid metals under electric fields is expected to contribute to the accurate regulation of their morphologies. To this end, herein, an electrochemical device was fabricated using EGaIn, and experiments were conducted by adjusting the potential and the cathode shape. Further, the mechanism of the deformation was analyzed in detail. When a potential was applied, EGaIn droplets deformed into fractal dendrites under circular, polygonal, and nonpolygonal electric fields. Dendrite symmetry was influenced by the cathode shape, as the resulting electric fields varied in shape. The results of this study will aid in precisely controlling the behaviors of LMs and their alloys using electric fields. This topic is suitable for upper-division undergraduates who possess a basic understanding of electrochemistry. Through these experiments, students may explore the effects of potential on the morphology of EGaIn and analyze experimental phenomena such as electrowetting, dendrite formation, and surface oxidation, thereby developing a preliminary understanding of interfacial tension and electrocapillarity. Additionally, these experiments encourage undergraduates to actively participate in laboratory work, which helps foster their enthusiasm for chemistry.
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- 2024
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21. Expert consensus on One Health for establishing an enhanced and integrated surveillance system for key infectious diseases
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Cheng, Yanpeng, Zhang, Zhen, Shu, Yuelong, Ren, Lili, Min, Kang, Kong, Dongfeng, Shi, Xiaolu, Lv, Qiuying, Chen, Zhigao, Li, Yinghui, Zhang, Renli, Lu, Puxuan, Lu, Yan, Liu, Tingting, Chen, Nixuan, Xiong, Huawei, Du, Chen, Yuan, Jun, Wang, Liang, Liu, Rongqi, Chen, Weihong, Li, Xueyun, Lin, Qihui, Li, Gang, Zhang, Xindong, Yuan, Jianhui, Wang, Tieqiang, Guo, Yongchao, Lu, Jianhua, Zou, Xuan, and Feng, Tiejian
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China has been continuously improving its monitoring methods and strategies to address key infectious diseases (KIDs). After the severe acute respiratory syndrome epidemic in 2003, China established a comprehensive reporting system for infectious diseases (IDs) and public health emergencies. The relatively lagging warning thresholds, limited warning information, and outdated warning technology are insufficient to meet the needs of comprehensive monitoring for modern KIDs. Strengthening early monitoring and warning capabilities to enhance the public health system has become a top priority, with increasing demand for early warning thresholds, information, and techniques, thanks to constant innovation and development in molecular biology, bioinformatics, artificial intelligence, and other identification and analysis technologies. A panel of 31 experts has recommended a fourth-generation comprehensive surveillance system targeting KIDs (41 notifiable diseases and emerging IDs). The aim of this surveillance system is to systematically monitor the epidemiology and causal pathogens of KIDs in hosts such as humans, animals, and vectors, along with associated environmental pathogens. By integrating factors influencing epidemic spread and risk assessment, the surveillance system can serve to detect, predict, and provide early warnings for the occurrence, development, variation, and spread of known or novel KIDs. Moreover, we recommend comprehensive ID monitoring based on the fourth-generation surveillance system, along with a data-integrated monitoring and early warning platform and a consortium pathogen detection technology system. This series of considerations is based on systematic and comprehensive monitoring across multiple sectors, dimensions, factors, and pathogens that is supported by data integration and connectivity.This expert consensus will provides an opportunity for collaboration in various fields and relies on interdisciplinary application to enhance comprehensive monitoring, prediction, and early warning capabilities for the next generation of ID surveillance. This expert consensus will serve as a reference for ID prevention and control as well as other related activities.
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- 2024
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22. Effect of public health interventions on COVID-19 cases: an observational study
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Qiu, Weihong, He, Heng, Zhang, Peng, Yang, Wenwen, Shi, Tingming, Wang, Xing, Chen, Ailian, Xie, Li, Yang, Meng, Wang, Dongming, Li, Mingyan, and Chen, Weihong
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BackgroundAs the epidemic of COVID-19 is gradually controlled in China, a summary of epidemiological characteristics and interventions may help control its global spread.MethodsData for COVID-19 cases in Hubei Province (capital, Wuhan) was extracted until 7 March 2020. The spatiotemporal distribution of the epidemic in four periods (before 10 January, 10–22 January, 23 January–6 February and 7 February–7 March) was evaluated, and the impacts of interventions were observed.ResultsAmong 67 706 COVID-19 cases, 52 111 (76.97%) were aged 30–69 years old, and 34 680 (51.22%) were women. The average daily attack rates (95% CI) were 0.5 (0.3 to 0.7), 14.2 (13.2 to 15.1), 45.7 (44.0 to 47.5) and 8.6 (7.8 to 9.3) cases per 106people in four periods, and the harmonic means (95% CI) of doubling times were 4.28 (4.01 to 4.55), 3.87 (3.78 to 3.98), 5.40 (4.83 to 6.05) and 45.56 (39.70 to 52.80) days. Compared with the first period, daily attack rates rose rapidly in the second period. In the third period, 14 days after 23 January, the daily average attack rate in and outside Wuhan declined by 33.8% and 48.0%; the doubling times increased by 95.0% and 133.2%. In the four periods, 14 days after 7 February, the daily average attack rate in and outside Wuhan decreased by 79.1% and 95.2%; the doubling times increased by 79.2% and 152.0%.ConclusionsThe public health interventions were associated with a reduction in COVID-19 cases in Hubei Province, especially in districts outside of Wuhan.
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- 2021
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23. Comparison of Risk of Silicosis in Metal Mines and Pottery Factories
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Wang, Dongming, Zhou, Min, Liu, Yuewei, Ma, Jixuan, Yang, Meng, Shi, Tingming, and Chen, Weihong
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Little is known about the different risk of silicosis in metal mines and pottery factories. We aimed to compare the silicosis risks among silica-exposed workers in different industrial circumstances.
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- 2020
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24. Triiodothyronine Attenuates Silica-Induced Oxidative Stress, Inflammation, and Apoptosis via Thyroid Hormone Receptor α in Differentiated THP-1 Macrophages
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Gan, Shiming, Yang, Meng, Fan, Lieyang, Xie, Li, Xu, Yiju, Wang, Bin, Xu, Tao, Yu, Linling, Ma, Jixuan, and Chen, Weihong
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Alveolar macrophage (AM) injury and inflammatory response are key processes in pathological damage caused by silica. However, the role of triiodothyronine (T3) in silica-induced AM oxidative stress, inflammation, and mitochondrial apoptosis remained unknown. To investigate the possible effects and underlying mechanism of T3 in silica-induced macrophage damage, differentiated human acute monocytic leukemia cells (THP-1) were exposed to different silica concentrations (0, 50, 100, 200, and 400 μg/mL) for 24 h. Additionally, silica-activated THP-1 macrophages were treated with gradient-dose T3 (0, 5, 10, 20, and 40 nM) for 24 h. To illuminate the potential mechanism, we used short hairpin RNA to knock down the thyroid hormone receptor α (TRα) in the differentiated THP-1 macrophages. The results showed that T3 decreased lactate dehydrogenase and reactive oxygen species levels, while increasing cell viability and superoxide dismutase in silica-induced THP-1 macrophages. In addition, silica increased the expression of interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α), and T3 treatment reduced those pro-inflammatory cytokines secretion. Compared with silica-alone treated groups, cells treated with silica and T3 restored the mitochondrial membrane potential loss and had reduced levels of cytochrome cand cleaved caspase-3 expressions. Lastly, we observed that TRα-knockdown inhibited the protective effects of T3 silica-induced THP-1 macrophages. Together, these findings revealed that T3 could serve as a potential therapeutic target for protection against silica-induced oxidative stress, inflammatory response, and mitochondrial apoptosis, which are mediated by the activation of the T3/TRα signal pathway.
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- 2020
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25. Mean platelet volume mediated the relationships between heavy metals exposure and atherosclerotic cardiovascular disease risk: A community-based study
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Zhu, Chunmei, Wang, Bin, Xiao, Lili, Guo, Yanjun, Zhou, Yun, Cao, Limin, Yang, Shijie, and Chen, Weihong
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Background Heavy metals were related to increased risk of atherosclerotic cardiovascular disease (ASCVD). However, potential mechanisms under such associations remain unclear. We aimed to investigate the mediating role of mean platelet volume in the associations between heavy metals exposure and 10-year ASCVD risk.Method Urinary heavy metals and mean platelet volume were measured in 3081 adults from the Wuhan-Zhuhai cohort in China. The associations between urinary heavy metals, mean platelet volume and 10-year ASCVD risk were separately analyzed through generalized linear models and logistic regression models. Mediation analyses were conducted to assess the role of mean platelet volume in the associations between urinary heavy metals and 10-year ASCVD risk.Results After adjusting for potential confounders, 10-year ASCVD risk was positively associated with urinary iron (odds ratio (OR) = 1.142, 95% confidence interval (1.038–1.256)), copper (OR = 1.384 (1.197–1.601)), zinc (OR = 1.520 (1.296–1.783)), cadmium (OR = 1.153 (0.990, 1.342)) and antimony (OR = 1.452 (1.237–1.704)), and negatively related with urinary barium (OR = 0.905 (0.831–0.985)). Also, we found significant dose–response relationships between urinary iron, zinc, antimony and mean platelet volume, as well as between mean platelet volume and 10-year ASCVD risk (all pfor trends < 0.05). Furthermore, mediation analyses indicated that mean platelet volume mediated 17.55%, 6.15% and 7.38% of the associations between urinary iron, zinc, antimony and 10-year ASCVD risk, respectively (all pvalue < 0.05).Conclusions Elevated concentrations of urinary iron, copper, zinc, cadmium and antimony were associated with increased risk of 10-year ASCVD. Mean platelet volume partially mediated the associations of urinary iron, zinc and antimony with 10-year ASCVD risk.
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- 2020
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26. Honeycomb Borophene Fragment Stabilized in Polyanionic Sandwich Lithium Salt: A New Type of Two-Dimensional Material with Superconductivity
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Chen, Weihong, Yan, Luo, Li, Ying, Liu, Jingwei, Wu, Di, Chen, Wei, Yu, Guangtao, Zhou, Liujiang, and Li, Zhiru
- Abstract
For seeking new types of two-dimensional (2D) materials based on honeycomb borophene, honeycomb borophene fragments stabilized by Li atoms in sandwich molecules are found theoretically. This is based on our understanding on the hexagonal B6ring with two-electron deficiency and Li atoms as suitable electron donors. In these sandwich molecules, each hexagonal B6ring unit of honeycomb borophene fragments is sandwiched between two Li atoms, forming stable sandwich lithium salts due to electron transfer from Li atoms to the borophene fragment. In the sandwich lithium salts, the middle planar layer of honeycomb borophene fragment polyanions is sandwiched between two Li+layers. Owing to the large size effect, the lithium salt (7Li)7+B2414–(7Li)7+including the planar polyanion sheet B2414–with a high valence of −14 can serve as an electron reservoir unusually exhibiting two different behaviors of the electron donor and electron acceptor. Furthermore, material property calculations show that this 2D sandwich lithium salt (Li2B2sheet) is demonstrated to be thermally and mechanically stable. Remarkably, the Li2B2sheet is not only a metal 2D material with a Dirac cone but also an intrinsic superconductor with the superconducting transition temperature Tc≈ 6.2 K. This work provides a new potential two-dimensional material for practical application.
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- 2020
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27. Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China
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Zhou, Min, Xiao, Lili, Yang, Shijie, Wang, Bin, Shi, Tingming, Tan, Aijun, Wang, Xing, Mu, Ge, and Chen, Weihong
- Abstract
BackgroundExposure to zinc was suggested to be associated with pulmonary damage, but whether zinc exposure affects lung function remains unclear.ObjectivesTo quantify the association between urinary zinc and lung function and explore the potential mechanisms.MethodsUrinary zinc and lung function were measured in 3917 adults from the Wuhan-Zhuhai cohort and were repeated after 3 years of follow-up. Indicators of systemic inflammation (C reactive protein), lung epithelium integrity (club cell secretory protein-16) and oxidative damage (8-hydroxy-2′-deoxyguanosine and 8-isoprostane) were measured at baseline. Linear mixed models were used to estimate the exposure–response relationship between urinary zinc and lung function. Mediation analyses were conducted to assess mediating roles of inflammation and oxidative damage in above relationships.ResultsEach 1-unit increase in log-transformed urinary zinc values was associated with a 35.72 mL decrease in forced vital capacity (FVC) and a 24.89 mL decrease in forced expiratory volume in 1 s (FEV1) in the baseline analyses. In the follow-up analyses, there was a negative association between urinary zinc and FVC among participants with persistent high urinary zinc levels, with an estimated change of −93.31 mL (95% CI −178.47 to −8.14). Furthermore, urinary zinc was positively associated with restrictive ventilatory impairment. The mediation analyses suggested that C reactive protein mediated 8.62% and 8.71% of the associations of urinary zinc with FVC and FEV1, respectively.ConclusionUrinary zinc was negatively associated with lung function, and the systemic inflammation may be one of the underlying mechanisms.
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- 2020
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28. BCS: Bidirectional Cross-Interface Scheduling for Sustainable End-to-End Data Delivery in IoT
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Qin, Hua, Chen, Weihong, Cao, Buwen, He, Jianxin, and Peng, Yang
- Abstract
In this era of Internet of Things (IoT), a variety of battery-powered devices communicate with each other or some remote gateways via wireless multihop communications. Although Wi-Fi has been shown to be of great benefit to a wide range of IoT applications due to its high data rate, high reliability, and native IP compatibility, it is inherently energy-hungry and potentially suffers from a dilemma: more (less) frequent use of Wi-Fi results in shorter (longer) delay but higher (lower) energy consumption. This dilemma becomes the major obstacle in the use of Wi-Fi in long-term but delay-bounded IoT applications. To address this, we propose a bidirectional cross-interface scheduling (BCS) scheme, which leverages the widely used low-power ZigBee to collaborate with the high data rate and reliable Wi-Fi for sustainable and reliable end-to-end (E2E) data delivery in IoT. The objective is to maximize network lifetime while satisfying certain required E2E delay bound. Extensive simulations and testbed experiments have been conducted. The results show that the network lifetime of BCS is 33.4% and 346.9% longer than those of a state-of-the-art scheme and the IEEE 802.11's standard power-saving scheme with the default settings, respectively.
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- 2019
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29. Dose-response relationships between polycyclic aromatic hydrocarbons exposure and platelet indices.
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Yuan, Chunjie, Hou, Jian, Zhou, Yun, Hu, Chen, Sun, Huizhen, Chen, Weihong, and Yuan, Jing
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POLYCYCLIC aromatic hydrocarbons ,PYRENE ,LYMPHOCYTES ,METABOLITES ,BIOLOGICAL tags - Abstract
Abstract The relations of polycyclic aromatic hydrocarbons (PAHs) exposure with platelet indices remain unclear. Based on the baseline data from the Wuhan-Zhuhai Cohort Study, we used generalized linear model, multivariate logistic regression analysis and restricted cubic splines (RCS) to assess linear and nonlinear relationship of PAHs exposure with platelet indices. The results showed that among Wuhan individuals, there were the non-linear relations between total hydroxynaphthalene (ΣOHNa) and mean platelet volume (MPV) or ratio of mean platelet volume to platelet count (MPVP), total hydrophenanthrene (ΣOHPh) and MPV or platelet distribution width (PDW), the sum concentration of urinary monohydroxylated metabolites of PAHs (ΣOH-PAHs) and ratio of platelet count to lymphocyte count (PLR) or MPVP, 1-hydropyrene (1-OHP) and PLR or PDW. But among Zhuhai individuals, neither linear nor non-linear relations were found between each of OH-PAHs or ΣOH-PAHs and platelet indices. The findings indicate that serum MPV and MPVP may be independent biomarkers of effects of exposing to environmental PAHs on human bodies. Graphical abstract Image 1 Highlights • Wuhan individuals had higher levels of 8 OH-PAHs and ΣOH-PAHs than Zhuhai ones. • Wuhan individuals with high OH-PAHs had longitudinal changes in platelet indices. • Wuhan individuals with high OH-PAHs were at high risk of increased MPV and MPVP. • Relations of certain OH-PAHs with platelet indices were non-linear in Wuhan ones. Serum MPV and MPVP may be independent biomarkers for affecting adverse effects of environmental PAHs exposure on human bodies. [ABSTRACT FROM AUTHOR]
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- 2019
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30. Association between urinary polycyclic aromatic hydrocarbon metabolites and dyslipidemias in the Chinese general population: A cross-sectional study.
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Ma, Jixuan, Zhou, Yun, Liu, Yuewei, Xiao, Lili, Cen, Xingzu, Li, Wei, Guo, Yanjun, Kim, Myongho, Yuan, Jing, and Chen, Weihong
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POLYCYCLIC aromatic hydrocarbons ,METABOLITES ,DYSLIPIDEMIA ,CONFIDENCE intervals ,LOGISTIC regression analysis - Abstract
Abstract Background Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with metabolic diseases. However, relationships between PAH exposures and dyslipidemias have not been well addressed. Objectives To investigate associations between urinary PAH metabolite concentrations and dyslipidemias in the general population. Methods Twelve urinary PAH metabolites and four serum lipid profiles were measured in 3640 Chinese adults from the Wuhan-Zhuhai cohort. Dyslipidemias, including hyper-total cholesterol (HyperTC), hyper-triglyceride (HyperTG), hyper-low density lipoprotein cholesterol (HyperLDL-C), and hypo-high density lipoprotein cholesterol (HypoHDL-C) were classified according to the levels of serum lipids. Multiple logistic regression models were used to estimate the associations between urinary PAH metabolites and the prevalence of dyslipidemias. The effects of PAH exposure routes on dyslipidemias were further estimated by stratified analysis. Results We found positive exposure-response relationships between urinary PAH metabolites and the prevalence of dyslipidemias. Compared with the lowest tertile of urinary PAH metabolites, increased risk of HyperTC were observed in those in the highest tertiles; The odds ratios (ORs) and 95% confidence intervals were 1.23 (1.03, 1.47), 1.44 (1.21, 1.71), 1.19 (1.01, 1.42), and 1.43 (1.20, 1.71) for 1-OHNa, 9-OHFlu, 1-OHPh, and 4-OHPh, respectively. Participants in the highest tertiles of 1-OHNa and 2-OHFlu had higher risk for HyperLDL-C, and the ORs were 1.21 (1.01, 1.45) and 1.18 (0.98, 1.42), respectively. Among smokers, only urinary 1-OHNa was associated with increased risk of HyperTC (1.36, 1.08–1.73) and HyperLDL-C (1.33, 1.01–1.74). While the increasing urinary levels of 9-OHFlu, 1-OHPh, and 4-OHPh were significantly associated with increased risk of HyperTC among non-smokers. In addition, the associations between urinary PAH metabolites and dyslipidemias were more pronounced among non-smokers who are cooked for themselves and had long-term traffic exposure. Conclusion Elevated urinary PAH metabolites were associated with increased risks of HyperTC and HyperLDL-C. The source of PAH exposure could modify PAH species that affect dyslipidemias. Graphical abstract Image 1 Highlights • Urinary PAH metabolites were measured in general population of China. • Significant relationships were observed between the urinary PAH metabolites and the prevalence of dyslipidemias. • The source of PAH exposure could modify PAH species that affect dyslipidemias. [ABSTRACT FROM AUTHOR]
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- 2019
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31. Central obesity transition increased urinary levels of 8-hydroxydeoxyguanosine in male adults: A 3-year follow up study.
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Hu, Chen, Wang, Guiyang, Yin, Wenjun, Zhou, Yun, Hou, Jian, Wang, Xian, Chen, Weihong, and Yuan, Jing
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DNA damage ,CREATININE ,OBESITY ,HIGH performance liquid chromatography ,DEOXYGUANOSINE - Abstract
Abstract Objective Association of oxidative DNA damage with gain in anthropometric indices has not been fully elucidated. Methods In this study, participants (n = 1151) were derived from the baseline visit of Wuhan residents in the Wuhan-Zhuhai Cohort Study. The participants finished the physical examinations at both baseline and 3-year follow up. Urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) were measured by gradient-elution high performance liquid chromatography method and then calibrated by urinary creatinine (Cr) values. Results Generalized linear models showed that after adjusted for confounding factors, baseline central obesity individuals with a ≥2.5% hip circumference (HC) loss or >5% HC gain had a 0.290 μmol/mol Cr (95% confidence interval (CI): 0.108, 0.472) or 0.553 μmol/mol Cr (95% CI: 0.273, 0.833) increase in urinary 8-OHdG levels compared with those with a −2.5%–2.5% HC gain (both P < 0.05). Moreover, compared with non-central obesity at both baseline and 3-year follow-up, we observed that central obese men at both baseline and 3-year follow-up had a 0.46 μmol/mol Cr (95% CI: 0.16, 0.75) increased in urinary 8-OHdG levels. Conclusions HC gain showed dose-dependent associations with urinary 8-OHdG levels. Moreover, male central obesity at both baseline and 3-year follow-up had an increased risk for urinary 8-OHdG levels. Highlights • Adults with ≥2.5% HC loss increased urinary 8-OHdG levels. • Baseline central obesity with >5% HC gain was at higher risk of increasing 8-OHdG. • Developed central obesity during the 3-year follow-up had higher urinary 8-OHdG. [ABSTRACT FROM AUTHOR]
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- 2019
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32. Cardiometabolic traits mediated the relationship from urinary polycyclic aromatic hydrocarbons metabolites to heart rate variability reduction: A community-based study.
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Guo, Yanjun, Cao, Limin, Zhou, Yun, Xiao, Lili, Zhang, Xiaomin, Yuan, Jing, and Chen, Weihong
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AROMATIC compounds ,POLYCYCLIC compounds ,HEART beat ,URINALYSIS ,HYDROCARBON metabolism - Abstract
Abstract Polycyclic Aromatic Hydrocarbons (PAHs) exposure was related with metabolic syndrome (MetS) and heart rate variability (HRV) reduction, and HRV was also affected by cardiometabolic traits. However, the role of cardiometabolic traits in the associations from PAHs exposures to HRV was largely unknown. We conducted this study to investigate whether the relationship between PAHs exposure and HRV reduction was mediated by cardiometabolic traits. Levels of urinary polycyclic aromatic hydrocarbons metabolites (OH-PAHs), 10min-HRV, and metabolic traits were accurately measured for 2476 participants from Wuhan-Zhuhai (WHZH) cohort. Single mediator and multiple mediator models were used to evaluate the mediation effects of cadiometabolic traits. The concentrations of ΣOH-PAHs ranged from 4.20 to 8.63 mg/mmol Cr. When compared with the lowest tertile, ΣOH-PAHs in the highest tertile were significantly related with 20% (95% confidence interval [95%CI]:1%, 40%), 35% (95%CI: 14%, 56%), 22% (95%CI: 1%, 44%), and 38% (95%CI: 9%, 68%) decreases in very low frequency (VLF), low frequency (LF), high frequency (HF), and total power (TP) for participants with MetS, respectively. No statistically significant associations between ΣOH-PAHs and HRV indices were observed for participants without MetS. Similar results were found when we investigated the relationships between OH-PAHs and HRV indices by three groups of OH-PAHs (including total hydroxynaphthalene [ΣOHNa], total hydroxy fluorene [ΣOHFlu], and total hydroxyphenanthrene [ΣOHPh] metabolites). Further, mediation analysis suggested that cardiometabolic traits, including fasting glucose (GLU), high density lipoprotein (HDL), and blood pressure partially mediated the relationship from ΣOH-PAHs to HRV reduction. GLU was the strongest mediator, with mediation percentages of 15.70% for VLF, 14.70% for LF, 43.03% for HF, and 5.61% for TP. Our study found that the relationships between OH-PAHs and HRV reduction differed among participants with and without MetS, and these relationships were found to be partially mediated by cardiometabolic traits, especially fasting glucose. Further studies are encouraged to validate our findings and investigate potential mechanisms. Graphical abstract Image 1 Highlights • The relationships between OH-PAHs and HRV reduction differed among participants with and without MetS. • When grouped by parent PAH, total hydroxynaphthalene and hydroxyfluorene were significantly related with HRV reduction. • The relationship between OH-PAHs and HRV reduction were partially mediated by fasting glucose, HDL and blood pressure. • Our results highlighted cardiometabolic pathways in linking PAH exposure with cardiac autonomic dysfunction evaluating by HRV. The relationship between urinary polycyclic aromatic hydrocarbons metabolites (OH-PAHs) and HRV reduction was modified by metabolic status, and was partially mediated by fasting glucose, high density lipoprotein (HDL) and blood pressure. [ABSTRACT FROM AUTHOR]
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- 2018
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33. Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults.
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Wang, Mengyi, Zhou, Min, Tan, Qiyou, Yu, Linling, Dong, Chaoqian, Liang, Ruyi, Liu, Wei, Zhang, Yongfang, Li, Minjing, Nie, XiuQuan, Jing, Tao, and Chen, Weihong
- Subjects
IMMUNOGLOBULIN M ,BLOOD sugar ,HYPERGLYCEMIA ,HERBICIDES ,TRIAZINES ,ATRAZINE ,GLUCOSE metabolism ,TYPE 2 diabetes ,IMMUNOGLOBULINS - Abstract
The effects of triazine herbicides on glucose metabolism remain unclear. In this study, we aimed to assess the associations between serum triazine herbicides and glycemia-related risk indicators in general adults, and to evaluate the mediating role of natural immunoglobulin M antibodies (IgM) in the above associations among uninfected participants. We measured the concentrations of atrazine, cyanazine, and IgM in serum, as well as fasting plasma glucose (FPG), and fasting plasma insulin in 4423 adult participants from the Wuhan-Zhuhai cohort baseline population, enrolled in 2011–2012. Generalized linear models were used to evaluate the associations of serum triazine herbicides with glycemia-related risk indicators, and mediation analyses were performed to evaluate the mediating role of serum IgM in the above associations. The median levels of serum atrazine and cyanazine were 0.0237 μg/L and 0.0786 μg/L, respectively. Our study found significant positive associations of serum atrazine, cyanazine, and Σtriazine with FPG levels, risk of impaired fasting glucose (IFG), abnormal glucose regulation (AGR), and type 2 diabetes (T2D). Additionally, serum cyanazine and Σtriazine were found to be significant positive associated with the homeostatic model assessment of insulin resistance (HOMA-IR) levels. Significant negative linear relationships were observed in associations of serum IgM with serum triazine herbicides, FPG, HOMA-IR levels, the prevalence of T2D, and AGR (P < 0.05). Furthermore, we observed a significant mediating role by IgM in the associations of serum triazine herbicides with FPG, HOMA-IR, and AGR, with the proportions ranging from 2.96% to 7.71%. To ensure the stability of our findings, we conducted sensitivity analyses in normoglycemic participants and found that the association of serum IgM with FPG and the mediating role by IgM remained stable. Our results suggest that triazine herbicides exposure is positively associated with abnormal glucose metabolism, and decreasing serum IgM may partly mediate these associations. [Display omitted] • Serum samples were measured for atrazine and cyanazine among general urban adults. • Triazine herbicide exposure was associated with abnormal glucose metabolism. • Triazine herbicide exposure was negatively associated with serum IgM level. • Down-regulated serum IgM level was associated with abnormal glucose metabolism. • IgM mediated triazine herbicide exposure-associated abnormal glucose metabolism. [ABSTRACT FROM AUTHOR]
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- 2023
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34. Cross-sectional and longitudinal relationships between ozone exposure and glucose homeostasis: Exploring the role of systemic inflammation and oxidative stress in a general Chinese urban population.
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Tan, Qiyou, Wang, Bin, Ye, Zi, Mu, Ge, Liu, Wei, Nie, Xiuquan, Yu, Linling, Zhou, Min, and Chen, Weihong
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CITY dwellers ,OXIDATIVE stress ,OZONE ,C-reactive protein ,BLOOD sugar ,GLUCOSE - Abstract
The adverse health effects of ozone pollution have been a globally concerned public health issue. Herein we aim to investigate the association between ozone exposure and glucose homeostasis, and to explore the potential role of systemic inflammation and oxidative stress in this association. A total of 6578 observations from the Wuhan-Zhuhai cohort (baseline and two follow-ups) were included in this study. Fasting plasma glucose (FPG) and insulin (FPI), plasma C-reactive protein (CRP, biomarker for systemic inflammation), urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG, biomarker for oxidative DNA damage), and urinary 8-isoprostane (biomarker for lipid peroxidation) were repeatedly measured. After adjusting for potential confounders, ozone exposure was positively associated with FPG, FPI, and homeostasis model assessment of insulin resistance (HOMA-IR), and negatively associated with HOMA of beta cell function (HOMA-β) in cross-sectional analyses. Each 10 ppb increase in cumulative 7-days moving average ozone was associated with a 13.19%, 8.31%, and 12.77% increase in FPG, FPI, and HOMA-IR, respectively, whereas a 6.63% decrease in HOMA-β (all P < 0.05). BMI modified the associations of 7-days ozone exposure with FPI and HOMA-IR, and the effects were stronger in subgroup whose BMI ≥24 kg/m
2 . Consistently high exposure to annual average ozone was associated with increased FPG and FPI in longitudinal analyses. Furthermore, ozone exposure was positively related to CRP, 8-OHdG, and 8-isoprostane in dose-response manner. Increased CRP, 8-OHdG, and 8-isoprostane could dose-dependently aggravate glucose homeostasis indices elevations related to ozone exposure. Increased CRP and 8-isoprostane mediated 2.11−14.96% of ozone-associated glucose homeostasis indices increment. Our findings suggested that ozone exposure could cause glucose homeostasis damage and obese people were more susceptible. Systemic inflammation and oxidative stress might be potential pathways in glucose homeostasis damage induced by ozone exposure. [Display omitted] • Ozone exposure could cause glucose homeostasis disorder. • Effects of ozone exposure on FPI and HOMA-IR were more susceptible in obese people. • Ozone exposure was positively associated with CRP, 8-OHdG, and 8-isoprostane. • CRP, 8-OHdG, and 8-isoprostane aggravated glucose homeostasis harm caused by ozone. • CRP and 8-isoprostane partly mediated ozone-associated glucose homeostasis disorder. [ABSTRACT FROM AUTHOR]- Published
- 2023
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35. Obesity modifies the association of environmental pyrethroid exposure with glucose homeostasis in the US general adults.
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Liang, Ruyi, Feng, Xiaobing, Shi, Da, Wang, Bin, Zhang, Yongfang, Liu, Wei, Yu, Linling, Ye, Zi, Zhou, Min, and Chen, Weihong
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PYRETHROIDS ,ENVIRONMENTAL exposure ,HEALTH & Nutrition Examination Survey ,GLUCOSE ,BLOOD sugar - Abstract
Environmental pyrethroids are concerning due to their widespread residues and potential implications on human health. We aimed to assess the association of pyrethroid exposure with glucose homeostasis and examine the interaction between obesity and pyrethroid exposure. A total of 4233 US general adults from the National Health and Nutrition Examination Survey with measured urinary pyrethroid metabolites, fasting plasma glucose (FPG), fasting insulin (FINS), and glycated hemoglobin A1c (HbA1c) were included in the study. The homeostasis model assessment (HOMA2) calculator was utilized to assess insulin resistance (HOMA2-IR), insulin sensitivity (HOMA2-IS), and beta-cell function (HOMA2-β). We estimated the associations of pyrethroid metabolites with glucose homeostasis parameters (FPG, FINS, HbA1c, HOMA2-IR, HOMA2-IS, and HOMA2-β) using multivariate linear regression models and restricted cubic spline models and further assessed the interaction between obesity and pyrethroid metabolites on glucose dyshomeostasis. Urinary 3-phenoxybenzoic acid (3-PBA) was the most detected pyrethroid metabolite (81%) with a median concentration of 0.43 (interquartile range 0.20–1.01) μg/g urinary creatinine. Compared with the participants in the lowest quartile, those in the highest quartile of 3-PBA had a 1.93% (95% confidence interval: 0.46%, 3.42%), 6.69% (1.96%, 11.64%), 1.60% (0.64%, 2.57%), 7.06% (2.33%, 12.01%), −6.59% (−10.72%, −2.28%), and 1.10% (−2.69%, 5.04%) alteration in FPG, FINS, HbA1c, HOMA2-IR, HOMA2-IS, and HOMA2-β, respectively. The restricted cubic spline model displayed a linear positive association between 3-PBA and FPG, FINS, HbA1c, and HOMA2-IR, and a negative association with HOMA2-IS (all P for overall <0.05 and P for non-linear >0.05). Additionally, the association between urinary 3-PBA and FPG was modified by general obesity (P for interaction <0.05), with a more pronounced association observed in obese participants than in non-obese participants. Our findings suggested that pyrethroid exposure was associated with glucose dyshomeostasis. General obesity significantly heightened the association between pyrethroid exposure and increased FPG level. [Display omitted] • We assessed the link with glucose homeostasis of pyrethroids in US general adults. • Urinary pyrethroid metabolite 3-PBA was associated with glucose dyshomeostasis. • The relationship of urinary 3-PBA with FPG was modified by general obesity. • Obesity exacerbated the increased FPG associated with urinary 3-PBA. [ABSTRACT FROM AUTHOR]
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- 2023
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36. Epidemiological characteristics and transmission model of Corona Virus Disease 2019 in China.
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Wang, Dongming, Zhou, Min, Nie, Xiuquan, Qiu, Weihong, Yang, Meng, Wang, Xing, Xu, Tao, Ye, Zi, Feng, Xiaobing, Xiao, Yang, and Chen, Weihong
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- 2020
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37. Bidirectional association between nonalcoholic fatty liver disease and hypertension from the Dongfeng-Tongji cohort study.
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Liu, Peiyi, Tang, Yuhan, Guo, Xiaoping, Zhu, Xinhong, He, Meian, Yuan, Jing, Wang, Youjie, Wei, Sheng, Chen, Weihong, Zhang, Xiaomin, Miao, Xiaoping, and Yao, Ping
- Abstract
Abstract The relation between nonalcoholic fatty liver disease (NAFLD) and hypertension is not fully understood. To examine the effect of the change in NAFLD status on the risk of incident hypertension, and vice versa, 6704 eligible hypertension-free subjects and 9328 NAFLD-free subjects from the Dongfeng-Tongji cohort study at baseline were enrolled in the study. Among the hypertension-free subjects, development and persistence of NAFLD were associated with an increased odds ratio (OR) for incident hypertension (OR: 1.49, 95% confidence interval [CI]: 1.26–1.76, P <.0001; OR: 1.50, 95% CI: 1.27–1.78, P <.0001). However, the resolution of NAFLD was not a risk factor for incident hypertension. Among the NAFLD-free subjects, the risk of new-emerging NAFLD was robust for hypertension status both in no-yes (OR: 1.45, CI: 1.23–1.71) and yes-yes (OR: 1.61, CI: 1.35–1.92). Moreover, stratified analysis by diabetes and overweight/obese for the risk of incident NAFLD showed that incident hypertension (no-yes) and persistent hypertension (yes-yes) were associated with risk of incident NAFLD in subjects without diabetes or overweight/obesity. In the overweight/obese participants, persistent hypertension (yes-yes) was a risk factor for incident NAFLD (OR: 1.29, 95% CI: 1.01–1.64, P =.0387). Conclusively, incidence and persistence of NAFLD are associated with increased risk of hypertension, and vice versa. Highlights • There are bidirectional associations between nonalcoholic fatty liver disease (NAFLD) and hypertension. • Hypertension is associated with increased risk of NAFLD. • Incident hypertension and persistent hypertension were associated with risk of incident NAFLD in subjects without diabetes or overweight/obesity. [ABSTRACT FROM AUTHOR]
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- 2018
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38. Estimated individual inhaled dose of fine particles and indicators of lung function: A pilot study among Chinese young adults.
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Xu, Tian, Hou, Jian, Cheng, Juan, Zhang, Runbo, Yin, Wenjun, Huang, Cheng, Zhu, Xiaochuan, Chen, Weihong, and Yuan, Jing
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PULMONARY function tests ,HEALTH of Chinese people ,HEALTH of young adults ,ENVIRONMENTAL impact analysis ,PARTICULATE matter - Abstract
Fine particle (PM 2.5 )-related lung damage has been reported in most studies regarding environmental or personal PM 2.5 concentrations. To assess effects of personal PM 2.5 exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM 2.5 based on their microenvironmetal PM 2.5 concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1β on the final day. The high individual dose (median (IQR)) of inhaled PM 2.5 was 957 (948) μg/day. We observed a maximum FeNO increase (9.1% (95%CI: 2.2–15.5)) at lag 0 day, a maximum decrease of maximum voluntary ventilation (11.8% (95% CI: 4.6–19.0)) at lag 5 day and a maximum interleukin-1β increase (103% (95% CI: 47–159)) at lag 2 day for an interquartile range increase in the individual dose of inhaled PM 2.5 during the four seasons. Short-term exposure to PM 2.5 assessed by the individual dose of inhaled PM 2.5 was associated with higher airway and systemic inflammation and reduced lung function. Further studies are needed to understand better underlying mechanisms of lung damage following acute exposure to PM 2.5. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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39. A cross-interface design for energy-efficient and delay-bounded multi-hop communications in IoT.
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Qin, Hua, Chen, Weihong, Cao, Buwen, Zeng, Min, and Peng, Yang
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WIRELESS communications ,INTERNET of things ,ENERGY consumption ,GATEWAYS (Computer networks) ,STORAGE batteries - Abstract
The future Internet of Things (IoT) will enable Internet connectivity for a vast amount of battery-powered devices, which usually need to wirelessly communicate with each other or to some remote gateways through multi-hop communications. Although ZigBee has become a widely used communication technology in IoT, Wi-Fi, on the other hand, has its unique advantages such as high throughput and native IP compatibility, despite its potentially higher energy consumption. With the development of IoT, more and more IoT devices are equipped with multiple radio interfaces, such as both Wi-Fi and ZigBee. Inspired by this, we propose a cross-interface power saving management (CPSM) scheme, which leverages the existing low-power ZigBee interfaces to wake up the high-power Wi-Fi interfaces on demand towards enabling multi-hop communications in IoT. The objective is to minimize the network energy consumption while satisfying certain end-to-end delay requirements. The results of extensive simulations and prototype-based experiments have demonstrated that the energy consumption of our proposed CPSM is 79.2% and 68.9% lower than those of the IEEE 802.11’s standard power saving scheme and a state-of-the-art scheme in moderate traffic scenarios, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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40. Association of polycyclic aromatic hydrocarbons exposure with atherosclerotic cardiovascular disease risk: A role of mean platelet volume or club cell secretory protein.
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Hu, Chen, Hou, Jian, Zhou, Yun, Sun, Huizhen, Yin, Wenjun, Zhang, Youjian, Wang, Xian, Wang, Guiyang, Chen, Weihong, and Yuan, Jing
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POLYCYCLIC aromatic hydrocarbons ,CARDIOVASCULAR diseases risk factors ,PLATELET count ,INFLAMMATION ,POLLUTION - Abstract
Background Inflammation may play an important role in the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and atherosclerotic cardiovascular disease (ASCVD) risk. However, the underlying mechanisms remain unclear. Objectives To investigate the association of PAHs exposure with ASCVD risk and effects of mean platelet volume (MPV) or Club cell secretory protein (CC16) on the association. Methods A total of 2022 subjects (689 men and 1333 women) were drawn from the baseline Wuhan residents of the Wuhan-Zhuhai Cohort study. Data on demography and the physical examination were obtained from each participant. Urinary monohydroxy PAH metabolites (OH-PAHs) levels were measured by a gas chromatography-mass spectrometry. We estimated the association between each OH-PAHs and the 10-year ASCVD risk or coronary heart disease (CHD) risk using logistic regression models, and further analyze the mediating effect of MPV or plasma CC16 on the association by using structural equation modeling. Results The results of multiple logistic regression models showed that some OH-PAHs were positively associated with ASCVD risk but not CHD risk, including 2-hydroxyfluoren (β = 1.761; 95% CI: 1.194–2.597), 9-hydroxyfluoren (β = 1.470; 95% CI: 1.139–1.898), 1-hydroxyphenanthrene (β = 1.480; 95% CI: 1.008–2.175) and ΣOH-PAHs levels (β = 1.699; 95% CI: 1.151–2.507). The analysis of structural equation modeling shows that increased MPV and increased plasma CC16 levels contributed 13.6% and 15.1%, respectively, to the association between PAHs exposure and the 10-year ASCVD risk (p < 0.05). Conclusions Exposure to PAHs may increase the risk of atherosclerosis, which was partially mediated by MPV or CC16. [ABSTRACT FROM AUTHOR]
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- 2018
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41. Associations between urinary monohydroxy polycyclic aromatic hydrocarbons metabolites and Framingham Risk Score in Chinese adults with low lung function.
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Hou, Jian, Sun, Huizhen, Guo, Yanjun, Zhou, Yun, Yin, Wenjun, Xu, Tian, Cheng, Juan, Chen, Weihong, and Yuan, Jing
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POLYCYCLIC aromatic hydrocarbons ,CARDIOVASCULAR diseases ,MEDIATION ,LOGISTIC regression analysis ,HYDROCARBONS - Abstract
Previous studies have reported an association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function decline or cardiovascular diseases, or reduced lung function with 10-year cardiovascular (CV) risk. We analyzed risk factors for the 10-year Framingham CV risk using multiple logistic regression, and examined the mediational effect of reduced lung function on the association between exposure to PAHs and FRS using the post-exploratory structural equation modeling. Participants (n = 2268) were drawn from the Wuhan residents at baseline from the Wuhan-Zhuhai Cohort Study. They completed the physical examination, measurements of lung function and urinary monohydroxylated-PAHs (OH-PAHs). In all individuals, we found a dose-response relationship of PAHs exposure, forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) with the 10-year CV risk. The proportions of FEV1 and FVC mediation effects in association of PAH exposure with the10-year CV risk were 35% and 24%, respectively. The findings indicated that PAHs exposure or reduced lung function increased the 10-year CV risk. Impaired lung function may partly contribute to increase in the 10-year CV risk regarding exposure to PAHs. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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42. Association between sleep duration, sleep quality and hyperlipidemia in middle-aged and older Chinese: The Dongfeng–Tongji Cohort Study
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Wang, Dongming, Chen, Jianghao, Zhou, Yun, Ma, Jixuan, Zhou, Min, Xiao, Lili, He, Meian, Zhang, Xiaomin, Guo, Huan, Yuan, Jing, and Chen, Weihong
- Abstract
Aims This study aimed to evaluate the relationship between sleep duration, sleep quality and hyperlipidemia in middle-aged and older Chinese.Methods We included 20,712 individuals at baseline from September 2008 to June 2010, and they were followed-up until October 2013. Hyperlipidemia was defined according to the Chinese guidelines on the prevention and treatment of dyslipidemia in adults. Sleep duration was self-reported and sleep quality was evaluated with a questionnaire that was designed according to the Pittsburgh Sleep Quality Index. Logistic regression and Cox proportional hazard models were conducted to explore the associations.Results In the cross-sectional analyses, longer sleep duration (≥10 h) was significantly associated with higher prevalence of hyperlipidemia (odds ratio (OR) = 1.17, 95% confidence interval (CI) = 1.02–1.35) after adjusting for potential confounders. The ORs of hyperlipidemia were significantly elevated among participants with impaired sleep quality (OR = 1.14, 95% CI = 1.08–1.22) and poor sleep quality (OR = 1.20, 95% CI = 1.08–1.34) when compared to those with good sleep quality. In the longitudinal analyses, compared to participants with a sleep duration of 7–<8 h, those with a sleep duration of 9–<10 h (hazard ratio (HR) = 1.19, 95% CI = 1.04–1.35) and ≥10 h (HR = 1.27, 95% CI = 1.02–1.58) showed significantly higher risk of hyperlipidemia after adjusting for potential confounders. However, no statistically significant association was found between impaired or poor sleep quality and hyperlipidemia.Conclusions Longer sleep duration was significantly associated with higher risk of hyperlipidemia. Impaired or poor sleep quality were associated with elevated prevalence of hyperlipidemia, but not with the incidence of hyperlipidemia.
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- 2019
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43. Novel hepacivirus in Asian house shrew, China
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Guo, Hua, Cai, Chunlin, Wang, Bo, Zhuo, Fei, Jiang, Rendi, Wang, Ning, Li, Bei, Zhang, Wei, Zhu, Yan, Fan, Yi, Chen, Wushen, Chen, Weihong, Yang, Xinglou, and Shi, Zhengli
- Published
- 2019
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44. The potential role of plasma miR-4301 in PM2.5 exposure-associated lung function reduction.
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Song, Jiahao, Cheng, Man, Wang, Bin, Zhou, Min, Ye, Zi, Fan, Lieyang, Yu, Linling, Wang, Xing, Ma, Jixuan, and Chen, Weihong
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LUNGS ,PLASMA potentials ,VENTILATION ,POLYMERASE chain reaction ,MOVING average process - Abstract
The effect of PM 2.5 exposure on lung function reduction has been well-documented, but the underlying mechanism remains unclear. MiR-4301 may be involved in regulating pathways related to lung injury/repairment, and this study aimed to explore the potential role of miR-4301 in PM 2.5 exposure-associated lung function reduction. A total of 167 Wuhan community nonsmokers were included in this study. Lung function was measured and personal PM 2.5 exposure moving averages were evaluated for each participant. Plasma miRNA was determined by real-time polymerase chain reaction. A generalized linear model was conducted to assess the relationships among personal PM 2.5 moving average concentrations, lung function, and plasma miRNA. The mediation effect of miRNA on the association of personal PM 2.5 exposure with lung function reduction was estimated. Finally, we performed pathway enrichment analysis to predict the underlying pathways of miRNA in lung function reduction from PM 2.5 exposure. We found that each 10 μg/m
3 increase in the 7-day personal PM 2.5 moving average concentration (Lag0-7) was related to a 46.71 mL, 1.15%, 157.06 mL/s, and 188.13 mL/s reductions in FEV 1 , FEV 1 /FVC, PEF, and MMF, respectively. PM 2.5 exposure was negatively associated with plasma miR-4301 expression levels in a dose‒response manner. Additionally, each 1% increase in miR-4301 expression level was significantly associated with a 0.36 mL, 0.01%, 1.14 mL/s, and 1.28 mL/s increases in FEV 1 , FEV 1 /FVC, MMF, and PEF, respectively. Mediation analysis further revealed that decreased miR-4301 mediated 15.6% and 16.8% of PM 2.5 exposure-associated reductions in FEV 1 /FVC and MMF, respectively. Pathway enrichment analyses suggested that the wingless related-integration site (Wnt) signaling pathway might be one of the pathways regulated by miR-4301 in the reduction of lung function from PM 2.5 exposure. In brief, personal PM 2.5 exposure was negatively associated with plasma miR-4301 or lung function in a dose‒response manner. Moreover, miR-4301 partially mediated the lung function reduction associated with PM 2.5 exposure. [Display omitted] • MiR-4301 may play a role in PM 2.5 exposure-related lung function reduction. • PM 2.5 exposure was negatively associated with miR-4301 or lung function. • Pathway regulated by miR-4301 in PM 2.5 -related lung injury was predicted. [ABSTRACT FROM AUTHOR]- Published
- 2023
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45. Association between occupational noise exposure duration and heart rate variability among Chinese adults: The role of plasma miRNAs.
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Li, Wenzhen, Zhang, Haozhe, Xiao, Yang, Tao, Yueqing, Chen, Weihong, and Wang, Dongming
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OCCUPATIONAL exposure ,HEART beat ,MICRORNA ,RADIATION exposure ,ROOT-mean-squares ,DYSAUTONOMIA ,GENE expression - Abstract
We aimed to explore the association between occupational noise exposure duration and heart rate variability (HRV) and the underlying mechanism. A total of 449 subjects in a manufacturing company in Wuhan, China were included in our study and six candidate miRNAs (miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-1-3p, miR-92a-3p and miR-21–5p) were tested among 200 individuals. Information combining the work histories and the occupational noise monitoring records were used to calculate the exposure of occupational noise, HRV indices were measured by using 3-channel digital Holter monitors, including the standard deviation of all normal R-R intervals (SDNN), the root mean of the square of successive differences between adjacent normal NN intervals (r-MSSD), SDNN index, low-frequency power (LF), high-frequency power (HF) and TP (total power). We found a significant linear negative dose-response relationship between occupational noise exposure duration and HRV indices (P for overall <0.05, P for nonlinear >0.05), including SDNN, r-MSSD, SDNN index, LF and HF. In the continuous models, the β (95% CIs) for each 1-year occupational noise exposure were −0.002 (−0.004, −0.001) for SDNN, −0.002 (−0.004, −0.001) for r-MSSD, −0.002 (−0.004, −0.001) for SDNN index, and −0.006 (−0.012, −0.001) for HF. Meanwhile, we also found that occupational noise exposure duration was significantly associated with lower expression of five miRNAs, when adjusting for other covariates. The β (95% CIs) were −0.039 (−0.067, −0.011) for miRNA-200c-3p, −0.053 (−0.083, −0.022) for miRNA-200a-3p, −0.044 (−0.070, −0.019) for miRNA-200b-3p, −0.032 (−0.048, −0.017) for miRNA-92a-3p, and −0.063 (−0.089, −0.038) for miRNA-21–5p in the continuous models. In addition, we found a positive association between miRNA-1-3p and LF (β = 0.039, 95% CI = 0.002, 0.080). Our study suggests that occupational noise exposure duration is associated with cardiac autonomic dysfunction, and the role of miRNAs in noise induced HRV reduction needs to be confirmed in future studies. [Display omitted] • Occupational noise exposure duration is associated with reduced SDNN, SDNN index, and HF. • Occupational noise exposure duration is associated with lower miR-200c-3p, miR-200a-3p, miR-200b-3p, miR-92a-3p, and miR-21–5p. • The role of miRNAs in noise induced HRV reduction needs to be confirmed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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46. Pro-Active 4SCAR2.0 Therapy with NGS-MRD Disease Monitoring in High-Risk B Cell Leukemia Management
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Jiao, Cheng, Liu, Yuchen, Zhang, Rui, Chen, Weihong, and Chang, Lung-Ji
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- 2022
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47. Pro-Active 4SCAR2.0 Therapy with NGS-MRD Disease Monitoring in High-Risk B Cell Leukemia Management
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Jiao, Cheng, Liu, Yuchen, Zhang, Rui, Chen, Weihong, and Chang, Lung-Ji
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- 2022
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48. Short-term effects of ambient air pollution on pediatric outpatient visits for respiratory diseases in Yichang city, China.
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Liu, Yuewei, Xie, Shuguang, Yu, Qing, Huo, Xixiang, Ming, Xiaoyan, Wang, Jing, Zhou, Yun, Peng, Zhe, Zhang, Hai, Cui, Xiuqing, Xiang, Hua, Huang, Xiji, Zhou, Ting, Chen, Weihong, and Shi, Tingming
- Subjects
AIR pollution ,HEALTH ,OUTPATIENT medical care ,RESPIRATORY disease risk factors ,AIR quality monitoring stations - Abstract
Previous studies have suggested that short-term exposure to ambient air pollution was associated with pediatric hospital admissions and emergency room visits for certain respiratory diseases; however, there is limited evidence on the association between short-term air pollution exposure and pediatric outpatient visits. Our aim was to quantitatively assess the short-term effects of ambient air pollution on pediatric outpatient visits for respiratory diseases. We conducted a time-series study in Yichang city, China between Jan 1, 2014 and Dec 31, 2015. Daily counts of pediatric respiratory outpatient visits were collected from 3 large hospitals, and then linked with air pollution data from 5 air quality monitoring stations by date. We used generalized additive Poisson models to conduct linear and nonlinear exposure-response analyses between air pollutant exposures and pediatric respiratory outpatient visits, adjusting for seasonality, day of week, public holiday, temperature, and relative humidity. Each interquartile range (IQR) increase in PM 2.5 (lag 0), PM 10 (lag 0), NO 2 (lag 0), CO (lag 0), and O 3 (lag 4) concentrations was significantly associated with a 1.91% (95% CI: 0.60%, 3.23%), 2.46% (1.09%, 3.85%), 1.88% (0.49%, 3.29%), 2.00% (0.43%, 3.59%), and 1.91% (0.45%, 3.39%) increase of pediatric respiratory outpatient visits, respectively. Similarly, the nonlinear exposure-response analyses showed monotonic increases of pediatric respiratory outpatient visits by increasing air pollutant exposures, though the associations for NO 2 and CO attenuated at higher concentrations. These associations were unlikely modified by season. We did not observe significant association for SO 2 exposure. Our results suggest that short-term exposures to PM 2.5 , PM 10 , NO 2 , CO, and O 3 may account for increased risk of pediatric outpatient visits for respiratory diseases, and emphasize the needs for reduction of air pollutant exposures for children. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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49. PM2.5-related DNA methylation and the association with lung function in non-smokers.
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Mu, Ge, Nie, Xiuquan, Yang, Shijie, Ye, Zi, Cheng, Man, Fan, Lieyang, Qiu, Weihong, Tan, Qiyou, Zhou, Min, Guo, Yanjun, and Chen, Weihong
- Subjects
DNA methylation ,DNA adducts ,TOBACCO smoke ,METHYLATION ,FALSE discovery rate ,PULMONARY function tests ,NON-smokers ,LUNGS - Abstract
PM 2.5 exposure leads to lung function alteration. The potential pathway underlying above association, especially the role of DNA methylation is unclear. The objectives of this study are to evaluate the associations of personal PM 2.5 concentrations with DNA methylation at the epigenome-wide level, and investigate how PM 2.5 -related DNA methylation affects lung function. A total of 402 observations of non-smokers were selected from the Wuhan-Zhuhai cohort. PM 2.5 exposure was estimated through a model established in the same population. Blood DNA methylation levels were determined through Illumina Infinium MethylationEPIC BeadChips. Lung function was tested through spirometry on the day of blood sampling. The associations of PM 2.5 exposure with DNA methylation and DNA methylation with lung function were determined through linear mixed models. Ten PM 2.5 -related CpG sites (mapped to 7 different genes) were observed with false discovery rate <0.05. Methylation levels of cg24821877, cg24862131, cg23530876, cg11149743 and cg10781276 were positively associated with PM 2.5 concentrations. While methylation levels of cg10314909, cg08968107, cg18362281, cg24663971 and cg17834632 were negatively associated with PM 2.5 concentrations. The top CpG was cg24663971 (P = 1.51✕10
−9 ). Among the above 10 sites, significantly positive associations of methylation levels of cg24663971 with FVC%pred and FEV 1 %pred, and cg10314909 with FVC, FVC%pred, and FEV 1 %pred were observed. Age had modification effect on the associations between cg24663971 methylation and FVC%pred, and the associations were more obvious among participants with age ≥58 years. In conclusion, PM 2.5 exposure was associated with DNA methylation, and PM 2.5 -related DNA methylation was associated with lung function among Wuhan urban non-smokers. [Display omitted] • Ten CpGs were linked to PM 2.5 exposure with false discovery rate <0.05. • Cg24663971 and cg10314909 methylation was positively associated with lung function. • PM 2.5 exposure concentrations at the individual level were estimated. • Blood DNA methylation at the epigenome level were determined. [ABSTRACT FROM AUTHOR]- Published
- 2023
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50. Increasing incidence of asbestosis worldwide, 1990–2017: results from the Global Burden of Disease study 2017
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Yang, Meng, Wang, Dongming, Gan, Shiming, Fan, Lieyang, Cheng, Man, Yu, Linling, Wang, Bin, Li, Wei, Ma, Jixuan, Zhou, Min, and Chen, Weihong
- Abstract
Global incidence and temporal trends of asbestosis are rarely explored. Using the detailed information on asbestosis from the Global Burden of Disease (GBD) 2017, we described the age-standardised incidence rate (ASIR) and its average annual percentage change. A Joinpoint Regression model was applied to identify varying temporal trends over time. Although the use of asbestos has been completely banned in many countries, the ASIR of asbestosis increased globally from 1990 to 2017. Furthermore, the most pronounced increases in ASIR of asbestosis were detected in high-income North America and Australasia. These findings indicate that efforts to change the asbestos regulation policy are urgently needed.
- Published
- 2020
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