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2 results on '"Chick, Brent Y."'

1. Switching under selection: how CoREST controls endocrine therapy resistance in ER+breast cancer

Author

Chick, Brent Y. and Hargreaves, Diana C.

Abstract

New research shows that the CoREST complex controls the acquisition of endocrine therapy resistance in estrogen receptor-positive breast cancers. Profiling data show that this resistance transition is accompanied by a functional retargeting of CoREST on chromatin in coordination with cJUN and SWI/SNF (cBAF).

Published
2022
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2. RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling

Author

Chick, Brent Y. and Hargreaves, Diana C.

Abstract

New research reports that paused RNA polymerase II (RNAPII) enhances the targeting and activity of BAF chromatin remodelers. These findings suggest a new paradigm for understanding how the collaborative action of chromatin remodelers and the transcriptional machinery govern cell-type-specific chromatin accessibility.

Published
2023
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