Search

Purpose: To investigate the clinical outcomes of Visian implantable collamer lens (ICL) implantation according to lens size and implantation angle.Setting: Onnuri Smile Eye Clinic, Seoul, Republic of Korea.Design: Retrospective case series.Methods: This study included 566 eyes of 283 patients treated with ICL implantation. Patients were divided into three groups: horizontally implanted same-sized ICL (group A), horizontally implanted different sized-ICL (group B: large ICL and small ICL) and same sized-ICL implanted with a different implantation angle (group C: horizontal and vertical).Results: At 12-month follow-up, the mean vault was 0.78 ± 17, 0.48 ± 0.13, 0.71 ± 0.18 and 0.44 ± 0.16 mm when large and small sized ICL was used in group B (p< 0.001), and when ICL was horizontally and vertically implanted in group C (p= 0.021), respectively. And the mean SE was −0.11 ± 0.30, −0.34 ± 0.42, −0.3 ± 0.56 and −0.64 ± 0.66 dioptres (D), when the large and the small sized ICL was used group B (p= 0.039), and when the ICL was horizontally and vertically implanted in group C (p= 0.036), respectively. No significant difference in UDVA, IOP and ECD between both eyes in groups B and C was observed. No statistical difference was found in the vault between both eyes for groups B and C.Conclusions: The vault was significantly higher and the SE was significantly more hyperopic when a larger-sized ICL was used or the ICL was horizontally implanted compared to when the ICL was vertically implanted.

PURPOSE:To report a case of successful bilateral small incision lenticule extraction (SMILE) performed on a patient who had penetrating keratoplasty and astigmatic keratotomy in the right eye and penetrating keratoplasty in the left eye.METHODS:Case report.RESULTS:Astigmatic keratotomy was used to reduce astigmatism of the right eye because astigmatism was higher than the maximum correction limitation of SMILE. Bilateral SMILE was performed afterward. Although there were no difficulties during lenticule separation and removal of the right eye, wound dehiscence occurred during lenticule separation of the left eye. Two sutures were used at both ends of the incision, and the remainder of the procedure was successfully completed. Visual acuity improved to 20/50 in both eyes without correction, and the corrected distance visual acuities were 20/50 and 20/30 in the right and left eyes, respectively, at the 6-month postoperative visit.CONCLUSIONS:SMILE is a potentially effective alternative in correcting refractive errors in patients following penetrating keratoplasty. However, studies with a larger patient population with longer follow-up periods are needed to confirm these initial findings.[[J Refract Surg.2016;32(9):644–647.]

This study investigates whether the neurohormone melatonin can prevent the retinal neuronal injury caused by reactive oxygen species (ROS) in cultured human retinal neuronal cells. Cultures of human retinal neuronal cells established from a variety of donors were grown to 14 days and then subjected to experimental hypoxanthine/xanthine oxidase (HX/XO)-induced injury. Intracellular production of ROS by administration of HX/XO was confirmed by flow cytometry; the ROS resulted in both apoptotic and necrotic pattern of cell death in the retinal neuron cultures. The efficacy of melatonin against ROS injury was quantitated by MTT assay, enzyme immunoassay, and immunocytochemistry for neurofilament protein. The antioxidative effect of melatonin was compared with that of α-tocopherol. Retinal neuronal injury significantly reduced in a dose–response manner by a treatment of 1.0–8.0 mM α-tocopherol. Melatonin, in concentrations of more than 2.0 mM, also significantly reduced the injury. About 70% of cells are rescued by pretreatment with 1.0 mM α-tocopherol and 8.0 mM melatonin in the MTT assay. Our observations suggest that melatonin can rescue retinal neurons from ROS injury in human retinal cell cultures.