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Molecularly imprinted polymers (MIP) have been an attractive area of research for the past couple decades. Even though they constitute a well-established field of functional materials MIPs still have to make their way into commercial applications. The lack thereof may be explained in part by the absence of MIP systems aimed at analytes that are of relevance in everyday life. In this article two different sensing applications are presented each targeting a clinically relevant analyte. These include the first-ever MIP of high density lipoprotein (HDL), which is exploited as a cardiovascular biomarker, as well as a MIP targeting Dengue virus particles. In both cases the data presented suggests that MIPs targeting these two particular analytes show characteristic behavior that makes them potentially suitable for diagnostic purposes. [ABSTRACT FROM AUTHOR]