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Analogues of the NPY model peptide NPY 1‐4‐Aca‐25‐36 were synthesized by solid phase peptide synthesis using the tea‐bag method for parallel peptide synthesis. The affinity of the peptides as ligands to the NPY receptor in rat cerebral cortex was investigated. The model compound NPY 1‐4‐Aca‐25‐36 was a relatively poor ligand to the NPY receptor in rat brain (IC50= 0.40 μM). Arg35and Arg33were both important for ligand recognition by the NPY receptor. Substitutions in several positions in the region corresponding to the C‐terminal part of NPY resulted in analogues with only minor reduction of the affinity for the NPY receptor.

Analogues of the NPY model peptide NPY 1-4-Aca-25-36 were synthesized by solid phase peptide synthesis using the tea-bag method for parallel peptide synthesis. The affinity of the peptides as ligands to the NPY receptor in rat cerebral cortex was investigated. The model compound NPY 1-4-Aca-25-36 was a relatively poor ligand to the NPY receptor in rat brain (IC 50= 0.40 μM). Arg 35and Arg 33were both important for ligand recognition by the NPY receptor. Substitutions in several positions in the region corresponding to the C-terminal part of NPY resulted in analogues with only minor reduction of the affinity for the NPY receptor.