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WE have examined recently blood containing fibrinolysins in high titre. The blood was taken from a man who was later diagnosed as suffering from prostatic malignancy. The presence of high-titre fibrinolysins, raised formal acid phosphatase, and greatly reduced fibrinogen content, were all carried out by routine, accepted biochemical methods, and were fully diagnostic. It was then considered that there could be present a circulating auto-immunological factor which we might be able to demonstrate.