1. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial
- Author
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Lyttle, Mark D, Rainford, Naomi E A, Gamble, Carrol, Messahel, Shrouk, Humphreys, Amy, Hickey, Helen, Woolfall, Kerry, Roper, Louise, Noblet, Joanne, Lee, Elizabeth D, Potter, Sarah, Tate, Paul, Iyer, Anand, Evans, Vicki, Appleton, Richard E, Pereira, Matthew, Hardwick, Susie, Messahel, Shrouk, Noblet, Joanne, Lee, Elizabeth D, Greenwood-Bibby, Rachel, Buchanan, Mark, Lewis, Lucy, Hughes, Sharon, Hartshorn, Stuart, Rogers, Louise, Hopkins, Juliet, Lyttle, Mark D, Fernandez, Daphin, Potter, Sarah, Lavigne-Smith, Holly R, Moulsdale, Phoebe, Smith, Alice, Bingham, Tracey, Ross, James, Ramsey, Natasha, Hacking, Jo, Mullen, Niall, Corrigan, Paul P, Prudhoe, Sarah, Faza, Hani, Robinson, Gisela, Sunley, Rachel C, Smith, Coral J, Unsworth, Vanessa, Criddle, John, Laque, Martin, Sheedy, Alyce B, Anderson, Mark, Bell, Kathryn, Devine, Kirsty, Scott, Alex, Kumar, Ramesh, Armstrong, Sonia, Sutherland, Emer, Cantle, Fleur, Helyer, Sinead, Riozzi, Paul, Cotton, Hannah, Downes, Alice J, Mollard, Helen, Roland, Damian, Hay, Felix, Gough, Christopher, Finucane, Sonya, Bevan, Catherine, Ramsay, Rebecca, Walton, Emily, Maney, Julie-Ann, Dalzell, Elizabeth, Millar, Muriel, Howells, Rachel J, Appelboam, Andy, Mackle, Daisy, Small, Jennie, Neil, Ashleigh, Choudhery, Vince, MacLeod, Stewart, Browning, Jen, O'Neill, Thomas, Grahamslaw, Julia, Parikh, Ami, Skene, Imogen, Thomas, Rhys, Potier de la Morandiere, Katherine, Wilson, Jill L, Danziger, Donna, Burke, Derek, Ramlakhan, Shammi, Evans, Jayne, Morcombe, Julie, Gormley, Stuart, Barling, Jason M, Cathie, Katrina, Bayreuther, Jane, Ensom, Ruth, Iqbal, Yasser, Rounding, Sarah, Mulligan, Joanne, Bell, Claire, McLellan, Shona, Leighton, Shona, Sajjanhar, Tina, Nyirenda, Maggie, Crome, Laura, Williamson, Neil, Alcock, Anastasia, Edwards, Sara, Morgan, Jeff, Powell, Colin VE, Ramesh, Chaniyil A, Kamal-Uddin, Solomon, Linney, Mike, Vamvakiti, Katia, Floyd, Sharon, and Hobden, Gill
- Abstract
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status epilepticus.
- Published
- 2019
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